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1. 发明授权

US09903803B2 Flow cytometer signal peak identification employing dynamic thresholding 有权
公开(公告)号：US09903803B2
公开(公告)日：2018-02-27
申请号：US15316427
申请日：2015-06-03
申请人： Intellicyt Corporation
发明人： Andrew W. Smolak , Jean-Luc Fraikin , Erica Dawson Tenent , Kathy L. Rowlen
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1006 , G01N2015/1461
摘要： Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.

2. 发明申请

US20120061584A1 System and Method for Separating Samples in a Continuous Flow 有权
标题翻译：在连续流中分离样品的系统和方法
公开(公告)号：US20120061584A1
公开(公告)日：2012-03-15
申请号：US13321809
申请日：2010-05-21
申请人： Linda Trinkle , Thomas Duensing
发明人： Linda Trinkle , Thomas Duensing
IPC分类号： G01N21/01
CPC分类号： G01N15/0211 , G01N15/1012 , G01N15/1459 , G01N35/00 , G01N35/08 , G01N2015/1006
摘要： One embodiment of the present invention provides for a method for identifying within a single record the location of each of a plurality of samples suspected of containing particles of interest wherein the single record is obtained from a flowing stream of the plurality of samples passing through a particle analyzer. The method comprises introducing into a conduit the plurality of samples suspected of containing particles of interest wherein each ones of the plurality of samples are separated by fluid gaps to produce a plurality of samples separated by fluid gaps and wherein each of the plurality of samples further comprises marker particles. The plurality of samples separated by fluid gaps are flowed through the conduit as a flowing sample stream to a detector of a particle analyzer, which may be a flow cytometer. The particles of interest are detected as the samples pass the detector of the particle analyzer.
摘要翻译：本发明的一个实施例提供了一种用于在单个记录中识别怀疑含有感兴趣的颗粒的多个样品中的每一个的位置的方法，其中单个记录是从多个样品通过颗粒的流动流获得的分析仪该方法包括将许多怀疑含有感兴趣的颗粒的样品引入导管中，其中多个样品中的每一个样品被流体间隙分离以产生由流体间隙分离的多个样品，并且其中多个样品中的每一个进一步包含标记颗粒。通过流体间隙分离的多个样品作为流动的样品流流过导管，进入可以是流式细胞仪的颗粒分析仪的检测器。当样品通过粒子分析仪的检测器时，检测到感兴趣的颗粒。

3. 发明授权

US10048191B2 Methods and apparatus for real-time detection and clearing of a clog 有权
公开(公告)号：US10048191B2
公开(公告)日：2018-08-14
申请号：US15411366
申请日：2017-01-20
申请人： Intellicyt
发明人： Aaron B. Kennington
IPC分类号： A61B6/00 , G01N15/14
摘要： A flow cytometer apparatus and methods for detecting and clearing a clog therein are disclosed. An example method for detecting a clog may include (i) detecting, via a fault detection system of a flow cytometer, a first plurality of events associated with a first aliquot from a first sample well, (ii) determining a count of the first plurality of events associated with the first aliquot, (iii) determining whether the count of the first plurality of events is below a minimum count tolerance and (iv) (a) if the count of the first plurality of events is below the minimum count tolerance, then determining that the flow cytometer has a clog, (b) if the count of the first plurality of events is equal to or above the minimum count tolerance, then detecting a second plurality of events associated with a second aliquot from a second sample well.

4. 发明授权

US09880085B2 Flow cytometer system including flow cytometer, autosampler and system integration structure 有权
公开(公告)号：US09880085B2
公开(公告)日：2018-01-30
申请号：US15127732
申请日：2015-03-13
申请人： IntelliCyt Corporation
发明人： Garrett S. Wilson , Braden L. Smith , Michael A. Artinger , Francis Kevin Kohlmeier , Christopher H. Converse
IPC分类号： B01L9/00 , G01N33/00 , C12Q1/68 , G01N15/14 , B01L3/00 , G01N35/10
CPC分类号： G01N15/1404 , B01L3/502 , B01L2200/026 , B01L2300/0609 , B01L2300/0858 , B01L2300/0867 , B01L2300/123 , G01N1/10 , G01N15/1459 , G01N35/00 , G01N35/1095 , G01N2015/1409
摘要： A flow cytometer system includes a flow cytometer, an autosampler and a system integration structure to accommodate interconnection and interface of the flow cytometer and autosampler for operation together and providing for convenient interface with equipment for handling process liquids.

5. 发明授权

US09797917B2 Contact sensing probe and methods of use for microplate liquid sampling 有权
公开(公告)号：US09797917B2
公开(公告)日：2017-10-24
申请号：US14798115
申请日：2015-07-13
申请人： Intellicyt
发明人： Stephen M. Barnes , Aaron B. Kennington
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/1011
摘要： An apparatus and method for detecting microplate well surface contact and setting standoff is provided. The apparatus may include a sample probe, coupled to a spring-loaded carriage, and a sensor configured to detect when the sample probe is in contact with a surface. The sample probe is moved toward a surface of a well in a well-plate until the sample end of the sample probe contacts the surface, whereby the carriage allows the probe to be displaced. Displacement of the probe is detected by the sensor and further downward movement of the carriage is stopped. A processor records the location of the sample probe and sets standoff based on the recorded location.

