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81. 发明申请

US20100155243A1 System and Method For the Separation of Analytes 有权
标题翻译：分析物分离系统和方法
公开(公告)号：US20100155243A1
公开(公告)日：2010-06-24
申请号：US12644341
申请日：2009-12-22
申请人： Thomas Wayne Schneider , James N. Baraniuk
发明人： Thomas Wayne Schneider , James N. Baraniuk
IPC分类号： G01N27/26 , B01D57/02
CPC分类号： G01N27/44795 , G01N27/44721 , G01N27/44791 , G01N33/558
摘要： A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).
摘要翻译：分离模块用于利用毛细管等电聚焦（“CIEF”）在第一微通道内，根据pI，即pI带分离或分离分析物。级分被堆叠以形成塞子，其数量由多个与第一微通道整体连接的平行的第二微通道确定，根据在每个单个微通道中发现的缓冲特性，分段被引导到该第一微通道中。在微通道内，使用毛细管电泳（“CE”），将栓塞根据不同的化学性质即“m / z”分离成蛋白质。

82. 发明申请

US20100147691A1 SYSTEMS AND METHODS FOR TRANSPORTING PARTICLES 有权
标题翻译：运输颗粒的系统和方法
公开(公告)号：US20100147691A1
公开(公告)日：2010-06-17
申请号：US12712855
申请日：2010-02-25
申请人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
发明人： Armin R. Völkel , David Biegelsen , Philip D. Floyd , Greg Anderson , Fred Endicott , Eric Peeters , Jaan Noolandi , Karen A. Moffat , Peter M. Kazmaier , Maria McDougall , Daniel G. Bobrow
IPC分类号： B01D57/02
CPC分类号： B03C5/028
摘要： Various particle transport systems and components for use in such systems are described. The systems utilize one or more traveling wave grids to selectively transport, distribute, separate, or mix different populations of particles. Numerous systems configured for use in two dimensional and three dimensional particle transport are described.
摘要翻译：描述了用于这种系统的各种粒子输送系统和部件。该系统利用一个或多个行波网来选择性地输送，分配，分离或混合不同粒子群。描述了配置用于二维和三维粒子传输的许多系统。

83. 发明申请

US20100147688A1 2-IN-1 BIOCHIP 审中-公开
公开(公告)号：US20100147688A1
公开(公告)日：2010-06-17
申请号：US12161114
申请日：2006-01-19
申请人： Mohamed Roshdy Soliman El Hadidy
发明人： Mohamed Roshdy Soliman El Hadidy
IPC分类号： G01N27/00 , B01D57/02
CPC分类号： B01L3/502753 , B01L3/502715 , B01L2200/027 , B01L2200/0631 , B01L2200/10 , B01L2300/0645 , G01N27/4473 , G01N27/44791 , G01N33/492
摘要： This invention relates to the Capillary Electrophoresis (CE) Biochip. This chip uses the technology of CE combined with conductivity detection to determine: blood Electrolytes (EL) of K3 Na, Ca & Li using “EL Biochip” and to monitor water quality using “L Biochip”. Our in use technology enables to develop a small chip, reliable, easy to use, inexpensive and capable for rapid whole blood testing anywhere. Once this technique is developed, a generic system is obtained, and multitude of ions can be tested at once on the same device. Our chips are using same hardware (layout) and can be optimized to test other ions. The “2-in-1 Biochip” is a multi application versatile system, having two chips : “EL Biochip” : a point-of-care blood analysis chip, for diagnosis & therapeutic follow-up. “L-Biochip”: an on-site environmental monitoring liquids chip, to monitor water quality & guarding against water born diseases outbreaks.
摘要翻译：本发明涉及毛细管电泳（CE）生物芯片。该芯片采用CE与电导率检测技术结合使用“EL Biochip”测定K3 Na，Ca＆Li的血液电解质（EL），并使用“L Biochip”监测水质。我们的使用技术可以开发出小巧的芯片，可靠，易于使用，价格低廉，能够在任何地方快速全血测试。一旦开发了这种技术，就可以获得一个通用的系统，并且可以在同一个设备上同时测试大量的离子。我们的芯片使用相同的硬件（布局），可以进行优化，以测试其他离子。 “2合1生物芯片”是一种多应用多功能系统，具有两个芯片：“EL Biochip”：一种点对点血液分析芯片，用于诊断和治疗后续。 “生物芯片”：现场环境监测液体芯片，监测水质，防范出生水肿疾病爆发。

