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81. 发明授权

US10144977B2 Hyperhalophilic strain and use thereof for the degradation of carbon-containing substrates 有权
公开(公告)号：US10144977B2
公开(公告)日：2018-12-04
申请号：US15308457
申请日：2015-04-30
申请人： Institut De Recherche Pour Le Developpement (I.R.D.) , Societe Interoleagineuse D'Assistance et de Developpement (SIA)
发明人： Bernard Ollivier , Wajdi Ben Hania , France Thevenieau , Abdeljabbar Hedi , Marie-Laure Fardeau
IPC分类号： C12P7/62 , C08G63/06 , C12R1/00 , C12R1/01 , C12N1/06
摘要： The present invention relates to a novel hyperhalophilic strain and use thereof for the degradation of carbon-containing substrates, in particular making it possible to prepare novel polymers.

82. 发明授权

US10092619B2 Composition comprising peptides made by Lactococcus lactis strains 有权
公开(公告)号：US10092619B2
公开(公告)日：2018-10-09
申请号：US15357170
申请日：2016-11-21
申请人： Centro De Investigación En Alimentación Y Desarrollo, A.C. (CIAD) , Belinda Vallejo Galland , Aarón Fernando González Córdova
发明人： Belinda Vallejo Galland , Aarón Fernando González Córdova , Jóse Carlos Rodríguez Figueroa
IPC分类号： A23C9/13 , A61K38/08 , A61K35/744 , C12P21/00 , C12P21/06 , C12R1/00 , A23C9/123 , A61K35/74 , A23C9/152 , A23L2/52 , A61K35/742 , A61K38/10 , C12N1/20 , A23L33/135 , A23L2/38 , A61K9/00 , C12R1/01 , A61K35/00
摘要： New Lactococcus lactis strains, NRRL B-50571 and NRRL B-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower LDL-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation.

83. 发明授权

US09783832B2 Method for producing 2,3-butanediol using improved strains of Raoultella planticola 有权
公开(公告)号：US09783832B2
公开(公告)日：2017-10-10
申请号：US14415343
申请日：2013-07-22
申请人： BIOPOLIS, S.L. , UNIVERSIDAD COMPLUTENSE DE MADRID
发明人： Antonia Maria Rojas Martinez , Silvia Segarra Manzano , Alejandro Montesinos Paes , Marta Tortajada Serra , Daniel Ramon Vidal , Victoria Eugenia Santos Mazorra , Miguel Ladero Galan , Felix Garcia-Ochoa Soria , Vanessa Ripoll Morales , Alberto Rodriguez Martín
IPC分类号： C12P7/18 , C12R1/00 , C12R1/22 , C12N1/20 , C12N1/32 , C12R1/01 , C12N15/01
CPC分类号： C12P7/18 , C12N1/20 , C12N1/32 , C12N15/01 , C12R1/01
摘要： The invention relates to a method for producing 2,3-butanediol using improved strains of Raoultella planticola, and to novel mutant strains obtained by random mutagenesis from the bacterial species Raoultella planticola CECT843, that can be used in the industrial production of 2,3-butanediol from glycerol. The invention preferably relates to the Raoultella planticola strains designated IA1 and IIIA3 and deposited in the Spanish Type Culture Collection (CECT) under deposit number CECT8158 (corresponding to the strain designated IA1) and deposit number CECT8159 (corresponding to the strain designated IIIA3). The invention also relates to a method for producing 2,3-butanediol from glycerol by means of a biotechnological process using the novel strains of the invention.

84. 发明授权

US09737573B2 Preventive and/or ameliorative agent for diseases, stamina enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them 有权
公开(公告)号：US09737573B2
公开(公告)日：2017-08-22
申请号：US14444432
申请日：2014-07-28
申请人： TFK Co., Ltd.
发明人： Nobuhiro Toda , Yasuhiro Hidaka , Masaaki Ishikawa , Shuichi Kanno
IPC分类号： A61K35/74 , A23L33/00 , A23L33/135 , C12N1/20 , C12R1/00 , C12R1/01 , A61K35/00
CPC分类号： A61K35/74 , A23L33/135 , A61K2035/11 , C12N1/20 , C12R1/01
摘要： A purple non-sulfur bacteria useful in preventing and/or ameliorating at least one disease selected from the group consisting of inflammatory diseases, allergic diseases, and autoimmune diseases and having high safety is provided. A preventive and/or ameliorative agent is for at least one disease selected from the group consisting of inflammatory diseases, allergic diseases, and autoimmune diseases and includes at least one of a purple non-sulfur bacteria and a culture material obtained by culturing the purple non-sulfur bacteria. The purple non-sulfur bacteria includes Rhodobacter azotoformans.

