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81. 发明申请

US20170042870A1 TARGETED NANOPARTICLE COMPOSITIONS AND METHODS OF THEIR USE TO TREAT OBESITY 审中-公开
标题翻译：目标纳米材料组合物及其用于治疗肥胖症的方法
公开(公告)号：US20170042870A1
公开(公告)日：2017-02-16
申请号：US15119336
申请日：2015-02-13
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Yuan Xue , Xiaoyang Xu , Xueqing Zhang , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K31/4439 , A61K9/51 , A61K47/48
CPC分类号： A61K31/4439 , A61K9/5153 , A61K47/64 , A61K47/6933 , A61K47/6937
摘要： Nanoparticles having a positive feedback delivery system include an agent specific for a target in combination with a target inducing agent. Upon administration to a subject, the targeting moiety on the nanoparticles binds to available targets in the subject. The nanoparticles release the target inducing agent and, optionally, a therapeutic agent, at the site where the nanoparticles bind the target. The inducing agent causes additional targets to be expressed. More nanoparticles bind to the additional, induced targets. By inducing additional targets to be expressed at specific regions in the subject that require treatment, more nanoparticles can bind to the targets in that specific region of interest, increasing the concentration of nanoparticles at a specific area of subject is increased.
摘要翻译：具有正反馈递送系统的纳米颗粒包括与靶诱导剂组合的靶特异性试剂。在给予受试者时，纳米颗粒上的靶向部分结合受试者中的可用靶。在纳米颗粒结合靶标的位点处，纳米颗粒释放靶诱导剂和任选的治疗剂。诱导剂导致表达额外的目标。更多的纳米颗粒结合额外的诱导靶标。通过在需要治疗的受试者的特定区域诱导另外的靶标表达，更多的纳米颗粒可以结合到该特定的感兴趣区域中的靶标，增加受试者特定区域上的纳米颗粒的浓度。

82. 发明申请

US20170035696A1 Composition of analgesic bioadhesive healing microspheres 审中-公开
标题翻译：镇痛生物粘附愈合微球的组成
公开(公告)号：US20170035696A1
公开(公告)日：2017-02-09
申请号：US14817231
申请日：2015-08-04
申请人： Damaso Fernandez Gines
发明人： Damaso Fernandez Gines
IPC分类号： A61K9/16 , A61K31/08
CPC分类号： A61K9/1676 , A61K9/0014 , A61K9/1641 , A61K9/1652 , A61K9/5036 , A61K9/5153 , A61K31/08
摘要： A new composition of analgesic bioadhesive healing microspheres in which each microsphere comprises at least:a.—a layer of a polyanion, where the polyanion may be an alginate.b.—a core coated with a polyanion consisting of a triblock copolymer non-ionic surfactant; polexamer 188 or a mixture of them; and a volatile halogenated by-product anaesthetic ether agent of methyl-isopropyl-ether in contact with the internal part of the polyanion layer, which may be sevoflurane.c.—a coating of a polycation in contact with the external part of the polyanion layer, which may be chitosan.
摘要翻译： c。 - 与聚阴离子层的外部部分接触的聚阳离子涂层，其可以是壳聚糖。

