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81. 发明授权

US07811576B2 Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof 有权
标题翻译：啮齿动物乙型肝炎病毒核心蛋白作为疫苗平台及其使用方法
公开(公告)号：US07811576B2
公开(公告)日：2010-10-12
申请号：US12008059
申请日：2008-01-07
申请人： David R. Milich , Jean-Noel Billaud
发明人： David R. Milich , Jean-Noel Billaud
IPC分类号： A61K39/29 , A61K39/295 , C12N15/51 , C12N15/62
CPC分类号： A61K39/292 , A61K39/015 , A61K39/12 , A61K2039/5256 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2730/10122 , C12N2730/10134 , Y02A50/412
摘要： The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.
摘要翻译：本发明涉及肝炎病毒核心蛋白和核酸。特别地，本发明提供了包含用于疫苗制剂的重组肝炎病毒核心蛋白或核酸的组合物和方法。

82. 发明授权

US07763589B2 Compositions and methods for treating intracellular diseases 失效
标题翻译：用于治疗细胞内疾病的组合物和方法
公开(公告)号：US07763589B2
公开(公告)日：2010-07-27
申请号：US09466035
申请日：1999-12-17
申请人： Matti Sallberg , David R. Milich , William T. L. Lee
发明人： Matti Sallberg , David R. Milich , William T. L. Lee
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K39/292 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/55566 , A61K2039/57 , C12N2710/10343 , C12N2730/10122 , C12N2730/10134 , C12N2740/13043 , C12N2770/24234 , C12N2770/24322 , Y02A50/403 , Y02A50/412 , Y02A50/478
摘要： The present invention provides methods of treating intracellular infections comprising the step of administering a vector construct which directs the expression of at least one immunogenic portion of an antigen derived from an intracellular pathogen, and also administering to the warm-blooded animal a protein which comprises the immunogenic portion of the antigen, such that an immune response is generated.
摘要翻译：本发明提供了治疗细胞内感染的方法，包括施用指导来自细胞内病原体的抗原的至少一种免疫原性部分的表达的载体构建体的步骤，以及向温血动物施用包含抗原的免疫原性部分，使得产生免疫应答。

83. 发明申请

US20100129385A1 IMMUNOGENIC MOLECULES 审中-公开
标题翻译：免疫分子
公开(公告)号：US20100129385A1
公开(公告)日：2010-05-27
申请号：US11815847
申请日：2006-02-08
申请人： David C. Jackson , Weiguang Zeng
发明人： David C. Jackson , Weiguang Zeng
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/292 , A61K2039/543 , A61K2039/6018 , C07K2319/00 , C12N2710/16634 , C12N2730/10134
摘要： The present invention relates generally to the field of immunology and more particularly to molecules capable of stimulating a cellular immune response. More particularly, the present invention provides self-adjuvanting immunogenic molecules capable of stimulating an immune response to epitopes of a polypeptide irrespective of a subjects HLA type. The present invention further contemplates methods for the production and use of the self-adjuvanting immunogenic molecules and compositions comprising same useful in the vaccination of subjects against specific polypeptides.
摘要翻译：本发明一般涉及免疫学领域，更具体地涉及能够刺激细胞免疫应答的分子。更具体地，本发明提供能够刺激对多肽的表位的免疫应答的自佐剂免疫原性分子，而不管受试者HLA型。本发明进一步考虑了用于自身佐剂免疫原性分子的生产和使用的方法，以及包含用于针对特定多肽的受试者接种疫苗的组合物的组合物。

84. 发明申请

US20100080844A1 METHOD TO ENHANCE AN IMMUNE RESPONSE OF NUCLEIC ACID VACCINATION 有权
标题翻译：增强核酸疫苗免疫应答的方法
公开(公告)号：US20100080844A1
公开(公告)日：2010-04-01
申请号：US12566587
申请日：2009-09-24
申请人： Andrew David BACON , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
发明人： Andrew David BACON , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
IPC分类号： A61K9/127 , A61K31/7088 , A61P37/04 , A61P31/12 , A61P31/16
CPC分类号： A61K9/1277 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/5252 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , C07H21/04 , C12N7/00 , C12N2730/10134 , C12N2760/16134
摘要： A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.
摘要翻译：一种组合物，其包含与可操作地编码抗原性蛋白质和蛋白质蛋白质的核酸相关联的脂质体，其中所述组合物蛋白质与所述抗原蛋白质共享至少一个表位，并且其中所述核酸和所述组合物蛋白质与相同的脂质体相关联描述。与脂质体的混合物相比，组合物提供了改善的免疫应答，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