6. 发明授权

US09012235B2 Multi-sample particle analyzer and method for high throughput screening 有权
标题翻译：多样品粒子分析仪和高通量筛选方法
公开(公告)号：US09012235B2
公开(公告)日：2015-04-21
申请号：US13588984
申请日：2012-08-17
申请人： Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
发明人： Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
IPC分类号： G01N35/08 , G01N35/10
CPC分类号： G01N15/14 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0684 , B01L2300/0829 , B01L2300/0832 , B01L2300/0877 , B01L2400/0481 , G01N15/1404 , G01N35/08 , G01N35/1067 , G01N35/1074 , G01N35/1095 , G01N2015/0019
摘要： Embodiments of the present invention provide a system and method for analyzing a plurality of samples comprising obtaining with an autosampler a plurality of samples from a first plate having a plurality of sample wells wherein the autosampler has a plurality of probes for sampling a set of samples and wherein each probe of the plurality of probes is in communication with a separate flow cytometer via a separate conduit. The plurality of samples comprising particles is moved into a fluid flow stream for each separate conduit. Adjacent ones of the plurality of samples are separated from each other in the fluid flow stream by a separation gas, thereby forming a gas-separated fluid flow stream. The gas-separated fluid flow stream is independently guided to and through each separate flow cytometer.
摘要翻译：本发明的实施方案提供了一种用于分析多个样品的系统和方法，包括用自动进样器从具有多个样品孔的第一板获得多个样品，其中所述自动进样器具有用于对一组样品进行取样的多个探针，其中所述多个探针中的每个探针经由单独的导管与独立的流式细胞仪连通。将包含颗粒的多个样品移动到用于每个单独管道的流体流动流中。通过分离气体在流体流动流中将多个样品中的相邻的样品彼此分离，从而形成气体分离的流体流动流。气体分离的流体流被独立地引导并通过每个单独的流式细胞仪。

7. 发明授权

US10184878B2 Flow cytometer signal peak identification employing dynamic thresholding 有权
公开(公告)号：US10184878B2
公开(公告)日：2019-01-22
申请号：US15871731
申请日：2018-01-15
申请人： IntelliCyt Corporation
发明人： Andrew W. Smolak , Jean-Luc Fraikin , Erica Dawson Tenent , Kathy L. Rowlen
IPC分类号： G01N15/14 , G01N15/10
摘要： Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.

8. 发明授权

US09927346B2 Flow cytometer system including flow cytometer, autosampler and system integration structure 有权
公开(公告)号：US09927346B2
公开(公告)日：2018-03-27
申请号：US15715464
申请日：2017-09-26
申请人： IntelliCyt Corporation
发明人： Garrett S. Wilson , Braden L. Smith , Michael A. Artinger , Francis Kevin Kohlmeier , Christopher H. Converse
IPC分类号： B01L9/00 , G01N33/00 , C12Q1/68 , G01N15/14 , G01N35/10 , B01L3/00
CPC分类号： G01N15/1404 , B01L3/502 , B01L2200/026 , B01L2300/0609 , B01L2300/0858 , B01L2300/0867 , B01L2300/123 , G01N1/10 , G01N15/1459 , G01N35/00 , G01N35/1095 , G01N2015/1409
摘要： A flow cytometer system includes a flow cytometer, an autosampler and a system integration structure to accommodate interconnection and interface of the flow cytometer and autosampler for operation together and providing for convenient interface with equipment for handling process liquids.

9. 发明授权

US09897531B2 Flow cytometry sample separation methods and apparatus 有权
公开(公告)号：US09897531B2
公开(公告)日：2018-02-20
申请号：US14729838
申请日：2015-06-03
申请人： Intellicyt
发明人： Constantine I. Andreev , Matthew Hess , Joe Zock
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1425 , G01N2015/1415
摘要： A method for identifying sample boundaries of a plurality of samples is provided. The method includes moving a plurality of samples comprising particles into a fluid flow stream using a sampling probe and introducing marker beads into the fluid flow stream between adjacent samples in the plurality of samples via the sampling probe to produce a marker bead-separated plurality of samples in the fluid flow stream. Marker beads may be introduced into the fluid flow stream by introducing the marker beads from a chamber surrounding at least a portion of the sampling probe, or by introducing the marker beads from a cartridge having a pierceable membrane underlying at least one chamber, the at least one chamber containing marker beads. Sampling systems and apparatuses are also provided.

10. 外观设计

USD787701S1 Flow cytometer system shelf unit 有权
公开(公告)号：USD787701S1
公开(公告)日：2017-05-23
申请号：US29485766
申请日：2014-03-21
申请人： Intellicyt Corporation
设计人： Garrett S. Wilson , Braden L. Smith , Michael A. Artinger

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