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1. 发明授权

US09034891B2 Bicyclic heterocyclic spiro compounds 有权
标题翻译：双环杂环螺环化合物
公开(公告)号：US09034891B2
公开(公告)日：2015-05-19
申请号：US13804725
申请日：2013-03-14
申请人： Abraham Fisher , Nira Bar-Ner , Victoria Nachum
发明人： Abraham Fisher , Nira Bar-Ner , Victoria Nachum
IPC分类号： C07D513/10 , C07D498/10 , C07D491/10 , C07D491/20 , C07D495/10
CPC分类号： C07D513/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D498/10
摘要： There are provided certain bicyclic heterocyclic compounds that act as M1 muscarinic receptor modulators. Compositions containing these compounds and their use are also disclosed.
摘要翻译：提供某些作为M1毒蕈碱受体调节剂的双环杂环化合物。还公开了含有这些化合物的组合物及其用途。

2. 发明授权

US08591899B2 Diagnosis of Bacillus anthracis infection based on detection of bacterial secreted biomarkers 失效
标题翻译：基于细菌分泌生物标志物的检测对炭疽杆菌感染的诊断
公开(公告)号：US08591899B2
公开(公告)日：2013-11-26
申请号：US13257304
申请日：2010-03-22
申请人： Avigdor Shafferman , Ofer Cohen , Theodor Chitlaru , Sagit Sela-Abramovich , Orit Gat
发明人： Avigdor Shafferman , Ofer Cohen , Theodor Chitlaru , Sagit Sela-Abramovich , Orit Gat
IPC分类号： A61K39/40 , A61K39/00 , C07K16/00
CPC分类号： G01N33/56911 , C07K14/32 , C07K16/1278 , C12Q1/37 , G01N2333/32 , G01N2333/95
摘要： A novel and rapid diagnostic method for anthrax infection is provided. Three B. anthracis gene products are described, as well as antibodies against the same, which may be used for the detection and monitoring of anthrax infection. Kits for the diagnosis of anthrax are also provided.
摘要翻译：提供了一种新颖，快速的炭疽感染诊断方法。描述了三种炭疽芽孢杆菌基因产物，以及针对其的抗体，其可用于检测和监测炭疽感染。还提供了用于诊断炭疽的试剂盒。

3. 发明授权

US07572764B2 Uses of chemically-modified cholinesterases for detoxification of organophosporus compounds 失效
标题翻译：化学修饰的胆碱酯酶用于有机磷化合物的解毒
公开(公告)号：US07572764B2
公开(公告)日：2009-08-11
申请号：US10476338
申请日：2002-04-25
申请人： Ofer Cohen , Chanoch Kronman , Theodor Chitlaru , Baruch Velan , Avigdor Shafferman
发明人： Ofer Cohen , Chanoch Kronman , Theodor Chitlaru , Baruch Velan , Avigdor Shafferman
IPC分类号： A61K31/70 , A61K38/00
CPC分类号： C12N11/08 , A61K47/60 , C08G65/329 , C08L2203/02 , C12N9/18
摘要： A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.
摘要翻译：循环长寿命胆碱酯酶（ChE）蛋白，例如乙酰胆碱酯酶（AChE）或丁酰胆碱酯酶（BChE），其是用非抗原性聚合物修饰的ChE蛋白。 ChE可以是AChE，例如哺乳动物来源的或非哺乳动物来源的天然AChE，或重组AChE。重组AChE可以在一个或多个氨基酸残基处突变。 BChE可以是哺乳动物来源或非哺乳动物来源的天然BChE。

4. 发明申请

US20080306103A1 METHODS AND COMPOSITIONS FOR TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS AND NOVEL COMPOUNDS USEFUL THEREFOR 审中-公开
标题翻译：用于治疗中枢和外周神经系统疾病的方法和组合物及其有用的新型化合物
公开(公告)号：US20080306103A1
公开(公告)日：2008-12-11
申请号：US12138261
申请日：2008-06-12
申请人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
发明人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
IPC分类号： A61K31/438 , C07D495/10 , A61P43/00
CPC分类号： C07D513/10 , C07B2200/05 , C07D471/10 , C07D491/10
摘要： There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.
摘要翻译：提供了治疗涉及周围和中枢神经系统功能障碍的疾病的方法，包括给予一种或多种螺环化合物。还提供了可用于这些方法的药物组合物，用于制备这种药物组合物的化合物，用于制备用于实施这种方法的化合物的方法，以及一些新的这类化合物本身。

