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1. 发明授权

US09061267B2 Specific sorbent for binding proteins and peptides, and separation method using the same 有权
标题翻译：用于结合蛋白质和肽的比吸附剂，以及使用其的分离方法
公开(公告)号：US09061267B2
公开(公告)日：2015-06-23
申请号：US13515653
申请日：2010-12-17
申请人： Klaus Gottschall , Markus Arendt , Andres Kirschfeld , Christian Meyer , Markus Weis , Martin Welter , Lothar Ziser
发明人： Klaus Gottschall , Markus Arendt , Andres Kirschfeld , Christian Meyer , Markus Weis , Martin Welter , Lothar Ziser
IPC分类号： B01J20/26 , B01J43/00 , C07K1/18 , B01D15/38 , B01J20/32 , C07K1/22 , C07K16/06
CPC分类号： B01J20/267 , B01D15/3804 , B01J20/265 , B01J20/3242 , B01J20/3246 , B01J20/3248 , B01J20/3255 , B01J20/3282 , B01J20/3285 , B01J43/00 , C07K1/18 , C07K1/22 , C07K16/065
摘要： Sorbent comprising a solid support material, the surface of which comprises a first residue comprising a pyridyl ring, whose hydrogen atoms may be substituted, and a second residue comprising a carboxyl group. The first and second residues may be attached to a polymer which coats a carrier, but which polymer is not covalently grafted to the carrier. The sorbents can be used to separate or to increase the concentration and/or purity of a protein or peptide from a mixture containing the same.
摘要翻译：包含固体支持材料的吸附剂，其表面包含含有其氢原子可被取代的吡啶环的第一残基和包含羧基的第二残基。第一和第二残基可以连接到涂覆载体的聚合物，但是哪个聚合物不共价接枝到载体上。吸附剂可用于从含有该吸附剂的混合物中分离或增加蛋白质或肽的浓度和/或纯度。

2. 发明申请

US20150005487A1 SORBENT COMPRISING ON ITS SURFACE A CATIONIC OR PROTONIZABLE ALIPHATIC RESIDUE FOR THE PURIFICATION OF ORGANIC MOLECULES 有权
标题翻译：包含有机分子的阳离子或可分解残留残留物的表面活性剂
公开(公告)号：US20150005487A1
公开(公告)日：2015-01-01
申请号：US14344718
申请日：2012-09-17
申请人： INSTRACTION GMBH
发明人： Markus Arendt , Björn Degel , Thomas Schwarz , Gerhard Stumm , Martin Welter
IPC分类号： B01J20/286 , A61K31/47 , C07C215/12 , A61K31/573 , C07C225/06 , A61K31/337 , A61K31/724 , A61K31/365 , C07C211/09 , C07D295/185
CPC分类号： B01J20/286 , A61K31/337 , A61K31/365 , A61K31/47 , A61K31/573 , A61K31/724 , B01D15/3804 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J20/328 , B01J20/3285 , B01J2220/80 , C07B63/00 , C07C37/82 , C07C211/09 , C07C215/12 , C07C225/06 , C07D215/18 , C07D295/185 , C07D305/14 , C07D313/00 , C07D493/22 , C07H3/02 , C07H17/08 , C07C39/30
摘要： The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic application.
摘要翻译：本发明涉及包含固体支持材料的吸附剂，其表面包含通式（I）的残基，其中所述残基通过共价单键连接到本体固体的表面上的官能团支撑材料本身或固体支撑材料表面上的聚合物膜。此外，本发明涉及根据本发明的吸着剂用于纯化有机分子，特别是药学活性化合物，优选在色谱应用中的用途。

3. 发明授权

US11633718B2 Removal of bacteria from drinking water via filtration 有权
公开(公告)号：US11633718B2
公开(公告)日：2023-04-25
申请号：US16641049
申请日：2018-08-01
申请人： instrAction GmbH
发明人： Martin Welter , Christian Meyer , Kristian Lungfiel
IPC分类号： B01J20/26 , B01J20/28 , C02F1/28 , C02F1/50 , B01J20/32
摘要： The present invention relates to a method for producing biocidal, porous particles of a cross-linked polymer, and to the porous particles that can be produced according to the method of the invention. The invention further relates to porous particles of an amino-group-containing polymer (polyamine) having a relatively low swelling factor. The porous particles according to the invention are used to remove biological contaminants from water and to bind metal-containing ions from solutions. The present invention further relates to a filter cartridge which contains the porous cross-linked polymer particles according to the invention.

