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1. 发明授权

US07682630B2 Antitumor agent and process for producing the same 有权
标题翻译：抗肿瘤剂及其制备方法
公开(公告)号：US07682630B2
公开(公告)日：2010-03-23
申请号：US10514892
申请日：2004-02-02
申请人： Hiroshi Maeda , Khaled Greish
发明人： Hiroshi Maeda , Khaled Greish
IPC分类号： A61K47/48 , A61K33/24 , A61K9/51
CPC分类号： A61K33/24 , A61K9/1075 , A61K47/58 , A61K47/6907
摘要： The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA) and low molecule antitumor agent which is anthracyclins drug such as pirarubicin, doxorubicm, epirbicin, daunorbicin, acralbicin, or alkaloid antitumor agent such as cis-platinum, and taxol These polymeric antitumor agents may improve specificity to cancer cells so that it improves antitumor effect, while it may not be concentrated at normal organ or tissue, so that adverse effect may be diminished. These polymeric antitumor agents may be prepared by dissolving SMA and low molecule antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complex and recovering polymer fraction.
摘要翻译：本发明涉及通过苯乙烯马来酸共聚物（SMA）和低分子抗肿瘤剂之间的分子间键合或相互作用形成聚合物胶束复合物的聚合物抗肿瘤剂，其是蒽环类药物，例如吡柔比星，多柔比星，表赤霉素，柔红霉素，或生物碱抗肿瘤剂如顺铂和紫杉醇这些聚合抗肿瘤剂可以改善对癌细胞的特异性，从而提高抗肿瘤作用，而不会将其集中在正常的器官或组织，从而可能减少不良反应。这些聚合抗肿瘤剂可以通过将SMA和低分子抗肿瘤剂溶解在水溶液中，然后在水溶性碳二亚胺，氨基酸或多胺的存在下，调节pH以形成胶束复合物并回收聚合物级分来制备。

2. 发明申请

US20030157085A1 Antitumor agents 审中-公开
公开(公告)号：US20030157085A1
公开(公告)日：2003-08-21
申请号：US10314439
申请日：2002-12-09
申请人： Hiroshi Maeda
发明人： Hiroshi Maeda , Tomohiro Sawa , Takaaki Akaike
IPC分类号： A61K038/44 , A61K031/522
CPC分类号： C12Y117/03002 , A61K31/522 , A61K38/44 , A61K45/06 , A61K47/60 , C12N11/08 , A61K2300/00
摘要： An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration and of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.

3. 发明授权

US5464857A 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide derivatives and their use as therapeutic agents for maintaining blood pressure 失效
标题翻译： 2-苯基-4,4,5,5-四甲基咪唑啉-1-氧基-3-氧化物衍生物及其作为维持血压的治疗剂的用途
公开(公告)号：US5464857A
公开(公告)日：1995-11-07
申请号：US302872
申请日：1994-11-21
申请人： Hiroshi Maeda , Yoichi Miyamoto , Takaaki Akaike
发明人： Hiroshi Maeda , Yoichi Miyamoto , Takaaki Akaike
IPC分类号： A61K31/415 , C07D233/06 , C07D233/08 , C07D233/26
CPC分类号： C07D233/26 , A61K31/415 , C07D233/06 , C07D233/08
摘要： (1) The imidazoline derivative represented by the following general formula (1) ##STR1## where R.sup.1 is a substituent endowed with water solubility or fat solubility, particularly carboxyl group or carboxymethoxy group or a pharmaceutically acceptable salt thereof, (2) The method for producing the above-mentioned compound, and (3) A therapeutic agent containing as its active ingredient the above-mentioned imidazoline derivative or an imidazoline derivative wherein R.sup.1 indicated in the formula (1) is hydrogen atom. The imidazoline derivative set forth under (1) above is a novel substance; and this compound itself and its derivative having R.sup.1 as indicated in the general formula (1) is hydrogen atom are useful as a therapeutic agent for treatment of shock from the fall in blood pressure by virtue of their ability to remove excess NO which is the vascular endothelium-derived relaxing factor (EDRF).
摘要翻译： PCT No.PCT / JP93 / 00044 Sec。 371日期：1994年11月21日 102（e）1994年11月21日PCT PCT 1993年1月14日PCT公布。第WO94 / 15921号公报日期：1994年7月21日。（1）由以下通式（1）表示的咪唑啉衍生物：其中R1是具有水溶性或脂溶性的取代基，特别是羧基或羧甲氧基或药学上（2）上述化合物的制造方法，（3）作为活性成分的上述咪唑啉衍生物或咪唑啉衍生物的治疗剂，其中，式（1）所示的R 1为氢原子。上述（1）所述的咪唑啉衍生物是新物质; 并且该化合物本身及其如通式（1）所示的具有R 1的衍生物是氢原子可用作治疗血压下降的治疗剂，因为其能够除去作为血管的过量的NO 内皮衍生松弛因子（EDRF）。