5. 发明授权

US5296380A Method and kit for detecting explosives 失效
标题翻译：检测爆炸物的方法和试剂盒
公开(公告)号：US5296380A
公开(公告)日：1994-03-22
申请号：US939828
申请日：1992-09-03
申请人： Yair Margalit
发明人： Yair Margalit
IPC分类号： G01N21/78 , G01N31/22 , G01N33/22
CPC分类号： G01N31/22 , F41H11/134 , F42B35/00 , Y10T436/17 , Y10T436/173076 , Y10T436/173845 , Y10T436/19
摘要： In a color reaction method for detecting particular classes of explosives, a sample from a suspect source is subjected serially to the indicated reagents in the liquid phase, the reagents after the first being applied only if no color reaction has been obtained in the preceding test. The second and third reagents only are applied in presence of the preceding reagent(s). The first reagent is an alkaline solution of a diazotizable aminoaromatic azo-dye precursor, which detects nitroaromatic explosives. The second reagent is a strongly acidic reagent containing a nitrate to nitrite ion reducing agent and a diazo-coupler, which detects organic nitrates and nitramines. The third reagent is zinc powder suspended in a liquid, which detects inorganic nitrates. The fourth reagent is an aniline salt in a homogeneous strongly acidic solution including a water-miscible organic solvent, which detects chlorates and bromates. The invention includes also a test kit for use in the method.
摘要翻译：在用于检测特定类别的爆炸物的彩色反应方法中，将来自可疑源的样品连续地进入液相中指定的试剂，仅在前一试验中没有获得显色反应的情况下，首次施用试剂。第二和第三试剂仅在前一试剂存在下使用。第一种试剂是可重氮化氨基偶氮染料前体的碱性溶液，其可以检测硝基芳族炸药。第二种试剂是含有硝酸根至亚硝酸根离子还原剂和重氮偶合剂的强酸性试剂，其检测有机硝酸盐和硝胺。第三试剂是悬浮在液体中的锌粉，其检测无机硝酸盐。第四试剂是均匀强酸性溶液中的苯胺盐，其包括水混溶性有机溶剂，其检测氯酸盐和溴酸盐。本发明还包括用于该方法的测试试剂盒。

6. 发明公开

US20230337625A1 SYSTEM AND METHOD FOR ACTIVITY MONITORING OF ANIMALS IN HOMECAGES 审中-公开
公开(公告)号：US20230337625A1
公开(公告)日：2023-10-26
申请号：US17799947
申请日：2021-02-16
申请人： GOVERNMENT OF ISRAEL – THE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IIBR)
发明人： YARON VAGIMA , SHLOMY MAIMON , EFI YITZHAK
IPC分类号： A01K1/03 , G01V8/20
CPC分类号： A01K1/031 , G01V8/20
摘要： A homecage monitoring system including: a detection assembly including: a single detector including a retroreflective-sensor; a mounting assembly configured for mounting of the single detector thereto and for attachment of the mounting assembly to a cage rack adjacent to a homecage to be monitored; and a controller in data communication with the single detector and adapted for collecting the output data from the single detector.

7. 发明公开

US20230312877A1 NON-HALOGENATED MULTI-MELAMINE FLAME-RETARDANT COMPOUNDS AND SALTS THEREOF AND PROCESSES FOR THEIR PREPARATION 审中-公开
公开(公告)号：US20230312877A1
公开(公告)日：2023-10-05
申请号：US18023088
申请日：2021-08-18
申请人： STATE OF ISRAEL, PRIME MINISTERS OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH
发明人： Dana MIZRAHI
IPC分类号： C08K5/3492 , C08K5/5399 , C09K21/10 , C09K21/12 , C09K21/14
CPC分类号： C08K5/34922 , C08K5/34928 , C08K5/5399 , C09K21/10 , C09K21/12 , C09K21/14
摘要： Non-halogenated melamine compounds for use as flame retardants are characterized by having a TGA25 value of at least 200 degrees Centigrade, a TGA50 value of at least 300 degrees Centigrade, or a TGA75 value of at least 500 degrees Centigrade, as measured on a thermogravimetric analysis (TGA) curve produced at a heating rate of 10 degrees Centigrade per minute and at a 60 mL/min oxygen or nitrogen flow, said compounds being small molecules, linear or branched polymers, or salts thereof.

