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81. 发明申请

US20140371417A1 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 审中-公开
标题翻译：用于生产4-羟基丁酸酯，1,4-丁二醇和相关化合物的微生物和方法
公开(公告)号：US20140371417A1
公开(公告)日：2014-12-18
申请号：US14262461
申请日：2014-04-25
申请人： Genomatica, Inc.
发明人： Priti PHARKYA , Anthony P. BURGARD , Stephen J. VAN DIEN , Robin E. OSTERHOUT , Mark J. BURK , John D. TRAWICK , Michael P. KUCKINSKAS , Brian STEER
IPC分类号： C12N9/04 , C12P17/04 , C12P13/00 , C12P19/32 , C12P7/18 , C12P7/62 , C12P7/24
CPC分类号： C12P7/18 , C07C31/207 , C07C47/19 , C07C211/09 , C07D307/33 , C12N1/20 , C12N9/0006 , C12N9/13 , C12N15/52 , C12P7/24 , C12P7/42 , C12P7/62 , C12P13/001 , C12P13/005 , C12P17/04 , C12P19/32 , C12Y208/03
摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
摘要翻译：本发明提供具有4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A和/或腐胺途径的非天然存在的微生物，其能够产生4-羟基丁酸酯，其中微生物生物体包含一种或多种遗传修饰。本发明另外提供使用微生物生产4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰-CoA和/或腐胺或相关产品的方法。

82. 发明申请

US20140322777A1 PROCESS OF SEPARATING COMPONENTS OF A FERMENTATION BROTH 审中-公开
标题翻译：分离发酵组分的方法
公开(公告)号：US20140322777A1
公开(公告)日：2014-10-30
申请号：US14066598
申请日：2013-10-29
申请人： Genomatica, Inc.
发明人： Warren Clark , Michael Japs , Mark J. Burk
IPC分类号： C07C29/76 , C12P7/18
CPC分类号： C07C29/76 , C12P7/18 , C07C31/207
摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.
摘要翻译：从发酵液中分离1,4-丁二醇（1,4-BDO）的方法包括从含有细胞的固体部分中分离富含1,4-BDO的液体级分，从所述液体馏分中除去水，从所述液体馏分，并纯化1,4-BDO。生产1,4-BDO的方法包括在发酵罐中培养产生1,4-BDO的微生物足够长的时间以产生1,4-BDO。产生1,4-BDO的微生物包括具有1,4-BDO途径的微生物，其具有编码1,4-BDO途径酶的一种或多种外源基因和/或一种或多种基因中断。生产1,4-BDO的方法还包括分离1,4-BDO。

83. 发明申请

US20140316146A1 PROCESS FOR PRODUCING 1,4- BUTANEDIOL BY HYDROGENATING DIALKYL MALEATE IN MIXED LIQUID/VAPOR PHASE 有权
标题翻译：通过在混合液体/蒸气相中氢化二烷基马来酸生产1,4-丁二醇的方法
公开(公告)号：US20140316146A1
公开(公告)日：2014-10-23
申请号：US14358863
申请日：2011-11-25
申请人： Flavio Simola , Marco Scarsella , Paolo De Filippis
发明人： Flavio Simola , Marco Scarsella , Paolo De Filippis
IPC分类号： C07C29/17 , C07D307/08 , C07D307/20
CPC分类号： C07C29/172 , C07C29/149 , C07C29/177 , C07C67/303 , C07D307/08 , C07D307/20 , C07D307/33 , C07C31/207 , C07C69/40
摘要： A process for the production of 1,4-butanediol and tetrahydrofuran by catalytic hydrogenation of dialkyl maleates includes the following steps: a) hydrogenating a stream of dialkyl maleate in a first stage of reaction over suitable catalysts to produce dialkyl succinate; b) further hydrogenating the dialkyl succinate in a second stage of reaction, by using a different suitable catalyst, for producing mainly 1,4-butanediol, together with gamma-butyrolactone and tetrahydrofuran as co-products. In both stages of reaction the conditions, as hydrogen/organic feed ratio, pressure and temperature, are such to maintain the reactors in mixed liquid/vapor phase.
摘要翻译：通过马来酸二烷基酯的催化氢化生产1,4-丁二醇和四氢呋喃的方法包括以下步骤：a）在合适的催化剂上的第一反应阶段将马来酸二烷基酯流加氢以制备琥珀酸二烷基酯; b）在第二阶段的反应中，通过使用不同的合适的催化剂，以γ-丁内酯和四氢呋喃作为副产物主要生产1,4-丁二醇，进一步氢化琥珀酸二烷基酯。在反应的两个阶段，作为氢/有机进料比，压力和温度的条件使得反应器保持在混合液/气相中。

