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81. 发明授权

US4871366A Soft tissue implants for promoting tissue adhesion to same 失效
标题翻译：用于促进组织粘附的软组织植入物
公开(公告)号：US4871366A
公开(公告)日：1989-10-03
申请号：US198612
申请日：1988-05-23
申请人： Andreas F. von Recum , Francis W. Cooke
发明人： Andreas F. von Recum , Francis W. Cooke
IPC分类号： A61F2/00 , A61L27/30
CPC分类号： A61L27/306 , A61F2/0077 , A61F2310/00407
摘要： A soft tissue implant comprises a flexible main body portion, having tissue-facing surfaces and a thin layer of pure titanium covering the tissue-facing surfaces. A method of promoting tissue adhesion of a soft tissue host to the tissue-facing surfaces of a soft tissue implant comprising a strip of polyethylene terephthalate velour comprises the steps of cleaning the strip with a low-residue detergent and rinsing same with fresh distilled water; refluxing the strip in distilled water for one hour at a temperature of less than 30.degree. C.; drying the strip in a room-temperature desicator for several days; sterilizing the strip and packaging same; degasing the strip and storing same in a dust-free environment; removing the strip from the packaging and mounting the strip in the vacuum evaporator at an approximate angle of incidence of 90.degree. from a pure titanium metal evaporant; evacuating the vacuum evaporator to a vacuum of about 2.times.10.sup.-5 Torr; evaporating the titanium by direct resistance heating same; coating the strip with a layer of pure titanium on the order of one micron thick; and resterilizing and implanting the titanium-coated strip into the tissue host.
摘要翻译：软组织植入物包括具有面向组织的表面的柔性主体部分和覆盖面向组织的表面的纯钛薄层。促进软组织宿主组织粘附到包括聚对苯二甲酸乙二醇酯丝绒条的软组织植入物的面向组织的表面的方法包括用低残留洗涤剂清洗条并用新鲜蒸馏水冲洗的步骤; 在低于30℃的温度下将条带在蒸馏水中回流1小时。在室温干燥器中干燥条数天; 对条带进行消毒和包装; 在无尘环境下对带材进行脱胶并将其储存; 从包装中取出条带，并将该条带放置在真空蒸发器中，与纯钛金属蒸发器的入射角约为90°; 将真空蒸发器抽真空至约2×10 -5乇的真空度; 通过直接电阻加热蒸发钛; 用一层厚度的一层纯钛涂层条; 并将钛涂层的条再生并植入组织宿主体内。

82. 发明授权

US4783107A Method and apparatus for controlling impact force during rapid robotic acquisition of object 失效
标题翻译：用于在物体快速自动获取过程中控制冲击力的方法和装置
公开(公告)号：US4783107A
公开(公告)日：1988-11-08
申请号：US120755
申请日：1987-11-12
申请人： Joey K. Parker , Frank W. Paul
发明人： Joey K. Parker , Frank W. Paul
IPC分类号： B25J13/08 , B25J15/00 , B25J15/02 , B66C1/00
CPC分类号： B25J15/0253 , B25J13/082 , B25J15/0004 , Y10S294/907
摘要： Proximity sensors are used to sense impending contact, i.e., a point of close approach, between a finger of a robot hand and an object. Each finger is equipped with force sensors so that finger touch force with the object can be measured and controlled. The hand is controlled by a dedicated microprocessor, which communicates with a robot arm controller through 8 digital input/output lines. A novel "bi-modal" control system uses information from the proximity sensors to control both solenoid (on/off) valves and a proportional servovalve which are alternatively switched into an operative mode in a pneumatic circuit which powers the pneumatic actuators of the hand. This control design achieves the two goals of rapid object acquisition and low interaction forces. Each finger of the hand is capable of implementing an acquisition strategy in which mislocated objects can be acquired.
摘要翻译：接近传感器用于感测机器人手的手指与物体之间的即将接触，即紧密接近的点。每个手指配备有力传感器，从而可以测量和控制与物体的手指触摸力。手由一个专用微处理器控制，通过8个数字输入/输出线与机器人手臂控制器进行通讯。一种新颖的“双模式”控制系统使用来自接近传感器的信息来控制螺线管（开/关）阀和比例伺服阀，该比例伺服阀在为手的气动致动器供电的气动回路中交替切换到操作模式。该控制设计实现了快速物体采集和低相互作用力的两个目标。手的每个手指能够实现可以获取错位对象的获取策略。

83. 发明授权

US4771742A Method for continuous camlobe phasing 失效
公开(公告)号：US4771742A
公开(公告)日：1988-09-20
申请号：US4334
申请日：1987-01-15
申请人： Michael T. Nelson , Alvon C. Elrod
发明人： Michael T. Nelson , Alvon C. Elrod
IPC分类号： F01L1/04 , F01L1/08 , F01L1/34 , F01L1/344 , F01L1/352 , F01L13/00 , F02B3/06 , F02D13/02 , F02D15/04
CPC分类号： F01L1/344 , F01L1/08 , F01L1/34413 , F01L1/352 , F01L13/0057 , F02D13/0215 , F02D13/0261 , F02D15/04 , F01L2001/0473 , F01L2001/3521 , F02B3/06 , F02D2013/0292 , Y02T10/18 , Y10T74/2101
摘要： A method of attaining a desired engine performance comprises the steps of changing the angular position of a variable camlobe (or cam) member relative to a fixed camlobe (or cam) member from a first angular position to a second angular position. In changing from the first to the second angular position, the variable camlobe (or cam) member moves in a predetermined direction relative to the direction of rotation of a camshaft. The predetermined direction and the magnitude of the angular movement of the variable camlobe (or cam) member is dependent at least in part upon at least one desired operating condition of the engine. The method further comprises changing the angular position of both camlobe (or cam) members relative to a reference point of a drive pulley. This change in the angular position of both of the camlobe (or cam) members relative to the reference point involves movement of the camlobes (or cams) in a direction relative to the direction of rotation of a camshaft. The direction and magnitude of this movement is based at least in part upon at least one desired operating condition of the engine.

