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1. 发明授权

US07964202B2 Method for treatment of common acne 有权
标题翻译：治疗常见痤疮的方法
公开(公告)号：US07964202B2
公开(公告)日：2011-06-21
申请号：US12076859
申请日：2008-03-24
申请人： Sandrine Orsoni , Nathalie Willcox
发明人： Sandrine Orsoni , Nathalie Willcox
IPC分类号： A61K8/02 , A61K31/07 , A61K31/075
CPC分类号： A61K31/20 , A61K9/0014 , A61K9/06 , A61K31/07 , A61K31/19 , A61K31/192 , A61K31/327 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, said dermatological/cosmetic composition having physical stability without loss of viscosity over time at a temperature ranging from 4° C. to 40° C., said dermatological/cosmetic composition having a stable flow threshold over time as measured by viscosity measurements for rheograms which measure a shear stress τ for a given rate gradient γ and which measure a rate gradient γ for a given shear stress τ, the yield value (τ0) being extrapolated visually or by calculation.
摘要翻译：适于预防或治疗细胞分化和/或增殖和/或角质化疾病（包括预防或治疗常见痤疮）的皮肤病学/化妆品组合物在生理学上可接受的培养基中包含（i）至少一种分散的类视色素，（ii）分散的苯甲酰基过氧化物，游离或包封形式，和（iii）至少一种不依赖于pH的胶凝剂，所述皮肤病学/化妆品组合物在4℃至40℃的温度下具有物理稳定性而不会随时间流失而粘度降低，所述皮肤病学/化妆品组合物具有稳定的时间流动阈值，通过测量给定速率梯度γ的剪切应力τ的流变图的粘度测量值测量，并且测量给定剪切应力τ的速率梯度γ，屈服值（τ0 ）通过视觉或计算进行外推。

2. 发明申请

US20110027367A1 ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS 审中-公开
公开(公告)号：US20110027367A1
公开(公告)日：2011-02-03
申请号：US12902931
申请日：2010-10-12
申请人： Michael Graeber , Janusz Czernielewski
发明人： Michael Graeber , Janusz Czernielewski
IPC分类号： A61K9/00 , A61K31/192 , A61P17/10 , A61K8/368 , A61Q17/04
CPC分类号： A61K31/192 , A61K8/36 , A61K8/362 , A61K8/368 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/07 , A61K31/203 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/6903 , A61Q17/04 , A61Q19/007 , A61Q19/008 , C07C2603/74 , Y10S514/859
摘要： Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.

3. 发明授权

US07838558B2 Administration of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid for the treatment of dermatological disorders 有权
标题翻译：施用6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘甲酸，用于治疗皮肤病
公开(公告)号：US07838558B2
公开(公告)日：2010-11-23
申请号：US12103182
申请日：2008-04-15
申请人： Michael Graeber , Janusz Czernielewski
发明人： Michael Graeber , Janusz Czernielewski
IPC分类号： A01N37/10 , A01N37/00 , A61K31/19 , A61K31/185 , A61K8/02
CPC分类号： A61K31/192 , A61K8/36 , A61K8/362 , A61K8/368 , A61K9/0014 , A61K9/06 , A61K9/08 , A61K31/07 , A61K31/203 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/6903 , A61Q17/04 , A61Q19/007 , A61Q19/008 , C07C2103/74 , C07C2603/74 , Y10S514/859
摘要： Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.
摘要翻译：具有炎性或增殖成分的皮肤疾病用含有0.3重量％的6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘酸（阿达帕林）或其盐的药物组合物进行处理，制成其药学上可接受的介质，有利地局部应用的凝胶，乳膏或洗剂。

4. 发明申请

US20080213347A1 Novel ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权
标题翻译： RAR受体的新型配体拮抗剂及其药物/化妆品应用
公开(公告)号：US20080213347A1
公开(公告)日：2008-09-04
申请号：US11978623
申请日：2007-10-30
申请人： Philippe Diaz , Catherine Raffin , Thibaud Biadatti
发明人： Philippe Diaz , Catherine Raffin , Thibaud Biadatti
IPC分类号： A61K9/127 , C07C63/06 , A61K31/192 , A61P31/12 , A61P17/06 , A61P17/10 , C07D213/80 , A61K31/455
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：

5. 发明申请

US20080176954A1 Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide 审中-公开
标题翻译：包含至少一种类视色素和过氧化苯甲酰的皮肤病学/美容凝胶
公开(公告)号：US20080176954A1
公开(公告)日：2008-07-24
申请号：US12076860
申请日：2008-03-24
申请人： Sandrine Orsoni , Nathalie Willcox
发明人： Sandrine Orsoni , Nathalie Willcox
IPC分类号： A61K31/07 , A61K31/327 , A61P17/10 , A61P17/14
CPC分类号： A61K31/20 , A61K9/0014 , A61K9/06 , A61K31/07 , A61K31/19 , A61K31/192 , A61K31/327 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° C. and 40° C.
摘要翻译：适于预防或治疗细胞分化和/或增殖和/或角质化疾病（包括预防或治疗常见痤疮）的皮肤病学/化妆品组合物在生理学上可接受的培养基中包含（i）至少一种分散的类视色素，（ii）分散的苯甲酰基过氧化物，游离或包封形式，和（iii）至少一种不依赖于pH的胶凝剂，其选自（a）聚丙烯酰胺胶凝剂，（b）与疏水链偶联的丙烯酸聚合物的胶凝剂，（c ）改性淀粉胶凝剂及其混合物，所述组合物在4℃至40℃的温度下保持良好的（i）和（ii）化学稳定性，而不会随时间降解。

