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1. 发明授权

US07858357B2 Immunization with bacterial ghost-based vaccines 有权
标题翻译：用细菌幽灵疫苗免疫
公开(公告)号：US07858357B2
公开(公告)日：2010-12-28
申请号：US12387373
申请日：2009-05-01
申请人： Cornelis Johannes Leenhouts , Ranjan Ramasamy , Anton Steen , Jan Kok , Girbe Buist , Oscar Paul Kuipers
发明人： Cornelis Johannes Leenhouts , Ranjan Ramasamy , Anton Steen , Jan Kok , Girbe Buist , Oscar Paul Kuipers
IPC分类号： C12N1/00 , C12N1/06
CPC分类号： C07K14/335 , A61K38/00 , C07K2319/00 , Y02A50/411 , Y10S530/81
摘要： Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.
摘要翻译：公开了改善蛋白质物质与革兰氏阳性菌细胞壁材料结合的方法。蛋白质物质包括AcmA细胞壁结合结构域，其同系物或其功能衍生物。该方法包括用能够从细胞壁材料除去细胞壁组分如蛋白质，脂磷壁酸或碳水化合物的溶液并使蛋白质物质与细胞壁材料接触的溶液来处理细胞壁材料。

2. 发明授权

US07393828B2 Modified MscL protein channel 有权
标题翻译：改良的MscL蛋白通道
公开(公告)号：US07393828B2
公开(公告)日：2008-07-01
申请号：US11437873
申请日：2006-05-19
申请人： Armagan Kocer , Martin Walko , George Thomas Robillard
发明人： Armagan Kocer , Martin Walko , George Thomas Robillard
IPC分类号： A61K47/48 , A61K9/127 , A61P35/00 , C07C381/04
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04 , Y02A50/473
摘要： The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E. coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
摘要翻译：本发明涉及药物递送领域，特别涉及用于化学修饰用于药物递送载体中的蛋白质通道的化合物和方法，用于治疗分子的受控和/或局部释放（例如小分子，肽，蛋白质或其他大分子）。提供能够控制机械敏感通道的通道活性的pH和/或光响应化合物，例如大肠杆菌的MscL通道蛋白或其功能等同物，以及这些化合物用于转化机械敏感通道蛋白进入pH和/或光响应通道。还提供了包含pH和/或光响应通道蛋白的药物递送载体。

3. 发明授权

US07393448B2 Method of binding a compound to a sensor surface 失效
标题翻译：将化合物与传感器表面结合的方法
公开(公告)号：US07393448B2
公开(公告)日：2008-07-01
申请号：US10764270
申请日：2004-01-23
申请人： Ewa Maria Rogalska , Renata Bilewicz , Denis Etienne Marie André Tagu , Alain Georges Ghislain Walcarius , Johannes Wemer , Karin Scholtmeijer , Rick Rink , Harm Jan Hektor
发明人： Ewa Maria Rogalska , Renata Bilewicz , Denis Etienne Marie André Tagu , Alain Georges Ghislain Walcarius , Johannes Wemer , Karin Scholtmeijer , Rick Rink , Harm Jan Hektor
IPC分类号： G01N27/327 , B05D3/00
CPC分类号： G01N33/5438 , C12Q1/004 , Y10T428/24917 , Y10T428/24926 , Y10T428/31504 , Y10T428/31678
摘要： The present invention relates to a method of non-covalently binding a compound to a sensor surface. The method comprises adsorbing a hydrophobin-like substance to at least a part of the sensor surface, such as an electrode. The invention further provides a sensor having a surface, at least a part of which is provided with a coating of a hydrophobin-like substance that comprises a non-covalently bonded compound.
摘要翻译：本发明涉及一种非共价结合化合物与传感器表面的方法。该方法包括将疏水蛋白样物质吸附到传感器表面的至少一部分，例如电极。本发明进一步提供了具有表面的传感器，其表面的至少一部分设置有包含非共价键合的化合物的疏水蛋白样物质的涂层。

