专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080234345A1 METHOD FOR REDUCING OR ALLEVIATING INFLAMMATION IN THE DIGESTIVE TRACT 审中-公开
标题翻译：用于减少或消除污染物中的炎症的方法
公开(公告)号：US20080234345A1
公开(公告)日：2008-09-25
申请号：US11851694
申请日：2007-09-07
申请人： Louis Anthony Tartaglia , Thomas Michael Barnes , Robert Mark Coopersmith , Scott Edward Malstrom , David William White , Dominic Picarella
发明人： Louis Anthony Tartaglia , Thomas Michael Barnes , Robert Mark Coopersmith , Scott Edward Malstrom , David William White , Dominic Picarella
IPC分类号： A61K31/4172 , A61P29/00 , A61P1/00
CPC分类号： A61K31/00 , A61K31/40 , A61K2300/00
摘要： A method is provided for reducing or alleviating inflammation or a pathological process associated therewith or secondary thereto in a subject having an inflammatory disease of the digestive tract. The method comprises administering to the subject an anti-inflammatorily effective amount of an ACE2 inhibitor.
摘要翻译：提供了一种减轻或缓解具有消化道炎性疾病的受试者的炎症或与其相关的或与之相关的病理过程的方法。该方法包括向受试者施用抗炎剂有效量的ACE2抑制剂。

2. 发明授权

US07321830B2 Identifying drugs for and diagnosis of benign prostatic hyperplasia using gene expression profiles 失效
标题翻译：使用基因表达谱鉴定良性前列腺增生的药物和诊断
公开(公告)号：US07321830B2
公开(公告)日：2008-01-22
申请号：US09960706
申请日：2001-09-24
申请人： William E. Munger , Prakash Kulkarni , Robert H. Getzenberg , Iwao Waga , Jun Yamamoto
发明人： William E. Munger , Prakash Kulkarni , Robert H. Getzenberg , Iwao Waga , Jun Yamamoto
IPC分类号： G06F19/00 , G01N33/50 , C12Q1/68 , C07H21/04
CPC分类号： G06F19/20 , C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G06F19/24 , Y02A90/26
摘要： The present invention relates to a computer system comprising a database for elucidating changes in gene expression in prostate tissue isolated from patients exhibiting different clinical states of prostate hyperplasia as compared to normal prostate tissue, as well as the identification of individual genes that are differentially expressed in diseased prostate tissue.
摘要翻译：本发明涉及一种计算机系统，其包括用于阐明从正常前列腺组织显示不同临床前列腺增生症状的患者分离的前列腺组织中基因表达变化的数据库，以及鉴定在正常前列腺组织中差异表达的个体基因患病前列腺组织。

3. 发明申请

US20070082332A1 Molecular cardiotoxicology modeling 失效
标题翻译：分子心脏毒理学建模
公开(公告)号：US20070082332A1
公开(公告)日：2007-04-12
申请号：US10338044
申请日：2003-01-08
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/142 , C12Q2600/158 , G01N2500/00 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知心脏毒素的组织或细胞中毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

