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1. 发明申请

US20140005060A1 METHOD AND SYSTEM FOR THE ANALYSIS OF HIGH DENSITY CELLS SAMPLES 有权
标题翻译：高密度细胞样品分析方法与系统
公开(公告)号：US20140005060A1
公开(公告)日：2014-01-02
申请号：US13692464
申请日：2012-12-03
申请人： Biodot, Inc. , Accupath Diagnostic Laboratories, Inc. (d.b.a U.S. Labs)
发明人： Mathew Moore , Miriam Reyes , David Baunoch , Thomas C. Tisone , Brendan O'Farrell
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00378 , B01J2219/00389 , B01J2219/00398 , B01J2219/00527 , B01J2219/00547 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00743 , C12Q1/6841 , G01N33/56966 , G01N33/57415 , G01N35/1016 , Y10S436/809
摘要： Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.
摘要翻译：公开了用于形成多个细胞样品的细胞阵列的方法，所述多个细胞样品基本上在单层上单独排列，特别适用于诊断分析。电池阵列由能够以精确，复杂图案分配小体积的高速分配装置形成。还公开了可以在其上形成细胞阵列的基底，以及用于对所形成的细胞阵列进行诊断分析的方法。

2. 发明申请

US20220305515A1 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 有权
公开(公告)号：US20220305515A1
公开(公告)日：2022-09-29
申请号：US17451310
申请日：2021-10-18
申请人： BioDot, Inc.
发明人： Yehuda Ivri , Thomas C. Tisone , Eric P. Kuo , Shane Gunsalus
IPC分类号： B05B17/06 , B01L3/02 , B01J19/00
摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

3. 发明授权

US11181448B2 Controlled printing of a cell sample for karyotyping 有权
公开(公告)号：US11181448B2
公开(公告)日：2021-11-23
申请号：US14440843
申请日：2013-11-04
申请人： Biodot, Inc.
发明人： Brian L. Kirk , Anthony V. Lemmo , Thomas C. Tisone
IPC分类号： G01N1/28 , G01N1/31 , G01N35/10
摘要： Methods and techniques for controlled printing of a cell sample for karyotyping are provided. The methods can involve matrix printing using on-the-fly printing or dispensing to accurately spread cells within at least one cell sample on a surface in preparation for karyotyping, and further analysis. Advantageously, the methods result in a uniform distribution of chromosomes of the cell suspension or sample on the surface of a substrate which can be substantially discretely identified, and also provide for efficiency in a subsequent staining process and any further analysis of the stained chromosomes using a microscope or other imaging device.

4. 发明申请

US20130206857A1 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 审中-公开
标题翻译：具有纵向传感器和可更换毛细管的压电分配器
公开(公告)号：US20130206857A1
公开(公告)日：2013-08-15
申请号：US13841978
申请日：2013-03-15
申请人： Biodot, Inc.
发明人： Yehuda Ivri
IPC分类号： B05B17/06
CPC分类号： B05B17/0653 , B05B17/0607 , B05B17/063 , B05B17/0669 , B05B17/0676 , F04B43/046 , F04F7/00
摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.
摘要翻译：提供了用于获取和分配预定体积的液体的系统，装置和方法，特别是用于在自动或手动生产DNA阵列和测定中获取和分配小体积流体的独特的压电分配器，其中液滴是以一滴式格式分配，体积可以在约几微摩尔至几纳升。分配器可以有利地使用一次性毛细管组件，同时期望地保持压电致动器用于随后的进一步使用，从而减轻流体的交叉污染的可能性，并提供经济和成本有效的方法，重复使用压电致动器用于进一步操作，各种待分配和转移的液体。独特的纵向传感器可将径向管位移传递到管的受控轴向运动。

5. 发明授权

US07470547B2 Methods and systems for dispensing sub-microfluidic drops 有权
标题翻译：用于分配亚微流体滴剂的方法和系统
公开(公告)号：US07470547B2
公开(公告)日：2008-12-30
申请号：US10909934
申请日：2004-08-02
申请人： Thomas C. Tisone , Michelle Rodriquez , Michael K. Cabourne
发明人： Thomas C. Tisone , Michelle Rodriquez , Michael K. Cabourne
IPC分类号： G01N1/10 , B01L3/02
CPC分类号： B01J19/0046 , B01D19/0047 , B01J2219/00369 , B01J2219/00371 , B01J2219/00409 , B01J2219/00412 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00691 , B01L3/0241 , B01L3/0265 , B01L3/0268 , B01L2400/027 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B05B1/3053 , B05B5/025 , B05B5/16 , B05B9/0423 , B05B15/658 , B05B17/0607 , G01N35/1002 , Y10T436/2575
摘要： The invention relates generally to dispensing of fluids and, in particular, to methods and systems for dispensing microfluidic or sub-microfluidic volumes of droplets of chemical, biological or other reagents or liquids. Embodiments of the invention have particular efficacy in accurately dispensing small drops having volumes from about 100 nL down into the picoliter range.
摘要翻译：本发明一般涉及流体分配，尤其涉及用于分配化学，生物或其他试剂或液体的微流体或亚微流体体积的液滴的方法和系统。本发明的实施方案具有将体积从约100nL的小滴精确分配到皮升范围内的特殊功效。