8. 发明授权

US08011224B2 Method and device for detecting and identifying chemical agents 失效
标题翻译：用于检测和识别化学试剂的方法和装置
公开(公告)号：US08011224B2
公开(公告)日：2011-09-06
申请号：US11631524
申请日：2005-06-01
申请人： Shai Kendler , Adi Zifman , Netzah Gratziany , Amnon Sharon , Gad Frishman
发明人： Shai Kendler , Adi Zifman , Netzah Gratziany , Amnon Sharon , Gad Frishman
IPC分类号： B01D53/02 , G01N1/40 , G01N30/62
CPC分类号： G01N1/405 , G01N35/1097
摘要： A feeding device for enriching and feeding a fluid sample into a chemical detector, the feeding device comprises (a) a sorbent element having a sorbent material for sorbing at least one target chemical present in the fluid sample; (b) a desorbing mechanism for generating conditions for the sorbent material to desorb the at least one target chemical out of the sorbent material, thereby to provide an enriched fluid sample; and (c) a loose connector, for providing a loose connection between the feeding device and the chemical detector, such that when the sorbent material desorbs the at least one target chemical, the chemical detector is fed by the enriched fluid sample, and when the sorbent material sorbs the at least one target chemical, the chemical detector is fed by environmental fluids.
摘要翻译：一种用于将流体样品富集和供给到化学检测器的进料装置，所述进料装置包括（a）吸附剂元件，其具有用于吸附流体样品中存在的至少一种目标化学物质的吸附剂材料; （b）解吸机构，用于产生用于吸附剂材料将吸附剂材料中的至少一种目标化学物质解吸的条件，从而提供富集的流体样品; 以及（c）松动的连接器，用于在所述进料装置和所述化学检测器之间提供松散的连接，使得当所述吸附材料解吸所述至少一种目标化学品时，所述化学检测器由富集的流体样品进料，吸附材料吸收至少一种目标化学物质，化学检测器由环境流体进料。

9. 发明授权

US07049321B2 Methods and pharmaceutical compositions for treatment of central and peripheral nervous system disorders and compounds useful therefor 失效
标题翻译：用于治疗中枢和周围神经系统疾病的方法和药物组合物及其有用的化合物
公开(公告)号：US07049321B2
公开(公告)日：2006-05-23
申请号：US10429277
申请日：2003-05-02
申请人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
发明人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
IPC分类号： A61K31/438 , C07D417/04
CPC分类号： C07D513/10 , C07B2200/05 , C07D471/10 , C07D491/10
摘要： There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more Spiro compounds. Also provided and pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.
摘要翻译：提供了治疗涉及周围和中枢神经系统功能障碍的疾病的方法，包括施用一种或多种螺环化合物。还提供了可用于这些方法的药物组合物，用于制备这种药物组合物的化合物，用于制备用于实施这些方法的化合物的方法，以及一些新的这类化合物本身。

10. 发明授权

US5480612A Kit for detecting explosives 失效
标题翻译：用于检测炸药的试剂盒
公开(公告)号：US5480612A
公开(公告)日：1996-01-02
申请号：US105714
申请日：1993-08-12
申请人： Yair Margalit
发明人： Yair Margalit
IPC分类号： G01N21/78 , G01N31/22 , G01N33/22 , G01N37/00
CPC分类号： G01N31/22 , F41H11/134 , F42B35/00 , Y10T436/17 , Y10T436/173076 , Y10T436/173845 , Y10T436/19
摘要： A kit for detecting nitroaromatic, organic nitrate, nitramine, inorganic nitrate, and chlorate and bromate explosives is characterized by the fact that for the detection of an inorganic nitrate, a reagent is used which comprises zinc powder suspended in a liquid comprising at least one water-miscible organic solvent, while for the detection of chlorates or bromates, a reagent is used which comprises an aniline salt in a homogeneous strongly acidic solution including at least one water-miscible organic solvent.
摘要翻译：用于检测硝基芳族化合物，有机硝酸盐，硝胺，无机硝酸盐和氯酸盐和溴酸盐炸药的试剂盒的特征在于，为了检测无机硝酸盐，使用试剂，其包含悬浮在包含至少一种水的液体中的锌粉末而对于氯酸盐或溴酸盐的检测，使用的试剂包括在包含至少一种水混溶性有机溶剂的均相强酸性溶液中的苯胺盐。

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