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1. 发明授权

US10182859B2 Medical device for the transport of subcooled cryogenic fluid through a linear heat exchanger 有权
公开(公告)号：US10182859B2
公开(公告)日：2019-01-22
申请号：US12548321
申请日：2009-08-26
申请人： John M. Baust , John G. Baust , Roy Cheeks , Anthony Robilotto , Kristi Snyder
发明人： John M. Baust , John G. Baust , Roy Cheeks , Anthony Robilotto , Kristi Snyder
IPC分类号： A61B18/02
摘要： A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic probe.

2. 发明授权

US08740891B2 Flexible multi-tubular cryoprobe 有权
标题翻译：灵活多管式冷冻探针
公开(公告)号：US08740891B2
公开(公告)日：2014-06-03
申请号：US12744001
申请日：2008-11-19
申请人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
发明人： Alexei V. Babkin , Peter J. Littrup , Robert V. Duncan , William J. Nydam
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0262
摘要： A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from −200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.
摘要翻译：一种柔性多管式冷冻探针，包括用于接收来自流体源的近临界低温流体的入口流并用于排出低温流体出口流的壳体。多个流体输送管被牢固地附接到壳体。这包括一组入口流体输送管，用于从壳体接收入口流; 以及用于将出口流排放到壳体的一组出口流体输送管。每个流体输送管由在-200℃至环境温度的全部温度范围内保持柔性的材料形成。每个流体输送管的内径在约0.10mm至1.0mm之间的范围内，壁厚在约0.01mm至0.30mm的范围内。端盖定位在多个流体输送管的端部，以提供从入口流体输送管到出口流体输送管的流体转移。

3. 发明授权

US08439905B2 Nucleation enhanced surface modification to support physical vapor deposition to create a vacuum 有权
标题翻译：成核增强表面改性以支持物理气相沉积以产生真空
公开(公告)号：US08439905B2
公开(公告)日：2013-05-14
申请号：US12562301
申请日：2009-09-18
申请人： John M. Baust , John G. Baust , Roy Cheeks , Anthony Robilotto , Kristi Snyder
发明人： John M. Baust , John G. Baust , Roy Cheeks , Anthony Robilotto , Kristi Snyder
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/0422 , A61B18/02 , A61B2017/00084 , A61B2017/22051 , A61B2018/00041 , A61B2018/00101 , A61B2018/0022 , A61B2018/00982 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61B2090/064 , A61F7/123 , A61F2007/0056
摘要： The device of the invention takes the form of a catheter/probe and is a closed loop system in which cryogen is delivered along the length of the catheter/probe to the tip where freezing occurs, and then recirculated. The device is a tube within a tube and comprises a number of parts including supply and return (internal) tubes, outer sheath (external tube) seaJed to the inner tubes at one or both ends with a gas filled lumen between the internal and external tubes. The lumen of the external tube is filled with a saturated gas which solidifies upon cooling, thereby creating a vacuum along the catheter length and providing for insulation between the inner and outer tubes, and preventing freezing along the probe shaft length. The outside surface of the internal tubes is modified to potentiate gas nucleation on the outer surfaces of the internal tubes when cooled.
摘要翻译：本发明的装置采用导管/探针的形式，并且是闭合循环系统，其中冷冻剂沿着导管/探针的长度被递送到发生冷冻的尖端，然后再循环。该装置是管内的管，并且包括多个部件，包括供应和返回（内部）管，外护套（外管）在一个或两个端部处连接到内管上的内管和内管之间的气体填充管。外管的内腔填充有饱和气体，其在冷却时固化，从而沿导管长度产生真空，并提供内管和外管之间的绝缘，并防止沿着探针轴长度的冻结。改变内管的外表面，以在冷却时加强内管外表面上的气体成核。

