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1. 外观设计

USD1042788S1 Illuminator device 有权
公开(公告)号：USD1042788S1
公开(公告)日：2024-09-17
申请号：US29762987
申请日：2020-12-20
申请人： Cerus Corporation
设计人： Daniel Church , Matthew Goulet , Lloyd Ison , Tracey Kirkman , Marc Stern , Charles Weber
摘要： FIG. 1 is a left frontal elevated perspective view of the illuminator device.
FIG. 2 is a front view of the illuminator device.
FIG. 3 is a back view of the illuminator device.
FIG. 4 is a left view of the illuminator device.
FIG. 5 is a right view of the illuminator device.
FIG. 6 is a top view of the illuminator device; and,
FIG. 7 is a bottom view of the illuminator device.
The scope of this disclosure extends to the entirety of the illuminator device.

2. 发明公开

US20240173351A1 PLASMA COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20240173351A1
公开(公告)日：2024-05-30
申请号：US18326924
申请日：2023-05-31
申请人： Cerus Corporation
发明人： Laurence CORASH , Richard BENJAMIN , Elan WEINER , Johannes VERMEIJ
IPC分类号： A61K35/16 , A61K9/00 , A61P7/00
CPC分类号： A61K35/16 , A61K9/0019 , A61P7/00
摘要： Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.

3. 发明授权

US11235090B2 Kits and methods for preparing pathogen-inactivated platelet compositions 有权
公开(公告)号：US11235090B2
公开(公告)日：2022-02-01
申请号：US15910836
申请日：2018-03-02
申请人： Cerus Corporation
发明人： Tovo David , Betsy Donnelly , Anna Erickson , Naheed Mufti
IPC分类号： A61K35/19 , A61L2/00 , A61M1/02 , A61M1/36 , A61M1/34
摘要： Provided are methods for preparing pathogen-inactivated platelet compositions, as well as processing sets and compositions related thereto.

4. 发明申请

US20150157665A1 PATHODEN-INACTIVATED RED BLOOD CELL COMPOSITIONS 有权
标题翻译： PATHODEN灭活红血球细胞组成
公开(公告)号：US20150157665A1
公开(公告)日：2015-06-11
申请号：US14530415
申请日：2014-10-31
申请人： Cerus Corporation
发明人： Naheed MUFTI , Anna Erickson , Anne North
IPC分类号： A61K35/18 , A01N1/02
CPC分类号： A61K35/18 , A01N1/02 , A01N1/0215 , A01N1/0226 , A01N43/42 , A01N2300/00 , A61K35/00 , A61L2/0082 , A01N25/00 , A01N37/44 , A01N37/46
摘要： The present invention provides pathogen-inactivated red blood cell compositions suitable for infusion into a subject.
摘要翻译：本发明提供了适合于输注到受试者的病原体灭活的红细胞组合物。

5. 发明授权

US07655392B2 Quenching methods for red blood cell inactivation process 有权
标题翻译：红细胞灭活过程的淬火方法
公开(公告)号：US07655392B2
公开(公告)日：2010-02-02
申请号：US11264195
申请日：2005-10-31
申请人： Adonis Stassinopoulos
发明人： Adonis Stassinopoulos
IPC分类号： A01N1/00
CPC分类号： A61L2/0088 , A01N1/0205 , A01N1/0215 , A61K31/198
摘要： Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.
摘要翻译：提供了用于在用包含核酸结合配体和官能团的病原体灭活化合物处理红细胞组合物或改善亲电基团形成功能基团时，改善猝灭不需要的副反应的方法。在一些实施方案中，改进的方法使用适当高浓度的淬灭剂，其包含能够与亲电子基团共价反应的亲核官能团，其中处理在期望的pH范围内进行以提供足够的淬灭。用于某些方法的优选猝灭剂包括硫醇，例如谷胱甘肽，其已被适当中和，使得加入红细胞组合物导致所需浓度的猝灭剂在所需pH范围为6.8至8.5。

6. 发明授权

US07611831B2 Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix 有权
标题翻译：用固定在基质中的多孔颗粒吸附病原体灭活化合物
公开(公告)号：US07611831B2
公开(公告)日：2009-11-03
申请号：US11243822
申请日：2005-10-04
申请人： Derek J. Hei
发明人： Derek J. Hei
IPC分类号： A01N1/02 , A61K35/14 , C12N7/06 , C12M1/00 , C07K1/22
CPC分类号： A61M1/3679 , A01N1/0215 , A01N1/0231 , A61K35/18 , A61L2/00 , A61L2/0082 , A61L2202/22 , A61M1/0209 , A61M1/0218 , A61M1/3686 , B01J20/20 , B01J20/26 , B01J20/261 , B01J20/28004 , B01J20/28014 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/28057 , B01J20/28064 , B01J20/28066 , B01J20/28078 , B01J20/28083 , B01J20/28085 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.
摘要翻译：提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约100μm至约1500μm。该装置可用于从诸如血液制品的生物组合物中吸附和去除病原体灭活化合物。