84. 发明申请

US20140135537A1 PROCESS CONTROL WITH RAMAN SPECTROSCOPY 有权
标题翻译：具有拉曼光谱的过程控制
公开(公告)号：US20140135537A1
公开(公告)日：2014-05-15
申请号：US13675503
申请日：2012-11-13
申请人： LYONDELL CHEMICAL TECHNOLOGY. L.P.
发明人： Daniel F. White , Brian A. Salisbury , Jenny M. Oran Osment
IPC分类号： C07C29/17
CPC分类号： C07C29/16 , C07C29/141 , C07C29/172 , C07C29/44 , C07C29/48 , C07C31/207
摘要： Embodiments of the present disclosure include methods of effecting process control in a reaction system for the production of 1,4-butanediol, the method including determining at least one property of a sample from the reaction system using Raman spectroscopy, and adjusting at least one parameter of the reaction system in response to the at least one determined property. Embodiments may also include methods of producing 1,4-butanediol, the method including reacting allyl alcohol with carbon monoxide and hydrogen in the presence of a solvent and a catalyst to produce a reactor fluid, sampling the reaction, determining at least one property of the sample using Raman spectroscopy, and adjusting the reaction in response to the at least one determined property.
摘要翻译：本公开的实施方案包括在用于生产1,4-丁二醇的反应体系中进行过程控制的方法，所述方法包括使用拉曼光谱测定来自反应体系的样品的至少一种性质，以及调整至少一个参数的响应于所述至少一个确定的性质。实施方案还可以包括生产1,4-丁二醇的方法，所述方法包括在溶剂和催化剂存在下使烯丙醇与一氧化碳和氢反应以产生反应器流体，对反应进行取样，确定反应器的至少一种性质样品使用拉曼光谱，并且响应于至少一个确定的性质来调节反应。

85. 发明授权

US08704016B2 SMB process for the purification of ethanol and butanediol with integrated regeneration 有权
标题翻译： SMB方法用于纯化乙醇和丁二醇的综合再生
公开(公告)号：US08704016B2
公开(公告)日：2014-04-22
申请号：US13837355
申请日：2013-03-15
申请人： OROCHEM Technologies, Inc.
发明人： Deepak Sharma , Rahul K. Keswani , Wahab Mahmood , Asha A. Oroskar
IPC分类号： C07C29/76
CPC分类号： C07C29/76 , C07C31/08 , C07C31/207
摘要： Disclosed is an improved SMB process incorporating novel regeneration steps for the separation of ethanol associated oxygenates such as butanediol from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. Applicant discovered that increasing the number of raffinate streams alone or in combination with a hot regeneration zone within the SMB cycle can significantly reduce the capital and operating costs associated with the incorporation of the SMB process in a complex for the production of ethanol and butanediol from biofermentation effluent. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods.
摘要翻译：公开了一种改进的SMB方法，其结合新生的再生步骤，用于在衍生自生物发酵过程的有机化合物存在下，将乙醇相关氧化物如丁二醇从乙醇和相关的含氧化合物的稀混合物分离在水中。申请人发现，随着SMB循环中单独或与热再生区结合的萃余液流的数量增加，可显着降低与在生物发酵中生产乙醇和丁二醇的复合物中引入SMB方法相关的资本和操作成本流出物。该方法可用于从含水稀释浓度的乙醇的有机化合物的稀释含水混合物中除去水，并通过发酵，生物提取，生物催化和酶法，通过常规蒸馏方法经济可回收而产生。

