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81. 发明申请

US20150057940A1 MODIFYING A COSMETIC PRODUCT BASED ON A MICROBE PROFILE 有权
标题翻译：基于MICROBE配置文件修改化妆品
公开(公告)号：US20150057940A1
公开(公告)日：2015-02-26
申请号：US14294508
申请日：2014-06-03
申请人： Elwha LLC
发明人： Michael H. Baym , Roderick A. Hyde , Jordin T. Kare , Eric C. Leuthardt , Gary L. McKnight , Tony S. Pan , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号： G06F19/00
CPC分类号： G06F19/704
摘要： Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.
摘要翻译：描述了用于基于包括成分 - 微生物相互作用数据集在内的微生物分布修饰化妆品的系统和方法，所述成分 - 微生物相互作用数据集包括与参考化妆品成分与参考微生物类型之间的相互作用相关的信息; 以及计算设备，其包括被配置为接收与个体的微生物谱相关联的信息的电路，接收与化妆品的成分列表相关联的信息，将所述个体的微生物谱和所述化妆品的成分列表与成分 - 微生物相互作用数据集，鉴定化妆品的成分列表中的至少一种化妆品成分与个体的微生物概况中的一种或多种类型的微生物中的至少一种之间的相互作用，推荐对成分列表进行响应到一个识别的交互，并向用户报告推荐的修改。

82. 发明申请

US20150011620A1 ANTI-INVASIVE COMPOUNDS 有权
标题翻译：防静电化合物
公开(公告)号：US20150011620A1
公开(公告)日：2015-01-08
申请号：US14375270
申请日：2013-01-30
申请人： Universiteit Gent
发明人： Marc Bracke , Christian Stevens , Tine De Ryck , Bart Roman , Barbara Vanhoecke
IPC分类号： C07C49/223 , C07D307/46 , G06F19/00
CPC分类号： C07C49/223 , A61K31/12 , A61K31/34 , C07D307/46 , G06F19/704
摘要： The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.
摘要翻译：本发明涉及抗侵入化合物领域和预测所述化合物的抗侵袭活性的方法及其在预防和/或治疗与不期望的细胞侵袭相关的疾病中的用途; 特别地，本发明涉及抗侵入性查耳酮样化合物领域。

83. 发明申请

US20140329717A1 PREDICTING TOXICITY OF A COMPOUND OVER A RANGE OF CONCENTRATIONS 有权
标题翻译：化合物对浓度范围的预测毒性
公开(公告)号：US20140329717A1
公开(公告)日：2014-11-06
申请号：US14334453
申请日：2014-07-17
申请人： CELLOMICS, INC.
发明人： Suk Jin Hong , Richik Niloy Ghosh
IPC分类号： G01N33/50 , G06T7/00
CPC分类号： G01N33/5014 , G01N33/5067 , G01N2500/10 , G06F19/704 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.
摘要翻译：预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。