85. 发明授权

US09533015B2 Lactococcus lactis strains 有权
标题翻译：乳酸乳球菌菌株
公开(公告)号：US09533015B2
公开(公告)日：2017-01-03
申请号：US14525090
申请日：2014-10-27
申请人： Centro De Investigación En Alimentacion Y Desarrollo, A.C. (CIAD) , Belinda Vallejo Galland , Aarón Fernando González Córdova
发明人： Belinda Vallejo Galland , Aarón Fernando González Córdova , Jóse Carlos Rodríguez Figueroa
IPC分类号： C12N1/20 , A61K35/744 , C12P21/00 , C12P21/06 , C12R1/00 , A23C9/123 , A61K35/74 , A23C9/152 , A23L2/52 , A61K35/742 , A61K38/08 , A61K38/10 , A61K35/00
CPC分类号： A61K38/08 , A23C9/123 , A23C9/1234 , A23C9/152 , A23C9/1526 , A23L2/382 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2240/41 , A61K9/0053 , A61K9/0095 , A61K35/74 , A61K35/742 , A61K35/744 , A61K38/10 , A61K2035/115 , C12N1/20 , C12P21/00 , C12P21/06 , C12R1/00 , C12R1/01
摘要： New Lactococcus lactis strains, NRRL B-50571 and NRRL B-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower LDL-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation.
摘要翻译：新的乳酸乳球菌菌株，NRRL B-50571和NRRL B-50572以及含有该乳酸菌的细菌制剂具有生产降低血压，降低LDL-胆固醇（坏胆固醇）和呈现抗氧化性能以获得更好心血管的生物活性肽的能力健康。这些生物活性肽可以在食品中生产用于生产食品，例如功能性食品，或者它们可以由蛋白质来源生产，随后作为制剂的一部分添加到食物中或作为食品补充剂的一部分或药物制剂。

86. 发明授权

US09518279B2 Bacterial strain Rhodococcus aetherivorans VKM Ac-2610D producing nitrile hydratase, method of its cultivation and method for producing acrylamide 有权
标题翻译：细菌菌株红球菌aetherivorans VKM Ac-2610D生产腈水合酶，其培养方法和丙烯酰胺生产方法
公开(公告)号：US09518279B2
公开(公告)日：2016-12-13
申请号：US14140150
申请日：2013-12-24
申请人： Kemira Oyj
发明人： Sergey Vladimirovich Kozulin , Tatiana Nicolaevna Kozulina , Alexey Sergeevich Kozulin
IPC分类号： C12P13/02 , C12R1/00 , C12N1/20
CPC分类号： C12N1/20 , C12P13/02 , C12R1/00 , C12R1/01 , C12Y402/01084
摘要： The invention relates to a bacterial strain belonging to the genus Rhodococcus which is a producer of a nitrile hydratase. The invention also relates to a method for producing acrylamide by hydration of acrylonitrile using a biomass of the bacterial strain and to a method of culturing the bacterial strain.
摘要翻译：本发明涉及属于腈水合酶的生产者的红球菌属的细菌菌株。本发明还涉及通过使用细菌菌株的生物质使丙烯腈水合制备丙烯酰胺的方法和培养细菌菌株的方法。

87. 发明申请

US20140367089A1 METHOD OF GRAVITY ASSISTED MICROBIOLOGICALLY ENHANCED OIL RECOVERY BY IMPROVING THE DISTRIBUTION OF NUTRIENTS INTRODUCED INTO OIL PRODUCING ROCK FORMATIONS 有权
标题翻译：通过改进引入生产岩屑的营养物质的分布来帮助微生物增强油回收方法
公开(公告)号：US20140367089A1
公开(公告)日：2014-12-18
申请号：US14307048
申请日：2014-06-17
申请人： TITAN OIL RECOVERY, INC.
发明人： Alan James Sheehy , Bradley Ray Govreau , Colin Kenneth Hill , Michael Thomas Carroll , Brian W. G. Marcotte
IPC分类号： C12R1/00
CPC分类号： C09K8/582
摘要： A method of improving oil recovery includes the step of selecting an oil containing rock formation having geologic structures and well completions with vertical permeability that allow a structurally high water injection point. Through a series of analyses a nutrient water mixture is determined and injected at the injection point to stimulate resident microorganisms through gravity dispersion of nutrient materials. A period of limitation is allowed to permit changes in the size or hydrophobic properties of the microorganisms. Through interaction with the stimulated resident microorganisms, oil, trapped in a pore space, is freed to accumulate with upward gravity separation for production.
摘要翻译：提高采收率的方法包括选择具有地质结构的油层岩层和具有垂直渗透性的井完井的步骤，其允许结构上高的注水点。通过一系列分析，确定营养水混合物并在注射点注射，以通过营养物质的重力分散来刺激常驻微生物。允许限制时间允许微生物的大小或疏水性质的变化。通过与受刺激的常驻微生物的相互作用，被捕获在孔隙空间中的油被释放，以向上的重力分离积累生产。