83. 发明申请

US20170027961A1 COMPOSITIONS FOR THE TREATMENT OF CATARACTS 审中-公开
标题翻译：用于治疗病毒的组合物
公开(公告)号：US20170027961A1
公开(公告)日：2017-02-02
申请号：US15221550
申请日：2016-07-27
申请人： Catacore, Inc.
发明人： Sam L. Nguyen
IPC分类号： A61K31/575 , A61K9/00
CPC分类号： A61K31/575 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/5153 , A61K47/10 , A61K47/38 , A61K2300/00
摘要： In one embodiment, the present application discloses an aqueous ophthalmic composition for the treatment of eye diseases, lesions and injuries, comprising: a) one steroid, or a combination of at least two steroids selected from the group consisting of lanosterol, dihydrolanosterol, 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol, 4,4-dimethylcholesta-8,24-dien-3β-ol, 4,4-dimethylcholesta-8-en-3β-ol, 4,4-dimethylcholesta-8(9),14-dien-3β-ol, 14-desmethyl lanosterol, lathosterol, Δ7,24-cholestadienol, cholesterol, cholesta-7-enol, cholesteryl ester, 7-dehydrocholesterol, desmosterol, 7-dehydrodesmosterol, zymosterol, 27-hydroxycholesterol, cholesta-7,24-dien-3-β-ol, cholesta-8(9)-en-3-β-ol, 5α-cholestan-3β-ol-6-one, 5-cholesten-3β,25-diol, 5-cholesten-3β,25-OSO3H (5-cholesten-3β,25-sulfate), 5-cholesten-3β-OSO3H,25-ol (5-cholesten-3β-sulfate,25-ol), 5-cholesten-3β,25-diol, disulfate, and their esters thereof, or a pharmaceutically acceptable salt thereof, in a concentration effective for the treatment and/or prophylaxis of the eye diseases, lesions and injuries; and b) a pharmaceutical excipient; and methods of treatment using such compositions.
摘要翻译：在一个实施方案中，本申请公开了一种用于治疗眼部疾病，损伤和损伤的眼用组合物，其包含：a）一种类固醇或至少两种选自下组的类固醇的组合：羊毛甾醇，二羟基甾醇， 4-二甲基胆甾-8（9），14,24-三烯-3β-醇，4,4-二甲基胆甾-8,24-二烯-3β-醇，4,4-二甲基胆甾-8-en-3β-醇，4 ，4-二甲基胆甾烷-8（9），14-二烯-3β-醇，14-去甲基羊毛甾醇，lathosterol，Δ7,24-胆固醇二醇，胆固醇，胆甾烯-7-烯醇，胆固醇酯，7-脱氢胆固醇，脱氢降冰片烯醇，十八醇，27-羟基胆固醇，胆甾烯-7,24-二烯-3-β-醇，胆石甾-8（9）-en-3-β-醇，5α-胆甾烷-3β-醇-6-酮，5 - 胆固醇-3β，25-二醇，5-胆甾烯-3β，25-OSO3H（5-胆甾烯-3β，25-硫酸盐），5-胆甾烯-3β-OSO3H，25-（5-胆甾烯-3β硫酸盐， 25-ol），5-胆甾烯-3β，25-二醇，二硫酸盐及其酯，或其药学上可接受的盐，其浓度为有效治疗和/或预防眼睛疾病，损伤和损伤; 和b）药物赋形剂; 和使用这种组合物的治疗方法。

84. 发明授权

US09556214B2 Compounds, compositions, and methods for the treatment of cancers 有权
标题翻译：用于治疗癌症的化合物，组合物和方法
公开(公告)号：US09556214B2
公开(公告)日：2017-01-31
申请号：US14654086
申请日：2013-12-19
申请人： PLACON THERAPEUTICS, INC.
发明人： Mark T. Bilodeau , Craig A. Dunbar , Timothy E. Barder , Edward R. Lee , Rossitza G. Alargova , Danille N. Rockwood , Rajesh Shinde , Patrick Lim Soo , Benoît Moreau
IPC分类号： A61K31/282 , C07F15/00 , A61K9/51
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/08 , A61K9/5153 , A61K47/26 , A61K47/34 , C07F15/0093 , Y10T428/298
摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
摘要翻译：本教导涉及用于治疗癌症的化合物和组合物。在一些实施方案中，组合物包含具有至少一个羧酸酯或氨基甲酸酯配体的铂（IV）络合物。

