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81. 发明申请

US20120237950A1 ANALYSIS CHIP, ANALYSIS SYSTEM, AND ANALYSIS METHOD 审中-公开
标题翻译：分析芯片，分析系统和分析方法
公开(公告)号：US20120237950A1
公开(公告)日：2012-09-20
申请号：US13421934
申请日：2012-03-16
申请人： Yoshikatsu Imai , Daisuke Niwa
发明人： Yoshikatsu Imai , Daisuke Niwa
IPC分类号： G01N33/53 , C12M1/40 , G01N21/59 , G01N27/26 , G01N21/64 , G01N21/76
CPC分类号： G01N27/3272 , G01N21/05 , G01N21/645 , G01N21/76 , G01N2021/0325 , G01N2021/0346
摘要： An analysis chip for quantitative analysis by using a competitive reaction is provided. The analysis chip for analyzing a target substance to be identified in a liquid sample includes a base, and a flow path formed on the base. The flow path includes an introduction portion, for introducing the liquid sample; a reaction portion, disposed at a downstream side of the introduction portion, for subjecting the liquid sample to a competitive reaction; a discharge portion, disposed at a downstream side of the reaction portion; and a blocking portion, disposed between the reaction portion and the discharge portion, for inhibiting the flow of the liquid sample from the reaction portion to the discharge portion. The reaction portion accommodates a carrier prefixed with a specific binding substance for specifically binding the target substance to be identified or a competitive substance of the target substance to be identified.
摘要翻译：提供了一种通过使用竞争反应进行定量分析的分析芯片。用于分析在液体样品中识别的目标物质的分析芯片包括基底和形成在基底上的流路。流路包括用于引入液体样品的引入部分; 反应部分，设置在引入部分的下游侧，用于使液体样品经受竞争反应; 排出部，设置在所述反应部的下游侧; 以及设置在反应部分和排出部分之间的阻挡部分，用于抑制液体样品从反应部分流到排出部分。反应部分容纳预先用特异性结合物质预先特异性结合待鉴定的目标物质或待鉴定目的物质的竞争性物质的载体。

82. 发明申请

US20120231959A1 PERSONALIZED MEDICAL MANAGEMENT SYSTEM, NETWORKS, AND METHODS 审中-公开
标题翻译：个人化医疗管理系统，网络和方法
公开(公告)号：US20120231959A1
公开(公告)日：2012-09-13
申请号：US13412386
申请日：2012-03-05
申请人： Jeffrey J. ELTON , Jayanthi SRINIVASAN , Victoria JOSHI , Raju KUCHERLAPATI , M. Kathleen Behrens WILSEY
发明人： Jeffrey J. ELTON , Jayanthi SRINIVASAN , Victoria JOSHI , Raju KUCHERLAPATI , M. Kathleen Behrens WILSEY
IPC分类号： G06Q50/22 , C40B60/10 , C40B20/00 , C12M1/40 , G06Q50/24 , C12Q1/68
CPC分类号： G06Q50/22 , G06Q50/24 , G16B50/00 , G16H50/70
摘要： Disclosed herein are systems and methods for the assignment of therapeutic pathways to members of a network of oncology. The systems and methods allow for storage of disparate information in a database and determine a uniform semantics for all of the stored information. In addition, the systems and methods allow for the calculation of treatment pathways based on patient information as well as publicly-available information relating to particular diseases, and for the refinement of those treatment pathways as new information is added. Robot-assisted genomic labs permit automated genetic testing, which is integrated with the system.
摘要翻译：本文公开了用于将治疗途径分配给肿瘤学网络的成员的系统和方法。系统和方法允许在数据库中存储不同的信息，并确定所有存储信息的统一语义。此外，系统和方法允许基于患者信息以及与特定疾病相关的公开获得的信息来计算治疗途径，并且在添加新信息时对这些治疗途径进行细化。机器人辅助基因组实验室允许自动化基因检测，与系统集成。

