专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US09193845B2 Thermoplastic polymer composition 有权
标题翻译：热塑性聚合物组成
公开(公告)号：US09193845B2
公开(公告)日：2015-11-24
申请号：US14492554
申请日：2014-09-22
申请人： MILLIKEN & COMPANY
发明人： Haihu Qin , Darin L. Dotson , Eduardo Torres , Sanjeev K. Dey , Francisco Alvarez
IPC分类号： C08K5/20 , C08K5/00 , C07C233/81 , C07C233/64 , C07C235/56 , C07C233/63 , C07C233/65 , C07C233/66 , C07C233/75 , C07C233/87
CPC分类号： C08K5/20 , C07C233/63 , C07C233/64 , C07C233/65 , C07C233/66 , C07C233/75 , C07C233/81 , C07C233/87 , C07C235/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C08K5/0083
摘要： The invention provides a compound conforming to the structure of Formula (CX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CX) as a nucleating agent.
摘要翻译：本发明提供符合式（CX）结构的化合物。本发明还提供一种包含聚烯烃聚合物和符合式（CX）结构的化合物作为成核剂的热塑性聚合物组合物。

82. 发明申请

US20150087759A1 THERMOPLASTIC POLYMER COMPOSITION 有权
标题翻译：热塑性聚合物组合物
公开(公告)号：US20150087759A1
公开(公告)日：2015-03-26
申请号：US14492567
申请日：2014-09-22
申请人： MILLIKEN & COMPANY
发明人： Darin L. Dotson , Mary Angela Cooley
IPC分类号： C08K5/29
CPC分类号： C08K5/29 , C07C233/64 , C07C233/81 , C07C251/24 , C08K5/0083 , C08K5/17 , C08L23/06 , C08L23/02
摘要： The invention provides a compound conforming to the structure of Formula (CXX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CXX) as a nucleating agent.
摘要翻译：本发明提供符合式（CXX）结构的化合物。本发明还提供一种包含聚烯烃聚合物和符合式（CXX）结构的化合物作为成核剂的热塑性聚合物组合物。

83. 发明申请

US20150051416A1 RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND 有权
标题翻译：铑催化剂和生产胺化合物的方法
公开(公告)号：US20150051416A1
公开(公告)日：2015-02-19
申请号：US14388383
申请日：2013-03-28
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人： Mitsuhisa Yamano , Masatoshi Yamada , Hirotsugu Usutani
IPC分类号： C07F15/00 , B01J31/24
CPC分类号： C07F15/0073 , B01J31/24 , B01J31/2495 , B01J2231/645 , B01J2531/822 , C07B53/00 , C07B2200/07 , C07C51/412 , C07C231/18 , C07C241/04 , C07C309/30 , C07C2601/14 , C07C2601/16 , C07D471/04 , C07F9/5027 , C07C243/38 , C07C233/47 , C07C233/81 , C07C59/255
摘要： [Problem] Provision of a superior rhodium catalyst and a production method of amine compound.[Solving Means] A rhodium complex coordinated with a compound represented by the formula
摘要翻译： [问题]提供优异的铑催化剂和胺化合物的制备方法。 [解决方案]与由式表示的化合物配位的铑络合物

84. 发明申请

US20140296256A1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR 审中-公开
公开(公告)号：US20140296256A1
公开(公告)日：2014-10-02
申请号：US14307149
申请日：2014-06-17
申请人： RENASCIENCE CO., LTD.
发明人： Toshio MIYATA , Kenji MURANO , Nagahisa YAMAOKA , Akihisa MAEDA
IPC分类号： C07D409/12 , C07D333/36 , C07D295/192 , C07D215/14 , C07D217/16 , C07D307/66 , C07D405/12
CPC分类号： C07D409/12 , C07C233/81 , C07D213/56 , C07D215/14 , C07D217/16 , C07D295/192 , C07D307/42 , C07D307/54 , C07D307/66 , C07D333/24 , C07D333/36 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
摘要翻译：本发明提供了具有纤溶酶原激活物抑制剂-1抑制活性的新化合物和包含该化合物作为活性成分的PAI-1抑制剂。本发明还提供了具有对PAI-1活性的抑制作用并且有效预防和治疗其起始与PAI-1活性相关的各种疾病的药物组合物。