84. 发明申请

US20100108517A1 Concentration and Cleanup of Nucleic Acid Samples 有权
标题翻译：核酸样品的浓缩和清除
公开(公告)号：US20100108517A1
公开(公告)日：2010-05-06
申请号：US12687091
申请日：2010-01-13
申请人： Karl O. VOSS
发明人： Karl O. VOSS
IPC分类号： B01D57/02
CPC分类号： C12N15/1017
摘要： Methods and devices are described for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, PNA). Various embodiments provide for pH-mediated sample concentration and cleanup of nucleic acid samples with channel devices (e.g., cross-T format, microchannel devices).
摘要翻译：描述了用于浓缩和清除含有生物分子分析物（例如多核苷酸，例如DNA，RNA，PNA）的样品的方法和装置。各种实施方案提供pH介导的样品浓度并用通道装置（例如，交叉T格式，微通道装置）清除核酸样品。

85. 发明申请

US20100089757A1 GRADIENT ELUTION ELECTROPHORESIS AND DETECTORLESS ELECTROPHORESIS APPARATUS 有权
标题翻译：梯度电解电泳和无电极电泳设备
公开(公告)号：US20100089757A1
公开(公告)日：2010-04-15
申请号：US12577494
申请日：2009-10-12
申请人： David J. Ross , Sam Forry , Jason Kralj
发明人： David J. Ross , Sam Forry , Jason Kralj
IPC分类号： B01D57/02 , G01N27/26
CPC分类号： G01N27/44713 , B01D57/02 , G01N27/4473 , G01N2030/285
摘要： A microfluidic apparatus and method for performing electrophoretic separation of compounds. The apparatus comprises: a) A first container for containing a sample fluid; b) a second container for containing a separation buffer fluid; c) a channel of a first length having an inlet end and an outlet end, the inlet end connected to the first container and the outlet end connected to the second container; d) a voltage device electrically connected to the first container and the second container, the voltage device facilitating adjustment of the amount of voltage to the first container and the second container; e) a controller for controlling the velocity flow of the sample fluid through the channel from the first container towards the second container; and f) a measuring device for measuring the current through the channel. The method comprises the steps of: a) providing a separation buffer; b) providing a sample solution in fluid contact with the separation buffer; c) applying an electric field to the separation buffer; and d) producing a variable bulk flow of the separation buffer in a direction substantially aligned with said electric field. Fluid contact between the separation buffer and the sample solution is made through a separation column having a length in the range of from approximately 0.01 mm to approximately 5 mm. By the foregoing, compounds can be sequentially detected and quantified.
摘要翻译：用于进行化合物电泳分离的微流体装置和方法。该装置包括：a）容纳样品流体的第一容器; b）用于容纳分离缓冲液的第二容器; c）具有入口端和出口端的第一长度的通道，入口端连接到第一容器，出口端连接到第二容器; d）与第一容器和第二容器电连接的电压装置，该电压装置有助于调节第一容器和第二容器的电压量; e）控制器，用于控制样品流体通过通道从第一容器朝向第二容器的速度流动; 以及f）用于测量通过通道的电流的测量装置。该方法包括以下步骤：a）提供分离缓冲液; b）提供与分离缓冲液流体接触的样品溶液; c）向分离缓冲器施加电场; 以及d）在与所述电场基本对齐的方向上产生分离缓冲液的可变体积流。分离缓冲液和样品溶液之间的流体接触通过长度在约0.01mm至约5mm范围内的分离柱制成。通过上述，可以顺序地检测和定量化合物。

86. 发明申请

US20100035228A1 Monitored separation device 有权
标题翻译：监测分离装置
公开(公告)号：US20100035228A1
公开(公告)日：2010-02-11
申请号：US11091605
申请日：2005-03-28
申请人： George William Jackson , Richard Coale Willson , George Edward Fox
发明人： George William Jackson , Richard Coale Willson , George Edward Fox
IPC分类号： C12Q1/70 , G01N27/26 , B01D57/02 , G01N33/53
CPC分类号： C12N15/1003 , B01D57/02 , G01N27/44721
摘要： A device for separating and purifying useful quantities of particles comprises: a. an anolyte reservoir connected to an anode, the anolyte reservoir containing an electrophoresis buffer; b. a catholyte reservoir connected to a cathode, the catholyte reservoir also containing the electrophoresis buffer; c. a power supply connected to the anode and to the cathode; d. a column having a first end inserted into the anolyte reservoir, a second end inserted into the catholyte reservoir, and containing a separation medium; e. a light source; f. a first optical fiber having a first fiber end inserted into the separation medium, and having a second fiber end connected to the light source; g. a photo detector; h. a second optical fiber having a third fiber end inserted into the separation medium, and having a fourth fiber end connected to the photo detector; and i. an ion-exchange membrane in the anolyte reservoir.
摘要翻译：用于分离和净化有用量的颗粒的装置包括：a。连接到阳极的阳极电解液储存器，含有电泳缓冲液的阳极电解液储存器; b。连接阴极的阴极电解液储存器，阴极电解液储存器还含有电泳缓冲液; C。连接到阳极和阴极的电源; d。柱，其具有插入所述阳极电解液容器的第一端，插入所述阴极电解液容器中的第二端，并且包含分离介质; e。光源; F。第一光纤，其具有插入到所述分离介质中的第一光纤端，并且具有连接到所述光源的第二光纤端; G。光电检测器 H。第二光纤，其具有插入到所述分离介质中的第三光纤端，并且具有连接到所述光检测器的第四光纤端; 和我。阳极电解液容器中的离子交换膜。