4. 发明授权

US07169383B1 Attaching substances to micro-organisms 有权
标题翻译：将物质附着于微生物
公开(公告)号：US07169383B1
公开(公告)日：2007-01-30
申请号：US09554354
申请日：1998-11-12
申请人： Girbe Buist , Cornelis Johannes Leenhouts , Gerard Venema , Jan Kok
发明人： Girbe Buist , Cornelis Johannes Leenhouts , Gerard Venema , Jan Kok
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： C12N9/2414 , A01N63/02 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/315 , C07K14/37 , C07K2319/00 , C12N9/2408 , C12N9/2462 , C12N9/86
摘要： The invention relates to surface display of proteins on micro-organisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian and plant cells, and bacteria. The invention provides a proteinaceous substance comprising a reactive group and at least one attaching peptide which comprises a stretch of amino acids having a sequence corresponding to at least a part of the consensus amino acid sequence listed in FIG. 10 and comprises a method for attaching a proteinaceous substance to the cell wall of a micro-organism comprising the use of said attaching peptide.
摘要翻译：本发明涉及通过将异源蛋白质靶向和锚定到诸如酵母，真菌，哺乳动物和植物细胞以及细菌的细胞的外表面上的微生物上蛋白质的表面显示。本发明提供了包含反应性基团和至少一种附着肽的蛋白质物质，其包含一段氨基酸，其氨基酸序列对应于图1中列出的共有氨基酸序列的至少一部分。并且包括将蛋白质物质附着到包含使用所述附着肽的微生物的细胞壁的方法。

5. 发明申请

US20060258587A1 Modified MscL protein channel 有权
标题翻译：改良的MscL蛋白通道
公开(公告)号：US20060258587A1
公开(公告)日：2006-11-16
申请号：US11437873
申请日：2006-05-19
申请人： Armagan Kocer , Martin Walko , George Robillard
发明人： Armagan Kocer , Martin Walko , George Robillard
IPC分类号： A61K38/16 , C07K14/245
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04 , Y02A50/473
摘要： The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E. coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
摘要翻译：本发明涉及药物递送领域，特别涉及用于化学修饰用于药物递送载体中的蛋白质通道的化合物和方法，用于治疗分子的受控和/或局部释放（例如小分子，肽，蛋白质或其他大分子）。提供能够控制机械敏感通道的通道活性的pH和/或光响应化合物，例如大肠杆菌的MscL通道蛋白或其功能等同物，以及这些化合物用于转化机械敏感通道蛋白进入pH和/或光响应通道。还提供了包含pH和/或光响应通道蛋白的药物递送载体。

6. 发明授权

US07067639B2 Method to provide bacterial ghosts provided with antigens 失效
公开(公告)号：US07067639B2
公开(公告)日：2006-06-27
申请号：US10321857
申请日：2002-12-16
申请人： Cornelis J. Leenhouts , Ranjan Ramasamy , Anton Steen , Jan Kok , Girbe Buist , Oscar P. Kuipers
发明人： Cornelis J. Leenhouts , Ranjan Ramasamy , Anton Steen , Jan Kok , Girbe Buist , Oscar P. Kuipers
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K45/00 , A61K47/00 , C12N1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/335 , A61K38/00 , C07K2319/00 , Y02A50/411 , Y10S530/81
摘要： Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material.

