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81. 发明申请

US20120301904A1 MULTIPROTEIN ASSEMBLIES 审中-公开
标题翻译：多媒体组合
公开(公告)号：US20120301904A1
公开(公告)日：2012-11-29
申请号：US13457481
申请日：2012-04-26
申请人： Vishwanath R. Lingappa , Clarence R. Hurt , Debendranath Dey
发明人： Vishwanath R. Lingappa , Clarence R. Hurt , Debendranath Dey
IPC分类号： G01N33/53 , C12N1/00
CPC分类号： G01N33/68 , C12N7/00 , C12N2740/16051 , C12N2760/16151 , C12N2770/24251 , C12N2770/36151 , C12P21/02 , G01N2333/065 , G01N2500/02 , G01N2500/20 , Y02A50/51
摘要： The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.
摘要翻译：本发明提供了组合物和方法，用于研究与疾病相关的多种蛋白质组装的形成。还提供了用于筛选通过防止组装或破坏多蛋白组件的功能来预防和/或治疗这些疾病的潜在效用的候选化合物的测定。

82. 发明授权

US07807455B2 Method to confer cell culture replication activity to different Hepatitis C virus isolates 失效
标题翻译：赋予不同丙型肝炎病毒分离株细胞培养复制活性的方法
公开(公告)号：US07807455B2
公开(公告)日：2010-10-05
申请号：US10543633
申请日：2004-02-09
申请人： Jay Grobler , Osvaldo Flores , Eric J. Markel
发明人： Jay Grobler , Osvaldo Flores , Eric J. Markel
IPC分类号： C12N15/00 , C12Q1/68 , C12Q1/70 , C07H21/00
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24243 , C12N2770/24251
摘要： The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.
摘要翻译：本发明的特征在于使用来自不同分离株的HCV编码序列产生HCV复制子的方法。特征性方法是基于NS3氨基酸位置470在赋予不同HCV分离株的细胞培养复制活性方面发现的重要性。

83. 发明申请

US20100144014A1 METHOD FOR AMPLIFYING HCV IN AEDES MOSQUITOES 审中-公开
标题翻译：用于在多发性硬化中放大HCV的方法
公开(公告)号：US20100144014A1
公开(公告)日：2010-06-10
申请号：US12448420
申请日：2007-12-20
申请人： Emmanuel Drouet , Yassine Rechoum , Florence Fouque
发明人： Emmanuel Drouet , Yassine Rechoum , Florence Fouque
IPC分类号： C12N7/01 , C12N5/07
CPC分类号： C12N7/00 , A01K67/033 , C12N2770/24251
摘要： A process for amplifying hepatitis C virus (HCV) in vivo is provided. The method includes ingestinga viral source by female Aedes vexans or Aedes caspius mosquitoes, andrearing the mosquitoes for a time necessary to amplify the virus.
摘要翻译：提供了一种在体内扩增丙型肝炎病毒（HCV）的方法。该方法包括由雌性伊蚊（Aedes vexans）或白纹伊蚊（Aedes caspius mosquitoes）摄取病毒源，并且将蚊子饲养一段时间以扩大病毒。

84. 发明授权

US07674612B2 Infectious, chimeric hepatitis C virus, methods of producing the same and methods of use thereof 有权
标题翻译：传染性，嵌合型丙型肝炎病毒，其制备方法及其使用方法
公开(公告)号：US07674612B2
公开(公告)日：2010-03-09
申请号：US11366839
申请日：2006-03-03
申请人： Charles Rice , Brett D Lindenbach , Matthew J Evans , Christopher Jones
发明人： Charles Rice , Brett D Lindenbach , Matthew J Evans , Christopher Jones
IPC分类号： C12N15/09 , C12N15/51 , C12N7/00 , C12N7/01 , C12N7/04 , C07H21/00 , C12N15/00
CPC分类号： C12N7/00 , A61K2039/525 , C07K2319/61 , C12N15/86 , C12N2770/24243 , C12N2770/24251 , C12N2840/203 , C12Q1/18 , G01N33/5767 , G01N2333/18 , G01N2500/00
摘要： The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis.
摘要翻译：本发明提供感染性重组丙型肝炎病毒（HCV），以及包含其的载体，细胞和动物。本发明提供生产感染性重组HCV的方法及其在鉴定抗HCV治疗剂中的用途以及与HCV发病机制相关的HCV序列。