85. 发明申请

US20170000740A9 COMBINATION THERAPEUTIC NANOPARTICLES 审中-公开
标题翻译：组合治疗纳米颗粒
公开(公告)号：US20170000740A9
公开(公告)日：2017-01-05
申请号：US14782618
申请日：2014-04-09
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC.
发明人： Shanta Dhar , Rakesh Kumar Pathak
IPC分类号： A61K9/50 , A61K31/222 , C07C69/78 , A61K47/48 , A61K31/663 , C07J5/00 , A61K33/24 , A61K31/573
CPC分类号： A61K9/50 , A61K9/5153 , A61K31/222 , A61K31/573 , A61K31/663 , A61K33/24 , A61K47/482 , A61K47/48246 , A61K47/55 , A61K47/593 , A61K47/64 , A61K47/6937 , C07C69/78 , C07J5/0053
摘要： Nanoparticles that include a chemotherapeutic agent and an anti-inflammatory are particularly cytotoxic to prostate cancer cells.
摘要翻译：包括化学治疗剂和抗炎剂的纳米颗粒对前列腺癌细胞特别是细胞毒性。

86. 发明授权

US09522190B2 Polymeric nanoparticle solution composition and its manufacturing process 有权
标题翻译：聚合物纳米颗粒溶液组成及其制备工艺
公开(公告)号：US09522190B2
公开(公告)日：2016-12-20
申请号：US14362234
申请日：2012-12-07
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION
发明人： Sa-Won Lee , Joong-Woong Cho , Gyeong-Hae Kim , Min-Hyo Seo
IPC分类号： A61K47/34 , A61K9/51 , A61K31/337 , A61K31/436 , A61K9/14
CPC分类号： A61K47/34 , A61K9/14 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/436
摘要： Disclosed are a polymeric drug carrier-containing pharmaceutical composition with enhanced stability in its solution state and a method for stabilizing the same. More particularly, disclosed are a pharmaceutical aqueous solution composition for storage under refrigeration containing a polymeric drug carrier comprising an amphiphilic block copolymer comprised of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative fixed with a di- or tri-valent metal ion at its terminal carboxyl group and having preservation stability for at least 6 months, preferably at least 12 months when stored under refrigeration, and a method for stabilizing the same.
摘要翻译：公开了一种在其溶液状态下具有增强的稳定性的含聚合物药物载体的药物组合物及其稳定化方法。更具体地，公开了一种用于在冷藏下储存的药物水溶液组合物，其含有包含亲水嵌段和疏水嵌段的两亲性嵌段共聚物的聚合物药物载体和用二价或三价金属离子固定的聚乳酸衍生物在其末端羧基上保存稳定性至少6个月，优选至少12个月，并且其稳定方法。

87. 发明申请

US20160361382A1 MICROBICIDAL COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译：微生物组合物和治疗病毒感染的方法
公开(公告)号：US20160361382A1
公开(公告)日：2016-12-15
申请号：US15180963
申请日：2016-06-13
申请人： University of Louisville Research Foundation, Inc.
发明人： Jill Steinbach-Rankins , Kenneth Palmer
IPC分类号： A61K38/16 , A61K31/675 , A61K31/522 , A61K9/00 , A61K47/48
CPC分类号： A61K38/16 , A61K9/0034 , A61K9/0043 , A61K9/5153 , A61K31/522 , A61K31/675 , A61K45/06 , A61K47/593 , A61K47/6953 , Y02A50/389 , A61K2300/00
摘要： A composition is provided comprising an electrospun fiber having a surface with a biological adhesive moiety conjugated to the surface of the electrospun fiber. The biological adhesive moiety included in the composition can be a lectin such as griffithsin. The composition can further include an effective amount of an antiviral agent encapsulated by an electrospun fiber. Nanoparticles including a microbicide conjugated to the surface of the nanoparticle can also be included in the composition. Methods of treating a viral infection are also provided and include administering to a subject an effective amount of a composition comprising an electrospun fiber having a surface and a biological adhesive moiety conjugated to the surface of the electrospun fiber.
摘要翻译：提供了一种组合物，其包含具有与电纺丝纤维表面共轭的生物粘合剂部分的表面的电纺纤维。包含在组合物中的生物粘合剂部分可以是凝集素如格里菲素。组合物还可以包含有效量的由电纺纤维包封的抗病毒剂。包括与纳米颗粒表面缀合的杀微生物剂的纳米颗粒也可以包括在组合物中。还提供了治疗病毒感染的方法，包括向受试者施用有效量的包含具有与电纺丝纤维表面共轭的表面和生物粘合剂部分的电纺纤维的组合物。

