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1. 发明授权

US09805165B2 Handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test 有权
公开(公告)号：US09805165B2
公开(公告)日：2017-10-31
申请号：US13144438
申请日：2010-01-13
申请人： Qing Xiang , Jill Lindsey Osborne , Ryan Davey , Francois Dupoteau
发明人： Qing Xiang , Jill Lindsey Osborne , Ryan Davey , Francois Dupoteau
IPC分类号： G01N35/00 , G06F19/00 , G01N33/487 , G01N21/78 , G01N21/84 , G01N21/77
CPC分类号： G06F19/3418 , G01N21/78 , G01N21/8483 , G01N33/48792 , G01N2021/7786 , G06F19/00 , G16H40/63
摘要： A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an uploading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step.

2. 发明授权

US09719983B2 Method for stabilizing quantum-dots 有权
公开(公告)号：US09719983B2
公开(公告)日：2017-08-01
申请号：US14397314
申请日：2013-04-26
申请人： FIO CORPORATION
发明人： Bo Qi
IPC分类号： G01N33/52 , G01N21/64 , C09K11/02 , B82Y30/00
CPC分类号： G01N33/525 , B82Y30/00 , C09K11/02 , C09K11/883 , G01N21/6428 , Y10T436/10
摘要： A method for stabilizing quantum dots is disclosed, wherein the method includes the introduction of a first monomer into a miniemulsion system. In certain embodiments, the first monomer is a crosslinking polymer. In certain embodiments, a second monomer is added to the system to stabilize the quantum dots. In addition, a method of increasing the brightness of the quantum dots by adding a redox initiator system at a low temperature to reduce fluorescence quenching is also disclosed.

3. 发明申请

US20140316732A1 QUALITY CONTROL SYSTEM, METHOD AND COMPUTER READABLE MEDIUM FOR USE WITH BIOLOGICAL/ENVIRONMENTAL DIAGNOSTIC TEST DEVICES, USERS AND CONSUMABLES 审中-公开
标题翻译：质量控制系统，使用生物/环境诊断测试设备的方法和计算机可读介质，用户和消耗品
公开(公告)号：US20140316732A1
公开(公告)日：2014-10-23
申请号：US14359068
申请日：2012-11-19
申请人： FIO CORPORATION
发明人： François Dupoteau
IPC分类号： G01N35/00
CPC分类号： G01N35/00 , G06F19/3418 , G06Q50/22 , G16H10/40 , Y02A90/22 , Y02A90/26
摘要： A quality control (QC) system collects data associated with biological/environmental diagnostic test devices, users and consumables, and identifies corresponding parameters. The system determines when the data are outside the parameters, and then generates corresponding QC improvement data. A database receives and stores the QC improvement data for use in improved QC procedures. A related method and computer readable medium are also disclosed.
摘要翻译：质量控制（QC）系统收集与生物/环境诊断测试设备，用户和耗材相关的数据，并识别相应的参数。系统确定数据何时超出参数，然后生成相应的QC改进数据。数据库接收并存储QC改进数据，以用于改进的QC程序。还公开了相关方法和计算机可读介质。

4. 发明授权

US08597729B2 Systems and methods for manufacturing quantum dot-doped polymer microbeads 有权
标题翻译：制造量子点掺杂聚合物微珠的系统和方法
公开(公告)号：US08597729B2
公开(公告)日：2013-12-03
申请号：US12666112
申请日：2008-06-23
申请人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
发明人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： B05D1/02 , B05D1/26 , B05D1/34 , B05D1/42 , B05B1/34 , B05B7/26 , B32B5/16
CPC分类号： C40B20/04 , B01J2219/005 , B01J2219/00551 , B01J2219/00576 , C08L25/14 , C08L35/06
摘要： In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.
摘要翻译：在用于形成微珠的方法和系统中，聚合物溶液包括溶解在溶剂中的颗粒和聚合物。聚合物溶液流流入室中。聚焦流体将聚合物流接触并聚焦在室中。聚焦流体和聚焦聚合物流作为单一流动流从腔室流出。悬滴从单流流的前端分离形成微珠。聚焦流体与聚合物溶液反应以在微珠的表面形成官能团，用于与生物识别分子结合。在该系统中，流动聚焦装置包括成形为限定腔室的流动聚焦体。还公开了根据方法和系统形成的微珠。