84. 发明申请

US20140141462A1 System and Method for Automated Determination of the Relative Effectiveness of Anti-Cancer Drug Candidates 有权
标题翻译：自动测定抗癌药物候选药物相对效力的系统和方法
公开(公告)号：US20140141462A1
公开(公告)日：2014-05-22
申请号：US13803623
申请日：2013-03-14
申请人： DiaTech Oncology
发明人： Mathieu Perree , Allan E. Hallquist , Olivier Petit
IPC分类号： G01N33/50
CPC分类号： G01N33/5011 , G01N33/5044 , G06F19/704 , G06F19/709
摘要： A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and enables user selection of desired drug testing parameters in relation to a virtual well plate associated with a physical well plate of a spectrophotometer. The computer system causes the spectrophotometer to start a drug test, wherein the physical well plate includes at least one test well containing viable cancer cells; and at least one drug candidate in a predetermined concentration; and at least one control well containing the viable cancer cells alone. The system records the optical density of the well at a predetermined wavelength at selected time intervals for a selected duration of time, and stores the optical density and time measurements in the database. An activity value is calculated from the optical density and time measurements, and a correlation is displayed between the activity value and the drug candidate's ability to induce apoptosis in the cancer cells.
摘要翻译：提供了一种计算机系统来确定抗癌药物的相对有效性。该界面具有可选择的选项，包括管理药物测试参数的选项，并且使用户可以选择相关于与分光光度计的物理井板相关联的虚拟井板所需的药物测试参数。计算机系统使得分光光度计开始药物测试，其中物理井板包括至少一个含有活的癌细胞的测试孔; 和至少一种预定浓度的候选药物; 以及含有单独存活的癌细胞的至少一个对照孔。该系统以选定的时间间隔将预定波长的阱的光密度记录在选定的时间内，并将光密度和时间测量值存储在数据库中。从光密度和时间测量计算活性值，并且在活性值和药物候选物诱导癌细胞凋亡的能力之间显示相关性。

85. 发明申请

US20140065642A1 SYSTEMS AND METHODS FOR CHARACTERIZATION OF MOLECULES 有权
标题翻译：用于表征分子的系统和方法
公开(公告)号：US20140065642A1
公开(公告)日：2014-03-06
申请号：US14049249
申请日：2013-10-09
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/543
CPC分类号： G01N33/57434 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/96441 , G01N2333/96455 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/704 , G16H50/50
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

86. 发明授权

US08655633B2 Method of predicting the physical properties of polyurethane materials 有权
标题翻译：预测聚氨酯材料物理性能的方法
公开(公告)号：US08655633B2
公开(公告)日：2014-02-18
申请号：US13066628
申请日：2011-04-19
申请人： Augusto C Ibay
发明人： Augusto C Ibay
IPC分类号： G06F7/60 , G06G7/48 , C08J9/00
CPC分类号： C08G18/4018 , C08G2101/0025 , C08G2101/005 , C08G2105/02 , G06F19/704
摘要： The specification relates to the formulation of polyurethane materials particularly polyurethane and polyisocyanurate foams. The specified method allows the formulator to mathematically predict the final physical properties of the polyurethane and polyisocyanurate foams by using the algorithm described herein.
摘要翻译：本说明书涉及聚氨酯材料，特别是聚氨酯和聚异氰脲酸酯泡沫的配方。指定的方法允许配制者通过使用本文所述的算法数学地预测聚氨酯和聚异氰脲酸酯泡沫的最终物理性质。

87. 发明授权

US08655600B2 Method and system of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility 有权
标题翻译：估计用于预测离子迁移率的分子的横截面积的方法和系统
公开(公告)号：US08655600B2
公开(公告)日：2014-02-18
申请号：US13264042
申请日：2010-04-15
申请人： Keith George Richardson , Iain David Grant Campuzano
发明人： Keith George Richardson , Iain David Grant Campuzano
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G06F19/701 , G01N27/622 , G06F17/18 , G06F19/16 , G06F19/704
摘要： A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterization of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs.
摘要翻译：估计用于预测离子迁移率的分子的横截面积的方法提供气相相互作用半径测定和横截面算法计算，以提供结构相关异构体的分离和表征。更具体地，本发明提供了通过利用用于估计这些药物的分子的横截面积的新算法将分子结构的差异与预定的抗癌药物的抗癌活性的差异相关联的方法。