6. 发明申请

US20120304929A1 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 有权
标题翻译：具有纵向传感器和可更换毛细管的压电分配器
公开(公告)号：US20120304929A1
公开(公告)日：2012-12-06
申请号：US13355150
申请日：2012-01-20
申请人： Yehuda Ivri
发明人： Yehuda Ivri
IPC分类号： F04B43/09 , B05C5/00 , B05C11/00 , B65D83/00
CPC分类号： F04B43/046 , B01J2219/00378 , B05B15/62 , B05B17/0607 , B05B17/0623 , F04F7/00
摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.
摘要翻译：提供了用于获取和分配预定体积的液体的系统，装置和方法，特别是用于在自动或手动生产DNA阵列和测定中获取和分配小体积流体的独特的压电分配器，其中液滴是以一滴式格式分配，体积可以在约几微摩尔至几纳升。分配器可以有利地使用一次性毛细管组件，同时期望地保持压电致动器用于随后的进一步使用，从而减轻流体的交叉污染的可能性，并提供经济和成本有效的方法，重复使用压电致动器用于进一步操作，各种待分配和转移的液体。独特的纵向传感器可将径向管位移传递到管的受控轴向运动。

7. 发明授权

US08323882B2 Method and system for the analysis of high density cells samples 有权
标题翻译：用于分析高密度细胞样品的方法和系统
公开(公告)号：US08323882B2
公开(公告)日：2012-12-04
申请号：US12833879
申请日：2010-07-09
申请人： Mathew Moore , Miriam Reyes , David Baunoch , Thomas Tisone , Brendan O'Farrell
发明人： Mathew Moore , Miriam Reyes , David Baunoch , Thomas Tisone , Brendan O'Farrell
IPC分类号： C12Q1/00
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00378 , B01J2219/00389 , B01J2219/00398 , B01J2219/00527 , B01J2219/00547 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00743 , C12Q1/6841 , G01N33/56966 , G01N33/57415 , G01N35/1016 , Y10S436/809
摘要： Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.
摘要翻译：公开了用于形成多个细胞样品的细胞阵列的方法，所述多个细胞样品基本上在单层上单独排列，特别适用于诊断分析。电池阵列由能够以精确，复杂图案分配小体积的高速分配装置形成。还公开了可以在其上形成细胞阵列的基底，以及用于对所形成的细胞阵列进行诊断分析的方法。

8. 发明申请

US20080227663A1 SYSTEMS AND METHODS FOR HIGH SPEED ARRAY PRINTING AND HYBRIDIZATION 审中-公开
标题翻译：用于高速阵列印刷和混合的系统和方法
公开(公告)号：US20080227663A1
公开(公告)日：2008-09-18
申请号：US12016961
申请日：2008-01-18
申请人： Thomas C. Tisone , Holger Eickhoff
发明人： Thomas C. Tisone , Holger Eickhoff
IPC分类号： C40B60/12 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00529 , B01J2219/00596 , B01J2219/00695 , B01J2219/00698 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0268 , B01L2300/0838 , B01L2400/0478 , B01L2400/065 , C12M41/00 , C12Q1/6837 , C12Q1/686 , Y10T436/11 , Y10T436/112499 , Y10T436/119163 , Y10T436/2575
摘要： Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.
摘要翻译：提供了用于高速排列，杂交，定量开发和/或测定的新颖和改进的系统和方法。一些实施例提供基于网络的阵列格式。一些其他实施例提供了基于片材的排列格式。一些实施方案使用滴下试验或杂交模式。在一些实施方案中，使用基本惰性的基底。在一些其它实施例中，利用交互式衬底。

9. 发明授权

US11998939B2 Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube 有权
公开(公告)号：US11998939B2
公开(公告)日：2024-06-04
申请号：US17451310
申请日：2021-10-18
申请人： BioDot, Inc.
发明人： Yehuda Ivri , Thomas C. Tisone , Eric P. Kuo , Shane Gunsalus
IPC分类号： B05B17/06 , B01J19/00 , B01L3/02
CPC分类号： B05B17/0669 , B01J19/0046 , B01L3/0268 , B05B17/0684 , B01J2219/00367 , B01J2219/00378 , B01J2219/00722 , B01L2300/0838 , B01L2300/123 , B01L2300/165 , B01L2400/0481
摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

10. 发明申请

US20170203322A1 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 审中-公开
公开(公告)号：US20170203322A1
公开(公告)日：2017-07-20
申请号：US15326457
申请日：2015-07-24
申请人： BioDot, Inc.
发明人： Yehuda Ivri , Thomas Tisone , Eric P. Kuo , Shane Gunsalus
IPC分类号： B05B17/06 , B01J19/00 , B01L3/02
CPC分类号： B05B17/0669 , B01J19/0046 , B01J2219/00367 , B01J2219/00378 , B01J2219/00722 , B01L3/0268 , B01L2300/0838 , B01L2300/123 , B01L2300/165 , B01L2400/0481 , B05B17/0684
摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

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