85. 发明授权

US08785473B2 Plasminogen activator inhibitor-1 inhibitor 有权
标题翻译：纤溶酶原激活物抑制剂-1抑制剂
公开(公告)号：US08785473B2
公开(公告)日：2014-07-22
申请号：US13262259
申请日：2010-03-31
申请人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
发明人： Toshio Miyata , Kenji Murano , Nagahisa Yamaoka , Akihisa Maeda
IPC分类号： A61K31/4709 , C07D217/26 , C07D217/16
CPC分类号： C07D409/12 , C07C233/81 , C07D213/56 , C07D215/14 , C07D217/16 , C07D295/192 , C07D307/42 , C07D307/54 , C07D307/66 , C07D333/24 , C07D333/36 , C07D405/04 , C07D405/10 , C07D405/12
摘要： The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
摘要翻译：本发明提供了具有纤溶酶原激活物抑制剂-1抑制活性的新化合物和包含该化合物作为活性成分的PAI-1抑制剂。本发明还提供了具有对PAI-1活性的抑制作用并且有效预防和治疗其起始与PAI-1活性相关的各种疾病的药物组合物。

86. 发明申请

US20140113012A1 COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS 有权
标题翻译：化合物和诱导重塑的方法
公开(公告)号：US20140113012A1
公开(公告)日：2014-04-24
申请号：US14007306
申请日：2012-03-26
申请人： Peter Schultz , Laure Bouchez
发明人： Peter Schultz , Laure Bouchez
IPC分类号： C07D295/135 , A61K31/423 , C07D277/66 , A61K31/428 , C07D249/06 , A61K31/4192 , C07D215/14 , A61K31/47 , C07D241/24 , A61K31/4965 , A61K31/5375 , C07C255/50 , C07D209/48 , C07D277/46 , C07D257/04 , A61K45/06 , C12N5/077 , C07D263/57
CPC分类号： A61K31/5375 , A61K9/0024 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/277 , A61K31/357 , A61K31/365 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4188 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/593 , A61K31/728 , A61K36/54 , A61K38/1816 , A61K38/1825 , A61K38/23 , A61K38/39 , A61K45/06 , C07C233/75 , C07C233/80 , C07C233/81 , C07C255/50 , C07C255/57 , C07C255/60 , C07D209/48 , C07D215/14 , C07D241/24 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/46 , C07D277/66 , C07D295/135 , C12N5/0655 , A61K2300/00
摘要： The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.
摘要翻译：本发明提供了通过将间充质干细胞诱导成软骨细胞来改善关节炎和关节损伤的化合物和组合物。

87. 发明授权

US08686154B2 Compounds and compositions for delivering active agents 失效
标题翻译：用于递送活性剂的化合物和组合物
公开(公告)号：US08686154B2
公开(公告)日：2014-04-01
申请号：US12482320
申请日：2009-06-10
申请人： Donald J. Sarubbi , Eugene N. Barantsevitch
发明人： Donald J. Sarubbi , Eugene N. Barantsevitch
IPC分类号： C07D211/60 , A61K31/445
CPC分类号： C07D209/48 , A61K9/1617 , A61K31/195 , A61K31/445 , A61K31/4965 , A61K31/727 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K45/06 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30 , A61K2300/00
摘要： Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的载体化合物及其组合物。也提供给药和制备方法。

88. 发明授权

US08569535B2 Substituted benzoylamino-indan-2-carboxylic acids and related compounds 有权
标题翻译：取代的苯甲酰氨基 - 茚满-2-羧酸及相关化合物
公开(公告)号：US08569535B2
公开(公告)日：2013-10-29
申请号：US12627546
申请日：2009-11-30
申请人： Thomas Joseph Caulfield , Jennifer Williford Clemens , Robert S. Francis , Brian Scott Freed , Stanly John , Tieu-Binh Le , Brian Pedgrift , Antonio Daniel Ramos , Gerard Charles Rosse , Martin Smrcina , David Squire Thorpe , William Shelly Wire , Jianhong Zhao
发明人： Thomas Joseph Caulfield , Jennifer Williford Clemens , Robert S. Francis , Brian Scott Freed , Stanly John , Tieu-Binh Le , Brian Pedgrift , Antonio Daniel Ramos , Gerard Charles Rosse , Martin Smrcina , David Squire Thorpe , William Shelly Wire , Jianhong Zhao
IPC分类号： C07C229/00
CPC分类号： C07D333/78 , C07C233/52 , C07C233/63 , C07C233/81 , C07C235/42 , C07C235/54 , C07C235/62 , C07C235/84 , C07C237/42 , C07C255/13 , C07C255/57 , C07C311/09 , C07C311/29 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/26 , C07C2603/28 , C07C2603/74 , C07D213/81 , C07D307/79 , C07D333/68 , C07D401/04
摘要： The present invention relates to novel compounds of the formula Ia: in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity, and are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
摘要翻译：本发明涉及式Ia的新化合物：其任何立体异构体形式或任何比例的立体异构形式的混合物或其生理上可接受的盐，其中取代基如本文所述。本发明化合物具有CXCR5抑制活性，并且特别可用于治疗或预防与人CXCR5受体的调节相关的各种炎性疾病，例如类风湿性关节炎，多发性硬化，狼疮，克罗恩病。

