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    • 84. 发明申请
    • Liquid handling for filtration and preparative chromatography
    • 液体处理过滤和制备色谱
    • US20060027500A1
    • 2006-02-09
    • US10910065
    • 2004-08-03
    • Karl Schick
    • Karl Schick
    • B01D61/00
    • B01D61/142B01D15/14B01D15/18B01D61/22
    • A method and system are provided for high-precision separation of pharmaceutical or biotechnology liquids. The separation can be in accordance with direct flow filtration, tangential flow filtration or preparative chromatography. Movement of the pharmaceutical or biotechnology liquid within a flow path is controlled according to a selected pattern. Selected patterns include automatically and progressively increasing the flow rate within the unit, automatically and progressively increasing the pressure within the unit or initially proceeding according to a relatively high constant flow rate and switching to a relatively high constant pressure at a time when a given parameter is attained.
    • 提供了用于药物或生物技术液体的高精度分离的方法和系统。 分离可以根据直接流过滤,切向流过滤或制备色谱法。 根据所选择的图案来控制流路内的药物或生物技术液体的移动。 所选择的模式包括自动逐渐增加单元内的流量,自动逐渐增加单元内的压力或者根据相对较高的恒定流速初始进行,并且在给定参数为 达到了
    • 88. 发明授权
    • Automatic shut-off for water treatment system
    • 自动关闭水处理系统
    • US06939470B2
    • 2005-09-06
    • US10244721
    • 2002-09-16
    • David W. BaarmanEric K. Bartkus
    • David W. BaarmanEric K. Bartkus
    • B01D61/10B01D61/12B01D61/22C02F1/44G01M3/26B01D61/00
    • B01D61/10B01D61/12B01D61/22C02F1/44
    • A water treatment system including an automatic shut-off control valve. The system preferably includes inflow and outflow sensors that monitor flow through the system and a pressure sensor that senses back pressure in a downstream plumbing system. If the sensors sense different flows, a leak in the system is assumed and the control valve is closed. In one embodiment, the flowing back pressure is monitored by the pressure sensor to detect leaks in the plumbing system. In another embodiment, the valve is closed after a specific volume of water flow is sensed and the pressure sensor measures static back pressure in the plumbing system to detect a leak. In yet another embodiment, incremental amounts of water are released by the valve and subsequent back pressures are tested to detect a leak. Optionally, the system includes a control to shut-off a water supply when a water treatment device enclosure is accessed.
    • 一种包括自动关闭控制阀的水处理系统。 系统优选地包括监测通过系统的流量的流入和流出传感器以及感测下游管道系统中的背压的压力传感器。 如果传感器检测到不同的流量,则假定系统中有泄漏并且控制阀关闭。 在一个实施例中,回流压力由压力传感器监测以检测管道系统中的泄漏。 在另一个实施例中,在检测到特定体积的水流之后,关闭阀,并且压力传感器测量管道系统中的静态背压以检测泄漏。 在另一个实施例中,通过阀释放增量的水,并且测试随后的背压以检测泄漏。 可选地,系统包括当访问水处理装置外壳时关闭供水的控制。
    • 90. 发明申请
    • Filter methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses
    • 用于从用于单层沉积,分析或其他用途的样品悬浮液中捕获所需量的材料的过滤方法
    • US20050150841A1
    • 2005-07-14
    • US11010897
    • 2004-12-13
    • Gary Ferguson
    • Gary Ferguson
    • B01D61/22G01N1/28G01N15/06C02F1/00
    • G01N15/0618B01D61/22G01N1/2813G01N1/4077Y10T436/25375
    • The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs sensors to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow. Typically, pressure is used to provide a means to cause the sample suspension to flow through the filter, which is preferably a membrane filter for monolayer deposition. In some embodiments a novel syringe provides this pressure, functioning as a vacuum source. The filter apparatus may be further automated to process a plurality of samples, simultaneously.
    • 本发明是一种具有捕获悬浮在液体或气体中用于单层沉积,分析或其它用途的所需量的材料的方法的过滤装置。 采用新颖的过滤装置来捕获可用于各种样品组分的纯化或富集的材料,或者可以观察或分析捕获的材料。 或者,颗粒材料可以用作蛋白质或化学品的运输机制,其又可以被评估或使用。 过滤装置使用传感器来感测压力并调节,停止或以其他方式控制样品流。 压力传感器基本上监测通过过滤器的样品悬浮液的流速,通常在与在过滤器上捕获所需量的材料相关联的预定压力下进行响应。 与压力传感器集成的单独的阀门或阀门提供了一种调节样品流量的方法。 通常,使用压力来提供使样品悬浮液流过过滤器的手段,过滤器优选是用于单层沉积的膜过滤器。 在一些实施方案中,新颖的注射器提供这种作为真空源的压力。 过滤装置可以进一步自动化以同时处理多个样品。