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81. 发明申请

US20230088226A1 MULTI-CHANNEL PIPETTING SYSTEM OF IMPROVED DESIGN 有权
公开(公告)号：US20230088226A1
公开(公告)日：2023-03-23
申请号：US17907007
申请日：2021-03-25
申请人： GILSON SAS
发明人： Bruno Dudek , Stéphane Guichardon
IPC分类号： B01L3/02
摘要： A device for a multi-channel pipetting system, comprising a piston holder, a guide rod of the piston holder, which guide rod is mounted slidably in a guide member, a plurality of pistons having a bottom end housed slidably in a suction chamber, and a piston head mounted on the piston holder by way of a mechanical connection. The mechanical connection comprises two contact points which conjointly define a piston-head rotation axis oriented orthogonally with respect to the transverse direction and to the longitudinal central axis of the pipetting system, and the device additionally comprises, associated with the piston, return spring which force the piston head upward against the piston holder, so as to establish the two contact points.

82. 发明授权

US11602744B2 Pipette with adjustable dosing volume 有权
公开(公告)号：US11602744B2
公开(公告)日：2023-03-14
申请号：US16993484
申请日：2020-08-14
申请人： Eppendorf AG
发明人： Peter Molitor , Florian Tesch
IPC分类号： B01L3/02
摘要： A pipette with an adjustable dosing volume comprises a housing connected to at least one seat configured to releasably hold a pipette tip. A displacement device is positioned within the housing and configured to aspirate and discharge liquid from the pipette tip. A stroke rod is coupled to the displacement element and configured to be longitudinally displaced relative to the housing to displace the displacement device. A catch sleeve is rotatably mounted within the housing and is connected to the stroke rod. An adjusting sleeve configured to engage a transducer shaft that is rotatably mounted within the housing and comprises a countershaft of a gearbox that is configured to be shifted between different shift stages. Each shift stage comprises different gear ratios between a rotational speed of the adjusting sleeve and a rotational speed of the catch sleeve. The different gear ratios enable coarse volume adjustment and fine volume adjustment.

83. 发明申请

US20230075131A1 AUTOMATED SOLID PHASE EXTRACTION USING FILTER TIPS 有权
公开(公告)号：US20230075131A1
公开(公告)日：2023-03-09
申请号：US18056150
申请日：2022-11-16
申请人： DPX technologies, LLC
发明人： William E. BREWER , Kaylee R. MASTRIANNI
IPC分类号： G01N33/543 , B01L3/02 , B01L3/00 , C07K1/34 , G01N1/40
摘要： Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.

84. 发明授权

US11590491B2 Automatic liquid transfer optimization pipetting apparatus and method 有权
公开(公告)号：US11590491B2
公开(公告)日：2023-02-28
申请号：US16959020
申请日：2018-12-27
申请人： FORMULATRIX, INC.
发明人： David Wikholm , Rasmus Lindblom
IPC分类号： B01L3/02
摘要： An automatic liquid transfer optimization pipetting apparatus and method is disclosed. Namely, a liquid handling apparatus includes a pump supplying a nozzle (i.e., a pipette tip) via a conduit, one or more pressure sensors, and an electronic controller, and wherein the pipette tip is submerged in a liquid. Further, a method of automatic liquid transfer optimization pipetting includes the steps of actuating the pump to move a designated volume of liquid and then allowing the system to settle to a steady state after completion of pump actuation.

85. 发明授权

US11590489B2 Particle-drop structures and methods for making and using the same 有权
公开(公告)号：US11590489B2
公开(公告)日：2023-02-28
申请号：US16550105
申请日：2019-08-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Dino Di Carlo , Chueh-Yu Wu
IPC分类号： B01L3/02 , B01L3/00 , G01N33/543 , C12N1/04 , C12N5/071 , C12N5/0783 , C12Q1/6806
摘要： Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