88. 发明授权

US09517270B2 Lipocationic polymers and uses thereof 有权
标题翻译：脂质聚合物及其用途
公开(公告)号：US09517270B2
公开(公告)日：2016-12-13
申请号：US14962422
申请日：2015-12-08
申请人： The Board of Regents of the University of Texas System
发明人： Daniel J. Siegwart , Jing Hao , Kejin Zhou , Jason Miller , Petra Kos , Lian Xue
IPC分类号： A61K47/34 , C07H21/02 , C07H21/04 , A61K47/28 , A61K47/24 , A61K47/22 , C08G65/48 , C08G63/91 , A61K31/713
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/5153 , A61K31/713 , A61K47/22 , A61K47/24 , A61K47/28 , C08G63/688 , C08G63/912 , C08G65/48 , C12N15/113 , C12N2310/14
摘要： Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
摘要翻译：通过开环聚合制备的聚合物，其包含可用于递送核酸如miRNA或siRNA的组合物中的氨基。在一些实施方案中，本文还提供了包含本文所述的聚合物和核酸的组合物。在一些实施方案中，这些组合物用于在体内沉默一种或多种基因或治疗疾病或病症。

89. 发明申请

US20160356732A1 THERAPEUTIC POLYMERIC NANOPARTICLE COMPOSITIONS WITH HIGH GLASS TRANSITION TEMPERATURE OR HIGH MOLECULAR WEIGHT COPOLYMERS 有权
标题翻译：具有高玻璃转变温度或高分子量共聚物的治疗性聚合物纳米材料组合物
公开(公告)号：US20160356732A1
公开(公告)日：2016-12-08
申请号：US15016529
申请日：2016-02-05
申请人： BIND Therapeutics, Inc.
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： G01N25/48
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。本发明的其它方面包括制备这种纳米颗粒的方法。

90. 发明申请

US20160324935A1 NITRIC OXIDE SYNTHASE NANOPARTICLES FOR TREATMENT OF VASCULAR DISEASE 有权
标题翻译：用于治疗血管疾病的硝酸氧合酶纳米颗粒
公开(公告)号：US20160324935A1
公开(公告)日：2016-11-10
申请号：US15097757
申请日：2016-04-13
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Vinod Labhasetwar , Jaspreet K. Vasir , Maram K. Reddy
IPC分类号： A61K38/44 , A61L31/16 , A61L31/04 , A61F2/82 , A61L29/04 , A61K9/48 , A61M25/10 , A61K9/50 , A61L29/16
CPC分类号： A61K38/44 , A61F2/82 , A61F2210/0076 , A61F2310/0097 , A61K9/0019 , A61K9/4866 , A61K9/5031 , A61K9/5153 , A61L29/048 , A61L29/16 , A61L31/047 , A61L31/16 , A61L2300/254 , A61L2300/412 , A61L2300/606 , A61M25/10 , A61M2025/105 , C12Y114/13039
摘要： A sustained-release composition for stimulating endothelial cell growth including a nitric oxide synthase within a nanoparticle comprising a biocompatible polymer is described. The sustained-release composition can be administered as part of a pharmaceutical composition, or can be coated on a medical device. The nitric oxide synthase-containing nanoparticles can be used in a method of inducing endothelium formation in a blood vessel.
摘要翻译：描述了用于刺激内皮细胞生长的持续释放组合物，包括在包含生物相容性聚合物的纳米颗粒内的一氧化氮合酶。缓释组合物可以作为药物组合物的一部分施用，或者可以涂覆在医疗装置上。含有一氧化氮合酶的纳米颗粒可用于诱导血管内皮细胞形成的方法。

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