85. 发明申请

US20100068218A1 Optimized Multi-Epitope Constructs and Uses Thereof 失效
标题翻译：优化多表位构造及其应用
公开(公告)号：US20100068218A1
公开(公告)日：2010-03-18
申请号：US12408472
申请日：2009-03-20
申请人： Alessandro SETTE , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Marie Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T.F. Huang , Scott D. Power
发明人： Alessandro SETTE , Robert Chesnut , Mark J. Newman , Brian D. Livingston , Lilia Marie Babe , Yiyou Chen , Lawrence M. Deyoung , Manley T.F. Huang , Scott D. Power
IPC分类号： A61K39/29 , C07K14/02
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , A61K2039/605 , A61K2039/645 , C07K14/005 , C12N2730/10122 , C12N2730/10134
摘要： The invention relates to the field of biology. In particular, it relates to multi-epitope nucleic acid and peptide vaccines and methods of designing such vaccines to provide increased immunogenicity.
摘要翻译：本发明涉及生物学领域。特别地，其涉及多表位核酸和肽疫苗以及设计这种疫苗以提供增加的免疫原性的方法。

86. 发明申请

US20100049491A1 Method and System for Optimizing Minigenes and Peptides Encoded Thereby 审中-公开
标题翻译：用于优化由此编码的微生物和肽的方法和系统
公开(公告)号：US20100049491A1
公开(公告)日：2010-02-25
申请号：US12330079
申请日：2008-12-08
申请人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
发明人： Alessandro SETTE , Robert Chestnut , Brian D. Livingston , Denise Marie Baker , Mark J. Newman , David H. Brown
IPC分类号： G06F17/50 , G06F19/00
CPC分类号： A61K39/29 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2730/10122 , C12N2730/10134 , C12N2740/16022 , C12N2740/16034 , G16B15/00 , G16B20/00 , G16B30/00 , G16B40/00
摘要： The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid insertions at the junctions of the multi-epitope constructs so as to minimize the number of junctional epitopes and provide vaccines with increased immunogenicity.
摘要翻译：本发明涉及生物学领域。特别地，本发明涉及一种用于设计优化的多表位疫苗的方法和系统，其具有在多表位构建体的连接处具有氨基酸插入的选择的组合，以便最小化连接表位的数目并提供具有增加的免疫原性的疫苗。

87. 发明申请

US20100034850A1 VACCINE 有权
标题翻译：疫苗
公开(公告)号：US20100034850A1
公开(公告)日：2010-02-11
申请号：US12440054
申请日：2007-09-07
申请人： Herve De Hemptinne , Michel Duchene , Anne Mary , Marc Sonveaux
发明人： Herve De Hemptinne , Michel Duchene , Anne Mary , Marc Sonveaux
IPC分类号： A61K39/13 , A61K39/08 , A61K39/05 , A61K39/10 , A61P31/04
CPC分类号： A61K39/13 , A61K39/0016 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/12 , A61K39/292 , A61K39/385 , A61K2039/521 , A61K2039/5252 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/6031 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , C12N2770/32671 , Y02A50/466 , Y02A50/484
摘要： The standard dose of polio vaccines contains 40 D-antigen units of inactivated poliovirus type 1 (Mahoney), 8 D-antigen units of inactivated poliovirus type 2 (MEF-1), and 32 D-antigens units of inactivated poliovirus type 3 (Saukett). The present invention teaches that reduced doses of inactivated poliovirus can maintain adequate or improved level of protection against polio.
摘要翻译：脊髓灰质炎疫苗的标准剂量包含40种D型抗体单位的灭活脊髓灰质炎病毒1型（Mahoney），8种D型抗原单位的灭活脊髓灰质炎病毒2型（MEF-1）和32种D-抗原单位的灭活脊髓灰质炎病毒3型（Saukett ）。本发明教导减少剂量的灭活脊髓灰质炎病毒可以保持足够或改善的脊髓灰质炎防护水平。