5. 发明授权

US08360321B2 System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology 有权
标题翻译：通过量子点光学编码技术生成的多重荧光光谱信号的去卷积系统和方法
公开(公告)号：US08360321B2
公开(公告)日：2013-01-29
申请号：US12594430
申请日：2008-04-02
申请人： Jeongjin Lee , Warren Che Wor Chan , Qing Xiang , Jesse Klostranec
发明人： Jeongjin Lee , Warren Che Wor Chan , Qing Xiang , Jesse Klostranec
IPC分类号： G06K7/10
CPC分类号： C40B20/04 , G01J3/4406 , G01N2021/6417 , G01N2021/6441 , G01N2201/1293
摘要： A method deconvolves a multiplexed fluorescence spectral signal into its component single-color fluorescence spectra emitted by contributing fluorophore types. A spectral database contains a parameter set for each of the component spectra. Optical codes are received as the multiplexed signals. A sliding window technique estimates a number and location of local peaks for the component spectra. Allowable variation ranges are assigned for the corresponding parameter sets. Each multiplexed signal is deconvolved into a sum of parametric values to generate a list of its component spectra. Encoded and received optical codes, in the form of multiplexed signals, are decoded and identified by their component spectra and contributing fluorophore types. A system for deconvolving the multiplexed signals includes a spectral database containing the parameter sets, a detection element receiving the optical codes, and a signal processor encoded to analyze and deconvolve the multiplexed signals.
摘要翻译：一种方法将多路复用的荧光光谱信号去卷积成由贡献荧光团类型发射的组分单色荧光光谱。光谱数据库包含每个分量光谱的参数集。作为复用信号接收光码。滑动窗口技术估计分量光谱的局部峰值的数量和位置。为相应的参数集分配允许的变化范围。每个复用的信号被去卷积成参数值的和以产生其分量谱的列表。以多路复用信号的形式编码和接收的光学代码通过其分量光谱和贡献的荧光团类型进行解码和识别。用于对多路复用信号进行解卷积的系统包括包含参数集的频谱数据库，接收光学代码的检测元件以及被编码为对多路复用信号进行解卷积的信号处理器。

6. 发明申请

US20110165688A1 SINGLE-USE HANDHELD DIAGNOSTIC TEST DEVICE, AND AN BIOLOGICAL AND ENVIRONMENTAL TEST SAMPLES 有权
标题翻译：单次使用手持式诊断测试装置，以及生物和环境试验样品
公开(公告)号：US20110165688A1
公开(公告)日：2011-07-07
申请号：US13061284
申请日：2009-08-31
申请人： Francois Dupoteau , Shlomit Dekel
发明人： Francois Dupoteau , Shlomit Dekel
IPC分类号： G01N33/00 , G01N33/48
CPC分类号： G01N33/48792 , A61B5/0077 , A61B5/1171 , A61B5/1172 , A61B5/1176 , G01N21/17 , G01N21/77 , G06F19/00 , G16H40/63 , Y10T436/12
摘要： In a single-use handheld diagnostic test device and an associated system and method, a biological and/or environmental test sample is received and reacted with reagents. The test device tests a single sample and includes a sensor to detect test data. The test device mates with, and transmits the test data to, an electronic device. A processor of the electronic device applies algorithms to the test data to generate highly sensitive and accurate quantitative test results. A presentation element of the electronic device presents the test results to a user. The test device is adapted for disposal, or for sterilization and re-use, after the electronic device receives the test data. The electronic device may be, for example, a mobile communications device, a personal digital assistant, a laptop computer, a navigation device, a digital audio player, a camera, or a gaming device.
摘要翻译：在一次性手持式诊断测试装置和相关系统和方法中，接收生物和/或环境试验样品并与试剂反应。测试设备测试单个样品，并包括一个传感器来检测测试数据。测试设备与电子设备配合并将测试数据发送到电子设备。电子设备的处理器对测试数据应用算法，以产生高灵敏度和准确的定量测试结果。电子设备的呈现元件将测试结果呈现给用户。测试装置适用于在电子设备接收测试数据之后进行处置或灭菌和重新使用。电子设备可以是例如移动通信设备，个人数字助理，膝上型计算机，导航设备，数字音频播放器，照相机或游戏设备。

