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81. 发明授权

US5990146A Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation 失效
标题翻译：苯并咪唑用于抑制蛋白酪氨酸激酶介导的细胞增殖
公开(公告)号：US5990146A
公开(公告)日：1999-11-23
申请号：US135470
申请日：1998-08-17
申请人： Diane Harris Boschelli , William Alexander Denny , Annette Marian Doherty , James Marino Hamby , Sonya Shah Khatana , James Bernard Kramer , Brian Desmond Palmer , Howard Daniel Hollis Showalter
发明人： Diane Harris Boschelli , William Alexander Denny , Annette Marian Doherty , James Marino Hamby , Sonya Shah Khatana , James Bernard Kramer , Brian Desmond Palmer , Howard Daniel Hollis Showalter
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/5377 , C07D235/06 , A61K31/415 , C07D235/08
CPC分类号： C07D235/06 , A61K31/4184 , A61K31/4439 , A61K31/5377
摘要： Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
摘要翻译：以下式I的苯并咪唑是蛋白酪氨酸激酶的抑制剂，可用于治疗细胞增殖。该化合物特别可用于治疗癌症，动脉粥样硬化，再狭窄和牛皮癣。

82. 发明授权

US5977376A Herbicidal 2-benzoylcyclohexane-1,3-diones and related compounds 失效
标题翻译：除草剂2-苯甲酰基环己烷-1,3-二酮及其相关化合物
公开(公告)号：US5977376A
公开(公告)日：1999-11-02
申请号：US118367
申请日：1998-07-17
申请人： Kouichi Araki , Takako Brett , Kei Domom , Atsushi Go , Masahito Ito , Hideshi Mukaida , Yukiko Oe
发明人： Kouichi Araki , Takako Brett , Kei Domom , Atsushi Go , Masahito Ito , Hideshi Mukaida , Yukiko Oe
IPC分类号： C07D233/54 , C07D233/60 , C07D235/06 , C07D249/04 , C07D249/06 , C07D249/08 , C07D257/04 , C07D521/00 , A01N43/80
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/04 , C07D249/06 , C07D249/08 , C07D257/04
摘要： The invention relates to compounds of formula (I): ##STR1## and to their use as herbicides.
摘要翻译：本发明涉及式（I）的化合物：及其作为除草剂的用途。

83. 发明授权

US5872117A 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same 失效
标题翻译： 1,2-乙二醇衍生物及其盐，其制备方法和包含其的脑功能改善剂
公开(公告)号：US5872117A
公开(公告)日：1999-02-16
申请号：US964323
申请日：1997-11-04
申请人： Satoshi Ono , Tetsuo Yamafuji , Hisaaki Chaki , Mutsuko Maekawa , Yozo Todo , Hirokazu Narita
发明人： Satoshi Ono , Tetsuo Yamafuji , Hisaaki Chaki , Mutsuko Maekawa , Yozo Todo , Hirokazu Narita
IPC分类号： C07C217/10 , C07C217/76 , C07C229/12 , C07C233/18 , C07C271/44 , C07C271/46 , C07C271/58 , C07C311/08 , C07C311/21 , C07C317/22 , C07C323/19 , C07D207/08 , C07D207/14 , C07D207/16 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/28 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/34 , C07D211/14 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/70 , C07D211/74 , C07D213/26 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/82 , C07D215/14 , C07D215/22 , C07D215/227 , C07D217/04 , C07D233/54 , C07D235/06 , C07D239/42 , C07D241/04 , C07D241/42 , C07D259/00 , C07D265/30 , C07D277/24 , C07D277/62 , C07D277/64 , C07D279/12 , C07D295/088 , C07D295/092 , C07D307/42 , C07D307/79 , C07D307/80 , C07D309/12 , C07D317/54 , C07D319/18 , C07D333/16 , C07D333/28 , C07D333/44 , C07D333/54 , C07D333/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D453/02 , C07D521/00 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54
CPC分类号： C07C217/10 , C07C217/76 , C07C229/12 , C07C233/18 , C07C271/44 , C07C271/46 , C07C271/58 , C07C311/08 , C07C311/21 , C07C317/22 , C07C323/19 , C07D207/08 , C07D207/14 , C07D207/16 , C07D207/22 , C07D207/27 , C07D207/28 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/34 , C07D211/14 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/70 , C07D211/74 , C07D213/26 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/74 , C07D213/82 , C07D215/14 , C07D215/227 , C07D217/04 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/06 , C07D239/42 , C07D241/04 , C07D241/42 , C07D249/08 , C07D259/00 , C07D265/30 , C07D277/24 , C07D277/62 , C07D277/64 , C07D279/12 , C07D295/088 , C07D307/42 , C07D307/79 , C07D307/80 , C07D309/12 , C07D317/54 , C07D319/18 , C07D333/16 , C07D333/28 , C07D333/44 , C07D333/54 , C07D333/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D453/02 , C07C2101/02 , C07C2101/08 , C07C2101/10 , C07C2102/08 , C07C2102/10
摘要： This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebrovascular dementia, senile dementia, Alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy.
摘要翻译：本发明涉及1,2-乙二醇衍生物及其盐，其制备方法和包含其的脑功能改善剂。本发明的脑功能改善剂可用于治疗脑血管性痴呆，老年痴呆，阿尔茨海默氏痴呆，缺血性脑病后遗症和脑中风。