4. 发明申请

US20070020618A1 Process to study changes in gene expression in T lymphocytes 审中-公开
标题翻译：研究T淋巴细胞基因表达变化的过程
公开(公告)号：US20070020618A1
公开(公告)日：2007-01-25
申请号：US11408059
申请日：2006-04-21
申请人： Yatindra Prashar , Sherman Weissman
发明人： Yatindra Prashar , Sherman Weissman
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6809 , G01N33/505
摘要： Methods are disclosed to identify T lymphocyte genes that are differentially expressed upon exposure to a pathogen (viral or bacterial), immunogen, antigen, or in a sterile inflammatory disease, autoimmune disease, immunodeficiency disease, lymphocytic cancers, or graft versus host rejection. The method involves the preparation of a gene expression profile of a T lymphocyte population exposed to a pathogen or isolated from a subject having one of the aforementioned pathologies and comparing that profile to a profile prepared from quiescent T lymphocytes. The present invention is useful for identifying cytokine genes, genes encoding cell surface receptors and genes encoding intermediary signalling molecules. Related methods for identifying therapeutic or prophylatic immunomodulatory agents are present. Articles of manufacture are disclosed that comprise selected grouping of nucleic acids, affixed to a solid support, that correspond to genes that are differentially expressed in various populations or subpopulations of T lymphocytes at variations stages of T cell differentiation, in quiescent versus activated T lymphocytes or normal versus diseased T lymphocytes.
摘要翻译：公开了鉴定暴露于病原体（病毒或细菌），免疫原，抗原或无菌炎性疾病，自身免疫性疾病，免疫缺陷病，淋巴细胞性癌症或移植物与宿主排斥中差异表达的T淋巴细胞基因的方法。该方法涉及制备暴露于病原体或从具有上述病理学的受试者分离的T淋巴细胞群体的基因表达谱，并将其与由静止T淋巴细胞制备的分布进行比较。本发明可用于鉴定细胞因子基因，编码细胞表面受体的基因和编码中间信号分子的基因。存在用于鉴定治疗性或预防性免疫调节剂的相关方法。公开了包含选定的核酸组合，其固定在固体支持物上，所述核酸对应于在T细胞分化的不同阶段，在静止与活化的T淋巴细胞中在T淋巴细胞的不同种群或亚群中差异表达的基因，或正常与病态的T淋巴细胞。

5. 发明授权

US06951721B2 Method for determining the haplotype of a human BRCA1 gene 失效
标题翻译：确定人类BRCA1基因单体型的方法
公开(公告)号：US06951721B2
公开(公告)日：2005-10-04
申请号：US09923327
申请日：2001-08-08
申请人： Patricia D. Murphy
发明人： Patricia D. Murphy
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00 , C07K14/4702 , C12Q1/6827 , C12Q1/6886 , C12Q2600/172
摘要： Methods for identifying functional allele profiles of a given gene are disclosed. Functional allele profiles comprise the commonly occurring alleles in a population, and the relative frequencies at which such alleles of a given gene occur. Functional allele profiles are useful in treatment and diagnosis of diseases, for genetic and pharmacogenetic applications and for evaluating the degree to which the gene(s) are under selective pressure.
摘要翻译：公开了用于鉴定给定基因的功能性等位基因谱的方法。功能等位基因谱包括群体中常见的等位基因，以及发生给定基因的这种等位基因的相对频率。功能等位基因谱可用于治疗和诊断疾病，用于遗传和药物遗传学应用，并用于评估基因在选择压力下的程度。

6. 发明授权

US6109776A Method and system for computationally identifying clusters within a set of sequences 失效
标题翻译：用于计算地识别一组序列内的簇的方法和系统
公开(公告)号：US6109776A
公开(公告)日：2000-08-29
申请号：US63450
申请日：1998-04-21
申请人： Juergen Haas
发明人： Juergen Haas
IPC分类号： G06F17/30 , G06F19/22 , G06F19/24 , G01N1/00 , C12Q1/68 , G01N31/00 , G06G7/48
CPC分类号： G06F19/24 , G06F19/22
摘要： A method and system for computationally analyzing an initial set of patterns in order to identify subsets of patterns, called clusters, that contain common sub-patterns. The patterns of the initial set of patterns are represented as linear sequences of subunits, and the common sub-patterns occur as sub-sequences of subunits within the linear sequences starting at different positions within the different linear sequences. Variations in the offset and in the sequence of subunits within a common sub-pattern are considered in the analysis. In one embodiment, an initial set of oligonucleotide sequences that are produced by various biochemical techniques are computationally analyzed to identify clusters that may correspond to a number of different binding sites for DNA-binding proteins within one or more double-stranded DNA duplexes. The method places each oligonucleotide sequence within a new cluster and calculates an initial information weight matrix for that cluster. Then, other sequences from the initial set of sequences are added to the cluster and the information weight matrix of the cluster is re-computed until the information content of the information weight matrix falls below a threshold value.
摘要翻译：一种用于计算分析初始图案集的方法和系统，以便识别包含公共子模式的称为簇的图案子集。初始模式集合的模式被表示为子单元的线性序列，并且公共子模式作为从不同线性序列内的不同位置开始的线性序列内的子单元的子序列出现。在分析中考虑了共同子模式中偏移量和子单元序列的变化。在一个实施方案中，通过各种生物化学技术产生的初始寡核苷酸序列集合被计算分析以鉴定可以对应于一个或多个双链DNA双链体内DNA结合蛋白的多个不同结合位点的簇。该方法将每个寡核苷酸序列置于新的簇内，并计算该簇的初始信息权重矩阵。然后，将来自初始序列集合的其他序列添加到群集，并且重新计算群集的信息加权矩阵，直到信息加权矩阵的信息内容低于阈值。

