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1. 发明授权

US09803240B2 Stabilized nucleic acid dark quencher-fluorophore probes 有权
公开(公告)号：US09803240B2
公开(公告)日：2017-10-31
申请号：US14215272
申请日：2014-03-17
申请人： Biosearch Technologies, Inc.
发明人： Ronald M. Cook , Matt Lyttle
IPC分类号： C07H19/073 , C07H19/06 , C09B31/02 , C12Q1/68 , C07D219/04
CPC分类号： C12Q1/6876 , C07D219/04 , C07H19/06 , C07H19/073 , C09B31/02
摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

2. 发明授权

US09435796B2 Cyanine dyes 有权
公开(公告)号：US09435796B2
公开(公告)日：2016-09-06
申请号：US13179345
申请日：2011-07-08
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/68 , G01N33/542 , C12Q1/37
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

3. 发明申请

US20140194611A1 STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES 有权
标题翻译：稳定的核酸深色探针 - 荧光探针
公开(公告)号：US20140194611A1
公开(公告)日：2014-07-10
申请号：US14215272
申请日：2014-03-17
申请人： Biosearch Technologies, Inc.
发明人： Ronald M. Cook , Matt Lyttle
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C07D219/04 , C07H19/06 , C07H19/073 , C09B31/02
摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.
摘要翻译：本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些在共同拥有的美国专利申请公开No.2007 / 0059752中。

4. 发明授权

US08674094B2 Stabilized nucleic acid dark quencher-fluorophore probes 有权
标题翻译：稳定的核酸暗猝灭剂 - 荧光团探针
公开(公告)号：US08674094B2
公开(公告)日：2014-03-18
申请号：US13193517
申请日：2011-07-28
申请人： Ronald M. Cook , Matt Lyttle
发明人： Ronald M. Cook , Matt Lyttle
IPC分类号： C07F9/6512 , C07F9/655
CPC分类号： C12Q1/6876 , C07D219/04 , C07H19/06 , C07H19/073 , C09B31/02
摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.
摘要翻译：本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些在共同拥有的美国专利申请公开No.2007 / 0059752中。

5. 发明申请

US20100136567A1 CYANINE DYES 有权
公开(公告)号：US20100136567A1
公开(公告)日：2010-06-03
申请号：US12652625
申请日：2010-01-05
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C12Q1/68 , C07D209/02 , C07F9/02 , C07K2/00 , C07H21/00 , C12Q1/37
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

6. 发明申请

US20100130733A1 LUMINESCENT METAL ION COMPLEXES 有权
标题翻译：发光金属离子复合物
公开(公告)号：US20100130733A1
公开(公告)日：2010-05-27
申请号：US12644002
申请日：2009-12-21
申请人： RONALD M. COOK , MATT LYTTLE , MARY KATHERINE JOHANNSON
发明人： RONALD M. COOK , MATT LYTTLE , MARY KATHERINE JOHANNSON
IPC分类号： C07H19/16 , C07H21/00 , C07H19/167 , C07H19/06 , C07H19/00
CPC分类号： C07F15/0053 , C07B2200/11 , C09B56/00 , C09B57/10 , Y10T436/143333
摘要： The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.
摘要翻译：本发明提供用于广泛的生物和化学研究的发光金属离子络合物。本发明的发光金属离子络合物包含与载体分子共价结合的金属离子螯合组分。还提供了制造和使用发光金属离子络合物的方法。

7. 发明申请

US20060035262A1 Dark quenchers for donor-acceptor energy transfer 审中-公开
公开(公告)号：US20060035262A1
公开(公告)日：2006-02-16
申请号：US11226852
申请日：2005-09-13
申请人： Ronald Cook , Matt Lyttle , Daren Dick
发明人： Ronald Cook , Matt Lyttle , Daren Dick
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

8. 发明授权

US11034677B2 Coumarin-based compounds and related methods 有权
公开(公告)号：US11034677B2
公开(公告)日：2021-06-15
申请号：US14998576
申请日：2016-01-19
申请人： Biosearch Technologies, Inc.
发明人： Anthony de Jesus Sanchez
IPC分类号： C07D405/06 , C07H21/04 , C07D491/16 , C07D491/052 , C07D311/12
摘要： The present invention generally relates to coumarin-based compounds that can be used for the labeling of biological molecules, as well as related synthetic and testing methods. The coumarin-based compounds typically survive conditions necessary for automated synthesis of nucleic acids without undergoing any substantial degree of degradation or alteration.

9. 发明申请

US20160199491A1 Compounds compositions and methods including thermally labile moieties 审中-公开
标题翻译：化合物组合物和方法包括热不稳定部分
公开(公告)号：US20160199491A1
公开(公告)日：2016-07-14
申请号：US14545280
申请日：2015-04-15
申请人： Biosearch Technologies, Inc.
发明人： Ronald Michael Cook , Brett Michael Cook , Matthew H. Lyttle
IPC分类号： A61K41/00 , A61K31/7076 , C07H19/10 , B01J19/24 , A61K31/708 , A61K31/7072 , C12N15/113 , C12P19/34 , C07H19/20 , A61K31/7068
CPC分类号： A61K41/0042 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , B01J19/24 , B01J2219/00051 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/113 , C12N2310/314 , C12N2330/30 , C12P19/34 , Y02P20/55
摘要： The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure XO—CH2—SM-B-A. The substituent X is H, an acid labile protecting group, a solid support, —P(O—R1)NR2R3, —P(O)(OH)H, —P(O)(OR1)H, —P(O)(OH)2, —P(O)(OH)O—P(O)(OH)OP(O)(OH)2 or salts thereof. The substituent R1 is CNE (i.e., cyanoethyl), alkyl, or heteroalkyl and R2 and R3 are independently alkyl. The substituent SM is a sugar moiety or analogue thereof that is not a natural furanosyl, B is a base moiety or analogue thereof, and A is a moiety attached to a nitrogen on or in the base moiety of the structure —C(O)OR4, wherein R4 is tertiary alkyl.
摘要翻译：本发明一般涉及包含一种或多种热不稳定保护基团的化合物，包括该化合物的组合物，制备化合物的方法和组合物以及使用该化合物和组合物的方法。一方面，本发明涉及XO-CH2-SM-B-A结构的化合物。取代基X为H，酸不稳定保护基，固体载体，-P（O-R1）NR2R3，-P（O）（OH）H，-P（O）（OR1）H，-P（O）（OH）2，-P（O）（OH）O-P（O）（OH）OP（O）（OH）2或其盐。取代基R 1是CNE（即氰乙基），烷基或杂烷基，R 2和R 3独立地是烷基。取代基SM是不是天然呋喃糖基的糖部分或其类似物，B是碱基部分或其类似物，A是与结构-C（O）OR 4的碱基部分上或其上的氮连接的部分其中R4是叔烷基。

10. 发明授权

US08436153B2 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US08436153B2
公开(公告)日：2013-05-07
申请号：US12652625
申请日：2010-01-05
申请人： Tim Carter , Mark Reddington
发明人： Tim Carter , Mark Reddington
IPC分类号： C09B23/02 , C09B23/06 , C09B23/08 , C07H19/00 , C12Q1/68
CPC分类号： G01N33/542 , C12Q1/37 , C12Q2337/00 , G01N2333/95
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可以通过促进它们与其它物质共轭的连接体部分官能化。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

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