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1. 发明授权

US10519185B2 Methods of preparing substituted nucleoside analogs 有权
公开(公告)号：US10519185B2
公开(公告)日：2019-12-31
申请号：US15905526
申请日：2018-02-26
申请人： Alios BioPharma, Inc.
发明人： Vladimir Serebryany , Jyanwei Liu , Leonid Beigelman
IPC分类号： C07H1/00 , C07H19/06 , C07H23/00
摘要： Disclosed herein are methods of preparing a nucleoside analog, Compound (I): or a pharmaceutically acceptable salt thereof, which is useful in treating diseases and/or conditions such as viral infections, and intermediates thereof.

2. 发明授权

US10208045B2 Aza-pyridone compounds and uses thereof 有权
公开(公告)号：US10208045B2
公开(公告)日：2019-02-19
申请号：US15065627
申请日：2016-03-09
申请人： Alios BioPharma, Inc.
发明人： Robert Than Hendricks , Leonid Beigelman , David Bernard Smith , Antitsa Dimitrova Stoycheva
IPC分类号： C07D487/04 , C07H17/02 , C07D519/00 , A61K45/06 , A61K31/215
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compound. Examples of an orthomyxovirus viral infection include an influenza infection.

3. 发明授权

US10144755B2 Substituted nucleosides, nucleotides and analogs thereof 有权
公开(公告)号：US10144755B2
公开(公告)日：2018-12-04
申请号：US15256345
申请日：2016-09-02
申请人： ALIOS BIOPHARMA, INC.
发明人： Leonid Beigelman , Guangyi Wang , David Bernard Smith
IPC分类号： C07H19/10 , C07H19/06 , C07H19/20 , C07H19/173 , C07H19/16 , C07H19/207 , C07H19/213
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

4. 发明授权

US09603864B2 Substituted nucleosides, nucleotides and analogs thereof 有权
公开(公告)号：US09603864B2
公开(公告)日：2017-03-28
申请号：US14746500
申请日：2015-06-22
申请人： ALIOS BIOPHARMA, INC.
发明人： Lawrence M. Blatt , Leonid Beigelman , Julian Alexander Symons , David Bernard Smith
IPC分类号： A01N43/04 , A61K31/70 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/6558 , C07F9/6574
CPC分类号： A61K31/708 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65586 , C07F9/65742
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

5. 发明授权

US09012427B2 Pharmaceutical combinations comprising a thionucleotide analog 有权
标题翻译：包含硫代核苷酸类似物的药物组合
公开(公告)号：US09012427B2
公开(公告)日：2015-04-21
申请号：US13797511
申请日：2013-03-12
申请人： Alios BioPharma, Inc. , Vertex Pharmaceuticals Inc.
发明人： Lawrence M Blatt , Leonid Beigelman , Hua Tan , Julian Alexander Symons , David Bernard Smith , Min Jiang , Tara Lynn Kieffer , Cornelis Arie Rijnbrand
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7072 , A61K31/4709 , A61K31/4178 , A61K31/497 , A61K31/381 , A61K38/55
CPC分类号： A61K31/7072 , A61K31/381 , A61K31/4178 , A61K31/4709 , A61K31/497 , A61K38/55 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases and/or conditions with a pharmaceutical composition that can include a thionucleotide analog in combination therapy with other agents.
摘要翻译：本文公开了可以包括用于与其它试剂组合治疗的硫代核苷酸类似物的药物组合物。本文还公开了用药物组合物治疗疾病和/或病症的方法，所述药物组合物可以包含硫代核苷酸类似物与其它药剂组合治疗。

6. 发明授权

US08980865B2 Substituted nucleotide analogs 有权
标题翻译：取代的核苷酸类似物
公开(公告)号：US08980865B2
公开(公告)日：2015-03-17
申请号：US13722472
申请日：2012-12-20
申请人： Alios BioPharma, Inc.
发明人： Guangyi Wang , Leonid Beigelman
IPC分类号： A01N43/04 , A61K31/70 , C07H19/04 , C07H19/00 , C07H19/20 , C07H19/10 , C07H19/048 , A61K31/7072 , A61K31/7056 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/207
CPC分类号： C07H19/20 , A61K31/381 , A61K31/497 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/10 , C07H19/207
摘要： Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.
摘要翻译：本文公开了硫代磷酸酯核苷酸类似物，例如硫代磷酰胺酸酯前药和硫代磷酸酯（包括α-硫代磷酸酯，α-硫代二磷酸酯和α-硫代三磷酸酯），合成硫代磷酸酯核苷酸类似物如硫代磷酰胺酸酯前药和硫代磷酸酯的方法和治疗病毒感染的方法，例如具有硫代磷酸酯核苷酸类似物的HCV，癌症和/或寄生虫病，例如硫代磷酰胺酸酯前药和硫代磷酸酯。