7. 发明授权

US06903191B2 Method of purifying a hydrophobin present in a hydrophobin-containing solution 失效
标题翻译：纯化含有疏水蛋白的溶液中疏水蛋白的方法
公开(公告)号：US06903191B2
公开(公告)日：2005-06-07
申请号：US10182806
申请日：2001-02-02
申请人： Marcel Leo de Vocht , Herman Abel B. Wösten , Joseph Gerard H. Wessels
发明人： Marcel Leo de Vocht , Herman Abel B. Wösten , Joseph Gerard H. Wessels
IPC分类号： C07K14/00 , C07K1/14 , C07K14/375 , C07K1/00
CPC分类号： C07K14/375
摘要： The invention relates to a method of purifying a hydrophobin present in a hydrophobin-containing solution. According to the invention the solution is contacted with a surface for the adsorption to that surface, and separated from a solution depleted in hydrophobin. Subsequently the surface is contacted with a solution containing a surfactant at a temperature lower than 90° C. Desorbed hydrophobin is separated from said surface.
摘要翻译：本发明涉及纯化含有疏水蛋白的溶液中的疏水蛋白的方法。根据本发明，该溶液与用于吸附到该表面的表面接触，并与从疏水蛋白中消耗的溶液分离。随后在低于90℃的温度下将表面与含有表面活性剂的溶液接触。从所述表面分离脱附的疏水蛋白。

8. 发明申请

US20080138401A1 Delivery vehicle comprising a modified MscL protein channel 有权
标题翻译：包含修饰的MscL蛋白通道的递送载体
公开(公告)号：US20080138401A1
公开(公告)日：2008-06-12
申请号：US11978743
申请日：2007-10-29
申请人： Armagan Kocer , Martin Walko , George Thomas Robillard
发明人： Armagan Kocer , Martin Walko , George Thomas Robillard
IPC分类号： A61K9/133 , A61K47/42
CPC分类号： A61K9/127 , A61K9/1271 , A61K47/6911 , C07C381/04 , Y02A50/473
摘要： The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g., small molecules, peptides, proteins or other macromolecules). Provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.
摘要翻译：本发明涉及药物递送领域，特别涉及用于化学修饰用于药物递送载体中的蛋白质通道的化合物和方法，用于治疗分子的受控和/或局部释放（例如小分子，肽，蛋白质或其他大分子）。提供了包含pH和/或光响应通道蛋白的药物递送载体。

9. 发明授权

US07312311B2 Attaching substances to microorganisms 有权
公开(公告)号：US07312311B2
公开(公告)日：2007-12-25
申请号：US11590738
申请日：2006-10-30
申请人： Girbe Buist , Cornelis J. Leenhouts , Gerard Venema , Jan Kok
发明人： Girbe Buist , Cornelis J. Leenhouts , Gerard Venema , Jan Kok
IPC分类号： C07K1/00
CPC分类号： C12N9/2414 , A01N63/02 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/315 , C07K14/37 , C07K2319/00 , C12N9/2408 , C12N9/2462 , C12N9/86
摘要： The invention relates to surface display of proteins on microorganisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian, plant cells, and bacteria. The invention provides a proteinaceous substance comprising a reactive group and at least one attaching peptide including a stretch of amino acids having a sequence corresponding to at least a part of the consensus amino acid sequence listed in FIG. 10 and further includes a method for attaching a proteinaceous substance to the cell wall of a microorganism comprising the use of the attaching peptide.

10. 发明申请

US20060276676A1 Non-symmetrical gelling agent 有权
公开(公告)号：US20060276676A1
公开(公告)日：2006-12-07
申请号：US11432735
申请日：2006-05-11
申请人： Kjeld van Bommel , Johannes van Esch
发明人： Kjeld van Bommel , Johannes van Esch
IPC分类号： C07C233/00
CPC分类号： B01J20/29 , A61K8/64 , A61K9/0014 , A61K9/0048 , A61K9/06 , A61K47/18 , A61K47/22 , A61K2800/48 , A61Q19/00 , B01J20/291 , C04B35/632 , C07C233/63 , C07C237/22 , C07C323/60 , C07C2601/14 , C07D215/38 , C07D401/12
摘要： The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of such a gelator or thickener. A gelator or thickener according to the invention may, for instance, be used for pharmaceutical or cosmetic purposes. It may further be used as a support material in chromatographic materials or catalytically active materials.

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