4. 发明授权

US5629211A Veterinary diagnostic test 失效
标题翻译：兽医诊断试验
公开(公告)号：US5629211A
公开(公告)日：1997-05-13
申请号：US642409
申请日：1996-05-03
申请人： Kazuhiro Tsutsumi
发明人： Kazuhiro Tsutsumi
IPC分类号： G01N33/50 , G01N33/52 , G01N33/84 , G01N33/20
CPC分类号： G01N33/52 , G01N33/84
摘要： A composite reagent, for a veterinary diagnostic test, which contains a color reagent substance to produce a color by reacting with either one or both of magnesium (Mg) ions and calcium (Ca) ions, a polyoxyethylene alkylphenyl ether, and a masking agent for interfering metal ions in a urine of an animal other than the Mg ions and the Ca ions.
摘要翻译：一种用于兽医诊断试验的复合试剂，其含有通过与镁（Mg）离子和钙（Ca）离子中的任一种或两者反应产生颜色的着色剂物质，聚氧乙烯烷基苯基醚和用于在Mg离子和Ca离子以外的动物的尿中的干扰金属离子。

5. 发明授权

US09636426B2 Polymer-type fluorescent molecule probe 有权
公开(公告)号：US09636426B2
公开(公告)日：2017-05-02
申请号：US14342879
申请日：2012-09-05
申请人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
发明人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号： A61Q5/12 , A61K49/00 , A61B1/04 , A61B1/313 , G01N33/574 , G01N33/58 , A61K41/00 , G01N21/33 , G01N21/64 , A61K47/48
CPC分类号： A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585
摘要： The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.

6. 发明申请

US20120122995A1 Anti-Inflammatory Agent and Cancer-Preventive Agent Comprising Canolol or Prodrug Thereof and Pharmaceutical, Cosmetic and Food Comprising the Same 有权
标题翻译：抗炎剂和包含其中的安非他酮或前药的癌症预防剂以及包含其的药物，化妆品和食品
公开(公告)号：US20120122995A1
公开(公告)日：2012-05-17
申请号：US13354507
申请日：2012-01-20
申请人： Hiroshi Maeda , Tetsuya Tsukamoto , Masae Tatematsu
发明人： Hiroshi Maeda , Tetsuya Tsukamoto , Masae Tatematsu
IPC分类号： A61K31/09 , A61P29/00
CPC分类号： A61K31/09
摘要： An anti-inflammatory agent or cancer-preventive agent comprising 4-vinyl-2,6-dimethoxyphenol of the formula (1): or a PD thereof.
摘要翻译：包含式（1）的4-乙烯基-2,6-二甲氧基苯酚或其PD的抗炎剂或防癌剂。

7. 发明授权

US07026488B2 Antitumor agents and process for producing the same 有权
标题翻译：抗肿瘤剂及其制备方法
公开(公告)号：US07026488B2
公开(公告)日：2006-04-11
申请号：US10484726
申请日：2002-08-29
申请人： Hiroshi Maeda , Tomohiro Sawa
发明人： Hiroshi Maeda , Tomohiro Sawa
IPC分类号： C07D209/56 , C07D53/00
CPC分类号： C07D487/22 , A61K47/60
摘要： Anticancer agents which contain as the active ingredient, a heme oxygenase inhibitory metalloporphyrin derivatives which are conjugated with amphipathic or water-soluble polymers (in particular, Zn-protoporphyrin (ZnPP) conjugated with polyethylene glycol). Because of being conjugated to amphipathic or water-soluble polymers, such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable anticancer effect owing to tumor selective delivery.
摘要翻译：含有作为活性成分的抗癌剂，与两亲性或水溶性聚合物（特别是与聚乙二醇缀合的锌原卟啉（ZnPP））缀合的血红素氧合酶抑制性金属卟啉衍生物。由于与两亲性或水溶性聚合物（例如聚乙二醇）缀合，可以通过静脉内注射施用活性成分，并且由于肿瘤选择性递送而具有显着的抗癌作用。