83. 发明申请

US20120231534A1 Spectrometric device 审中-公开
标题翻译：光谱仪
公开(公告)号：US20120231534A1
公开(公告)日：2012-09-13
申请号：US12932824
申请日：2011-03-07
申请人： Wallace E. Carroll , R. David Jackson
发明人： Wallace E. Carroll , R. David Jackson
IPC分类号： C12M1/40 , G01N21/00 , G01J3/00
CPC分类号： G01N21/255 , G01J3/42 , G01N21/51 , G01N21/82 , G01N33/49 , G01N33/4905 , G01N2021/3185 , G01N2201/0621
摘要： The present invention provides improved spectrometric devices useful for measuring optical quantities of a component, including a solid state LED emitter, having at least one wavelength that is matched to the wavelength that is useful for the spectral analysis of the component of interest, a photodetection cell and an optimizing configuration and permits control of the LED emitter and the detector sensitivity to provide a range of detection for the signals corresponding to the optical density of a sample being analyzed and that affords sensitivity for a desired component of a sample by minimizing the error associated with electronic components and signals. Preferred embodiments also include configurations for determining an anticoagulant therapy value that may be used to determine treatment for a patient.
摘要翻译：本发明提供了可用于测量包括固态LED发射器的组件的光学量的改进的光谱测量装置，其具有与用于感兴趣组件的光谱分析的波长匹配的至少一个波长，光电检测单元并且优化配置并且允许对LED发射器的控制和检测器灵敏度，以提供对应于正在分析的样品的光密度的信号的检测范围，并通过最小化相关误差来提供对样品的期望分量的灵敏度具有电子元件和信号。优选实施方案还包括用于确定可用于确定患者治疗的抗凝血剂治疗值的配置。

84. 发明申请

US20120208192A1 NUCLEIC ACID AMPLIFICATION EMPLOYING TEMPERATURE OSCILLATION 审中-公开
标题翻译：核酸放大使用温度振荡
公开(公告)号：US20120208192A1
公开(公告)日：2012-08-16
申请号：US13394098
申请日：2010-09-08
申请人： Martin Lee , Andrea Hamilton
发明人： Martin Lee , Andrea Hamilton
IPC分类号： C12Q1/68 , G01N21/64 , C12M1/40 , G01N21/76
CPC分类号： C12Q1/686 , C12Q1/6865 , C12Q2527/113 , C12Q2527/101 , C12Q2521/119
摘要： A method for carrying out an isothermal nucleic acid amplification reaction at a predetermined temperature, said method comprising changing the temperature of the reaction mixture away from the said predetermined temperature and allowing it to return to the predetermined temperature at least once during the amplification reaction so as to cause a temperature oscillation in particular of up to 15° C., for example of from 2-10° C. Apparatus adapted to carry out the method forms a further aspect of the invention.
摘要翻译：一种在预定温度下进行等温核酸扩增反应的方法，所述方法包括将反应混合物的温度从所述预定温度改变，并使其在扩增反应期间至少返回到预定温度，以便导致温度振荡，特别是高达15℃，例如2-10℃。适于实施该方法的设备形成本发明的另一方面。

85. 发明申请

US20120196304A1 DETECTION APPARATUS 审中-公开
标题翻译：检测装置
公开(公告)号：US20120196304A1
公开(公告)日：2012-08-02
申请号：US13311519
申请日：2011-12-05
申请人： Robert DEES , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
发明人： Robert DEES , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
IPC分类号： G01N33/53 , C12M1/40
CPC分类号： G01N33/54373
摘要： The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.
摘要翻译：本发明部分涉及用于检测试剂的方法，试剂和装置。本发明还部分涉及包括但不限于流动池，测定室，试剂储存器输送单元和用于保持测定室的装置的组合物。本发明还提供了用于各种检测装置的各种部件和组件的组合。本发明还涉及一种便携式检测装置，其可以在现场使用或在一个关注点处使用，并且不限于专门的实验室或被高技能用户使用。

86. 发明申请

US20120190008A1 GENERIC PCR 有权
标题翻译：一般PCR
公开(公告)号：US20120190008A1
公开(公告)日：2012-07-26
申请号：US13192259
申请日：2011-07-27
申请人： Meike Eickhoff , Niclas Hitziger , Anke Mussmann , Thomas W. Myers , Christopher Newhouse , Nicolas Newton , John Niemiec , Nancy Schoenbrunner , Edward S. Smith , Stephen G. Will , Heike Wilts , Dirk Zimmermann
发明人： Meike Eickhoff , Niclas Hitziger , Anke Mussmann , Thomas W. Myers , Christopher Newhouse , Nicolas Newton , John Niemiec , Nancy Schoenbrunner , Edward S. Smith , Stephen G. Will , Heike Wilts , Dirk Zimmermann
IPC分类号： C12Q1/68 , C12M1/40 , C12Q1/70 , C12P19/34
CPC分类号： C12Q1/6806 , C12N15/1096 , C12Q1/686 , C12Q2521/107
摘要： The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
摘要翻译：本发明提供了扩增可能存在于流体样品中的至少第一和第二靶核酸的方法。本发明还提供了用于进行所述扩增的试剂盒和分析系统。

