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81. 发明授权

US08389932B2 Stacked-electrode peptide-fragmentation device 有权
标题翻译：堆叠电极肽断裂装置
公开(公告)号：US08389932B2
公开(公告)日：2013-03-05
申请号：US13000169
申请日：2009-06-30
申请人： Guo-Zhong Li , Joseph A. Jarrell
发明人： Guo-Zhong Li , Joseph A. Jarrell
IPC分类号： H01J49/26 , B01D59/44
CPC分类号： H01J49/0072 , H01J49/065
摘要： A chemical processing apparatus includes a fragmentation device that includes a linear set of stacked electrodes and a voltage control module that forms DC potential wells of opposite polarity for mutual confinement of opposite polarity ions. A method of protein analysis includes confining positive peptide ions and negatively charged reagent anions in, respectively, first and second DC potential wells in a fragmentation device, mixing the ions, in the fragmentation device, and analyzing ion fragments formed in the mixture.
摘要翻译：一种化学处理设备包括一个包括线性堆叠电极组的分段装置和形成相反极性的直流电势阱的电压控制模块，用于相互限制相反极性的离子。蛋白质分析的方法包括将分离的分离装置中的第一和第二DC势阱中的正肽离子和带负电荷的试剂阴离子限制在裂解装置中，并分析混合物中形成的离子碎片。

82. 发明授权

US08384027B2 Ion guide array 有权
标题翻译：离子导向阵列
公开(公告)号：US08384027B2
公开(公告)日：2013-02-26
申请号：US13119264
申请日：2009-09-17
申请人： John B. Hoyes , David Langridge
发明人： John B. Hoyes , David Langridge
IPC分类号： H01J49/42
CPC分类号： H01J49/062 , G01N27/622 , H01J49/02 , H01J49/065
摘要： An ion guide array is disclosed comprising a first ion guide section and a second ion guide section and optionally further ion guide sections. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. The electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section.
摘要翻译：公开了一种离子导向阵列，其包括第一离子引导部分和第二离子引导部分以及任选的其它离子引导部分。每个离子引导部分可以包括具有孔的多个电极，在使用中离子通过该孔传播。在第一离子引导部的出口设置有转印部，离子从第一离子引导部径向地传递到第二离子引导部。转印部分中的电极可以具有使得离子能够从第一离子导向部径向地传递到第二离子引导部的径向孔。

83. 发明授权

US08299427B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08299427B2
公开(公告)日：2012-10-30
申请号：US12522841
申请日：2007-01-23
申请人： Kazuo Mukaibatake
发明人： Kazuo Mukaibatake
IPC分类号： H01J49/00
CPC分类号： H01J49/065
摘要： An object of the present invention is to provide a mass spectrometer having an optical ion transport system where the efficiency for generating and converting fragment ions can be increased, and which can transport the generated fragment ions efficiently to the rear stage, and in order to achieve this object, the mass spectrometer for ionizing a sample in an ionization chamber 10 and drawing the ionized sample into a mass spectrometric chamber 18 is provided with an ion transport optical system having electrodes 17, 200-1 and 200-2 provided so as to surround an optical ion axis, and is characterized in that the above described electrodes 17, 200-1 and 200-2 have an inclined surface which is inclined so as to spread in the direction in which ions progress along the above described optical ion axis.
摘要翻译：本发明的目的是提供一种具有光离子传输系统的质谱仪，其中可以增加产生和转换碎片离子的效率，并且可以将产生的碎片离子有效地输送到后级，并且为了实现该目的是将离子化室10中的样品电离并将离子化样品拉入质谱室18的质谱仪具有离子传输光学系统，该离子传输光学系统具有设置为围绕的电极17,200-1和200-2 光学离子轴，其特征在于，上述电极17,200-1和200-2具有倾斜表面，该倾斜表面沿着离子沿着上述光离子轴线前进的方向扩展。