8. 发明授权

US4809462A Method of exterminating insects under the floor of a house or building 失效
标题翻译：在房屋或建筑物的地板下消灭昆虫的方法
公开(公告)号：US4809462A
公开(公告)日：1989-03-07
申请号：US906015
申请日：1986-09-11
申请人： Hiroshi Maeda
发明人： Hiroshi Maeda
IPC分类号： A01M1/14 , A01M1/24 , B05B7/14 , E04B1/72 , A01M1/20
CPC分类号： B05B7/1404 , A01M1/14 , A01M1/245 , B05B7/1486 , E04B1/72 , A01M2200/011
摘要： A method of exterminating harmful insects under the floor of a house or building comprises spraying insecticide into the enclosed area under the floor of the house or building. For the purposes of this patent application the meaning of the word insecticide encompasses substances which deter insect presence as well as substances which kill insects. The insecticide used, is in the form of a fine adhesive powder which is loaded into an airtight dispenser. The dispenser has an opening for the insecticide to pass through. The opening is initially blocked by insecticide while pressure inside the dispenser is increased. Subsequently, insecticide is forced out the dispenser opening and delivered to a nozzle which sprays the insecticide under the building floor at a high exit velocity. The air in the enclosed area under the floor of the building is stirred up by the fluid energy delivered by the jet of fine powser insecticide. The insecticide mixes with the disturbed air to be distributed to, and to coat exposed surfaces and adhere in crevices in the area under the building floor.
摘要翻译：灭菌房屋或建筑物地板下的有害昆虫的方法包括将杀虫剂喷洒在房屋或建筑物地板下的封闭区域内。为了本专利申请的目的，杀虫剂一词的含义包括阻止昆虫存在的物质以及杀死昆虫的物质。使用的杀虫剂是加载到气密分配器中的精细粘合剂粉末的形式。分配器具有用于杀虫剂通过的开口。开口最初被杀虫剂阻挡，同时分配器内的压力增加。随后，杀虫剂被迫离开分配器开口并被输送到喷嘴，喷嘴以高出口速度将杀虫剂喷洒在建筑物地板下方。建筑物地板下方封闭区域的空气被细粉杀虫剂喷射的液体能量搅动。杀虫剂与受干扰的空气混合，分配到暴露的表面并涂覆在建筑物地板下方的裂缝中。

9. 发明授权

US11036203B2 Fabrication system, fabrication estimation system, information processing apparatus, fabricating apparatus, fabricating method, and recording medium 有权
公开(公告)号：US11036203B2
公开(公告)日：2021-06-15
申请号：US16352026
申请日：2019-03-13
申请人： Wataru Sugawara , Hiroshi Maeda , Yoshinobu Takeyama , Tsukasa Matsuoka , Yoichi Ito , Shingo Nagatsuka
发明人： Wataru Sugawara , Hiroshi Maeda , Yoshinobu Takeyama , Tsukasa Matsuoka , Yoichi Ito , Shingo Nagatsuka
IPC分类号： G05B19/4099 , B33Y50/02 , G01B11/24 , B29C64/393 , G06F30/20
摘要： A fabrication system for fabricating a three-dimensional object includes processing circuitry. The processing circuitry estimates, according to a fabrication condition and fabrication data, a three-dimensional object to be fabricated according to the fabrication data and corrects the fabrication data according to an estimation result of the three-dimensional object estimated by the processing circuitry.

10. 发明授权

US10946109B2 Polymer-type fluorescent molecule probe 有权
公开(公告)号：US10946109B2
公开(公告)日：2021-03-16
申请号：US15488952
申请日：2017-04-17
申请人： Hiroshi Maeda
发明人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号： A61B1/04 , A61K49/00 , A61B1/313 , G01N21/33 , G01N21/64 , A61K41/00 , G01N33/574 , G01N33/58 , A61K47/58
摘要： The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.

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