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1. 发明授权

US4486410A Heat defibrinogenation of AHF preparation 失效
标题翻译： AHF制剂的热脱纤维蛋白原化
公开(公告)号：US4486410A
公开(公告)日：1984-12-04
申请号：US578724
申请日：1984-02-09
申请人： Joseph D. Fisher
发明人： Joseph D. Fisher
IPC分类号： A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , C07K14/755
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83
摘要： Antihemophilic factor (AHF), a blood component necessary for clotting of normal whole blood, is extracted from cryoprecipitate containing AHF and fibrinogen as its principal components by: rapidly raising and thereafter lowering the temperature of the cryoprecipitate suspension to selectively denature the fibrinogen in the suspension; and separating the AHF-rich supernatant from the denatured fibrinogen.
摘要翻译：从含有AHF和纤维蛋白原作为其主要成分的冷沉淀物中提取抗凝血因子（AHF），其是正常全血凝血所必需的血液成分，通过以下方式提取：快速升高并随后降低冷沉淀物悬浮液的温度以选择性地使悬浮液中的纤维蛋白原变性 ; 并从变性纤维蛋白原分离富含AHF的上清液。

2. 发明授权

US4414149A Glycine.sup.8 -D-arginine.sup.24 calcitonin 失效
标题翻译：甘氨酸8-D-精氨酸24降钙素
公开(公告)号：US4414149A
公开(公告)日：1983-11-08
申请号：US471982
申请日：1983-03-04
申请人： Ronald C. Orlowski , Jay K. Seyler
发明人： Ronald C. Orlowski , Jay K. Seyler
IPC分类号： A61K38/00 , C07K14/585 , C07C103/52
CPC分类号： C07K14/5855 , A61K38/00 , Y10S930/28
摘要： New peptides are disclosed which have biological activity of the same type as known calcitonins which have both a D-amino acid in position 24 instead of the natural L-amino acid and are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
摘要翻译：公开了具有与已知降钙素相同类型的生物活性的新肽，其具有位置24的D-氨基酸而不是天然L-氨基酸，并且是天然降钙素的取代类似物。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素肽的方法。

3. 发明授权

US4401593A Glycine - 8 calcitonin 失效
标题翻译：甘氨酸-8降钙素
公开(公告)号：US4401593A
公开(公告)日：1983-08-30
申请号：US348472
申请日：1982-02-12
申请人： Ronald C. Orlowski , Jay K. Seyler
发明人： Ronald C. Orlowski , Jay K. Seyler
IPC分类号： C07K14/585 , C07C103/52
CPC分类号： C07K14/585 , Y10S530/855 , Y10S530/857
摘要： New peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
摘要翻译：公开了具有与已知降钙素相同类型的生物活性并且是天然降钙素的取代类似物的新肽。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素肽的方法。

4. 发明授权

US4397780A Leucine.sup.22 -calcitonin 失效
标题翻译：亮氨酸22降钙素
公开(公告)号：US4397780A
公开(公告)日：1983-08-09
申请号：US348396
申请日：1982-02-12
申请人： Ronald C. Orlowski , Jay K. Seyler
发明人： Ronald C. Orlowski , Jay K. Seyler
IPC分类号： A61K38/00 , C07K14/585 , C07C103/52
CPC分类号： C07K14/585 , A61K38/00 , Y10S530/855 , Y10S530/857
摘要： Two new peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
摘要翻译：公开了两种具有与已知降钙素相同类型的生物活性的新肽，它们是天然降钙素的取代类似物。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素肽的方法。

5. 发明授权

US4391747A Des asparagine-3-calcitonin 失效
标题翻译：天冬酰胺-3降钙素
公开(公告)号：US4391747A
公开(公告)日：1983-07-05
申请号：US348473
申请日：1982-02-12
申请人： Ronald C. Orlowski , Jay K. Seyler
发明人： Ronald C. Orlowski , Jay K. Seyler
IPC分类号： A61K38/00 , C07K14/585 , C07C103/52
CPC分类号： C07K14/585 , A61K38/00
摘要： Peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
摘要翻译：公开了具有与已知降钙素相同类型的生物活性并且具有比天然降钙素更短的氨基酸链的肽。还公开了可以转化成具有这种生物活性的肽的树脂肽; 以及用于制备所述树脂肽和所述降钙素肽的方法。

6. 发明授权

US4294826A Process for the preparation of highly purified antihemophilic factor 失效
标题翻译：制备高纯度抗血友病因子的方法
公开(公告)号：US4294826A
公开(公告)日：1981-10-13
申请号：US147441
申请日：1980-05-07
申请人： Fred Feldman
发明人： Fred Feldman
IPC分类号： A61K38/00 , C07K14/755 , A61K35/14 , A61K37/00
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/806 , Y10S530/83
摘要： An antihemophilic factor derived from human blood plasma, having about 1 to 10 units antihemophilic factor activity per mg of protein and being substantially free of denatured antihemophilic factor is prepared from material having 0.3 to 1.0 unit per mg of protein.
摘要翻译：具有每毫克蛋白质0.3至1.0单位的材料制备的源自人血浆的抗血友病因子，每毫克蛋白质具有约1至10单位的抗血友病因子活性并基本上不含变性的抗血友病因子。