84. 发明授权

US08134123B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08134123B2
公开(公告)日：2012-03-13
申请号：US12594450
申请日：2008-01-17
申请人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
发明人： Masaru Nishiguchi , Yoshihiro Ueno , Daisuke Okumura , Hiroto Itoi
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/065 , H01J49/4235
摘要： One virtual rod electrode is composed by a plurality of electrode plane plates arranged in the ion optical axis direction, and four virtual rod electrodes are arranged around the ion optical axis to form a virtual quadrupole rod type ion transport optical system (30). In one virtual rod electrode, the interval between the adjacent electrode plane plates is set to be large in the anterior area (30A) and small in the posterior area (30B). As the interval between electrodes becomes larger, high-order multipole field components increase and therefore the ion acceptance is increased, which enables an efficient acceptance of ions coming from the previous stage. On the other hand, if the interval between electrodes is small, the quadrupole field components relatively increase and the ion beam's convergence is improved. Therefore, ions can be effectively introduced into a quadrupole mass filter for example in the subsequent stage, which contributes to the enhancement of the mass analysis' sensitivity and accuracy.
摘要翻译：一个虚拟棒状电极由离子光轴方向排列的多个电极平面板构成，四根虚拟棒电极配置在离子光轴的周围，形成虚拟四极杆型离子传输光学系统（30）。在一个虚拟棒状电极中，相邻的电极平板之间的间隔在前部区域（30A）中被设定得较大，而后部区域（30B）较小。随着电极之间的间隔变大，高阶多极场分量增加，因此离子接受度增加，这使得能够有效地接受来自前一阶段的离子。另一方面，如果电极之间的间隔小，则四极场成分相对增加，离子束的会聚也提高。因此，离子可以有效地引入四极质量过滤器中，例如在后续阶段，这有助于提高质量分析的灵敏度和精度。

85. 发明授权

US07960693B2 Microengineered electrode assembly 有权
标题翻译：微电极组件
公开(公告)号：US07960693B2
公开(公告)日：2011-06-14
申请号：US12220321
申请日：2008-07-23
申请人： Richard Syms , Alan Finlay
发明人： Richard Syms , Alan Finlay
IPC分类号： H01J49/42
CPC分类号： H01J3/14 , H01J49/0018 , H01J49/065
摘要： Microengineered stacked ring electrode assemblies capable of acting as either RF or DC ion guides in an ion optical system, and method of fabricating same are described. The electrodes are fabricated using planar processing as sets of grooved, proud features formed in a layer of material lying on an insulating substrate. Two such structures are then stacked together to form a set of diaphragm electrodes with closed pupils. Arrangements for fabrication by patterning, etching and bonding are described, together with methods for tapering the electrode pupils or otherwise varying the ion path.
摘要翻译：描述了能够在离子光学系统中用作RF或DC离子导向器的微工程堆叠环形电极组件及其制造方法。这些电极使用平面加工制造成为在位于绝缘衬底上的材料层中形成的一组带槽的引人注目的特征。然后将两个这样的结构堆叠在一起以形成具有闭合瞳孔的一组隔膜电极。描述通过图案化，蚀刻和接合进行制造的布置以及用于使电极瞳孔逐渐变细或以其它方式改变离子路径的方法。

86. 发明授权

US07919747B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07919747B2
公开(公告)日：2011-04-05
申请号：US12297481
申请日：2007-04-30
申请人： Martin Green , Jason Lee Wildgoose , Steven Derek Pringle , Daniel James Kenny
发明人： Martin Green , Jason Lee Wildgoose , Steven Derek Pringle , Daniel James Kenny
IPC分类号： H01J49/00 , H01J49/44
CPC分类号： H01J49/065 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/36 , H01J49/4235 , Y10T436/24
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.
摘要翻译：公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。在离子导向器或质量分析器（2）的出口处产生伪势垒。伪势垒的幅度或深度与离子的质荷比成反比。一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，从而离子引导或质量分析器（2）以与其质荷比相反的顺序发射离子。

87. 发明申请

US20100301206A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100301206A1
公开(公告)日：2010-12-02
申请号：US12744379
申请日：2008-11-24
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
摘要翻译：提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。一个或多个瞬态DC电压波（8,9）被施加到电极（2）。试剂阴离子和分析物阳离子排列成在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过一个或多个瞬态直流电压波（8 ，9）。

