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1. 发明授权

US08672999B2 Prosthetic heart valve assemblies 有权
标题翻译：假心瓣膜组件
公开(公告)号：US08672999B2
公开(公告)日：2014-03-18
申请号：US13279754
申请日：2011-10-24
申请人： Douglas S. Cali , Keith E. Myers
发明人： Douglas S. Cali , Keith E. Myers
IPC分类号： A61F2/24
CPC分类号： B23K26/324 , A61F2/2415 , A61F2220/0075 , B23K26/32 , B23K26/40 , B23K2103/16 , B23K2103/30 , B23K2103/38 , B23K2103/42 , B23K2103/50 , Y10T156/1054
摘要： A prosthetic heart valve assembly comprises a plurality of leaflets configured to replace the function of a native heart valve. Each leaflet comprises laminar pericardium tissue. Each leaflet has a coaptation edge formed by laser cutting. The tissue layers of each leaflet are fused together along an entire length of the coaptation edge, and tissue adjacent each coaptation edge does not have significant thermal energy damage.
摘要翻译：假体心脏瓣膜组件包括构造成替代天然心脏瓣膜功能的多个小叶。每片小叶均包含层状心包组织。每个小叶具有通过激光切割形成的接合边缘。每个叶片的组织层沿着接合边缘的整个长度融合在一起，并且每个接合边缘附近的组织不具有显着的热能损伤。

2. 发明申请

US20040138743A1 Prosthetic heart value 有权
标题翻译：假体心脏价值
公开(公告)号：US20040138743A1
公开(公告)日：2004-07-15
申请号：US10751549
申请日：2004-01-05
申请人： 3f Therapeutics, Inc.
发明人： Keith Myers , Christine Nguyen
IPC分类号： A61F002/24
CPC分类号： A61F2/2415 , A61F2/2412 , A61F2220/0075
摘要： A tubular prosthetic semilunar or atrioventricular heart valve is formed by cutting flat, flexible leaflets according to a pattern. The valve is constructed by aligning the side edges of adjacent leaflets so that the leaflet inner faces engage each other, and then suturing the leaflets together with successive stitches along a fold line adjacent the side edges. The stitches are placed successively from a proximal in-flow end of each leaflet toward a distal out-flow end. During operation, when the leaflets open and close, the leaflets fold along the fold line. Distal tabs extend beyond the distal end of each leaflet. The successive stitches terminate proximal of the distal tab portion so that no locked stitches are placed along the distal portion of the fold line. The tab portions of adjacent leaflets are folded over each other and sewn together to form commissural attachment tabs. The commissural tabs provide commissural attachment points to accommodate sutures and the like in order to secure the tab to a vessel wall, if a semilunar valve, and papillary muscles and/or chordae tendineae if an atrioventricular valve.
摘要翻译：通过根据图案切割扁平的柔性小叶形成管状假体半月室或房室心脏瓣膜。瓣膜通过对齐相邻小叶的侧边缘而构成，使得小叶内表面彼此接合，然后沿着邻近侧边缘的折叠线连续缝合缝合传单。针迹从每个小叶的近端流动端朝向远端外流端连续放置。在操作期间，当传单打开和关闭时，传单沿着折叠线折叠。远端翼片延伸超过每个小叶的远端。连续的针脚终止在远侧翼片部分的近侧，使得沿折叠线的远端部分没有设置锁定的线迹。相邻小叶的翼片部分彼此折叠并缝合在一起以形成连续的连接片。连合片提供连合连接点以适应缝合线等，以便如果手术瓣膜，则将突片固定到血管壁，如果是半月瓣，以及如果房室瓣膜，则乳头肌和/或腱索。

3. 发明申请

US20040078072A1 Delivery system for a stentless valve bioprosthesis 审中-公开
公开(公告)号：US20040078072A1
公开(公告)日：2004-04-22
申请号：US10724342
申请日：2003-11-26
申请人： 3f Therapeutics, Inc.
发明人： Hosheng Tu , Rodolfo C. Quijano
IPC分类号： A61F002/06
CPC分类号： A61F2/2436 , A61F2/2412 , A61F2/2475
摘要： The current invention discloses a catheter and a method for delivering a stentless bloprosthesis in a body channel, the method comprising percutaneously introducing a catheter into the body channel, wherein the catheter contains said stentless bloprosthesis at a retracted state; and disengaging said stentless bioprosthesis out of a distal opening of the catheter by a pulling mechanism associated with the catheter structure.

