专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07399586B2 Modulation of biological signal transduction by RNA interference 失效
标题翻译：通过RNA干扰调节生物信号转导
公开(公告)号：US07399586B2
公开(公告)日：2008-07-15
申请号：US10444795
申请日：2003-05-23
申请人： Richard Klinghoffer , Stephen Patrick Lewis
发明人： Richard Klinghoffer , Stephen Patrick Lewis
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/03 , C12N15/00 , C07N21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/3517 , C12N2310/53 , C12Y301/03048
摘要： Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase (PTP) class of enzymes that mediate signal transduction, and with certain MAP kinase kinases (MKK). In certain preferred embodiments siRNA modulate signal transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-ε, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation of PTP-mediated biological signal transduction has uses in diseases associated with defects in cell proliferation, cell differentiation and/or cell survival, such as metabolic disorders (including diabetes and obesity), cancer, autoimmune disease, infectious and inflammatory disorders and other conditions. The invention also provides siRNA polynucleotides that interfere with expression of chemotherapeutic target polypeptides, such as DHFR, thymidylate synthetase, and topoisomerase I.
摘要翻译：提供了与小干扰RNA（siRNA）多核苷酸相关的组合物和方法，涉及生物信号转导的调节。显示干扰介导信号转导的酶的蛋白酪氨酸磷酸酶（PTP）类成员和某些MAP激酶激酶（MKK）的成员的表达的siRNA多核苷酸。在某些优选实施方案中，siRNA调节包含SHP2，cdc14a / b，cdc25A / B / C，KAP，PTP-ε，PRL-3，CD45，双特异性磷酸酶-3（DSP-3），MKK-4和 /或MKK-7。 PTP介导的生物信号转导的调节在与细胞增殖，细胞分化和/或细胞存活缺陷相关的疾病中使用，例如代谢紊乱（包括糖尿病和肥胖症），癌症，自身免疫性疾病，感染性和炎症性疾病和其他病症。本发明还提供干扰化学治疗靶多肽如DHFR，胸苷酸合成酶和拓扑异构酶I的表达的siRNA多核苷酸。

2. 发明授权

US07279299B2 DSP-10 dual-specificity phosphatase 失效
标题翻译： DSP-10双特异性磷酸酶
公开(公告)号：US07279299B2
公开(公告)日：2007-10-09
申请号：US11186448
申请日：2005-07-21
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N9/16 , C12Q9/48
CPC分类号： C12Q1/42 , A61K38/00 , C12N9/16 , C12Y301/03016 , C12Y301/03048 , G01N33/573 , G01N2500/04
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation, and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-10底物去磷酸化的双特异性磷酸酶DSP-10及其多肽变体。多肽可用于例如鉴定抑制DSP-10活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

3. 发明申请

US20050176124A1 DSP-3 dual-specificity phosphatase 失效
标题翻译： DSP-3双特异性磷酸酶
公开(公告)号：US20050176124A1
公开(公告)日：2005-08-11
申请号：US10658661
申请日：2003-09-08
申请人： Ralf Luche , Bo Wei
发明人： Ralf Luche , Bo Wei
IPC分类号： C12N9/16 , C07H21/04
CPC分类号： G01N33/573 , A61K2039/505 , C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-3底物去磷酸化的双特异性磷酸酶DSP-3及其多肽变体。多肽可用于例如鉴定抑制DSP-3活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

4. 发明申请

US20020182203A1 DSP-15 dual-specificity phosphatase 失效
标题翻译： DSP-15双特异性磷酸酶
公开(公告)号：US20020182203A1
公开(公告)日：2002-12-05
申请号：US09955732
申请日：2001-09-18
申请人： CEPTYR, Inc.
发明人： Ralf M. Luche , Bo Wei
IPC分类号： A61K038/46 , C07H021/04 , C12N009/16 , C12P021/02 , C12N005/06
CPC分类号： C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-15, and polypeptide variants thereof that stimulate dephosphorylation of DSP-15 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-15 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-15底物去磷酸化的双特异性磷酸酶DSP-15及其多肽变体。多肽可用于例如鉴定抑制DSP-15活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

5. 发明申请

US20060008889A1 DSP-10 dual-specificity phosphatase 失效
标题翻译： DSP-10双特异性磷酸酶
公开(公告)号：US20060008889A1
公开(公告)日：2006-01-12
申请号：US11186448
申请日：2005-07-21
申请人： Ralf Luche , Bo Wei
发明人： Ralf Luche , Bo Wei
IPC分类号： C12N9/16 , C07H21/04 , C12P21/06
CPC分类号： C12Q1/42 , A61K38/00 , C12N9/16 , C12Y301/03016 , C12Y301/03048 , G01N33/573 , G01N2500/04
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation, and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-10底物去磷酸化的双特异性磷酸酶DSP-10及其多肽变体。多肽可用于例如鉴定抑制DSP-10活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

6. 发明授权

US06902919B2 DSP-12 and DSP-13 dual-specificity phosphatases 失效
标题翻译： DSP-12和DSP-13双特异性磷酸酶
公开(公告)号：US06902919B2
公开(公告)日：2005-06-07
申请号：US09775925
申请日：2001-02-01
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12N9/16 , C12N15/55 , C12N9/12 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-12和DSP-13底物去磷酸化的双特异性磷酸酶DSP-12和DSP-13及其多肽变体。多肽可用于例如鉴定抑制DSP-12和/或DSP-13活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

