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    • 2. 发明授权
    • System for monitoring play of a golfer
    • 监视高尔夫球的系统
    • US5097416A
    • 1992-03-17
    • US464897
    • 1990-01-16
    • Gordon H. Matthews
    • Gordon H. Matthews
    • A63B57/00A63B69/36A63B71/06G01S1/68
    • A63B71/0619A63B57/00A63B69/3691A63B71/0622A63B71/0686G01S1/68A63B2220/12A63B2220/805A63B2225/15A63B2225/54A63B71/0605
    • A system for monitoring play of a golfer (24,26) comprises Location Information Transmitters (LIT) (52, 54, 56) at predetermined locations within a golf course and a Mobile Electronic Transmitter/Receiver (METAR) (48, 50) carried in association with a golfer (24,26) on a golf bag (30) or a golf cart (28).A METAR (48) transmits a METAR code to a LIT (54), which then transmits its LIT code and the received METAR code to a Tracking Center (22) display terminal. Golf course personnel can monitor the display terminal and determine play of golfers (24, 26), golf cart (28, 34) utilization and golf hole (10, 14) utilization. When the golfer (24) causes a slow play indication, the Tracking Center (22) is notified and the slow golfer (24) is asked to increase the rate of play or leave the golf course. The METAR (48) transmission may be begun in response to the METAR (48) receiving an LIT code periodically transmitted by an LIT (52, 54, 56) over a restricted transmission range (58, 60, 62).When the METAR (48) arrives within an LIT (54) transmission range (60), the METAR (48) receives a LIT code and subsequently initiates a counter to measure time required by the golfer (24) to move within transmission range (62) of a next LIT (56). If the counter exceeds a prescribed time, then a display on the METAR (48) indicates slow play.
    • 用于监视高尔夫球手(24,26)的播放的系统包括在高尔夫球场内的预定位置处的位置信息发射器(LIT)(52,54,56)和携带的移动电子发射器/接收器(MET 50)(48,50) 与高尔夫球袋(30)或高尔夫球车(28)上的高尔夫球手(24,26)相关联。 一个METAR(48)将一个METAR代码发送给一个LIT(54),该LIT(54)然后将其LIT代码和接收到的METAR代码发送到跟踪中心(22)显示终端。 高尔夫球场人员可以监控显示终端,并确定高尔夫球手(24,26),高尔夫球车(28,34)利用率和高尔夫球场(10,14)利用率。 当高尔夫球手(24)引起缓慢的游戏指示时,通知跟踪中心(22),慢球员(24)被要求增加游戏速度或离开高尔夫球场。 响应于接收到在限制传输范围(58,60,62)上由LIT(52,54,56)周期性发送的LIT码的METAR(48),可以开始METAR(48)传输。 当METAR(48)到达LIT(54)传输范围(60)内时,METAR(48)接收LIT码并随后启动计数器以测量高尔夫球手(24)在传输范围内移动所需的时间(62 )的下一个LIT(56)。 如果计数器超过规定时间,则METAR(48)上的显示表示缓慢播放。
    • 4. 发明授权
    • Stable pharmaceutical composition
    • 稳定的药物组成
    • US4857552A
    • 1989-08-15
    • US203836
    • 1988-06-08
    • Leonard S. RosenbergCheryl BlackEarl R. SpeicherDietmar Wagenknecht
    • Leonard S. RosenbergCheryl BlackEarl R. SpeicherDietmar Wagenknecht
    • A61K9/00A61K9/08A61K31/19A61K31/195A61K31/215A61K31/22A61K47/12A61P9/12A61P25/02
    • A61K9/0019A61K31/195A61K31/215A61K47/12
    • An injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions comprising an effective amount of methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol) for treating such a cardiac condition, said composition comprising about 1 mg to 250 mg of esmolol per milliliter of said injectable pharmaceutical composition; 0.01 to 0.02M buffer; said composition having a pH range of 4.5 to 5.5, the esmolol degrading in aqueous solution to produce 3-[4-(3-propionic acid)phenoxy]-1-isopropylamino-2-propanol hydrochloride, said 3-[4-(3-propionic acid)-phenoxyl]-1-isopropylamino-2-propanol hydrochloride having a pK in the pH range of said composition to thereby act as a secondary buffer to increase the buffer capacity and minimize the change in pH as degradation occurs, whereby the stability of esmolol in an aqueous composition is enhanced.
    • 一种用于治疗心脏病症的可注射的水性药物组合物,其包含有效量的用于治疗这种心脏病症的3- [4-(2-羟基-3-异丙基氨基)丙氧基]苯丙酸甲酯(艾司洛尔),所述组合物包含约 每毫升所述可注射药物组合物1mg至250mg艾司洛尔; 0.01〜0.02M缓冲液; 所述组合物的pH范围为4.5至5.5,艾司洛尔在水溶液中降解以产生3- [4-(3-丙酸)苯氧基] -1-异丙基氨基-2-丙醇盐酸盐,所述3- [4-(3 - 丙酸) - 苯氧基] -1-异丙基氨基-2-丙醇盐酸盐,其在所述组合物的pH范围内具有pK,从而充当二级缓冲液,以增加缓冲能力,并且随着劣化发生使pH的变化最小化,由此 艾司洛尔在水性组合物中的稳定性得到提高。