85. 发明申请

US20100047767A1 PATHOGEN BINDING 审中-公开
标题翻译：病态绑定
公开(公告)号：US20100047767A1
公开(公告)日：2010-02-25
申请号：US12524966
申请日：2008-02-04
申请人： Prabhjyot Dehal , David Pritchard , Claire Geekie
发明人： Prabhjyot Dehal , David Pritchard , Claire Geekie
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/554 , C07K14/00
CPC分类号： G01N33/566 , C07K2319/23 , C12N7/00 , C12N2770/24251 , G01N33/569 , G01N33/576 , G01N2333/095 , G01N2333/11 , G01N2333/16 , G01N2333/18 , G01N2333/70514 , G01N2333/70525 , G01N2333/70596
摘要： Provided is a method for determining the presence or absence of a pathogen in a sample, which method comprises: a) contacting the sample with a whole or a part of a cell surface receptor protein capable of binding the pathogen; b) allowing the cell surface receptor protein or part thereof to bind the pathogen; c) determining the presence or absence of the pathogen bound to the receptor protein or part thereof.
摘要翻译：提供了一种用于确定样品中病原体存在或不存在的方法，该方法包括：a）使样品与能够结合病原体的细胞表面受体蛋白质的全部或部分接触; b）允许细胞表面受体蛋白或其部分结合病原体; c）确定与受体蛋白质或其部分结合的病原体的存在或不存在。

86. 发明申请

US20090311770A1 Method of collecting microorganisms using fine particles, method of collecting nucleic acids using fine particles, and kits for use in the these methods 审中-公开
标题翻译：使用细颗粒收集微生物的方法，使用细颗粒收集核酸的方法，以及用于这些方法的试剂盒
公开(公告)号：US20090311770A1
公开(公告)日：2009-12-17
申请号：US11919475
申请日：2006-05-19
申请人： Satoshi Hashiguchi , Mitsuharu Hirai , Toshiya Hosomi
发明人： Satoshi Hashiguchi , Mitsuharu Hirai , Toshiya Hosomi
IPC分类号： C12N1/02 , C12N7/02 , C12N1/20 , C12N5/06
CPC分类号： C12N7/00 , C12N1/02 , C12N15/1013 , C12N2730/10151 , C12N2740/16051 , C12N2770/24251 , C12Q1/24
摘要： The present invention provides a method of collecting microorganisms and a method of collecting nucleic acids, which both can be carried out easily and can achieve a high collection rate. A method of collecting microorganisms according to the present invention includes a microorganism adsorption step of bringing a sample into contact with fine particles so as to cause microorganisms contained in the sample to be adsorbed onto the fine particles. In this method, the fine particles have a particle diameter of 6 μm or less and a specific surface area of 50 m2/g or less. Furthermore, a method of collecting nucleic acids according to the present invention includes: a microorganism adsorption step of causing microorganisms to be adsorbed onto fine particles; and a nucleic acid elution step of eluting nucleic acids from the microorganisms that have been adsorbed onto the fine particles. The microorganism adsorption step in this method is the microorganism collection method of the present invention. According to the collection methods of the present invention, microorganisms and nucleic acids can be collected easily and efficiently. Preferably, the fine particles are magnetic silica particles.
摘要翻译：本发明提供收集微生物的方法和收集核酸的方法，这两者都可以容易地进行并且可以实现高收集率。根据本发明的收集微生物的方法包括微生物吸附步骤，使样品与细颗粒接触，以使样品中所含的微生物吸附到微粒上。在该方法中，微粒的粒径为6μm以下，比表面积为50m 2 / g以下。此外，根据本发明的收集核酸的方法包括：使微生物吸附在细颗粒上的微生物吸附步骤; 以及从已经吸附到微粒上的微生物中洗脱核酸的核酸洗脱步骤。该方法中的微生物吸附步骤是本发明的微生物收集方法。根据本发明的收集方法，可以容易且有效地收集微生物和核酸。优选地，微粒是磁性二氧化硅颗粒。

87. 发明授权

US07524650B2 Antibodies directed against hepatitis C virus E1E2 complex, compositions of HCV particles, and pharmaceutical compositions 失效
标题翻译：针对丙型肝炎病毒E1E2复合物的抗体，HCV颗粒的组合物和药物组合物
公开(公告)号：US07524650B2
公开(公告)日：2009-04-28
申请号：US10550295
申请日：2004-03-31
申请人： Marie-Anne Petit , Colette Jolivet-Reynaud
发明人： Marie-Anne Petit , Colette Jolivet-Reynaud
IPC分类号： A61K39/395
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译：新的构象抗体针对HCV，更具体地针对单克隆抗体。颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒及其制备方法。