88. 发明授权

US08771669B1 Immunization and/or treatment of parasites and infectious agents by live bacteria 有权
标题翻译：用活细菌免疫和/或治疗寄生虫和感染因子
公开(公告)号：US08771669B1
公开(公告)日：2014-07-08
申请号：US13024189
申请日：2011-02-09
申请人： David Gordon Bermudes
发明人： David Gordon Bermudes
IPC分类号： A61K35/74 , A61K39/00 , C12R1/00 , C12R1/42
CPC分类号： A61K39/07 , A61K35/74 , A61K39/0208 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/542 , C07K14/81 , C12N15/74 , C12N2760/16134
摘要： Chimeric proteins are expressed, secreted or released by a bacterium to immunize against or treat a parasite, infectious disease or malignancy. The delivery vector may also be attenuated, non-pathogenic, low pathogenic, or a probiotic bacterium. The chimeric proteins include chimeras of, e.g., phage coat and/or colicin proteins, bacterial toxins and/or enzymes, autotransporter peptides, lytic peptides, multimerization domains, and/or membrane transducing (ferry) peptides. The active portion of the immunogenic chimeric proteins can include antigens against a wide range of parasites and infectious agents, cancers, Alzheimer's and Huntington's diseases, and have enhanced activity when secreted or released by the bacteria, and/or have direct anti-parasite or infectious agent activity. The activity of the secreted proteins is further increased by co-expression of a protease inhibitor that prevents degradation of the effector peptides. Addition of an antibody binding or antibody-degrading protein further prevents the premature elimination of the vector and enhances the immune response.
摘要翻译：嵌合蛋白由细菌表达，分泌或释放以免疫或治疗寄生虫，感染性疾病或恶性肿瘤。递送载体也可以是减毒，非致病性，低致病性或益生菌。嵌合蛋白包括例如噬菌体外壳和/或大肠杆菌素蛋白，细菌毒素和/或酶，自动转运肽，裂解肽，多聚化结构域和/或膜转导（转运）肽的嵌合体。免疫原性嵌合蛋白的活性部分可以包括针对广泛范围的寄生虫和感染因子，癌症，阿尔茨海默病和亨廷顿疾病的抗原，并且在细菌分泌或释放时具有增强的活性，和/或具有直接的抗寄生虫或感染性代理活动。分泌的蛋白质的活性通过蛋白酶抑制剂的共表达进一步增加，其阻止效应肽的降解。抗体结合或抗体降解蛋白的添加进一步阻止载体的过早消除并增强免疫应答。

89. 发明申请

US20100093074A1 Floating Oxygenation Circulator Platform (OCP) with Sub-Vortex Induction Means 有权
标题翻译：具有子涡流感应装置的浮动氧化循环器平台（OCP）
公开(公告)号：US20100093074A1
公开(公告)日：2010-04-15
申请号：US12251372
申请日：2008-10-14
申请人： William Frederick Tooley
发明人： William Frederick Tooley
IPC分类号： C12M1/06 , B01F3/04 , C12M1/09 , C12R1/00
CPC分类号： B01F3/04773 , B01F13/0049 , C02F3/206 , C12N13/00 , Y02W10/15 , Y02W10/37
摘要： A floating oxygenation circulator platform (OCP) is disclosed employing sub-vortex induction means to initiate numerous, gentle yet complex, tumbling, swirling, rolling, roiling or rotating sub-vortices spreading outward on the liquid surface. The circulator platform itself sets in motion a non-turbulent, high efficiency, bottom to top, primary toroidal vortex flow. Varied sub-vortex induction means, mounted on, made part of, attached to, extending out from or placed around the body of the circulator platform, induce sub-vortices to increase the surface exposure of the liquid and its contents, including microbes, nutrients and large molecules, to atmospheric oxygen and UV sunlight. The OCP and its sub-vortex induction means taken together act in the manner of a Rotating Inverse Biological Contactor (RIBC), labeled “inverse” because the liquid itself rotates and tumbles its contents into direct contact with the atmosphere and sunlight, in contrast to RBC devices where solid disks rotate in and out of a liquid.
摘要翻译：公开了一种浮动氧化循环器平台（OCP），其使用副涡流感应装置来启动在液体表面上向外扩展的许多柔和但复杂的翻滚，旋转，滚动，滚动或旋转副涡流。循环器平台本身将非湍流，高效率的底部到顶部的主环形涡流流动。安装在附件，从循环器平台的身体上延伸出或放置在循环器平台的周围的各种副涡流感应装置引起副涡旋，以增加液体及其内容物的表面暴露，包括微生物，营养物质大分子，大气氧和紫外线。由于液体本身旋转并使其内容物与大气和阳光直接接触，OCP及其副涡流感应装置以旋转反向生物接触器（RIBC）的方式起作用，标记为“反向”，与 RBC设备，其中固体盘旋转进出液体。