84. 发明授权

US5849759A Naphthyl-substituted benzimidazole derivatives as anti-coagulants 失效
标题翻译：萘基取代的苯并咪唑衍生物作为抗凝剂
公开(公告)号：US5849759A
公开(公告)日：1998-12-15
申请号：US570057
申请日：1995-12-08
申请人： Damian O. Arnaiz , Brian D. Griedel , Steven T. Sakata , Kenneth J. Shaw , Zuchun Zhao
发明人： Damian O. Arnaiz , Brian D. Griedel , Steven T. Sakata , Kenneth J. Shaw , Zuchun Zhao
IPC分类号： C07D235/04 , A61K31/00 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61P7/00 , A61P7/02 , C07C257/18 , C07D235/06 , C07D401/12 , C07D211/52
CPC分类号： C07D401/12
摘要： Compounds of formula (I): ##STR1## wherein: n, A, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants.
摘要翻译：式（I）的化合物：其中：n，A，R 1，R 2，R 3和R 4具有如本文所定义的含义或其药学上可接受的盐，可用作抗凝剂。

85. 发明授权

US5849732A Phenol compound having antioxidative activity and the process for preparing the same 失效
标题翻译：具有抗氧化活性的苯酚化合物及其制备方法
公开(公告)号：US5849732A
公开(公告)日：1998-12-15
申请号：US800680
申请日：1997-02-14
申请人： Toshikazu Suzuki , Hiroshi Ohmizu , Yoshimasa Hashimura , Hitoshi Kubota , Keiko Tanaka
发明人： Toshikazu Suzuki , Hiroshi Ohmizu , Yoshimasa Hashimura , Hitoshi Kubota , Keiko Tanaka
IPC分类号： C07C275/34 , C07C275/40 , C07C281/16 , C07C311/49 , C07C323/44 , C07C335/18 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/06 , C07D223/12 , C07D231/06 , C07D233/02 , C07D233/38 , C07D233/54 , C07D235/06 , C07D235/14 , C07D239/42 , C07D239/50 , C07D241/12 , C07D243/08 , C07D295/13 , C07D295/215 , C07D317/58 , C07D401/12 , C07D521/00 , C07C275/00 , A61K31/165 , C07C233/29 , C07C235/38 , C07D213/36 , C07D213/63
CPC分类号： C07D213/40 , C07C275/34 , C07C275/40 , C07C281/16 , C07C311/49 , C07C323/44 , C07C335/18 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/06 , C07D223/12 , C07D231/06 , C07D231/12 , C07D233/02 , C07D233/38 , C07D233/56 , C07D233/64 , C07D235/06 , C07D235/14 , C07D239/42 , C07D239/50 , C07D241/12 , C07D243/08 , C07D249/08 , C07D295/13 , C07D295/215 , C07D317/58 , C07D401/12 , C07C2101/14 , C07C2101/18
摘要： Disclosed are a phenol compound represented by the formula (1): ##STR1## wherein R.sup.0 represents H, alkyl or alkyloxy; R.sup.1 represents alkyl; R.sup.2 represents alkyl or alkyloxy; OR.sup.3 represents OH; R.sup.4 represents H, lower alkyl or acyl, each of the above substituents may be substituted; W represents O, S or NR.sup.7 ; where R.sup.7 represents H, alkyl, aryl, OH or alkyloxy, a group of the formula (2): ##STR2## represents an amino which may be mono- or di-substituted or heterocyclic group containing N atom, or a pharmaceutically acceptable salt thereof, and a process for preparing the same.
摘要翻译：公开了由式（1）表示的酚化合物：其中R 0表示H，烷基或烷氧基; R1代表烷基; R2代表烷基或烷氧基; OR3表示OH; R4代表H，低级烷基或酰基，上述取代基各取代; W表示O，S或NR7; 其中R 7表示H，烷基，芳基，OH或烷氧基，式（2）的基团：（2）表示可以是含有单或二取代或含杂环的N原子的氨基，其可接受的盐及其制备方法。