6. 发明申请

US20080159969A1 Pharmaceutical Or Cosmetic Composition Comprising Mequinol And At Least One Depigmenting Agent 审中-公开
标题翻译：包含Mequinol和至少一种脱色剂的药物或化妆品组合物
公开(公告)号：US20080159969A1
公开(公告)日：2008-07-03
申请号：US11596356
申请日：2005-05-13
申请人： Isabelle Pelisson , Andre Jomard , Cecile Cousin
发明人： Isabelle Pelisson , Andre Jomard , Cecile Cousin
IPC分类号： A61K8/30 , A61K31/351 , A61K31/20 , A61Q17/04 , A61P17/00 , A61Q19/02 , A61K31/19 , A61K31/375
CPC分类号： A61K8/365 , A61K8/347 , A61K8/362 , A61K8/42 , A61K8/498 , A61K8/602 , A61K8/676 , A61Q19/00 , A61Q19/02
摘要： The invention relates to a pharmaceutical or cosmetic composition comprising, in a physiologically acceptable medium, mequinol and at least one depigmenting agent, and to the use thereof.
摘要翻译：本发明涉及药物或化妆品组合物，其包含在生理学上可接受的介质中，喹诺酮和至少一种脱色剂及其用途。

7. 发明申请

US20070065471A1 Cosmetic/dermatological applications of PPAR receptor activators 审中-公开
标题翻译： PPAR受体激活剂的化妆品/皮肤病学应用
公开(公告)号：US20070065471A1
公开(公告)日：2007-03-22
申请号：US11444371
申请日：2006-06-01
申请人： Andre Jomard , Michel Rivier
发明人： Andre Jomard , Michel Rivier
IPC分类号： A61K8/49 , A61K8/46 , A61K31/427 , A61K31/195
CPC分类号： A61Q19/008 , A61K8/44 , A61K8/445 , A61K8/447 , A61K8/49 , A61K2800/70 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q19/10
摘要： Cosmetic/pharmaceutical compositions useful for regulating the size of sebaceous glands and, in particular, for inhibiting sebum production, or for treating pathologies entailing an overproduction of sebum, or for treating greasy skin and/or a scalp prone to dandruff, contain thus effective amounts of at least one activator of PPAR type receptors.
摘要翻译：用于调节皮脂腺的尺寸，特别是用于抑制皮脂产生，或用于治疗皮脂过度产生或用于治疗油腻皮肤和/或容易出现头皮屑的头皮的病态的化妆品/药物组合物含有有效量的至少一种PPAR受体激活剂。

8. 发明申请

US20070041910A1 Pharmaceutical spray compositions comprising a bioactive agent, at least one volatile silicone and a non-volatile oily phase 审中-公开
标题翻译：药物喷雾组合物，其包含生物活性剂，至少一种挥发性硅氧烷和非挥发性油相
公开(公告)号：US20070041910A1
公开(公告)日：2007-02-22
申请号：US11432410
申请日：2006-05-12
申请人： Franck Pitre , Laurent Fredon , Claire Mallard
发明人： Franck Pitre , Laurent Fredon , Claire Mallard
IPC分类号： A61L9/04 , A61K31/59
CPC分类号： A61K9/0014 , A61K9/12 , A61K31/573
摘要： Sprayable pharmaceutical compositions suited for improved transdermal penetration contain a) at least one bioactive agent, notably at least one derivative of vitamin D, (b) at least one volatile silicone and c) a non-volatile oily phase, formulated into d) a pharmaceutically acceptable vehicle therefor.
摘要翻译：适用于改善透皮渗透的可喷涂药物组合物包含a）至少一种生物活性剂，特别是维生素D的至少一种衍生物，（b）至少一种挥发性硅氧烷和c）非挥发性油相，配制成d）药学上因此可接受的车辆。

9. 发明申请

US20060128808A1 Method of using adapalene in acne maintenance therapy 审中-公开
标题翻译：阿达帕林在痤疮维持治疗中的应用
公开(公告)号：US20060128808A1
公开(公告)日：2006-06-15
申请号：US11009024
申请日：2004-12-13
申请人： Stephanie Arsonnaud , Pascale Soto
发明人： Stephanie Arsonnaud , Pascale Soto
IPC分类号： A61K31/192
CPC分类号： A61K31/194 , A61K31/167 , A61K31/192 , A61K31/365 , A61K31/401 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention provides for a method of using adapalene for the maintenance theray of acne vulgaris to prevent acne recurrence or reduce the severity of the acne recurrence.
摘要翻译：本发明提供了一种使用阿达帕林治疗寻常痤疮的方法，以防止痤疮复发或降低痤疮复发的严重性。

10. 发明申请

US20060115836A1 Utilization of FANCC, DAD1, GRIM19 and HADHII genes for the ultimate treatment of psoriasis 审中-公开
标题翻译：使用FANCC，DAD1，GRIM19和HADHII基因进行银屑病的最终治疗
公开(公告)号：US20060115836A1
公开(公告)日：2006-06-01
申请号：US11249305
申请日：2005-10-14
申请人： Valerie Trinquet , Patricia Rossio , Paul Fogel
发明人： Valerie Trinquet , Patricia Rossio , Paul Fogel
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： Polynucleotide probes relating to the FANCC, DAD1, GRIM19 and HADHII genes are useful for characterizing biological samples and for identifying compounds suited for the treatment of psoriasis.
摘要翻译：与FANCC，DAD1，GRIM19和HADHII基因相关的多核苷酸探针可用于表征生物样品和鉴定适合治疗牛皮癣的化合物。

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