7. 发明授权

US07445756B2 Fluid processing sets and organizers for the same 有权
标题翻译：流体加工套件和组织者相同
公开(公告)号：US07445756B2
公开(公告)日：2008-11-04
申请号：US10269444
申请日：2002-10-11
申请人： Joseph S. Moore , Daniel Lecour , Yvon Briere , James Laird
发明人： Joseph S. Moore , Daniel Lecour , Yvon Briere , James Laird
IPC分类号： B01L3/00 , B01L9/00
CPC分类号： A61J1/10 , A61L2/0011 , A61L2/0082 , A61L2/24 , A61L2202/22 , A61M1/0218 , A61M1/0236 , A61M1/0277 , A61M1/3681 , A61M1/3686 , B01J20/20 , B01J20/26
摘要： Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set including integrally connected containers and tubing and a holder or organizer for receiving at least some of the containers and tubing are disclosed.
摘要翻译：公开了用于用光处理生物流体的装置，系统和方法。公开了一种包括一体连接的容器和管道的一次性流体处理装置和用于容纳至少一些容器和管道的保持器或组织器。

8. 发明申请

US20040180321A1 Methods for quenching pathogen inactivators in biological materials 有权
标题翻译：在生物材料中淬灭病原体灭活剂的方法
公开(公告)号：US20040180321A1
公开(公告)日：2004-09-16
申请号：US10803109
申请日：2004-03-17
申请人： Cerus Corporation
发明人： David Cook , Adonis Stassinopoulos
IPC分类号： A01N001/02
CPC分类号： A61L2/0088
摘要： Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials comprising red blood cells. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.
摘要翻译：提供了用于猝灭病原体灭活化合物在包含红细胞的生物材料中的不希望的副反应的方法。在一个具体实施方案中，提供了用于猝灭病原体灭活化合物的不希望的副反应的方法，其包括可亲电子基团或能够形成亲电基团的官能团。在该实施方案中，用病原体灭活化合物和猝灭剂处理材料，其中猝灭剂包含能够与亲电子基团共价反应的亲核官能团。病原体灭活化合物上的亲电基团优选为非自由基阳离子基团。在一个实施方案中，病原体灭活化合物包括核酸结合配体和芥子基团，其中芥末基团能够在原位反应形成亲电子基团。优选的猝灭剂是硫醇，如谷胱甘肽。该方法允许在病原体灭活期间抑制含红细胞的材料中的红细胞的修饰。

9. 发明申请

US20030207247A1 Preparation of red blood cells having reduced immunogenicity 审中-公开
标题翻译：制备免疫原性降低的红细胞
公开(公告)号：US20030207247A1
公开(公告)日：2003-11-06
申请号：US10310618
申请日：2002-12-04
申请人： Cerus Corporation
发明人： Adonis Stassinopoulos , Shruti Mathur
IPC分类号： A01N001/02 , G01N033/567
CPC分类号： A61K47/6901
摘要： Methods are provided for the preparation of an RBC composition which has significantly reduced antigenicity. The methods of preparation of the red cell compositions involve the optimization of reaction conditions, in particular buffering conditions, for attaching antigen masking compounds to the red cells without significantly affecting the function of the red cells. The RBC compositions are of particular use for introduction into an individual in cases where the potential for an immune reaction is high, for example in alloimmunized blood recipients or in trauma situations where the possibility of transfusion of a mismatched unit of blood is higher. The RBC compositions of this invention provide a much lower risk of a transfusion associated immune reaction.
摘要翻译：提供了用于制备具有显着降低的抗原性的RBC组合物的方法。制备红细胞组合物的方法包括优化反应条件，特别是缓冲条件，用于将抗原掩蔽化合物连接到红细胞，而不显着影响红细胞的功能。 RBC组合物特别适用于在免疫反应的可能性高的情况下引入个体，例如在同种异体免疫的血液接受者中或在输血不匹配的血液单位的可能性较高的创伤情况下。本发明的RBC组合物提供低得多的输血相关免疫反应的风险。

10. 发明申请

US20030185804A1 Compounds for the photodecontamination of pathogens in blood 审中-公开
公开(公告)号：US20030185804A1
公开(公告)日：2003-10-02
申请号：US10213138
申请日：2002-08-06
申请人： Cerus Corporation
发明人： Susan Wollowitz , Stephen T. Isaacs , Henry Rapoport , Hans Peter Spielmann
IPC分类号： A61K045/00 , A01N001/02 , A61K031/366
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4null, 5null, and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.

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