88. 发明申请

US20100282957A1 Ion Population Control in a Mass Spectrometer Having Mass-Selective Transfer Optics 有权
标题翻译：具有质量选择性转移光学质谱仪的离子人口控制
公开(公告)号：US20100282957A1
公开(公告)日：2010-11-11
申请号：US12777088
申请日：2010-05-10
申请人： Eloy R. Wouters , Maurizio A. Splendore , Jae C. Schwartz
发明人： Eloy R. Wouters , Maurizio A. Splendore , Jae C. Schwartz
IPC分类号： H01J49/26 , G12B13/00 , H01J49/04
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/065
摘要： Methods for operating a mass spectrometer having at least one component having mass-dependent transmission, comprising: injecting a first sample of ions having a first mass range into an ion accumulator for a first injection time under first operating conditions suitable for optimizing transmission of ions of the first range; acquiring a full-scan mass spectrum of the first sample of ions; selecting ion species having a second mass range different than the first range; calculating a second injection time, the second injection time suitable for injecting a population of the selected ion species into the ion accumulator under second operating conditions suitable for optimizing transmission of ions of the second range; injecting a second sample of ions having the selected ion species into the ion accumulator for the second injection time under the second operating conditions; and acquiring a mass spectrum of ions derived from the selected ion species.
摘要翻译：用于操作具有至少一种具有质量依赖透射率的组分的质谱仪的方法包括：在适于优化离子的透射的第一操作条件下，将具有第一质量范围的离子的第一样品注入离子蓄积器中用于第一注入时间第一范围; 获取第一离子样品的全扫描质谱; 选择具有不同于所述第一范围的第二质量范围的离子物质; 计算第二注射时间，所述第二注射时间适合于在适于优化所述第二范围的离子的透射的第二操作条件下将所选择的离子物质的群体注入到所述离子蓄积器中; 在第二操作条件下将具有所选择的离子种类的离子的第二样品注入到离子蓄积器中用于第二注入时间; 并获取从所选择的离子种类衍生的离子的质谱。

89. 发明申请

US20090173880A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090173880A1
公开(公告)日：2009-07-09
申请号：US11720520
申请日：2005-12-02
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/065
摘要： An ion guide (7a) is disclosed comprising one or more layers of intermediate planar, plate or mesh electrodes (2). A first array of first electrodes (8a-8e) is provided on an upper surface and a second array of second electrodes (9a-9e) is arranged on a lower surface. An ion guiding region is formed within the ion guide (7a). One or more transient DC voltages or potentials are preferably applied to the first and second array of second electrodes (8a-8e, 9a-9e) in order to urge, propel, force or accelerate ions through or along the ion guide (7a).
摘要翻译：公开了一种离子导向器（7a），其包括一层或多层中间平面，板状或网状电极（2）。第一电极阵列（8a-8e）设置在上表面上，第二电极阵列（9a-9e）布置在下表面上。离子引导区域形成在离子导向器（7a）内。优选地将一个或多个瞬态DC电压或电位施加到第一和第二第二电极阵列（8a-8e，9a-9e），以促使，推动，强迫或加速离子通过或沿着离子导向器（7a）。

90. 发明申请

US20090026366A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20090026366A1
公开(公告)日：2009-01-29
申请号：US11908555
申请日：2006-03-10
申请人： Kazuo Mukaibatake , Shiro Mizutani
发明人： Kazuo Mukaibatake , Shiro Mizutani
IPC分类号： G01N23/00
CPC分类号： H01J49/065
摘要： In conventional mass spectrometers, if ions are converged by a radio-frequency electric field under the condition of relatively high gas pressure, the ions are decelerated and are delayed, or stagnated in an extreme case, to cause a decrease in the detection sensitivity or an appearance of a ghost peak. By contrast, in the mass spectrometer according to the present invention, lens electrodes 40 comprises four plate-shaped electrodes 41a through 41d, which are radially arranged around the ion optical axis C at intervals of 90 degrees from each other; the four electrodes placed in the plane being approximately perpendicular to the ion optical axis C form a group, and a plurality of the groups are arranged along the ion optical axis C direction at approximately even intervals. The radio-frequency voltages each applied to each of any pair of electrodes adjacent along the direction of the ion optical axis C have a given amount of phase shift. With this configuration, when ions enter the lens electrode 40, an ion acceleration effect is exerted in accordance with the amount of phase shift of the adjacent radio-frequency electric fields, and the ions are sequentially accelerated as they travel through the lens electrode 40. Consequently, a delay or stagnation of the ions can be avoided.
摘要翻译：在传统的质谱仪中，如果离子在较高的气体压力的条件下被射频电场会聚，则离子被减速并在极端情况下被延迟或停滞，导致检测灵敏度的降低或出现鬼峰。相反，在本发明的质谱仪中，透镜电极40包括四个平板状的电极41a〜41d，它们彼此以90度的间隔沿离子光轴C径向排列; 放置在垂直于离子光轴C的平面中的四个电极形成一组，并且沿离子光轴C方向以大致均匀的间隔布置多个组。分别施加到沿着离子光轴C的方向相邻的任何一对电极中的每一个电极的射频电压具有给定量的相移。利用这种结构，当离子进入透镜电极40时，根据相邻射频电场的相移量来施加离子加速效应，离子在穿过透镜电极40时依次加速。因此，可以避免离子的延迟或停滞。

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