7. 发明授权

US06852520B1 DSP-2 dual-specificity phosphatase 失效
标题翻译： DSP-2双特异性磷酸酶
公开(公告)号：US06852520B1
公开(公告)日：2005-02-08
申请号：US09527376
申请日：2000-03-16
申请人： Ralf M. Luche , Bo Wei
发明人： Ralf M. Luche , Bo Wei
IPC分类号： G01N33/50 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/22 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N15/52
CPC分类号： C12N9/16 , C12Y301/03016 , C12Y301/03048
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation of DSP-2 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-2 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-2底物去磷酸化的双特异性磷酸酶DSP-2及其多肽变体。多肽可用于例如鉴定抑制DSP-2活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

8. 发明申请

US20040043411A1 DSP-11 dual-specificity phosphatase 失效
标题翻译： DSP-11双特异性磷酸酶
公开(公告)号：US20040043411A1
公开(公告)日：2004-03-04
申请号：US10655073
申请日：2003-09-04
申请人： CEPTYR, Inc.
发明人： Ralf M. Luche , Bo Wei
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/16 , C12P021/02 , C12N005/06 , C07K016/40
CPC分类号： C12N9/16
摘要： Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-11, and polypeptide variants thereof that stimulate dephosphorylation of DSP-11 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-11 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
摘要翻译：提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。特别地，提供了刺激DSP-11底物去磷酸化的双特异性磷酸酶DSP-11及其多肽变体。多肽可用于例如鉴定抑制DSP-11活性的抗体和其它试剂。多肽和试剂可用于调节细胞增殖，分化和存活。

9. 发明申请

US20030215899A1 Reversible oxidation of protein tyrosine phosphatases 审中-公开
标题翻译：蛋白酪氨酸磷酸酶的可逆氧化
公开(公告)号：US20030215899A1
公开(公告)日：2003-11-20
申请号：US10366547
申请日：2003-02-12
申请人： CEPTYR, Inc. , Cold Spring Harbor Laboratory
发明人： Tzu-Ching Meng , Nicholas K. Tonks , Deborah E. Cool
IPC分类号： C12Q001/42
CPC分类号： C12Q1/42
摘要： The invention relates to a method of identifying any protein tyrosine phosphatase (PTP) that undergoes reversible modification of PTP active site invariant cysteine within a cell, such that the phosphatase is transiently protected from irreversible active site invariant cysteine-directed PTP inactivating agents. Methods related to regulation of PTPs by reactive oxygen species (ROS) in a cellular environment are provided. Multiple PTPs are shown to be reversibly oxidized and inactivated following treatment of cells with H2O2 or with physiological stimuli that promote ROS formation, and inhibition of PTP function is shown to contribute to ROS-induced mitogenesis. Transient oxidation of the PTP catalytic site invariant cysteine is exploited in methods to identify which of multiple candidate PTPs are components of a given biological signal transduction pathway, without a requirement for first specifically purifying any particular candidate PTP.
摘要翻译：本发明涉及一种鉴定在细胞内进行PTP活性位点不变半胱氨酸的可逆修饰的任何蛋白质酪氨酸磷酸酶（PTP）的方法，使得磷酸酶被不可逆活性位点不变半胱氨酸指导的PTP灭活剂瞬时保护。提供了与细胞环境中活性氧（ROS）调节PTP有关的方法。在用H 2 O 2处理细胞后，或者促进ROS形成的生理刺激，多个PTP被显示为可逆的氧化和灭活，并且显示PTP功能的抑制有助于ROS诱导的有丝分裂。 PTP催化位点不变半胱氨酸的瞬时氧化被用于鉴定多种候选PTP中的哪一种是给定生物信号转导途径的组分的方法，而不需要首先特异性纯化任何特定的候选PTP。

10. 发明授权

US07504389B2 Protein tyrosine phosphatase inhibitors and methods of use thereof 失效
标题翻译：蛋白酪氨酸磷酸酶抑制剂及其使用方法
公开(公告)号：US07504389B2
公开(公告)日：2009-03-17
申请号：US11280724
申请日：2005-11-15
申请人： Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Mario Schultz , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
发明人： Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Mario Schultz , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： C07F9/6541 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/65517
摘要： The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
摘要翻译：本发明提供了可用于调节蛋白酪氨酸磷酸酶-1b（PTP1B）酶的生物学活性的式（I）和式（II）的化合物。本发明的化合物可用于治疗其中PTP1B酶是因子的疾病和/或病症。这些疾病和/或病症包括但不限于1型糖尿病，2型糖尿病，葡萄糖耐量不足，胰岛素抵抗，肥胖症，高脂血症，高甘油三酯血症，高胆固醇血症，低HDL水平，动脉粥样硬化，血管再狭窄，炎性肠病，胰腺炎，脂肪细胞瘤，脂肪细胞癌，脂肪肉瘤，血脂异常，癌症和神经变性疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式