7. 发明授权

US08877731B2 Azido nucleosides and nucleotide analogs 有权
标题翻译：叠氮核苷和核苷酸类似物
公开(公告)号：US08877731B2
公开(公告)日：2014-11-04
申请号：US13236486
申请日：2011-09-19
申请人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
发明人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
IPC分类号： A61K31/70 , A01N43/04 , C07H19/00 , C07H19/04 , C07H19/10 , C07H19/048 , C07H19/20 , C07H19/167 , C07H19/173 , A61K31/7068 , C07H19/056 , C07H19/09 , A61K31/7056 , A61K45/06 , A61K31/7072 , A61K31/708 , A61K31/7105 , C07H19/11 , C07H19/067 , C07H19/19 , A61K31/7076 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译：本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。

8. 发明申请

US20110008289A1 HYPERGLYCOSYLATED POLYPEPTIDE VARIANTS AND METHODS OF USE 审中-公开
公开(公告)号：US20110008289A1
公开(公告)日：2011-01-13
申请号：US12542561
申请日：2009-08-17
申请人： LAWRENCE M. BLATT , SCOTT D. SEIWERT , JIN HONG
发明人： LAWRENCE M. BLATT , SCOTT D. SEIWERT , JIN HONG
IPC分类号： A61K38/21 , C07K14/52 , A61P37/00
CPC分类号： C07K14/555 , A61K38/00 , C07K14/56 , C07K14/565 , C07K14/57 , Y02A50/385 , Y02A50/387 , Y02A50/393
摘要： The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more native or non-native glycosylation sites. The present invention provides synthetic Type I interferon receptor polypeptide agonists comprising consensus or hybrid Type I interferon receptor polypeptide agonists, containing one or more native or non-native glycosylation sites, as well as erythropoietin and darbepoetin alfa, each of which are linked to a penetrating peptide that facilitates translocation of a substance across a biological barrier as well as pharmaceutical compositions, including oral formulations, of the same. The present invention further provides oral formulations of hyperglycosylated or protease-resistant, hyperglycosylated polypeptide variants, which polypeptide variants lack at least one protease cleavage site found in a parent polypeptide, and thus exhibit increased protease resistance compared to the parent polypeptide, which polypeptide variants further include (1) a carbohydrate moiety covalently linked to at least one non-native glycosylation site not found in the parent protein therapeutic or (2) a carbohydrate moiety covalently linked to at least one native glycosylation site found but not glycosylated in the parent protein therapeutic. The present invention further provides compositions, including oral pharmaceutical compositions, comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides containers, devices, and kits comprising the synthetic Type I interferon receptor polypeptide agonist, the hyperglycosylated polypeptide variant, or the hyperglycosylated, protease-resistant polypeptide variant. The present invention further provides therapeutic methods involving administering an effective amount of an oral pharmaceutical composition comprising a synthetic Type I interferon receptor polypeptide agonist, a hyperglycosylated polypeptide variant, or a hyperglycosylated, protease-resistant polypeptide variant to an individual in need thereof.

9. 发明申请

US20100240604A1 PROTECTED NUCLEOTIDE ANALOGS 审中-公开
标题翻译：保护核苷类似物
公开(公告)号：US20100240604A1
公开(公告)日：2010-09-23
申请号：US12728068
申请日：2010-03-19
申请人： Leonid Beigelman , Lawrence Blatt , Harri Lonnberg
发明人： Leonid Beigelman , Lawrence Blatt , Harri Lonnberg
IPC分类号： A61K31/7072 , C07H19/056 , A61K31/7056 , C07H19/10 , A61K31/7068 , A61P35/00 , A61P31/12 , A61P35/02 , A61P31/18 , A61P33/00 , A61P31/20 , A61P31/14 , A61P31/22
CPC分类号： C07H19/073 , C07F9/6512 , C07F9/65616 , C07H19/056 , C07H19/10 , C07H19/14 , C07H19/173 , C07H19/20
摘要： Disclosed herein are nucleotide analogs with protected phosphates, methods of synthesizing nucleotide analogs with protected phosphates and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the nucleotide analogs with protected phosphates.
摘要翻译：本文公开了具有被保护的磷酸盐的核苷酸类似物，与被保护的磷酸盐合成核苷酸类似物的方法以及用被保护的磷酸盐的核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

10. 发明授权

US10307439B2 Substituted nucleosides, nucleotides and analogs thereof 有权
公开(公告)号：US10307439B2
公开(公告)日：2019-06-04
申请号：US15423270
申请日：2017-02-02
申请人： ALIOS BIOPHARMA, INC.
发明人： Lawrence M. Blatt , Leonid Beigelman , Julian Alexander Symons , David Bernard Smith
IPC分类号： A01N43/04 , A61K31/70 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/6558 , C07F9/6574
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

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