4. 发明申请

US20100292766A1 HEAT EXCHANGE CATHETER WITH MULTI-LUMEN TUBE HAVING A FLUID RETURN PASSAGEWAY 审中-公开
标题翻译：具有流体返回通道的多管式热交换器
公开(公告)号：US20100292766A1
公开(公告)日：2010-11-18
申请号：US12623283
申请日：2009-11-20
申请人： THACH DUONG , JAY J. EUM , JENNY C. LIU
发明人： THACH DUONG , JAY J. EUM , JENNY C. LIU
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F2007/126
摘要： The catheter includes a multi-lumen tube having an outflow portion and an accessory portion. The accessory portion is integrally formed within an interior volume of the outflow portion. The accessory portion has a cross-section smaller than the outflow portion. The outflow portion is offset from the accessory portion such that they are integrally joined. The space between these portions defines a fluid return passageway and the space within the accessory portion defines an accessory passageway. A flexible outer sleeve cooperates with the multi-lumen tube to form a fluid inlet passageway. During operation, an inlet flow of warming fluid flows through the fluid inlet passageway formed between the outer sleeve and the multi-lumen tube. The flow continues around a distal end of the outflow portion of the multi-lumen tube, thus becoming an outlet flow of the warming fluid which is directed through the fluid return passageway.
摘要翻译：导管包括具有流出部分和附件部分的多腔管。附件部分一体地形成在流出部分的内部容积内。附件部分的横截面小于流出部分。流出部分从附件部分偏移，使得它们整体连接。这些部分之间的空间限定了流体返回通道，并且附件部分内的空间限定了附件通道。柔性外套管与多腔管配合以形成流体入口通道。在操作期间，加热流体的入口流动流过形成在外套管和多腔管之间的流体入口通道。流体在多腔管的流出部分的远端周围继续，从而变成被引导通过流体返回通道的加温流体的出口流。

5. 发明授权

US07621890B2 Heat exchange catheter with multi-lumen tube having a fluid return passageway 有权
标题翻译：具有多腔管的换热导管具有流体返回通道
公开(公告)号：US07621890B2
公开(公告)日：2009-11-24
申请号：US11417407
申请日：2006-05-04
申请人： Thach Duong , Jay J. Eum , Jenny C. Liu
发明人： Thach Duong , Jay J. Eum , Jenny C. Liu
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F2007/126
摘要： The catheter includes a multi-lumen tube having an outflow portion and an accessory portion. The accessory portion is integrally formed within an interior volume of the outflow portion. The accessory portion has a cross-section smaller than the outflow portion. The outflow portion is offset from the accessory portion such that they are integrally joined. The space between these portions defines a fluid return passageway and the space within the accessory portion defines an accessory passageway. A flexible outer sleeve cooperates with the multi-lumen tube to form a fluid inlet passageway. During operation, an inlet flow of warming fluid flows through the fluid inlet passageway formed between the outer sleeve and the multi-lumen tube. The flow continues around a distal end of the outflow portion of the multi-lumen tube, thus becoming an outlet flow of the warming fluid which is directed through the fluid return passageway.
摘要翻译：导管包括具有流出部分和附件部分的多腔管。附件部分一体地形成在流出部分的内部容积内。附件部分的横截面小于流出部分。流出部分从附件部分偏移，使得它们整体连接。这些部分之间的空间限定了流体返回通道，并且附件部分内的空间限定了附件通道。柔性外套管与多腔管配合以形成流体入口通道。在操作期间，加热流体的入口流动流过形成在外套管和多腔管之间的流体入口通道。流体在多腔管的流出部分的远端周围继续，从而变成被引导通过流体返回通道的加温流体的出口流。

6. 发明授权

US07485117B2 Detachable cryosurgical probe 有权
标题翻译：可拆卸式冷冻手术探针
公开(公告)号：US07485117B2
公开(公告)日：2009-02-03
申请号：US11529615
申请日：2006-09-28
申请人： Sanford D. Damasco , Thach Duong
发明人： Sanford D. Damasco , Thach Duong
IPC分类号： A61B18/02
CPC分类号： F25B9/02 , A61B18/02 , A61B2017/0046 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293 , F28D7/106 , F28F2255/18
摘要： A cryosurgical probe system includes a fluid supply line connectable at an inlet section to a source of cryogenic fluid; a fluid connector assembly securely connected to an outlet section of the fluid supply line for receiving fluid from the outlet section of the fluid supply line; and, a detachable cryosurgical probe detachably connectable to the fluid connector assembly. The cryosurgical probe system includes the capability of providing return fluid flow.
摘要翻译：冷冻手术探针系统包括可在入口部分连接到低温流体源的流体供应管线; 流体连接器组件，其牢固地连接到流体供应管线的出口部分，用于从流体供应管线的出口部分接收流体; 以及可拆卸地连接到流体连接器组件的可拆卸冷冻手术探针。冷冻手术探针系统包括提供回流流体的能力。