4. 发明申请

US20220159949A1 PARTICLES WITH BIOCIDAL COATING 有权
公开(公告)号：US20220159949A1
公开(公告)日：2022-05-26
申请号：US17437279
申请日：2020-03-13
申请人： instrAction GmbH
发明人： Martin Welter , Christian Meyer , Kristian Lungfiel
IPC分类号： A01N25/26 , B01J41/05 , B01J41/07 , B01J41/14 , B01J39/02 , B01J39/09 , B01J39/12 , A61L2/232 , C02F1/42 , C02F1/50
摘要： Process for the preparation of particles with antibacterial coating, which comprises the following steps: (a) providing an aqueous suspension containing a polyamine, a crosslinker and a porous organic or inorganic carrier material in particle form at a temperature lower than or equal to 10° C. in a mixer for coating the inorganic carrier material with the polyamine; (b) crosslinking the organic polymer in the pores of the inorganic carrier material and simultaneously removing water.

5. 发明申请

US20110257028A1 Method for selectively binding a substrate to sorbents by way of at least bivalent bonds 审中-公开
标题翻译：通过至少二价键选择性地将底物与吸附剂结合的方法
公开(公告)号：US20110257028A1
公开(公告)日：2011-10-20
申请号：US12807578
申请日：2010-09-09
申请人： Klaus Gottschall
发明人： Klaus Gottschall
IPC分类号： C40B30/04 , C07H1/00 , C07K1/107 , C07K16/00 , C12N7/00 , B01D15/08 , G01N33/53 , G01N33/573 , C12Q1/70 , C40B40/12 , C40B40/06 , C40B40/04 , C12N9/96 , C12N1/00
CPC分类号： B01J20/3253 , B01J20/3242 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3285 , G01N33/543
摘要： A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from a synthetic or natural first substrate, (ii) respectively applying at least two different groups capable of binding a second synthetic or natural substrate to one respective carrier, thereby forming at least one sorbent, whereby the groups are the same groups of step (i) or are groups that are complementary thereto, and the second substrate of step (ii) is the same or different from the first substrate according to step (i), and whereby the groups are determined such that the contributions of the Gibbs energies of the individual groups to the non-covalent bond with the second substrate yield a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs that results in an improved separation selectivity with respect to at least one substance to be separated off.
摘要翻译：一种用于制造具有至少两个能够结合底物的选择性结合的至少两个不同基团的吸附剂的方法，其特征在于其包括步骤（i）至（ii）：（i）确定至少两个能够结合来自合成或天然的第一底物的吸附剂的组，（ii）分别施加至少两个能够将第二合成或天然底物结合到一个相应载体上的不同基团，由此形成至少一种吸附剂，由此基团是步骤（i）的相同组或与其互补的基团，并且步骤（ii）的第二底物与根据步骤（i）的第一底物相同或不同，并且由此确定这些基团单个组的吉布斯能量对与第二衬底的非共价键的贡献产生吉布斯能量＆Dgr; G的负值，使得发生结合强化，导致改进相对于待分离的至少一种物质的ved分离选择性。

6. 发明授权

US11014071B1 Porous polymer material for bonding metal-containing ions or for purifying organic molecules 有权
公开(公告)号：US11014071B1
公开(公告)日：2021-05-25
申请号：US15777967
申请日：2016-11-25
申请人： instrAction GmbH
发明人： Martin Welter , Christian Meyer , Kristian Lungfiel , Thomas Schwarz
IPC分类号： B01D15/08 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/30 , B01J20/32 , C02F1/28 , C08J3/075 , B01D15/36 , C02F101/30 , C02F101/20
摘要： A method for producing porous particles of a cross-linked polymer, and porous particles that can be produced according to the method are disclosed. The porous particles of a crosslinked hydroxy- or amino-group-containing polymer have a relatively low swelling factor. A composite material contains the porous particles dispersed in a continuous aqueous phase. The porous particles, or the composite material, are used for purifying organic molecules and for bonding metals from solutions. A filter cartridge contains the porous particles of a cross-linked polymer or the composite material.