90. 发明授权

US5972872A Enzyme preparation with cellulytic activity 失效
标题翻译：酶制剂具有纤维素分解活性
公开(公告)号：US5972872A
公开(公告)日：1999-10-26
申请号：US870996
申请日：1997-06-06
申请人： Lene Lange , Jack Bech Nielsen , Martin Schulein
发明人： Lene Lange , Jack Bech Nielsen , Martin Schulein
IPC分类号： C12N9/42 , C11D3/386 , C11D11/00 , C12R1/00 , C12S3/08 , C12S11/00 , D06M16/00 , D06P5/02 , D06P5/15 , D21C5/00 , D21C5/02 , D21C9/00 , D21H17/00 , D21H21/10
CPC分类号： D21H21/10 , C11D3/38645 , D06M16/003 , D06P5/02 , D06P5/158 , D21C5/005 , D21C5/027 , D21H17/005 , Y02W30/648
摘要： The present invention relates to detergent compositions comprising an enzyme preparation with substantial cellulytic activity, especially endoglucanase activity, at alkaline conditions which is enzyme composition is derived from or producible by a fungus selected from the Basidiomycetous families Coprinaceae and Bolbitiaceae, preferably from the group of strains belonging to the genera Psathyrella, Podaxis, Panaeolus, Coprinus and Bolbitius, more preferably from the group of strains belonging to the species Coprinus micaceus, Coprinus domesticus, Coprinus ephemerus, Coprinus disseminatus, Coprinus radians, Coprinus picaceus, Coprinus frisei, Coprinus subimpatiens, Psathyrella candolleana, Psathyrella prona, Panaeolus semiovatus, Podaxis pistillaris and Bolbitius aleuriatus; and a method for providing a stone-washed look to textiles, especially to cellulosic fabric such as denim, using the mentioned enzyme preparation; and a method for improving the drainage of paper pulp or the de-inking of recycled paper using the mentioned enzyme preparation; and an enzyme preparation with substantial cellulytic activity at alkaline conditions which is enzyme composition is derived from or producible by a fungus selected from the Basidiomycetous families Coprinaceae and Bolbitiaceae, provided that the fungus does not belong to the species Coprinus cinereus.
摘要翻译：本发明涉及洗涤剂组合物，其包含在碱性条件下具有显着的纤维素分解活性，特别是内切葡聚糖酶活性的酶制剂，其是酶组合物衍生自或可由选自以下的真菌中产生的真菌：来自巴斯德氏酵母属家蝇科和博比氏菌科，优选来自菌株组属于Psathyrella，Podaxis，Panaeolus，Coprinus和Bolbitius属，更优选属于属于Coprinus micaceus，Coprinus domesticus，Coprinus ephemerus，Coprinus propaginatus，Coprinus radians，Coprinus picaceus，Coprinus frisei，Coprinus subimpatiens，Psathyrella 花椰菜，Psathyrella话，Panaeolus semiovatus，Podaxis pistillaris和Bolbitius aleuriatus; 以及使用所述酶制剂向纺织品，特别是纤维素织物如牛仔布提供经过洗涤的外观的方法; 以及使用所述酶制剂改进纸浆排出或再循环纸的脱墨的方法; 以及在碱性条件下具有显着的纤维素分解活性的酶制剂，其酶组成来自选自以下的真菌的产生或可生产，所述真菌选自巴斯德氏酵母属科罗班菌科和Bolbitiaceae，条件是该真菌不属于灰霉菌属（Coprinus cinereus）。

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