89. 发明申请

US20120226034A1 PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF 有权
标题翻译：制备苯甲腈化合物或其盐的方法
公开(公告)号：US20120226034A1
公开(公告)日：2012-09-06
申请号：US13474521
申请日：2012-05-17
申请人： Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
发明人： Yasuhiro Torisawa , Kaoru Abe , Yasuaki Muguruma , Shigekazu Fujita , Hidenori Ogawa , Naoto Utsumi , Masahiro Miyake
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X1 is a halogen atom, R1 and R2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
摘要翻译：本发明提供一种制备式（1）的苯并氮杂化合物的方法：其中X1是卤素原子，R1和R2是低级烷基，或其盐以及工业上高产率和高纯度的中间体苯甲酸化合物其可用作制备具有加压素拮抗活性的药学活性的2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。

90. 发明申请

US20120004405A1 COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT CFTR CELLULAR PROCESSING 审中-公开
标题翻译：具有修复突变CFTR细胞处理活性的化合物
公开(公告)号：US20120004405A1
公开(公告)日：2012-01-05
申请号：US13139243
申请日：2009-12-14
申请人： Peter Prehm
发明人： Peter Prehm
IPC分类号： C07H7/02 , C07C233/54
CPC分类号： C07C233/81 , C07C233/25 , C07H15/203
摘要： The present invention relates to a compound which is characterized by the formula (I) or a pharmaceutically acceptable salt, solvate, hydrate thereof, wherein the ring systems A and B are independently selected from a monosaccharide, aryl (preferably phenyl), a heteroaryl or cycloalkyl (preferably cyclohexan), preferably with all substituents in equatorial configurations; R1 is independently selected from alkyl (preferably C1 to C6), a substituted or unsubstituted phenyl, preferably CH3; R2 is H, alkyl (preferably C1 to C6), a carbohydrate in a glycosidic β-linkage, preferably H; R3, R4, R5, and R6 are independently selected from H, (OH) hydroxy, alkyl preferably C1 to C6, alkoxy (preferably C1 to C6), amino, alkylamino (preferably C1 to C6), halogen, benzylamino, or benzoylamino; X is O, NH, alkylamino (NR), CO, S; and Y is O, NH, alkylamino (NR), CO, S. The present invention also relates to the compound of the invention and, optionally, a pharmaceutically acceptable carrier, for use in the treatment of (for treating) and/or preventing a disease or medical condition which is associated with mutant CFTR.
摘要翻译：本发明涉及以式（I）化合物或其药学上可接受的盐，溶剂合物，水合物为特征的化合物，其中环系统A和B独立地选自单糖，芳基（优选苯基），杂芳基或环烷基（优选环己烷），优选具有赤道结构中的全部取代基; R 1独立地选自烷基（优选C 1至C 6），取代或未取代的苯基，优选CH 3; R2是H，烷基（优选C1至C6），糖苷键连接的碳水化合物，优选H; R3，R4，R5和R6独立地选自H，（OH）羟基，优选C1至C6烷基，烷氧基（优选C1至C6），氨基，烷基氨基（优选C1至C6），卤素，苄基氨基或苯甲酰氨基; X是O，NH，烷基氨基（NR），CO，S; 并且Y是O，NH，烷基氨基（NR），CO，S。本发明还涉及用于治疗（治疗）和/或预防的本发明化合物和任选的药学上可接受的载体与突变CFTR相关的疾病或医学病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式