86. 发明申请

US20230053912A1 LIQUID HANDLING SYSTEM 有权
公开(公告)号：US20230053912A1
公开(公告)日：2023-02-23
申请号：US17891011
申请日：2022-08-18
申请人： ABLE Labs Inc.
发明人： Sang Shin , Nam II Ko , Sang Young Park
IPC分类号： G01N35/10 , G01N35/00 , B01L3/02
摘要： An automated liquid handling system includes a transfer robot unit, a handling module, and a fixing unit which is coupled to a head of the robot unit and on which a pipette assembly is to be mounted, wherein the handling module is provided with a mounting part detachably mounted on the fixing unit. The fixing unit includes a body part, a fixing part hook formed at an upper portion of one side of the body part and a lower protrusion disposed at a lower portion of the one side of the body part, the mounting part includes a body, a movable hook part formed at an upper portion of one side of the body and a lower groove formed at a lower portion of the one side of the body to correspond to the lower protrusion, a catching step is formed at the lower groove, and the lower protrusion extends from the lower portion of the one side of the body part to support the catching step from below, and the movable hook part is hook-coupled to a fixing unit hook.

87. 发明授权

US11579160B2 Systems and methods for detection, analysis, isolation and/or harvesting of biological objects 有权
公开(公告)号：US11579160B2
公开(公告)日：2023-02-14
申请号：US16741864
申请日：2020-01-14
申请人： THE CLEVELAND CLINIC FOUNDATION , PARKER HANNIFIN CORPORATION
发明人： George F. Muschler , James K. Monnich , Edward J. Kwee , Kimerly A. Powell , Edward E. Herderick , Cynthia A. Boehm , Thomas R. Adams , Robert Germanoski , Frank Krakosh, III , James Dunn , Daniel Bantz
IPC分类号： G01N35/10 , C12M1/36 , B01L9/00 , B01L3/02 , G01B11/06 , G01B11/14
摘要： Systems and methods provide for detection and controlled interaction with one or more objects. The system can include an imaging subsystem (20), a tool subsystem (26) containing one or more tools, a stage subsystem (16) and a control system (40). The control system (40) can integrate controls for each of the other subsystems, which controls can be implement desired functions over a variety of process parameters to perform the controlled interaction.

88. 发明授权

US11577451B2 Bioprinter for the fabrication of tissue 有权
公开(公告)号：US11577451B2
公开(公告)日：2023-02-14
申请号：US17482823
申请日：2021-09-23
申请人： ORGANOVO, INC.
发明人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
IPC分类号： B33Y50/00 , B41J2/04 , B41J2/045 , B41J25/308 , B29C64/106 , C12M3/00 , C12M1/26 , B41J3/407 , B29C64/20 , C12N5/00 , B29C64/295 , B29C64/393 , B29C64/386 , B41J2/175 , B29C64/209 , B29C31/04 , B29C64/245 , B28B1/00 , B33Y30/00 , B33Y70/00 , B01L3/02 , B33Y50/02
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

89. 发明授权

US11577450B2 Methods for the fabrication of tissue via printing 有权
公开(公告)号：US11577450B2
公开(公告)日：2023-02-14
申请号：US17482062
申请日：2021-09-22
申请人： ORGANOVO, INC.
发明人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
IPC分类号： B33Y10/00 , B33Y50/00 , B41J2/04 , B41J2/045 , B41J25/308 , B41J29/393 , G06F3/12 , G06T17/00 , B29C64/106 , C12M3/00 , C12M1/26 , B41J3/407 , B29C64/20 , C12N5/00 , B29C64/295 , B29C64/393 , B29C64/386 , B41J2/175 , B29C64/209 , B29C31/04 , B29C64/245 , B29C64/112 , B29C64/40 , B28B1/00 , B33Y30/00 , B33Y70/00 , B01L3/02 , B33Y50/02
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

90. 发明申请

US20230043090A1 SYSTEMS AND METHODS FOR PIPETTE ROBOTS 有权
公开(公告)号：US20230043090A1
公开(公告)日：2023-02-09
申请号：US17972295
申请日：2022-10-24
申请人： Opentrons Labworks Inc.
发明人： Andrew SIGLER , Taylor Schlaff GOODMAN , Nicholas Pease STARNO , Jonathan Preston BADAL
IPC分类号： G01N35/00 , G01N35/10 , B01L3/02
摘要： Systems and methods applicable, for instance, to pipette robots. A pipette robot can perform one or more operations regarding deck calibration, one or more operations regarding pipette tip/probe calibration, one or more operations regarding pipette tip pick up, and/or one or more operations regarding tip ejection.

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