87. 发明申请

US20100025243A1 METHOD FOR ROBUST CONTROL OVER A SOLUABLE FACTOR MICROENVIRONMENT WITHIN A THREE-DIMENSIONAL GEL MATRIX 审中-公开
标题翻译：用于三维凝胶矩阵中的可溶因子微环境的稳健控制的方法
公开(公告)号：US20100025243A1
公开(公告)日：2010-02-04
申请号：US12184408
申请日：2008-08-01
申请人： David J. Beebe , Vinay V. Abhyankar , Michael W. Toepke
发明人： David J. Beebe , Vinay V. Abhyankar , Michael W. Toepke
IPC分类号： B01D57/02
CPC分类号： B01L3/5027
摘要： A method is provided of generating a gradient within gel matrix received in a channel of a microfluidic device. A source reservoir in communication with the input of the channel is filled with a first fluid. A sink reservoir in communication with the output of the channel is filled with a second fluid. A soluble factor is deposited in the source reservoir such that the soluble factor diffuses into the channel and forms the gradient. The soluble factor in source reservoir is replenished to maintain the gradient in a generally pseudo-steady state and the second fluid in the sink reservoir is replaced.
摘要翻译：提供了一种在微流体装置的通道中接收的凝胶基质内产生梯度的方法。与通道的输入连通的源储存器被第一流体填充。与通道的输出连通的水槽储存器被第二流体填充。可溶性因子沉积在源储存器中，使得可溶性因子扩散到通道中并形成梯度。补充源储层中的可溶性因子以将梯度保持在通常为假稳态，并且更换储槽中的第二流体。

88. 发明授权

US07635558B2 Method for analyzing nucleic acid and use thereof for evaluating the degree of mRNA editing of the serotonin 5-HT2C receptor 有权
标题翻译：核酸分析方法及其用于评价血清素5-HT 2C受体的mRNA编辑程度的方法
公开(公告)号：US07635558B2
公开(公告)日：2009-12-22
申请号：US10522592
申请日：2003-07-24
申请人： Jean-Jacques Madjar , Hervé Berthomme
发明人： Jean-Jacques Madjar , Hervé Berthomme
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07H21/00 , B01D57/02
CPC分类号： C12Q1/6827 , C12Q1/6813 , C12Q1/6837 , C12Q2537/143 , C12Q2527/107 , C12Q2525/101 , C12Q2565/131 , C12Q2521/107
摘要： The invention concerns a method for analyzing nucleic acids using a small-size probe array comprising deoxyinostines (dI) instead of deoxyguanogines (dG). The invention also concerns such probe arrays and their use in methods for detecting and/or quantifying target oilgonucleotides present in DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) molecules in a sample, in particular mRNA editing rate of the serotonin 5-HT2C receptor (5-HT2C-R). The invention further concerns a biochip or a reactor in liquid medium comprising such probe arrays as well as their uses, in particular for detecting and/or identifying genetic polymorphisms or for determining an mRNA editing rate, whether it is that of a 5-HT2C-R mRNA or any other RNA capable of being edited. The invention also concerns a method based on the isolation of a single strand conformation polymorphism (SSCP) enabling under specific analysis conditions the editing profile and/or rate of an mRNA capable of being edited to be obtained, as well as a method for diagnosing diseases or susceptibility to diseases associated with the degree of edition of an mRNA. Finally, the invention concerns a method for selecting compounds capable of modulating mRNA editing rate, in particular that of 5-HT2C-R, as well as the use of such compounds for preparing a pharmaceutical composition for treating organic fluid.
摘要翻译：本发明涉及使用包含脱氧肌苷（dI）而不是脱氧鸟苷（dG）的小尺寸探针阵列分析核酸的方法。本发明还涉及这种探针阵列及其在检测和/或定量存在于样品中的DNA（脱氧核糖核酸）或RNA（核糖核酸））分子中的靶油核苷酸的方法中的用途，特别是5-羟色胺5-HT 2C受体的mRNA编辑速率（5-HT 2C-R）。本发明还涉及包含这种探针阵列的液体培养基中的生物芯片或反应器，以及它们的用途，特别是用于检测和/或鉴定遗传多态性或用于确定mRNA编辑速率，无论是5-HT 2C- R mRNA或任何其他能够编辑的RNA。本发明还涉及基于分离单链构象多态性（SSCP）的方法，其能够在特定分析条件下使得能够获得编辑的mRNA的编辑谱和/或速率以及用于诊断疾病的方法或对与mRNA的编程程度相关的疾病的易感性。最后，本发明涉及一种选择能够调节mRNA编辑速率的化合物，特别是5-HT 2C-R的化合物的方法，以及这些化合物在制备用于治疗有机液体的药物组合物中的用途。