7. 发明申请

US20210078889A1 DEVICE FOR PURIFYING DRINKING WATER 有权
公开(公告)号：US20210078889A1
公开(公告)日：2021-03-18
申请号：US16963726
申请日：2019-01-23
申请人： instrAction GmbH
发明人： Martin Welter , Christian Meyer , Kristian Lungfiel
IPC分类号： C02F9/00 , B01D61/02 , B01D61/14 , C02F1/00
摘要： A device for the multi-stage, modular purification of drinking water is described, wherein a module comprises a chelating gel or a chelating and a bactericidal gel for heavy metal removal and/or for heavy metal removal and bacterial removal.

8. 发明申请

US20170106349A1 SPECIFIC SORBENT FOR BINDING PROTEINS AND PEPTIDES, AND SEPARATION METHOD USING THE SAME 审中-公开
公开(公告)号：US20170106349A1
公开(公告)日：2017-04-20
申请号：US14820670
申请日：2015-08-07
申请人： INSTRACTION GMBH
发明人： Klaus GOTTSCHALL , Markus ARENDT , Andres KIRSCHFELD , Christian MEYER , Markus WEIS , Martin WELTER , Lothar ZISER
IPC分类号： B01J20/286 , C07K1/22 , B01D15/38 , B01J20/32
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/3242 , B01J20/3255 , B01J20/327 , B01J20/3272 , B01J20/3282 , B01J20/3285 , C07K1/22
摘要： Sorbent comprising a solid support material, the surface of which comprises first residues comprising a binuclear heteroaromatic structure comprising besides carbon atoms at least one of the heteroatoms N, O, S, and second residues comprising a mononuclear heteroaromatic structure comprising besides carbon atoms at least one of the heteroatoms N, O, S.

9. 发明申请

US20140336355A1 ION-EXCHANGER MATERIAL WITH HIGH SALT-TOLERANCE 审中-公开
标题翻译：离子交换材料具有高耐盐性
公开(公告)号：US20140336355A1
公开(公告)日：2014-11-13
申请号：US14131954
申请日：2012-07-12
申请人： Markus Arendt , Gerhard Stumm , Martin Welter , Thomas Schwarz
发明人： Markus Arendt , Gerhard Stumm , Martin Welter , Thomas Schwarz
IPC分类号： C07K1/18
CPC分类号： C07K1/18 , B01J20/261 , B01J20/262 , B01J20/28004 , B01J20/28019 , B01J20/28083 , B01J20/28085 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/327 , B01J20/3282 , B01J20/3293 , B01J39/05 , B01J39/19 , B01J39/20 , B01J47/014 , B01J47/016
摘要： The present invention relates to a crosslinked sulphonated polymer or a crosslinked sulphonated polymer coated with a crosslinked polymer containing amino groups for use as an ion exchanger material of high salt tolerance for separating off macromolecules from a solution which originates from a biological source.
摘要翻译：本发明涉及一种交联磺化聚合物或交联磺化聚合物，该交联磺化聚合物涂覆有含有氨基的交联聚合物，用作高盐耐性的离子交换材料，用于将大分子从源自生物来源的溶液中分离出来。

10. 发明授权

US11433374B2 Sorbent for binding metals and production thereof 有权
公开(公告)号：US11433374B2
公开(公告)日：2022-09-06
申请号：US16735072
申请日：2020-01-06
申请人： instrAction GmbH
发明人： Christian Meyer , Martin Welter , Thomas Schwarz
IPC分类号： B01J20/32 , C02F1/28 , B01J20/34 , C02F101/20
摘要： The present invention relates to a sorbent which is suitable for binding metals from solutions, the production of a corresponding sorbent as well as the use of the sorbent for binding metals from solutions.

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