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81. 发明申请

US20160045608A1 LONG CIRCULATING NANOPARTICLES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于持续释放治疗药物的长期循环纳米颗粒
公开(公告)号：US20160045608A1
公开(公告)日：2016-02-18
申请号：US14922755
申请日：2015-10-26
申请人： BIND Therapeutics, Inc.
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： A61K47/48 , A61K9/16 , A61K31/519 , A61K31/436 , A61K31/337 , A61K31/475
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译：本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

82. 发明授权

US09259395B2 Tumor-targeting gas-generating nanoparticle, method for preparing the same, and tumor-targeting nanoparticle for drug delivery using the same 有权
标题翻译：肿瘤靶向产生气体的纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒
公开(公告)号：US09259395B2
公开(公告)日：2016-02-16
申请号：US13906963
申请日：2013-05-31
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Ick Chan Kwon , Kwang Meyung Kim , Kuiwon Choi , Heebeom Koo , Hyun Su Min , Inchan Youn
IPC分类号： A61B8/00 , A61K9/51 , A61K49/22 , A61K41/00 , A61K47/48 , A61K49/00 , A61K9/00
CPC分类号： A61K9/5146 , A61K9/0004 , A61K9/0009 , A61K9/0019 , A61K9/5153 , A61K41/0028 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/222 , A61K49/225
摘要： A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.
摘要翻译：肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒。由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。

83. 发明授权

US09255129B2 Modified polynucleotides encoding SIAH E3 ubiquitin protein ligase 1 有权
标题翻译：编码SIAH E3泛素蛋白连接酶的修饰多核苷酸1
公开(公告)号：US09255129B2
公开(公告)日：2016-02-09
申请号：US14107105
申请日：2013-12-16
申请人： Moderna Therapeutics, Inc.
发明人： Tirtha Chakraborty , Antonin de Fougerolles
IPC分类号： C07K14/47 , C12N9/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
摘要翻译：本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。

84. 发明授权

US09254311B2 Modified polynucleotides for the production of proteins 有权
标题翻译：用于生产蛋白质的修饰多核苷酸
公开(公告)号：US09254311B2
公开(公告)日：2016-02-09
申请号：US14390100
申请日：2013-03-09
申请人： Moderna Therapeutics, Inc.
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/47 , A61K38/17 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译：本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。

86. 发明授权

US09221891B2 In vivo production of proteins 有权
标题翻译：体内产生蛋白质
公开(公告)号：US09221891B2
公开(公告)日：2015-12-29
申请号：US14390106
申请日：2013-03-15
申请人： Moderna Therapeutics, Inc.
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C12N15/85 , C07K14/47 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译：本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。

87. 发明申请

US20150342883A1 Hyaluronidase and a Low Density Second PEG Layer on the Surface of Therapeutic-Encapsulated Nanoparticles to Enhance Nanoparticle Diffusion and Circulation 审中-公开
标题翻译：透明质酸酶和治疗性包封纳米颗粒表面上的低密度第二PEG层以增强纳米颗粒扩散和循环
公开(公告)号：US20150342883A1
公开(公告)日：2015-12-03
申请号：US14726770
申请日：2015-06-01
申请人： Drexel University
发明人： Hao Cheng , Hao Zhou
IPC分类号： A61K9/127 , A61K9/50 , A61K31/704
CPC分类号： A61K31/704 , A61K9/5153 , A61K47/6911 , Y10T428/2982
摘要： A delivery system comprising an organic nanoparticle, a hyaluronidase anchored or conjugated to the organic nanoparticle. The organic nanoparticle may be selected from a polymer-based nanoparticle, a lipid-based nanoparticle and nanoparticle formed by lipid-like molecules. In some embodiments, the hyaluronidase is covalently bound to a linker or spacer which, in turn, is anchored or covalently bound to the organic nanoparticle. The delivery system may also comprise an active pharmaceutical agent, a diagnostic agent, and/or a cellular membrane. The organic nanoparticle may further have a low density poly(ethylene glycol) layer on the surface. Methods for using the delivery system including for treating or diagnosing a disease are also provided. The organic nanoparticle provides enhanced diffusion/penetration through the extracellular matrix found in tumors, as well as increased circulation time in a human or animal body.
摘要翻译：包含有机纳米颗粒，锚定或与有机纳米颗粒缀合的透明质酸酶的递送系统。有机纳米颗粒可以选自基于聚合物的纳米颗粒，基于脂质的纳米颗粒和由类脂分子形成的纳米颗粒。在一些实施方案中，透明质酸酶共价结合到接头或间隔物上，接头或间隔物又被锚定或共价结合到有机纳米颗粒上。递送系统还可以包含活性药剂，诊断剂和/或细胞膜。有机纳米颗粒在表面上还可以具有低密度聚（乙二醇）层。还提供了包括用于治疗或诊断疾病的递送系统的使用方法。有机纳米粒子通过在肿瘤中发现的细胞外基质提供增强的扩散/穿透，以及增加人或动物体内的循环时间。

88. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

89. 发明授权

US09168225B2 Nano-hybrid delivery system for sequential utilization of passive and active targeting 有权
标题翻译：用于连续使用被动和主动瞄准的纳米混合输送系统
公开(公告)号：US09168225B2
公开(公告)日：2015-10-27
申请号：US13642868
申请日：2011-04-20
申请人： Seungpyo Hong , Ying Liu
发明人： Seungpyo Hong , Ying Liu
IPC分类号： A61K9/127 , A61K9/51 , A61K9/14
CPC分类号： A61K9/127 , A61K9/1273 , A61K9/14 , A61K9/146 , A61K9/5153
摘要： The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto.
摘要翻译：本发明的特征在于纳米杂交药物递送组合物，其组合用于预防和治疗疾病的被动和主动靶向。该组合物是具有与其连接的治疗剂和靶向剂的壳包封的多价聚合物支架。

90. 发明申请

US20150283095A1 NANOPARTICLES WITH BIODEGRADABLE AND BIOCOMPATIBLE POLYMER PLGA, LOADED WITH THE DRUG FOR HUMAN USE PENTOXIFYLLINE 审中-公开
标题翻译：具有可生物降解和生物聚合的聚合物PLGA的纳米颗粒，用于用于人类使用的戊二醛的药物
公开(公告)号：US20150283095A1
公开(公告)日：2015-10-08
申请号：US14443260
申请日：2013-11-15
申请人： UNIVERSIDAD DE SANTIAGO DE CHILE
发明人： Luis Ernerto Constandil Córdova , Paula Soledad Ibarra Durán , Cristian Andres Vilos Ortiz , Luis Velásquez Cumplido , Teresa Pelissier Serrano , Claudio Aurelio Laurido Fuenzalida , Alejandro Hernández Kunstmann
IPC分类号： A61K9/51 , A61K9/00 , A61K9/50 , A61K31/522
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/5089 , A61K9/5192 , A61K31/522
摘要： The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly(lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synthesis of the PLGA nanoparticles loaded with pentoxifylline, and to the use thereof in the effective treatment for the relief of chronic pain and for the prevention of chronic pain via the administration of a single dose.
摘要翻译：本发明涉及一种新型药物制剂，其包含负载药物己酮可可碱的可生物降解和生物相容性聚合物聚（乳酸 - 乙醇酸）酸（PLGA）的聚合物纳米颗粒，用于合成负载己酮可可碱的PLGA纳米颗粒的方法，以及其用于缓解慢性疼痛和通过施用单一剂量来预防慢性疼痛的有效治疗。

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