89. 发明申请

US20090308745A1 PROCESS FOR ENHANCED TOTAL ORGANIC CARBON REMOVAL WHILE MAINTAINING OPTIMUM MEMBRANE FILTER PERFORMANCE 有权
标题翻译：在保持最佳膜过滤效能的情况下增强总有机碳去除方法
公开(公告)号：US20090308745A1
公开(公告)日：2009-12-17
申请号：US12545584
申请日：2009-08-21
申请人： Gregg A. McLeod
发明人： Gregg A. McLeod
IPC分类号： G01N27/26 , B01D61/56 , B01D57/02
CPC分类号： C02F1/008 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/22 , B01D65/08 , B01D2311/04 , B01D2311/10 , B01D2311/12 , B01D2311/14 , B01D2311/16 , B01D2311/18 , B01D2311/246 , B01D2311/2642 , B01D2311/2649 , B01D2315/06 , B01D2321/04 , B01D2321/162 , B01D2321/164 , B01D2321/22 , C02F1/44 , C02F1/444 , C02F1/52 , C02F1/5236 , C02F1/66 , C02F9/00 , C02F2209/02 , C02F2209/03 , C02F2209/06 , C02F2209/20 , C02F2209/40 , C02F2301/08
摘要： A system and process for enhancing total organic carbon (“TOC”) removal from raw, untreated water while maintaining optimum membrane filter performance. The present invention overcomes many of the disadvantages of prior art water filtration systems by controlling the pH level of the water, prior to the water being directed through said membrane filter, so that the particulate charge of the water aligns with the electromagnetic surface charge of membrane filter. Maintaining the particulate charge of the water within an optimum charge window for the particular membrane filter enhances the membrane filter's performance by decreasing the fouling rate of the membrane filter.
摘要翻译：一种用于增强从未经处理的水中去除总有机碳（“TOC”）的系统和方法，同时保持最佳的膜过滤性能。本发明通过在水被引导通过所述膜过滤器之前控制水的pH值来克服现有技术水过滤系统的许多缺点，使得水的颗粒物质与膜的电磁表面电荷对准过滤。在特定膜过滤器的最佳充电窗口内保持水的微粒电荷通过降低膜过滤器的结垢率来增强膜过滤器的性能。

90. 发明申请

US20090253181A1 Universal sample preparation system and use in an integrated analysis system 审中-公开
标题翻译：通用样品制备系统，用于综合分析系统
公开(公告)号：US20090253181A1
公开(公告)日：2009-10-08
申请号：US12321594
申请日：2009-01-21
申请人： Mattias Vangbo , William D. Nielsen , Lullu I. Blaga , Seth Stern , Joanne Horn , Michael Van Nguyen , Stevan B. Jovanovich
发明人： Mattias Vangbo , William D. Nielsen , Lullu I. Blaga , Seth Stern , Joanne Horn , Michael Van Nguyen , Stevan B. Jovanovich
IPC分类号： C12P19/34 , B01D17/06 , B01D57/02 , B01L3/00 , G01N33/00 , C12M1/00 , G01N1/18
CPC分类号： G01N1/34 , B01D17/06 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0647 , B01L2200/10 , B01L2300/0819 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N1/40 , G01N27/44791 , G01N35/1095 , G01N2035/00158 , Y10T436/143333 , Y10T436/25375
摘要： The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.
摘要翻译：本发明提供用于将微芯片连接到墨盒和气动歧管的装置和方法。墨盒，微芯片和气动歧管可以与下游制备装置（如热调节装置和分离和分析装置）集成。

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