7. 发明授权

US07381207B2 Quick disconnect assembly having a finger lock assembly 有权
公开(公告)号：US07381207B2
公开(公告)日：2008-06-03
申请号：US11685058
申请日：2007-03-12
申请人： Thach Duong , Jay J. Eum
发明人： Thach Duong , Jay J. Eum
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00274 , A61B2017/0046 , A61B2018/00547 , A61B2018/0262 , A61B2090/3925
摘要： The quick disconnect assembly includes a reusable assembly including a distal end having a male lip thereon; and, a disposable assembly having quick disconnect capabilities when utilized with the reusable assembly. The disposable assembly includes a stem section; a finger lock element; and, a detachable handle assembly. The finger lock element includes a distal finger lock element section having a threaded inner surface for engagement with a threaded outer surface of the stem section; and, a plurality of radially spaced fingers extending proximally from the distal finger lock element section. Each finger has a) a ramped surface for operatively engaging an associated ramp section on the stem section during use; and, b) a female lip at a proximal end thereof. The detachable handle assembly includes a proximal handle section having a distal end having an inner surface that is operatively engaged with an outer surface of the finger lock element so as to resist relative rotation and axial motion therebetween. A distal handle section of the detachable handle assembly includes a distal handle section having an inner surface that is operatively engaged with another outer surface of the stem section so as to resist relative rotation and axial motion therebetween. A breakaway collar of the detachable handle assembly is positioned between the proximal handle section and the distal handle section. When the disposable assembly is attached, the breakaway collar is an integral unit which prevents relative rotation between the proximal handle section and the distal handle section, the female lip engaging the male lip at a distal end of the reusable assembly, thereby securing the reusable assembly to the disposable assembly. The quick disconnect assembly may be used to provide only a mechanical connection or it may be provided with components for providing fluid transfer. In another embodiment, instead of only providing for single use, multiple use of a detachable assembly is provided by eliminating the breakaway collar and utilizing spring biasing means.

8. 发明授权

US07207985B2 Detachable cryosurgical probe 有权
公开(公告)号：US07207985B2
公开(公告)日：2007-04-24
申请号：US10603883
申请日：2003-06-25
申请人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey Kurtzer
发明人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey Kurtzer
IPC分类号： A61B18/02 , A61B18/08
CPC分类号： A61B18/02 , A61B2017/0046 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： A cryosurgical probe system includes a fluid supply line connectable at an inlet section to a source of cryogenic fluid; a fluid connector assembly securely connected to an outlet section of the fluid supply line for receiving fluid from the outlet section of the fluid supply line; and, a detachable cryosurgical probe detachably connectable to the fluid connector assembly. The cryosurgical probe system includes the capability of providing return fluid flow.

9. 发明授权

US5928217A Urological stent therapy system and method 失效
公开(公告)号：US5928217A
公开(公告)日：1999-07-27
申请号：US179598
申请日：1998-10-26
申请人： Paul Mikus , William Moseley
发明人： Paul Mikus , William Moseley
IPC分类号： A61F2/00 , A61F2/04 , A61F2/88 , A61M31/00
CPC分类号： A61F2/88 , A61F2/04 , A61L31/022 , A61F2002/048 , A61F2250/0039 , A61L2400/16
摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.

10. 发明授权

US1755666A Method of nesting can bodies 失效
标题翻译：嵌套罐体的方法
公开(公告)号：US1755666A
公开(公告)日：1930-04-22
申请号：US17959827
申请日：1927-03-30
申请人： CONTINENTAL CAN CO
发明人： SCHAAL NORBERT J
IPC分类号： B21D51/26
CPC分类号： B21D51/2646

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