86. 发明授权

US08597918B2 Process of separating components of a fermentation broth 有权
标题翻译：分离发酵液组分的方法
公开(公告)号：US08597918B2
公开(公告)日：2013-12-03
申请号：US12793623
申请日：2010-06-03
申请人： Warren Clark , Michael Japs , Mark J. Burk
发明人： Warren Clark , Michael Japs , Mark J. Burk
IPC分类号： C12P7/18 , C12P7/02 , C12P7/00
CPC分类号： C07C29/76 , C12P7/18 , C07C31/207
摘要： A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.
摘要翻译：从发酵液中分离1,4-丁二醇（1,4-BDO）的方法包括从含有细胞的固体部分中分离富含1,4-BDO的液体级分，从所述液体馏分中除去水，从所述液体馏分，并纯化1,4-BDO。生产1,4-BDO的方法包括在发酵罐中培养产生1,4-BDO的微生物足够长的时间以产生1,4-BDO。产生1,4-BDO的微生物包括具有1,4-BDO途径的微生物，其具有编码1,4-BDO途径酶的一种或多种外源基因和/或一种或多种基因中断。生产1,4-BDO的方法还包括分离1,4-BDO。

87. 发明授权

US08476478B2 Process for producing hydrogenolysis products of polyhydric alcohols 有权
标题翻译：多元醇氢解产物的制备方法
公开(公告)号：US08476478B2
公开(公告)日：2013-07-02
申请号：US13398377
申请日：2012-02-16
申请人： Nobuyoshi Suzuki , Masazumi Tamura , Yohei Yoshikawa , Taku Mimura , Masakatsu Takahashi
发明人： Nobuyoshi Suzuki , Masazumi Tamura , Yohei Yoshikawa , Taku Mimura , Masakatsu Takahashi
IPC分类号： C07C29/60 , C07C29/132
CPC分类号： C07C29/60 , B01J23/002 , B01J23/72 , B01J23/745 , B01J29/146 , B01J35/006 , B01J35/023 , B01J37/03 , B01J37/031 , B01J2523/00 , C07C2601/14 , Y02P20/52 , C07C31/1355 , C07C31/20 , C07C31/202 , C07C31/207 , C07C31/225 , C07C31/205 , B01J2523/17 , B01J2523/31 , B01J2523/842
摘要： The present invention relates to a process for producing hydrogenolysis products of polyhydric alcohols with a good selectivity and a high yield, as well as hydrogenolysis catalysts used in the production process. The present invention provides (1) a process for producing a hydrogenolysis product of a polyhydric alcohol which includes the step of reacting the polyhydric alcohol with hydrogen in the presence of a catalyst containing a copper component, wherein the catalyst is a catalyst (A) containing the copper component, an iron component and an aluminum component, or a catalyst (B) containing the copper component and a silicon component; and (2) a hydrogenolysis catalyst for polyhydric alcohols which includes a copper component, an iron component and an aluminum component, and (3) a hydrogenolysis catalyst for polyhydric alcohols which includes a copper component and a silicon component.
摘要翻译：本发明涉及一种以高选择性和高收率生产多元醇的氢解产物的方法，以及用于生产过程中的氢解催化剂。本发明提供（1）一种多元醇氢解产物的制造方法，该方法包括在含有铜成分的催化剂的存在下使多元醇与氢反应的工序，其中，催化剂为含有铜组分，铁组分和铝组分，或含有铜组分和硅组分的催化剂（B）; 和（2）包含铜组分，铁组分和铝组分的多元醇氢解催化剂，和（3）包含铜组分和硅组分的多元醇氢解催化剂。

