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1. 发明申请

US20180325916A1 Dermal Delivery Compositions And Methods 审中-公开
公开(公告)号：US20180325916A1
公开(公告)日：2018-11-15
申请号：US16045338
申请日：2018-07-25
申请人： Agile Therapeutics, Inc.
发明人： Charles G. ARNOLD , Agis Kydonieus , Thomas M. Rossi , Alfred F. Altomari
IPC分类号： A61K31/567 , A61K47/20 , A61K47/32 , A61K31/57 , A61K47/12 , A61K9/00 , A61K9/70
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/57 , A61K47/12 , A61K47/20 , A61K47/32
摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.

2. 发明授权

US09782419B2 Transdermal contraceptive hormones delivery 有权
公开(公告)号：US09782419B2
公开(公告)日：2017-10-10
申请号：US14925223
申请日：2015-10-28
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/57 , A61K31/565 , A61K31/566 , A61K9/70 , A61K47/12 , A61K47/14 , A61K47/24 , A61K31/567 , A61K31/535 , A61K31/56 , A61K9/00
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/535 , A61K31/56 , A61K31/565 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.

3. 发明申请

US20160250226A1 DERMAL DELIVERY COMPOSITIONS AND METHODS 审中-公开
标题翻译： DERMAL DELIVERY组合物和方法
公开(公告)号：US20160250226A1
公开(公告)日：2016-09-01
申请号：US15151966
申请日：2016-05-11
申请人： Agile Therapeutics, Inc.
发明人： Charles G. ARNOLD , Agis KYDONIEUS , Thomas M. ROSSI , Alfred F. ALTOMARI
IPC分类号： A61K31/567 , A61K47/12 , A61K47/20 , A61K47/32 , A61K9/00 , A61K9/70
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/57 , A61K47/12 , A61K47/20 , A61K47/32
摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.
摘要翻译：公开了用于孕激素治疗孕激素透皮递送的组合物。还公开了包含该组合物的透皮递送装置。对于仅孕激素治疗，该组合物含有抗氧化剂并且不含有雌激素。对于涉及孕激素和雌激素的治疗，组合物含有孕激素，雌激素和另外的抗氧化剂。还公开了改善含有孕激素的组合物包含氧化剂的稳定性的方法。所述方法包括在组合物中包含一种或多种抗氧化剂。

4. 发明授权

US09198876B2 Contraceptive transdermal delivery of hormones 有权
标题翻译：激素的避孕透皮递送
公开(公告)号：US09198876B2
公开(公告)日：2015-12-01
申请号：US13123012
申请日：2009-10-07
申请人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K9/70 , A61K31/565 , A61K31/57
CPC分类号： A61K31/57 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/565 , A61K31/566 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.
摘要翻译：用于经皮递送激素的给药方案，其包括具有固定治疗间隔和固定休息间隔的28天治疗周期。

5. 发明申请

US20150037395A1 TRANSDERMAL HORMONE DELIVERY SYSTEM: COMPOSITIONS AND MTEHODS 审中-公开
标题翻译：超声波输送系统：组合物和麦克风
公开(公告)号：US20150037395A1
公开(公告)日：2015-02-05
申请号：US14519758
申请日：2014-10-21
申请人： Te-Yen CHIEN
发明人： Te-Yen CHIEN
IPC分类号： A61K9/70 , A61K31/57
CPC分类号： A61K9/7038 , A61K9/0014 , A61K9/7061 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/14 , A61K47/20 , A61K2300/00
摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.
摘要翻译：公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

6. 发明申请

US20140350493A1 DERMAL DELIVERY DEVICE WITH IN SITU SEAL 审中-公开
标题翻译：带密封件的DERMAL DELIVERY设备
公开(公告)号：US20140350493A1
公开(公告)日：2014-11-27
申请号：US14264427
申请日：2014-04-29
申请人： Agile Therapeutics, Inc.
发明人： Agis KYDONIEUS , Robert G. CONWAY , Thomas M. ROSSI
IPC分类号： A61K9/70 , A61K47/14 , A61K31/567 , A61K31/566 , A61K31/568 , A61K47/20 , A61K31/573
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the Al layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.
摘要翻译：本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫的Al层具有在所有方向上延伸超出Al层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂其周边在所有方向上延伸超出Al层的周边，其中覆盖层的剥离衬垫和PSA与Al层的周边彼此接触并彼此粘附以形成密封，以减少或防止挥发性成分损失。

7. 发明授权

US08883196B2 Transdermal hormone delivery system: compositions and methods 有权
标题翻译：透皮激素递送系统：组合物和方法
公开(公告)号：US08883196B2
公开(公告)日：2014-11-11
申请号：US14080948
申请日：2013-11-15
申请人： Agile Therapeutics, Inc
发明人： Te-Yen Chien
IPC分类号： A61F13/02 , A61L15/16 , A61F13/00 , A61K9/70 , A61K9/00 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/14 , A61K47/20
CPC分类号： A61K9/7038 , A61K9/0014 , A61K9/7061 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/14 , A61K47/20 , A61K2300/00
摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.
摘要翻译：公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

8. 发明授权

US08221785B2 Transdermal hormone delivery system: compositions and methods 有权
标题翻译：透皮激素递送系统：组合物和方法
公开(公告)号：US08221785B2
公开(公告)日：2012-07-17
申请号：US12556740
申请日：2009-09-10
申请人： Te-Yen Chien
发明人： Te-Yen Chien
IPC分类号： A61F13/02 , A61F13/00 , A61L15/16 , A61K9/70
CPC分类号： A61K9/7038 , A61K9/0014 , A61K9/7061 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/14 , A61K47/20 , A61K2300/00
摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.
摘要翻译：公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

9. 发明申请

US20200061080A1 TRANSDERMAL CONTRACEPTIVE HORMONES DELIVERY 审中-公开
公开(公告)号：US20200061080A1
公开(公告)日：2020-02-27
申请号：US16436435
申请日：2019-06-10
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/567 , A61K9/70 , A61K31/535 , A61K31/56 , A61K31/565 , A61K9/00
摘要： Dosing regimens for transdermal delivery of hormones comprising a variable treatment cycle and a fixed rest interval are disclosed.

10. 发明申请

US20180104258A1 TRANSDERMAL CONTRACEPTIVE HORMONES DELIVERY 审中-公开
公开(公告)号：US20180104258A1
公开(公告)日：2018-04-19
申请号：US15705039
申请日：2017-09-14
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/57 , A61K9/70 , A61K31/565 , A61K31/566
CPC分类号： A61K31/57 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/565 , A61K31/566 , A61K2300/00
摘要： Dosing regimens for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval are disclosed.

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