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    • 83. 发明申请
    • Medical Device Adapted to the Monitoring of Muscle Behaviour in Patients
    • 适用于监测患者肌肉行为的医疗器械
    • US20080262372A1
    • 2008-10-23
    • US11628118
    • 2005-06-03
    • Mario MantoRichard Van Der LindePiet Lammertse
    • Mario MantoRichard Van Der LindePiet Lammertse
    • A61B5/0488
    • A61B5/224A61B5/0488A61B5/1121A61B5/1126A61B5/6824A61B5/6825A61B5/6828
    • The present invention is related to a medical device for monitoring limb muscle behaviour in a patient, said limb corresponding to a leg, an arm, or the neck, said medical device comprising: a moving unit (1) adapted to receive a first part of a limb, said moving unit (1) presenting at least one degree of freedom (11) according to which the moving unit (1) may move; a haptic device (6) adapted to receive a second part of the limb and to measure in the form of an analogical signal the mechanical response of said second part to a movement of the moving unit (1); a set of electromyographic electrodes (4) able to measure in the form of an analogical signal the electrical activities in the muscle(s) of the limb; an analogical signal acquisition unit (9) able to acquire the analogical signals from the electromyographic electrodes and the haptic device (6) and converting said analogical signals into digital signals; a controller (8) able to process said digital signals and to control the moving unit (1).
    • 本发明涉及一种用于监测患者的肢体肌肉行为的医疗装置,所述肢体对应于腿部,手臂或颈部,所述医疗装置包括:移动单元(1),适于接收第一部分 所述移动单元(1)具有至少一个自由度(11),移动单元(1)可移动; 触觉装置(6),其适于接收所述肢体的第二部分并且以模拟信号的形式测量所述第二部分对所述移动单元(1)的运动的机械响应; 一组能够以模拟信号的形式测量肢体肌肉中的电活动的肌电图电极(4); 能够从肌电图电极和触觉装置(6)获取模拟信号并将所述模拟信号转换为数字信号的模拟信号获取单元(9); 能够处理所述数字信号并控制移动单元(1)的控制器(8)。
    • 84. 发明授权
    • Micro-invasive method for painless detection of analytes in extracellular space
    • 用于无细胞检测细胞外空间分析物的微创方法
    • US07409238B2
    • 2008-08-05
    • US11104666
    • 2005-04-13
    • Eric Jules Raskas
    • Eric Jules Raskas
    • A61B5/1455
    • G01N21/8507A61B5/14514A61B5/14532A61B5/14546A61B5/1455A61B5/1459A61B5/6825A61B10/0045A61B2010/008A61B2562/12B33Y80/00
    • A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
    • 一种检测细胞间空间中的至少一种分析物的方法包括将微针穿过角质层朝向受试者皮肤层的基底插入细胞间空间的步骤,其包含具有至少一种待检测分析物的间质液 所述微探针的尖端处的直径不大于约10-50微米。 该方法还包括光学测试邻近微探针远端的细胞外空间中的预定分析物,而不抽取间质液样品。 优选地,微探针主体包括覆盖微探针本体的远端光学尖端的传感器层,传感器层适于与待组织液中待检测的预定分析物相互作用,以及响应于传感器层与 预定分析物以信号检测所述预定分析物。