7. 发明申请

US20210405059A1 BIOMARKERS FOR EARLY DETERMINATION OF A CRITICAL OR LIFE THREATENING RESPONSE TO ILLNESS AND/OR TREATMENT RESPONSE 有权
公开(公告)号：US20210405059A1
公开(公告)日：2021-12-30
申请号：US17164628
申请日：2021-02-01
申请人： Fio Corporation
发明人： Kevin Kain , W. Conrad Liles , Laura Erdman , Andrea Conroy
IPC分类号： G01N33/68
摘要： The invention relates to the use of novel biomarkers and biomarker combinations having utility in the early determination of an individual's critical and/or life threatening response to illness and/or in predicting outcome of said illness. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention have utility in making the determination of an individual's critical and/or life threatening response to illness. In some embodiments, the biomarker and biomarker combinations are agnostic and are independent of the pre-identification and/or determination of the cause or nature of the illness. In some embodiments, the biomarkers and biomarker combinations can be utilized to select treatment and/or monitor the effectiveness of treatment interventions for an individual who has a critical illness.

8. 发明申请

US20180005515A1 BIO-THREAT ALERT SYSTEM 审中-公开
公开(公告)号：US20180005515A1
公开(公告)日：2018-01-04
申请号：US15703245
申请日：2017-09-13
申请人： Fio Corporation
发明人： Francois Dupoteau
IPC分类号： G08B27/00 , G08B31/00 , G06F19/00
CPC分类号： G08B27/005 , G08B31/00 , G16H50/80
摘要： In a bio-threat alert infrastructure system and method, an analyzing processor applies statistical algorithms to the collected quantitative data to precisely estimate event data, including time and position data, associated the development of a bio-threat. An encoding processor encodes the event data into a bio-threat alert signal. A transmitting element transmits the signal for reception by a bio-threat alert device. In the bio-threat alert device, and an associated method, a receiving element receives the signal. A decoding processor decodes the signal into the event data. A presentation element presents the event data to a user of the device.

9. 发明申请

US20140038853A1 FLOW FOCUSING METHOD AND SYSTEM FOR FORMING CONCENTRATED VOLUMES OF MICROBEADS, AND MICROBEADS FORMED FURTHER THERETO 有权
标题翻译：用于形成浓缩浓度的微生物的流动聚焦方法和系统，以及进一步形成的微生物
公开(公告)号：US20140038853A1
公开(公告)日：2014-02-06
申请号：US14047742
申请日：2013-10-07
申请人： FIO CORPORATION
发明人： Sebastian Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： C12Q1/70 , B29C47/08
CPC分类号： C12Q1/706 , B01F3/0807 , B01F13/0062 , B01F13/0827 , B01F13/0863 , B01J13/04 , B29C47/0813 , C08J3/14 , C08J3/21 , C12Q1/701
摘要： In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so as to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in the fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn.
摘要翻译：在用于形成浓缩体积的微珠的方法和系统中，聚合物溶液和/或悬浮液包括溶解和/或分散在介质中的聚合物。聚焦流体和聚合物溶液和/或悬浮液的液流流向流体浴，并且彼此相交，以聚焦聚合物溶液和/或悬浮液。聚合物溶液和/或悬浮液流在流体浴中形成微珠。从流体浴中抽出一些聚焦流体，以将微珠浓缩在流体浴中。该系统包括流动聚焦装置和含液体池。聚焦装置包括聚合物和聚焦喷嘴。电池包含流体槽，并具有出口，抽出聚焦流体。

10. 发明申请

US20120156490A1 SYSTEMS AND METHODS FOR MANUFACTURING QUANTUM DOT-DOPED POLYMER MICROBEADS 有权
标题翻译：制造量子聚合物微粒的系统和方法
公开(公告)号：US20120156490A1
公开(公告)日：2012-06-21
申请号：US12666112
申请日：2008-06-23
申请人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
发明人： Sebastien Fournier-Bidoz , Warren Che Wor Chan
IPC分类号： B32B5/16 , B29B9/00
CPC分类号： C40B20/04 , B01J2219/005 , B01J2219/00551 , B01J2219/00576 , C08L25/14 , C08L35/06
摘要： In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.
摘要翻译：在用于形成微珠的方法和系统中，聚合物溶液包括溶解在溶剂中的颗粒和聚合物。聚合物溶液流流入室中。聚焦流体将聚合物流接触并聚焦在室中。聚焦流体和聚焦聚合物流作为单一流动流从腔室流出。悬滴从单流流的前端分离形成微珠。聚焦流体与聚合物溶液反应以在微珠的表面形成官能团，用于与生物识别分子结合。在该系统中，流动聚焦装置包括成形为限定腔室的流动聚焦体。还公开了根据方法和系统形成的微珠。

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