7. 发明授权

US4228154A Purification of plasma albumin by ion exchange chromatography 失效
标题翻译：通过离子交换色谱法纯化血浆白蛋白
公开(公告)号：US4228154A
公开(公告)日：1980-10-14
申请号：US14837
申请日：1979-02-26
申请人： Joseph D. Fisher , Willie M. Curry , Michael E. Hrinda
发明人： Joseph D. Fisher , Willie M. Curry , Michael E. Hrinda
IPC分类号： A61K38/00 , C07K14/765 , A61K37/02 , C07G7/00
CPC分类号： C07K14/765 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： Purified plasma albumin is obtained by ion exchange chromatographic procedures and in the absence of process steps involving precipitation or desorption of the albumin.
摘要翻译：纯化的血浆白蛋白是通过离子交换色谱法获得的，并且不存在涉及白蛋白沉淀或解吸的工艺步骤。

8. 发明授权

US4151276A Method of suppressing gastric acid secretion by the oral administration of calcitonin 失效
标题翻译：通过口服降钙素抑制胃酸分泌的方法
公开(公告)号：US4151276A
公开(公告)日：1979-04-24
申请号：US576752
申请日：1975-05-12
申请人： Francine B. Caulin , James W. Bastian
发明人： Francine B. Caulin , James W. Bastian
IPC分类号： A61K38/23 , A61K35/46
CPC分类号： A61K38/23
摘要： A method of obtaining suppression of gastric acid secretion in a mammalian host by the oral administration of calcitonin to the host mammal, including man, to obtain the suppression of gastric acid secretion therein. The method is useful in the treatment of mammals having grastric or duodenal ulcers or other conditions which benefit from the suppression of gastric acidity.
摘要翻译：通过向宿主哺乳动物（包括人）口服降钙素来获得抑制哺乳动物宿主中胃酸分泌的方法，以获得其中胃酸分泌的抑制。该方法可用于治疗具有胃酸或十二指肠溃疡的哺乳动物或其它有利于抑制胃酸性的病症。

9. 发明授权

US4115928A Freeze-dry process and product 失效
标题翻译：冷冻干燥工艺和产品
公开(公告)号：US4115928A
公开(公告)日：1978-09-26
申请号：US425599
申请日：1973-12-17
申请人： Frank W. Reichenbacher
发明人： Frank W. Reichenbacher
IPC分类号： A01N1/02 , F26B5/04 , F26B5/06
CPC分类号： F26B5/04 , A01N1/0278 , A01N1/0289 , F26B5/06
摘要： An improvement in freeze-drying of skin tissue for use in treating wounds and diseased areas of the body wherein un-frozen skin is partially dried and frozen by drawing a vacuum across the skin before commencing the freeze-dry process, resulting in a novel product which reconstitutes more rapidly and more completely, and more nearly obtains the properties of fresh skin than obtainable by the product produced by the prior art process. In addition to the advantage of more efficient reconstitution, the method shortens the freeze-dry cycle and is less expensive.
摘要翻译：用于治疗身体的伤口和患病区域的皮肤组织的冷冻干燥的改进，其中在开始冷冻干燥过程之前，将未冷冻的皮肤部分干燥并通过在皮肤上抽真空而冷冻，得到新产品其更快速和更完全地重建，并且更接近地获得新鲜皮肤的性质，而不是由现有技术方法生产的产品获得的。除了更有效的重构的优点之外，该方法缩短了冷冻干燥循环并且成本更低。

10. 发明授权

US4089120A Production of macrospherical particles for anti-perspirants and the like 失效
标题翻译：生产用于防汗剂的大球形颗粒等
公开(公告)号：US4089120A
公开(公告)日：1978-05-16
申请号：US725752
申请日：1976-09-23
申请人： James F. Kozischek
发明人： James F. Kozischek
IPC分类号： A61K33/06 , A61J3/02 , A61K8/00 , A61K8/11 , A61K8/26 , A61K8/28 , A61K8/34 , A61K9/16 , A61Q15/00 , B01D1/18 , B01J2/02 , B01J2/04 , B05B3/10 , B29B9/00 , C08J3/12 , F26B7/00
CPC分类号： A61Q15/00 , A61K8/11 , A61K8/26 , A61K8/28 , B01J2/02 , A61K2800/412 , Y10S159/27
摘要： A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber. The filter is treated to produce hollow macrospheres having substantially smooth outer walls of such thickness that they can withstand normal shipment and handling without significant fragmentation.
摘要翻译：提供了一种制造中空的大球形颗粒的方法和装置。颗粒本身特别适合用作防汗剂。颗粒具有约10至74微米的直径，优选占15至44微米，并且大于单位密度。因此，他们不会深入肺部渗透。制备颗粒的方法包括提供含有制备颗粒的材料的溶液，通过离心力将溶液扩散通过小孔，使得所得中空颗粒的直径大于孔径，并将溶液液滴干燥一股热的空气。用于制造大球形颗粒的装置包括具有在喷雾干燥室内旋转的多孔烧结金属过滤器环的离心式雾化器。处理过滤器以产生具有这样厚度的基本平滑的外壁的中空宏观球体，使得它们能够承受正常的装运和处理而没有显着的碎裂。

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