88. 发明授权

US07504255B2 Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes 失效
标题翻译：用于在永生化人肝细胞中产生感染性丙型肝炎病毒的组合物和方法
公开(公告)号：US07504255B2
公开(公告)日：2009-03-17
申请号：US11506161
申请日：2006-08-17
申请人： Ratna Ray , Ranjit Ray , Arnab Basu , Tatsuo Kanda
发明人： Ratna Ray , Ranjit Ray , Arnab Basu , Tatsuo Kanda
IPC分类号： C12N5/00 , C12N5/02 , A01N63/00 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/275
CPC分类号： C12N7/00 , A61K2039/525 , C12N2770/24251 , C12Q1/18 , G01N33/5067 , G01N2333/18
摘要： The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77) transfected immortal human hepatocyte (IHH) capable of generating infectious HCV 1a virus particles in culture. Also disclosed are methods of using the cell line, or HCV 1a virus particles derived from said cell line, to screen for potential therapeutic agents which interfere with HCV 1a virus propagation to treat hepatic disease.
摘要翻译：本发明提供了一种在培养中能够产生感染性丙型肝炎病毒1a（HCV1a）颗粒的细胞系。公开了能够在培养中产生感染性HCV 1a病毒颗粒的HCV 1a（克隆H77）转染的永生人肝细胞（IHH）的组合物和方法。还公开了使用细胞系或源自所述细胞系的HCV 1a病毒颗粒筛选干扰HCV 1a病毒繁殖以治疗肝脏疾病的潜在治疗剂的方法。

89. 发明授权

US07455969B2 Highly permissive cell lines for hepatitis C virus RNA replication 有权
标题翻译：用于丙型肝炎病毒RNA复制的高度允许的细胞系
公开(公告)号：US07455969B2
公开(公告)日：2008-11-25
申请号：US10534571
申请日：2003-11-13
申请人： Charles M. Rice, III , Keril J. Blight
发明人： Charles M. Rice, III , Keril J. Blight
IPC分类号： C12Q1/68 , C12Q1/70 , C12N15/00 , C12N5/00 , C12N5/08 , C07H21/00
CPC分类号： C07K14/005 , C12N5/067 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24251
摘要： This invention relates generally to cells and cell lines that are permissive for hepatitis C virus (HCV) replication, and methods and materials for making and using them. The subject cell line referred to as Huh-7.5 has the A.T.C.C. designation number PTA-8561, having been deposited on Aug. 1, 2007.
摘要翻译：本发明一般涉及对丙型肝炎病毒（HCV）复制是允许的细胞和细胞系，以及用于制备和使用它们的方法和材料。称为Huh-7.5的主体细胞系具有A.T.C.C. 名称号码PTA-8561，已于2007年8月1日交存。

90. 发明授权

US07338759B1 HCV variants 有权
标题翻译： HCV变体
公开(公告)号：US07338759B1
公开(公告)日：2008-03-04
申请号：US10276051
申请日：2001-05-23
申请人： Charles M. Rice , Keril J. Blight
发明人： Charles M. Rice , Keril J. Blight
IPC分类号： C12Q1/70 , C12Q1/68 , C12N15/09 , C12P21/00 , C12N7/02 , C12N5/10 , C07H21/00
CPC分类号： A61K39/12 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2770/24222 , C12N2770/24243 , C12N2770/24251 , C12Q1/18 , G01N2333/18 , G01N2500/10
摘要： HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the provision of cells and host cells comprising the expression vectors. Methods for identifying a cell line that is permissive for infection with HCV are also provided, as are vaccines comprising the above polynucleotides in a pharmaceutically acceptable carrier. Additionally, methods for inducing immunoprotection to HCV in a primate are described, as are methods for testing a compound for inhibiting HCV replication.
摘要翻译：描述了HCV变体。变体包括包含非天然存在的HCV序列和HCV变体的多核苷酸，其具有转染效率和能够存活大于具有野生型多蛋白编码区的HCV的亚临床的能力。还描述了包含上述多核苷酸和HCV变体的表达载体，以及提供包含表达载体的细胞和宿主细胞。还提供了鉴定用于感染HCV的细胞系的方法，以及在药学上可接受的载体中包含上述多核苷酸的疫苗。此外，还描述了在灵长类动物中诱导HCV的免疫保护的方法，以及用于测试抑制HCV复制的化合物的方法。

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