4. 发明授权

US6092529A Replacement semilunar heart valves using flexible tubes 有权
标题翻译：替代半月心脏瓣膜使用柔性管
公开(公告)号：US6092529A
公开(公告)日：2000-07-25
申请号：US288998
申请日：1999-02-03
申请人： James L. Cox
发明人： James L. Cox
IPC分类号： A61F2/00 , A61F2/24 , A61L27/36 , G06Q40/04
CPC分类号： A61L27/3843 , A61F2/0095 , A61F2/2412 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3645 , A61L27/507 , G06Q40/04 , A61L2430/20 , Y10S623/90 , Y10S623/901
摘要： A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either "tacked" at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, including a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.
摘要翻译：公开了一种用于使用管状材料来代替半月瓣心脏瓣膜（即主动脉瓣或肺动脉瓣）的方法。为了创建这样的替换阀，从主动脉或肺动脉内部移除天然瓣膜，并将管状区段的入口端缝合到瓣膜环。管的出口（远端）在三个点处“向上”，或沿三条线纵向缝合; 任何一种方法将允许缝合线之间的组织襟翼起到可移动的尖角的作用。这种方法产生减少湍流的流动模式并且紧密地重复天然半月形阀的流动模式。还公开了一种制造物品，其包括以管状形式制造的无菌生物相容性合成材料，通过诸如挤出或涂覆圆柱形模制装置的方法，以避免需要缝合线或其它接缝以将平板的材料变成管状。合成管包装在密封的防水外壳内，保持管的无菌性。

5. 发明授权

US11534297B2 Surgical delivery device and method of use 有权
公开(公告)号：US11534297B2
公开(公告)日：2022-12-27
申请号：US16707502
申请日：2019-12-09
申请人： Medtronic 3F Therapeutics, Inc.
发明人： Andrzej M. Malewicz , David Elizondo , Matthew W. Weston
IPC分类号： A61F2/24 , A61F2/95 , B25B27/10
摘要： A delivery device for a stented heart valve includes a handle, an elongate shaft extending from a distal end of the handle, and a conical housing having a proximal end coupled to the elongate shaft and an open distal end, the conical housing having a conical lumen therein with a first internal diameter adjacent to the proximal end of the conical housing and a larger second internal diameter adjacent to the open distal end of the conical housing.

6. 发明申请

US20140039544A1 Method and Assembly for Distal Embolic Protection 审中-公开
标题翻译：远端栓塞保护方法与装配
公开(公告)号：US20140039544A1
公开(公告)日：2014-02-06
申请号：US13860749
申请日：2013-04-11
申请人： Medtronic 3F Therapeutics, Inc.
发明人： Bjarne Bergheim
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2/24 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2250/0003
摘要： Methods and assemblies are described for capturing embolic material in a blood vessel or other body cavity during cardiovascular or valve replacement and repair surgery, wherein access is provided through the apical area of the patient's heart. The distal embolic protection assembly generally comprises a sleeve having a lumen, an actuating member having proximal and distal ends, wherein the actuating member is movably disposed within the lumen, and a filter assembly coupled to the distal end of the actuating member. The filter assembly generally comprises a porous bag having an open proximal end, a collapsible and expandable frame that is coupled to the open proximal end of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag. The porous bag is configured such that it permits blood to perfuse freely through while capturing embolic material and other debris.
摘要翻译：描述了用于在心血管或瓣膜置换和修复手术期间在血管或其他体腔中捕获栓塞材料的方法和组件，其中通过患者心脏的顶端区域提供通路。远侧栓塞保护组件通常包括具有内腔的套筒，具有近端和远端的致动构件，其中致动构件可移动地设置在内腔内，以及联接到致动构件的远端的过滤器组件。过滤器组件通常包括多孔袋，其具有敞开的近端，可折叠和可扩张的框架，其联接到多孔袋的开口近端，以及至少一个支撑脊，其设置在多孔袋的纵向轴线的至少一部分上袋。多孔袋被构造成使得其允许血液在捕获栓塞材料和其它碎屑的同时自由地灌注。

7. 发明申请

US20100036474A1 METHOD AND ASSEMBLY FOR DISTAL EMBOLIC PROTECTION 有权
标题翻译：用于远端保护的方法和装配
公开(公告)号：US20100036474A1
公开(公告)日：2010-02-11
申请号：US12580525
申请日：2009-10-16
申请人： Bjarne Bergheim
发明人： Bjarne Bergheim
IPC分类号： A61F2/84 , A61M29/02
CPC分类号： A61F2/013 , A61F2/24 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2250/0003
摘要： Methods and assemblies are described for capturing embolic material in a blood vessel or other body cavity during cardiovascular or valve replacement and repair surgery, wherein access is provided through the apical area of the patient's heart. The distal embolic protection assembly generally comprises a sleeve having a lumen, an actuating member having proximal and distal ends, wherein the actuating member is movably disposed within the lumen, and a filter assembly coupled to the distal end of the actuating member. The filter assembly generally comprises a porous bag having an open proximal end, a collapsible and expandable frame that is coupled to the open proximal end of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag. The porous bag is configured such that it permits blood to perfuse freely through while capturing embolic material and other debris.
摘要翻译：描述了用于在心血管或瓣膜置换和修复手术期间在血管或其他体腔中捕获栓塞材料的方法和组件，其中通过患者心脏的顶端区域提供通路。远侧栓塞保护组件通常包括具有内腔的套筒，具有近端和远端的致动构件，其中致动构件可移动地设置在内腔内，以及联接到致动构件的远端的过滤器组件。过滤器组件通常包括多孔袋，其具有敞开的近端，可折叠和可扩张的框架，其联接到多孔袋的开口近端，以及至少一个支撑脊，其设置在多孔袋的纵向轴线的至少一部分上袋。多孔袋被构造成使得其允许血液在捕获栓塞材料和其它碎屑的同时自由地灌注。