7. 发明申请

US20070293498A1 Modulators of melanocortin receptor 失效
标题翻译：黑皮质素受体的调节剂
公开(公告)号：US20070293498A1
公开(公告)日：2007-12-20
申请号：US11878708
申请日：2007-07-26
申请人： Tricia Vos , Michael Patane , Michael Solomon , Christopher Blackburn , Mihaela Danca
发明人： Tricia Vos , Michael Patane , Michael Solomon , Christopher Blackburn , Mihaela Danca
IPC分类号： A61K31/40 , A61K31/166 , A61K31/4025 , A61K31/495 , A61P19/08 , A61P3/04 , C07D207/09 , C07D233/64 , C07D239/70 , C07D413/06 , C07D409/12 , C07D401/06 , C07D333/38 , C07D295/145 , C07D239/14 , C07D233/48 , C07C235/42 , A61P25/00 , A61K31/5375 , A61K31/4164 , A61K31/381
CPC分类号： C07C279/22 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/22 , C07D209/14 , C07D211/26 , C07D211/34 , C07D211/60 , C07D211/62 , C07D213/40 , C07D217/02 , C07D231/12 , C07D233/56 , C07D233/88 , C07D239/16 , C07D239/42 , C07D249/08 , C07D295/13 , C07D295/185 , C07D307/79 , C07D333/20 , C07D333/38 , C07D401/06 , C07D407/12 , C07D409/12 , C07D451/04 , C07D453/02 , C07D471/10
摘要： This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: wherein X is oxygen or sulfur; G is G1 or G2: L1, L2, L3 and Q are linker groups, and Rings A, B and C, and R1-R14 are described in the specification. The compounds are antagonists of melanocortin receptors.
摘要翻译：本发明提供了用于治疗黑皮质素受体相关疾病的化合物和方法，例如包括由癌症和其它慢性疾病引起的恶病质的体重减轻障碍。化合物由式I表示：其中X是氧或硫; G是G1或G2：L 1，L 2，L 3和Q是连接基，环A，B和C和在说明书中描述了R 1〜R 14。这些化合物是黑皮质素受体的拮抗剂。

8. 发明申请

US20070043515A1 Molecular toxicology modeling 失效
标题翻译：分子毒理学建模
公开(公告)号：US20070043515A1
公开(公告)日：2007-02-22
申请号：US11059535
申请日：2005-02-17
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/5014 , G01N33/5023 , G01N33/5067 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

9. 发明申请

US20070015147A1 Primary rat hepatocyte toxicity modeling 失效
标题翻译：原代大鼠肝细胞毒性建模
公开(公告)号：US20070015147A1
公开(公告)日：2007-01-18
申请号：US10357507
申请日：2003-02-04
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Orr , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Orr , Michael Elashoff
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/5014 , C12Q1/6876 , C12Q2600/158 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译：本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中的毒性标志物的鉴定。这些基因可用作药物筛选和毒性测定中的毒性标记。本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

10. 发明申请

US20070015146A1 Molecular nephrotoxicology modeling 审中-公开
公开(公告)号：US20070015146A1
公开(公告)日：2007-01-18
申请号：US10301856
申请日：2002-11-22
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： C12Q1/6876 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5044 , G16B25/00 , G16C20/30
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式