86. 发明授权

US5741804A Substituted benzimazoles which inhibit platelet aggrecation 失效
标题翻译：取代苯并咪唑抑制血小板聚集
公开(公告)号：US5741804A
公开(公告)日：1998-04-21
申请号：US446791
申请日：1995-05-30
申请人： Richard McCulloch Keenan , William Henry Miller
发明人： Richard McCulloch Keenan , William Henry Miller
IPC分类号： C07D277/22 , A61K31/34 , A61K31/343 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P7/02 , A61P9/08 , A61P9/10 , C07D209/42 , C07D235/06 , C07D235/16 , C07D235/30 , C07D235/32 , C07D263/56 , C07D277/62 , C07D307/79 , C07D401/12 , C07D497/04 , C07D498/04 , C07D235/12
CPC分类号： C07D235/32 , C07D235/16
摘要： This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
摘要翻译： PCT No.PCT / US93 / 11779 Sec。 371日期：1995年5月30日 102（e）日期1995年5月30日PCT提交1993年12月1日PCT公布。公开号WO94 / 12478 日期：1995年6月9日本发明涉及有效抑制血小板聚集的下式的化合物，用于实现这种活性的药物组合物和抑制血小板聚集的方法。

87. 发明授权

US5719141A 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amide derivatives 失效
标题翻译： 2,9-二氨基 - 和2-氨基-8-氨基甲酰基-4-羟基 - 链烷酰胺衍生物
公开(公告)号：US5719141A
公开(公告)日：1998-02-17
申请号：US525254
申请日：1995-09-08
申请人： Vittorio Rasetti , Heinrich Rueger , Jurgen Klaus Maibaum , Robert Mah , Markus Grutter , Nissim Claude Cohen
发明人： Vittorio Rasetti , Heinrich Rueger , Jurgen Klaus Maibaum , Robert Mah , Markus Grutter , Nissim Claude Cohen
IPC分类号： A61K31/16 , A61K31/165 , A61K31/40 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5355 , A61K31/538 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61P9/12 , C07C237/04 , C07C237/06 , C07C237/22 , C07C271/20 , C07C271/22 , C07D207/00 , C07D209/00 , C07D209/08 , C07D209/42 , C07D211/00 , C07D211/34 , C07D211/60 , C07D213/40 , C07D213/75 , C07D213/89 , C07D215/00 , C07D215/08 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D215/38 , C07D215/54 , C07D215/56 , C07D217/02 , C07D221/12 , C07D223/16 , C07D235/04 , C07D235/06 , C07D235/08 , C07D239/70 , C07D239/74 , C07D241/00 , C07D241/36 , C07D241/44 , C07D265/28 , C07D265/34 , C07D265/36 , C07D279/12 , C07D279/14 , C07D279/16 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D411/02 , C07D413/02
CPC分类号： C07D213/40 , C07C237/06 , C07C237/22 , C07C271/20 , C07D209/08 , C07D209/42 , C07D211/34 , C07D213/89 , C07D215/08 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D215/38 , C07D215/54 , C07D215/56 , C07D217/02 , C07D221/12 , C07D223/16 , C07D235/06 , C07D239/74 , C07D241/44 , C07D265/36 , C07D279/16 , C07D401/04 , C07D401/12 , C07D413/04
摘要： Compounds of the formula I ##STR1## in which R.sub.1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R.sub.2 and R.sub.3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R.sub.4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R.sub.5 is hydroxyl, lower alkanoyloxy or lower alkoxycarbonyloxy, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R.sub.7 is hydrogen or lower alkyl, or R.sub.6 and R.sub.7, together with the carbon atom with which they are bonded, are a cydoalkylidene radical and R.sub.8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.