8. 发明授权

US07101396B2 Minimally invasive valve replacement system 有权
标题翻译：微创瓣膜置换系统
公开(公告)号：US07101396B2
公开(公告)日：2006-09-05
申请号：US10680071
申请日：2003-10-06
申请人： Jason Artof , Tuoc Tan Nguyen , Keith E. Myers
发明人： Jason Artof , Tuoc Tan Nguyen , Keith E. Myers
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/243 , A61F2/2439 , A61F2/2496 , A61F2210/0019 , A61F2210/0028 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2250/0059
摘要： Methods and systems for minimally invasive replacement of a valve. The system includes a collapsible valve and anchoring structure, devices and methods for expanding the valve anchoring structure, adhesive means to seal the valve to the surrounding tissue, a catheter-based valve sizing and delivery system, native valve removal means, and a temporary valve and filter assembly to facilitate removal of debris material. The valve assembly comprises a valve and anchoring structure for the valve, dimensioned to fit substantially within the valve sinus.
摘要翻译：用于微创更换瓣膜的方法和系统。该系统包括可折叠阀和锚定结构，用于扩大阀锚定结构的装置和方法，用于将阀密封到周围组织的粘合装置，基于导管的阀门尺寸和输送系统，天然阀去除装置和临时阀和过滤器组件以便于去除碎屑物质。阀组件包括用于阀的阀和锚固结构，其尺寸被设计成基本上配合在阀窦内。

9. 发明授权

US07041132B2 Percutaneously delivered heart valve and delivery means thereof 有权
标题翻译：经皮输送的心脏瓣膜及其输送装置
公开(公告)号：US07041132B2
公开(公告)日：2006-05-09
申请号：US10222176
申请日：2002-08-16
申请人： Rodolfo C. Quijano , Hosheng Tu
发明人： Rodolfo C. Quijano , Hosheng Tu
IPC分类号： A61F2/06
CPC分类号： A61F2/243 , A61F2/2412 , A61F2/2418
摘要： This invention discloses a percutaneous delivered heart valve and delivery means thereof, wherein the percutaneous delivered heart valve is a twistedly foldable heart valve prosthesis comprising a generally cylindrical support element with a diameter, wherein the support element is twistedly foldable to a smaller diameter, a flexible heart valve with a plurality of valvular leaflets releasably attached to said support element, and a receptacle having a plurality of connecting members secured to the cylindrical support element, wherein the receptacle is releasably matched to an expanding element capable of untwisting the receptacle adapted for un-twisting and unfolding said heart valve.
摘要翻译：本发明公开了一种经皮输送的心脏瓣膜及其输送装置，其中经皮输送的心脏瓣膜是可折叠的心脏瓣膜假体，其包括具有直径的大致圆柱形的支撑元件，其中支撑元件可扭转成较小的直径，具有可释放地附接到所述支撑元件的多个瓣状小叶的心脏瓣膜和具有固定到所述圆柱形支撑元件的多个连接构件的容器，其中所述容器可释放地匹配于能够解开所述插座的膨胀元件，扭转和展开所述心脏瓣膜。

10. 发明申请

US20050165477A1 Percutaneously deliverable heart valve 审中-公开
标题翻译：经皮输送心脏瓣膜
公开(公告)号：US20050165477A1
公开(公告)日：2005-07-28
申请号：US11083702
申请日：2005-03-18
申请人： James Anduiza , Rodolfo Quijano , Hosheng Tu
发明人： James Anduiza , Rodolfo Quijano , Hosheng Tu
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0054
摘要： This invention discloses a percutaneously deliverable heart valve and delivery means thereof, wherein the percutaneously deliverable heart valve is a foldable heart valve prosthesis to replace a diseased valve of a patient comprising: a support structure with a diameter, wherein the support structure is foldable to a smaller diameter, the support structure comprising a plurality of crossbar frames, wherein each crossbar frame has a plurality of crossbars connected at an end of each crossbar; a flexible tissue heart valve with a plurality of valvular leaflets attached to the support structure; and a plurality of slidable ring connectors, wherein at least a slidable ring connector encircles a first crossbar from a first crossbar frame and a second crossbar from a second crossbar frame configured to coupling the first and the second crossbars.
摘要翻译：本发明公开了一种经皮输送的心脏瓣膜及其输送装置，其中经皮输送的心脏瓣膜是可折叠的心脏瓣膜假体以替代病人的患病瓣，包括：具有直径的支撑结构，其中支撑结构可折叠到较小的直径，所述支撑结构包括多个横梁，其中每个横梁框架具有在每个横梁的端部处连接的多个横梁; 柔性组织心脏瓣膜，其具有附接到支撑结构的多个瓣状小叶; 以及多个可滑动的环形连接器，其中至少一个可滑动的环形连接器环绕来自第一横杆框架的第一横杆和来自构造成联接第一和第二横杆的第二横梁的第二横杆。

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