87. 发明申请

US20120171718A1 Submerged Perfusion Bioreactor 失效
标题翻译：浸没式灌注生物反应器
公开(公告)号：US20120171718A1
公开(公告)日：2012-07-05
申请号：US13375785
申请日：2010-06-03
申请人： Dang Quang Svend Le , Jens Vinge Nygaard , Morten Foss , Flemming Besenbacher , Cody Bünger
发明人： Dang Quang Svend Le , Jens Vinge Nygaard , Morten Foss , Flemming Besenbacher , Cody Bünger
IPC分类号： C12M3/00 , B01D35/00 , C12M1/40 , C12N5/071 , C12P1/00
CPC分类号： C12M29/10 , B01F13/08 , B01F13/0827 , C12M27/00 , C12M27/02 , C12M27/10
摘要： A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.
摘要翻译：用于生物学目的的装置如细胞培养，酶反应或流体过滤具有具有第一和第二表面的主体。身体由身体中心的边缘和孔限定。孔由第一和第二板覆盖在第一和第二表面。第一和/或第二板具有允许液体介质进入孔的入口孔。旋转装置布置在第一和第二板之间的孔中。至少一个凹部是本体边缘中的空腔，其具有允许液体介质从身体流出的第一出口孔。至少一个出口通道将圆形孔与凹部连接。液体被泵送到设备的孔中并泵送通过至少一个出口通道。

88. 发明申请

US20120171678A1 APPARATUS FOR THERMAL CYCLING 有权
标题翻译：装置热循环
公开(公告)号：US20120171678A1
公开(公告)日：2012-07-05
申请号：US13417121
申请日：2012-03-09
申请人： George MALTEZOS , Matthew JOHNSTON , David GOODWIN , Axel SCHERER , Christopher I. WALKER
发明人： George MALTEZOS , Matthew JOHNSTON , David GOODWIN , Axel SCHERER , Christopher I. WALKER
IPC分类号： G01N21/75 , G01N21/64 , C12M1/40
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译：本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。

89. 发明申请

US20120122077A1 Method to Detect and Sequence Post Translationally Modified Peptides 有权
标题翻译：检测和顺序后翻译修饰肽的方法
公开(公告)号：US20120122077A1
公开(公告)日：2012-05-17
申请号：US13375124
申请日：2010-05-28
申请人： Christopher John Hughes , Therese McKenna , David Gordon , Daniel James Kenny
发明人： Christopher John Hughes , Therese McKenna , David Gordon , Daniel James Kenny
IPC分类号： H01J49/26 , G01N27/72 , C12M1/40 , H01J49/00 , C12Q1/25
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/0045 , Y10T436/24
摘要： A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.
摘要翻译：公开了一种检测和测序翻译后修饰的肽的方法，其中进行负离子前体扫描。然后执行负离子高分辨率MS扫描，然后确定并监测正离子模式下的MRM通道。然后进行正离子MS / MS扫描。

90. 发明申请

US20120107899A1 Heat-Stable Carbonic Anhydrases and Their Use 有权
标题翻译：热稳定性碳酸酐酶及其用途
公开(公告)号：US20120107899A1
公开(公告)日：2012-05-03
申请号：US13379294
申请日：2010-06-25
申请人： Martin Borchert , Paria Saunders
发明人： Martin Borchert , Paria Saunders
IPC分类号： C12N9/88 , C12N15/60 , C12N1/21 , C12M1/40 , C12N11/00 , C12S99/00 , C12N15/63
CPC分类号： C12N9/88 , B01D53/62 , B01D53/84 , B01D2251/95 , B01D2257/504 , C12P7/40 , C12Y402/01001 , Y02A50/2358 , Y02C10/02 , Y02C10/04 , Y02E50/12 , Y02P20/152 , Y02P20/52 , Y02P20/59
摘要： The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their extreme thermostability.
摘要翻译：本发明涉及碳酸酐淀粉酶在CO 2提取中的应用，例如来自烟道气，天然气，沼气或环境空气。碳酸酐酶由于其极端的热稳定性而特别适合于这些目的。

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