摘要翻译：其中R 1是芳基氨基，N-芳基-N-（低级烷氧基 - 低级烷基） - 氨基，N-芳基-N-芳基 - 低级烷基 - 氨基或杂环基的式I化合物（I）环碳原子，X是羰基或亚甲基，R2和R3彼此独立地是氢或低级烷基，或者与它们所键合的碳原子一起是亚环烷基，R4是氢，低级烷基，低级烷酰基或低级烷氧基羰基，R5是羟基，低级烷酰氧基或低级烷氧基羰基氧基，R6是氢，低级烷基，低级烯基，低级炔基，环烷基，环烷基 - 低级烷基，具有5-7个环原子的芳基 - 低级烷基或杂芳基 - 低级烷基在杂芳基环中，R 7为氢或低级烷基，或者R 6和R 7与它们所键合的碳原子一起为环亚烷基，R 8表示脂族，脂环族 - 脂族或杂芳基脂肪族基团，它们的盐可以是用作治疗药物的有效成分 t的高血压。

88. 发明授权

US5709845A Tricyclic functional dyes for contrast enhancement in optical imaging 失效
标题翻译：三重功能染料用于光学成像中的对比度增强
公开(公告)号：US5709845A
公开(公告)日：1998-01-20
申请号：US645376
申请日：1996-05-13
申请人： Raghavan Rajagopalan , Ella Y. Fung
发明人： Raghavan Rajagopalan , Ella Y. Fung
IPC分类号： C07D277/64 , A61K49/00 , C07D235/06 , C07D293/10 , C07D293/12 , C07D417/14 , G01N31/00 , G01N33/48
CPC分类号： A61K49/0021
摘要： This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1-C.sub.10 aryl, C.sub.1 -C.sub.10 carboxylalkyl, C.sub.1 -C.sub.10 alkyl sulfonate, mercapto alkyl and --(CH.sub.2).sub.m N(R.sup.6)(R.sup.7); W.sup.1 and W.sup.2 may be the same or different and are selected from the group consisting of --S--, --O--, --Se--, --Te--, --NR.sup.8 and C(R.sup.9)(R.sup.10); and m is about 0-10; R.sup.8 is hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, C.sub.1 -C.sub.10 mercaptoalkyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, C.sub.1 -C.sub.10 carboxylalkyl, C.sub.1 -C.sub.10 alkoxycarbonyl, C.sub.1 -C.sub.10 alkylthio, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7); R.sup.9 and R.sup.10 are independently hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 carboxyalkyl, C.sub.1 -C.sub.10 alkoxycarbonyl, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7); and A is selected from the group consisting of --(CH.sub.2).sub.m, --C(R.sup.9)(R.sup.10), --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) --O--, --S--, or --NR.sup.8.
摘要翻译：本发明提供以下通式的功能性染料：其中R 1，R 2和R 5可以相同或不同，并且选自氢，C 1 -C 10烷基，C 1 -C 10烷氧基，羟基，C 1 -C 10羟基烷基，C 1 -C 10烷氧基烷基，C 1 -C 10芳基，羧基，C 1 -C 10羧基烷基，卤素，硝基，C 1 -C 10烷氧基羰基，巯基，C 1 -C 10巯基烷基，C 1 -C 10烷硫基，磺酸酯基和 - （CH 2）（R6）（R7）其中R6和R7独立地是氢或C1-C10烷基，C1-C10酰基，R6和R7能够形成5,6或7元环，其可任选地被-O-取代， -NR8或-S-; R3和R4可以相同或不同，并且选自C1-C10烷基，C1-C10羟基烷基，C1-C10烷氧基烷基，C1-C10芳基，C1-C10羧基烷基，C1-C10烷基磺酸酯，巯基烷基和 - （CH 2）m N（R 6）（R 7）; W1和W2可以相同或不同，并且选自-S-，-O-，-Se-，-Te-，-NR8和C（R9）（R10）; m为约0-10; R8是氢，C1-C10烷基，C1-C10烷氧基，C1-C10巯基烷基，羟基，C1-C10羟基烷基，C1-C10烷氧基烷基，C1-C10芳基，C1-C10羧基烷基，C1-C10烷氧羰基，C1-C10烷硫基，和 - （CH 2）m N（R 6）（R 7）; R 9和R 10独立地是氢，C 1 -C 10烷基，C 1 -C 10烷氧基，C 1 -C 10羟基烷基，C 1 -C 10烷氧基烷基，C 1 -C 10羧基烷基，C 1 -C 10烷氧基羰基和 - （CH 2）m -N（R 6）（R 7）。并且A选自 - （CH 2）m，-C（R 9）（R 10）， - （CH 2）m -N（R 6）（R 7）-O-，-S-或-NR 8。