88. 发明授权

US07608274B2 Therapeutic processes and useful compositions therefor 有权
标题翻译：治疗方法及其有用的组合物
公开(公告)号：US07608274B2
公开(公告)日：2009-10-27
申请号：US10470611
申请日：2003-12-08
申请人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
发明人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
IPC分类号： A61K39/29
CPC分类号： A61K39/0005 , A61K38/00 , A61K39/001 , A61K39/12 , A61K39/292 , A61K2035/122 , A61K2039/5152 , A61K2039/542 , A61K2039/57 , C12N2730/10134
摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or administering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.
摘要翻译：本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。还提供了预防受试者感染的疫苗接种过程。所述新方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。本发明也提供有用的组合物。

89. 发明申请

US20090252759A1 IMMUNOGENIC COMPOSITION 有权
标题翻译：免疫组化
公开(公告)号：US20090252759A1
公开(公告)日：2009-10-08
申请号：US11917709
申请日：2006-06-23
申请人： Ralph Leon Biemans , Dominique ` Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
发明人： Ralph Leon Biemans , Dominique ` Boutriau , Carine Capiau , Philippe Denoel , Pierre Duvivier , Jan Poolman
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/145 , A61K39/292 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07H3/00 , C12N7/00 , C12N2730/10134 , C12N2760/16234 , C12N2760/16271 , C12N2770/32634 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： The present application relates to an immunogenic composition comprising at least 2 conjugates of N. meningitidis capsular saccharide and protein carrier, wherein said conjugates comprise at least 2 different N. meningitidis capsular saccharides selected from the group consisting of MenA, MenC, MenY and MenW, wherein at least one capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 1:2-1:5, and wherein at least one different capsular saccharide is conjugated to a protein carrier with a saccharide:protein ratio (w/w) between 5:1-1:1.99.
摘要翻译：本申请涉及包含脑膜炎奈瑟氏球菌荚膜糖蛋白和蛋白质载体的至少2种缀合物的免疫原性组合物，其中所述缀合物包含选自MenA，MenC，MenY和MenW的至少2种不同的脑膜炎奈瑟氏球菌荚膜糖，其中至少一种荚膜糖与蛋白质载体结合，其蛋白质比例（w / w）为1：2-1：5，并且其中至少一种不同的荚膜糖与蛋白质载体与糖结合：蛋白质比（w / w）在5：1-1：1.99之间。

90. 发明申请

US20090214586A1 Combination Vaccines With Whole Cell Pertussis Antigen 有权
标题翻译：组合疫苗与全细胞百日咳抗原
公开(公告)号：US20090214586A1
公开(公告)日：2009-08-27
申请号：US11886556
申请日：2006-03-16
申请人： Mario Contorni , Donatella Mannucci
发明人： Mario Contorni , Donatella Mannucci
IPC分类号： A61K39/385
CPC分类号： A61K39/095 , A61K39/0016 , A61K39/102 , A61K39/12 , A61K39/292 , A61K2039/521 , A61K2039/523 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6037 , A61K2039/627 , C12N2730/10134
摘要： Vaccines have been studied that comprise (a) D-T-Pw-HepB-Hib antigens and (b) one or more meningococcal conjugate antigens. A number of improvements and variations of these vaccines have been discovered. The vaccines can be prepared extemporaneously at the time of use by mixing together two components: (a) a first component comprising D, T, wP and HBsAg antigens; and (b) a second component comprising a Hib conjugate and one or more meningococcal conjugates.
摘要翻译：已经研究了包含（a）D-T-Pw-HepB-Hib抗原和（b）一种或多种脑膜炎球菌缀合物抗原的疫苗。已经发现了这些疫苗的一些改进和变化。疫苗可以在使用时通过将两种组分混合在一起而临时制备：（a）包含D，T，wP和HBsAg抗原的第一组分; 和（b）包含Hib缀合物和一种或多种脑膜炎球菌缀合物的第二组分。

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