88. 发明授权

US08647441B2 Method of fabricating semiconductor cleaners 有权
标题翻译：制造半导体清洁剂的方法
公开(公告)号：US08647441B2
公开(公告)日：2014-02-11
申请号：US13846595
申请日：2013-03-18
申请人： Infineon Technologies AG
发明人： Frank Weber
IPC分类号： B08B7/02
CPC分类号： G05D11/02 , C11D11/0047 , G06F19/704 , H01L21/0206
摘要： A method of manufacturing cleaning solvents is provided. The method includes selecting a small plurality of test solvents from a large plurality of perspective solvents. The equilibrium composition of a multi-component solution is preferably described by the Hansen solubility model. A small plurality of test solvents is applied to solute samples and the degree of dissolution or swelling recorded. Based on the degree of dissolution or swelling, at least one solvent is selected from the large plurality of perspective solvents based on the Hansen parameters.
摘要翻译：提供了制造清洗溶剂的方法。该方法包括从大量多个透视溶剂中选择少量的测试溶剂。多组分溶液的平衡组成优选用Hansen溶解度模型描述。施用少量测试溶剂来溶解样品，记录溶解或溶胀度。基于溶解或溶胀的程度，基于Hansen参数从至少一种溶剂中选择大量的透视溶剂。

89. 发明申请

US20130317793A1 ASSESSMENT OF SOLUTE PARTITIONING IN CRUDE OILS 审中-公开
标题翻译：原油中溶解分馏的评估
公开(公告)号：US20130317793A1
公开(公告)日：2013-11-28
申请号：US13895635
申请日：2013-05-16
申请人： Narasimhan SUNDARAM , Bryan M. KNICKERBOCKER , Steven WONG
发明人： Narasimhan SUNDARAM , Bryan M. KNICKERBOCKER , Steven WONG
IPC分类号： G06F17/50
CPC分类号： G06F17/5018 , C10G75/02 , F04C2270/0421 , G06F19/704
摘要： Partition coefficients for solutes in solvent-water systems are estimated based on corresponding values for the octanol-water system. The estimation of the partition coefficient includes correction factors based on the nature of the solute and the solvent. Petroleum fractions are an example of a suitable solvent for which a partition coefficient can be estimated, although other types of solvents can be used in developing a model for use in the estimation.
摘要翻译：溶剂 - 水体系中溶质的分配系数是根据辛醇 - 水体系的相应值估算的。分配系数的估计包括基于溶质和溶剂性质的校正因子。石油馏分是可以估计分配系数的合适溶剂的实例，尽管可以使用其它类型的溶剂来开发用于估计的模型。

90. 发明授权

US08571283B2 Method for simultaneously extracting the input function and pharmacokinetic parameters of an active ingredient 有权
标题翻译：同时提取活性成分的输入功能和药代动力学参数的方法
公开(公告)号：US08571283B2
公开(公告)日：2013-10-29
申请号：US13043969
申请日：2011-03-09
申请人： Renaud Maroy , Segolene De Gavriloff
发明人： Renaud Maroy , Segolene De Gavriloff
IPC分类号： G06K9/00
CPC分类号： G06F19/704
摘要： This extraction method in a structure of a living organism from a measurement image of the kinetics of the active ingredient comprising a plurality of regions of interest inside each of which the kinetics of the active ingredient are measured, comprises the following steps: determining (30) a plurality of sets of kinetics, the determined sets of kinetics being different from each other and each determined set of kinetics including several measured kinetics; defining (32) at least one kinetic model, parameters of the defined kinetics model being formed by the parameters of the input function and the pharmacokinetic parameters; estimating (34) the input function and the pharmacokinetic parameters by resolving the kinetic model defined from the determined set of kinetics; and deducing (36) the final input function and the final pharmacokinetic parameters.
摘要翻译：来自活性成分的活性成分的动力学的测定图像的活性成分的结构的提取方法包括测定活性成分的动力学的各个感兴趣区域，包括以下步骤：确定（30）多组动力学，确定的动力学集合彼此不同，并且每个确定的动力学集合包括几个测量的动力学; 定义（32）至少一个动力学模型，所定义的动力学模型的参数由输入函数的参数和药代动力学参数形成; 通过解决从确定的动力学集合定义的动力学模型来估计（34）输入函数和药代动力学参数; 并推导（36）最终输入函数和最终药代动力学参数。

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