89. 发明授权

US5705500A Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors 失效
公开(公告)号：US5705500A
公开(公告)日：1998-01-06
申请号：US478625
申请日：1995-06-07
申请人： Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
发明人： Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Michael L. Vazquez , James A. Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph J. McDonald
IPC分类号： A61K31/00 , A61K31/335 , A61K31/34 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/385 , A61K31/39 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/47 , A61K31/472 , A61P31/12 , C07C211/18 , C07C271/16 , C07C309/73 , C07C311/29 , C07C311/41 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/06 , C07D235/30 , C07D235/32 , C07D249/18 , C07D249/20 , C07D263/54 , C07D263/56 , C07D277/62 , C07D277/82 , C07D303/36 , C07D307/79 , C07D317/62 , C07D319/18 , C07D327/04 , C07D339/06 , C07D413/12 , A61K31/495 , A61K31/535 , A61K31/54 , C07D407/12 , C07D417/12
CPC分类号： C07D235/06 , C07C311/29 , C07C311/41 , C07C317/44 , C07D215/36 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/18 , C07D249/20 , C07D263/56 , C07D277/62 , C07D277/82 , C07D303/36 , C07D307/79 , C07D317/62 , C07D319/18
摘要： Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

90. 发明授权

US5693652A Benzimidazoles for ischemic heart conditions 失效
标题翻译：苯并咪唑用于缺血性心脏病
公开(公告)号：US5693652A
公开(公告)日：1997-12-02
申请号：US408867
申请日：1995-03-23
申请人： Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
发明人： Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
IPC分类号： C07D215/42 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/454 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P37/00 , A61P43/00 , B60S1/16 , B60S1/24 , C07D215/48 , C07D235/06 , C07D235/08 , C07D239/78 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/90 , C07D239/94 , C07D239/95 , C07D239/96 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/056 , C07D521/00 , F16C7/02 , F16C11/04 , C07D235/04
CPC分类号： C07D235/06 , C07D215/42 , C07D231/12 , C07D233/56 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/94 , C07D239/95 , C07D239/96 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/12 , C07D471/04 , C07D491/04
摘要： The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring: ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5 and R.sup.6 are described herein.
摘要翻译：本发明提供由以下通式（1）表示的含氮杂环化合物或其药理学上可接受的盐，其可用于各种缺血性心脏病等：（1）[式（1）中，环A 表示苯环，吡啶环或环己烷环：环B表示吡啶环，嘧啶环或咪唑环，R1，R2，R3，R4，R5和R6如本文所述。

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