88. 发明授权

US08410291B2 Processes for the production of hydrogenated products 有权
标题翻译：生产氢化产物的方法
公开(公告)号：US08410291B2
公开(公告)日：2013-04-02
申请号：US13051688
申请日：2011-03-18
申请人： Olan S. Fruchey , Leo E. Manzer , Dilum Dunuwila , Brian Terry Keen , Brooke Ashley Albin , Nye A. Clinton , Bernard Duane Dombek
发明人： Olan S. Fruchey , Leo E. Manzer , Dilum Dunuwila , Brian Terry Keen , Brooke Ashley Albin , Nye A. Clinton , Bernard Duane Dombek
IPC分类号： C07D307/00 , C07D305/00 , C07C27/04
CPC分类号： C07D307/08 , C07C29/149 , C07C51/02 , C07C51/412 , C07C51/43 , C07C51/445 , C07D307/33 , C07C31/207 , C07C55/10
摘要： A process for making a hydrogenated product includes providing a clarified DAS-containing fermentation broth, distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAS, at least some DAS, and at least about 20 wt % water, cooling and/or evaporating the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAS-containing liquid portion and a MAS-containing solid portion that is substantially free of DAS, separating the solid portion from the liquid portion, recovering the solid portion, hydrogenating the second solid portion in the presence of at least one hydrogenation catalyst to produce the hydrogenated product comprising at least one of THF, GBL or BDO, and recovering the hydrogenated product.
摘要翻译：制备氢化产物的方法包括提供澄清的含DAS的发酵液，蒸馏培养液以形成包含水和氨的塔顶馏出物，以及液体塔底物，其包括MAS，至少一些DAS和至少约20wt％水，冷却和/或蒸发塔底物，以及任选地向塔底物中加入抗溶剂，以获得足以使塔底物分离成含有DAS的液体部分的温度和组合物，以及基本上没有的含MAS的固体部分的DAS，将固体部分与液体部分分离，回收固体部分，在至少一种氢化催化剂的存在下氢化第二固体部分以产生包含THF，GBL或BDO中的至少一种的氢化产物，并回收氢化产物。

89. 发明申请

US20130030223A1 METHOD OF MAKING ALKYLENE GLYCOLS 有权
标题翻译：制备亚苄基甘露糖的方法
公开(公告)号：US20130030223A1
公开(公告)日：2013-01-31
申请号：US13631828
申请日：2012-09-28
申请人： H R D Corporation
发明人： Abbas HASSAN , Aziz Hassan , Rayford G. Anthony , Krishnan Viswanathan , Gregory G. Borsinger
IPC分类号： C07C29/10
CPC分类号： B01F7/00766 , B01F13/1013 , B01F13/1016 , B01J8/025 , B01J8/20 , B01J19/0066 , B01J19/1806 , B01J2219/00006 , B01J2219/00779 , C07C29/106 , C08G65/2696 , C07C31/202 , C07C31/205 , C07C31/207
摘要： Herein disclosed is a method of hydrating an alkylene oxide that includes introducing an alkylene oxide into water to form a first stream; flowing the first stream through a high shear device to produce a second stream; and contacting the second stream with a catalyst in a reactor to hydrate the alkylene oxide and form an alkylene glycol.
摘要翻译：本文公开了一种水合烯化氧的方法，其包括将烯化氧引入水中以形成第一料流; 使第一流流过高剪切装置以产生第二流; 以及使第二料流与反应器中的催化剂接触以使烯化氧水合并形成亚烷基二醇。

90. 发明申请

US20130029831A1 Homogeneous Process for the Hydrogenation of Carboxylic Acids and Derivatives Thereof 有权
标题翻译：羧酸及其衍生物氢化的均相方法
公开(公告)号：US20130029831A1
公开(公告)日：2013-01-31
申请号：US13588595
申请日：2012-08-17
申请人： Melvyn Kilner , Derek Vincent Tyers , Simon Peter Crabtree , Michael Anthony Wood
发明人： Melvyn Kilner , Derek Vincent Tyers , Simon Peter Crabtree , Michael Anthony Wood
IPC分类号： B01J31/40
CPC分类号： B01J31/2409 , B01J31/24 , B01J31/4023 , B01J31/4046 , B01J31/4053 , B01J2231/641 , B01J2531/0258 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/825 , B01J2531/842 , B01J2531/96 , C07C27/04 , C07C29/149 , Y02P20/52 , Y02P20/584 , C07C31/10 , C07C31/205 , C07C31/207 , C07C31/04
摘要： A homogenous process for the hydrogenation of the carboxylic acids and/or derivatives thereof in the presence of a catalyst comprising ruthenium, rhodium, iron, osmium or palladium, and an organic phosphine is described in which the hydrogenation is carried out in the presence of at least about 1% by weight water. A process for regenerating a catalyst comprising ruthenium, rhodium, iron, osmium or palladium and an organic phosphine is also described in which the regeneration is carried out in the presence of hydrogen and water.
摘要翻译：描述了在包含钌，铑，铁，锇或钯的催化剂和有机膦的存在下氢化羧酸和/或其衍生物的均匀方法，其中氢化在存在下进行至少约1重量％的水。还描述了一种用于再生含有钌，铑，铁，锇或钯和有机膦的催化剂的方法，其中再生在氢和水的存在下进行。

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