84. 发明授权

US4488319A Method of two-stage implantation of a joint prosthesis and prosthetic product 失效
标题翻译：关节假体和假体产品的两阶段植入方法
公开(公告)号：US4488319A
公开(公告)日：1984-12-18
申请号：US314798
申请日：1981-10-26
申请人： Andreas F. von Recum
发明人： Andreas F. von Recum
IPC分类号： A61F2/30 , A61F2/36 , A61F1/04
CPC分类号： A61F2/36 , A61F2/30 , A61F2/3609
摘要： A two step surgical technique for implantation of a joint prosthesis. A bone cavity adjacent the effected joint is prepared for receipt of a prosthetic stem having porosities therealong for dynamic bony interfacial fixation and a tip adapted for subsequent removable securement to a joint element. The effected joint is resectioned in a subsequent second surgical technique and the opposing joint component is prepared for receipt of a prosthetic joint. The prosthetic joint is then implanted and removably secured to said previously implanted stem. A two piece implantable prosthesis is also disclosed and claimed.
摘要翻译：用于植入关节假体的两步手术技术。制备邻近受影响的关节的骨腔，用于接收具有用于动态骨界面固定的孔隙度的假肢，以及用于随后可拆卸固定到关节元件的尖端。在随后的第二手术技术中切割受影响的关节，并且准备相对的关节部件以接收假体关节。然后将假体关节植入并可移除地固定到所述先前植入的茎。还公开并要求保护两件可植入假体。

85. 发明授权

US4159745A Crop uprooting and soil working apparatus 失效
标题翻译：作物根除土壤工作装置
公开(公告)号：US4159745A
公开(公告)日：1979-07-03
申请号：US859227
申请日：1977-12-09
申请人： Clarence E. Hood , Byron K. Webb , Yekutiel Alper
发明人： Clarence E. Hood , Byron K. Webb , Yekutiel Alper
IPC分类号： A01B39/19 , A01D25/04 , A01B39/12
CPC分类号： A01D25/044 , A01B39/19
摘要： An elongated bar soil working apparatus constructed so that a plurality of bars are supported in a parallel relationship for rotation in one or more horizontal planes and positioned closely adjacent each other whereby the corners of one bar will cooperate with the corners of an adjacent bar to effect a severing action on vines or other foliage moving therebetween whereby the bars are self-cleaning. Power drives are operatively associated with the bars for syncronous rotation of the bars whereby the corners of the bars will be simultaneously advanced through a common plane in closely positioned relationship to effect the severing action on the vines and other foliage located therebetween and prevent vine and foliage build up on the bars. The present apparatus includes a frame which will allow the apparatus to be removably supported by conventional tractor operable tool bar whereby the bars can be advanced through the soil to perform plant uprooting or other soil working operations.
摘要翻译：一种细长的条状土壤加工装置，其构造成使得多个杆以平行的关系支撑，以便在一个或多个水平面中旋转并且彼此靠近彼此定位，由此一个杆的角部将与相邻杆的角部配合以实现葡萄藤或其他植物在其间移动的切断动作，由此杆是自清洁的。功率驱动器可操作地与棒连接，用于杆的同步旋转，由此杆的角部将以紧密定位的关系同时前进通过共同的平面，以实现对位于其间的葡萄藤和其他叶子的切断作用，并防止藤蔓和叶子建立在酒吧。本装置包括框架，该框架将允许装置由常规的拖拉机可操作的工具杆可移除地支撑，由此杆可以推进通过土壤以执行植物连根拔地或其他土壤工作操作。

86. 发明公开

US20230191283A1 CHANNELED FIBERS IN SEPARATION OF BIOLOGICALLY ACTIVE NANOPARTICLES 审中-公开
公开(公告)号：US20230191283A1
公开(公告)日：2023-06-22
申请号：US18108828
申请日：2023-02-13
申请人： CLEMSON UNIVERSITY RESEARCH FOUNDATION
发明人： R. KENNETH MARCUS , TERRI F. BRUCE , LEI WANG , SISI HUANG , TYLER Y. SLONECKI , RHONDA REIGERS POWELL
IPC分类号： B01D15/32 , C07K14/47 , C12N9/00 , C12N15/10 , G01N1/40 , G01N33/50
CPC分类号： B01D15/327 , C07K14/47 , C12N9/00 , C12N15/10 , C12N15/1017 , G01N1/405 , G01N33/5005 , A61K35/68
摘要： A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

87. 发明授权

US11633355B2 Multi-functional particles and methods of using the same 有权
公开(公告)号：US11633355B2
公开(公告)日：2023-04-25
申请号：US16286898
申请日：2019-02-27
申请人： Clemson University Research Foundation
发明人： Jeoung Soo Lee
IPC分类号： A61K9/107 , A61K9/51 , A61K47/69 , A61K45/06 , A61P7/02 , A61P9/00 , A61K47/59 , A61K31/436 , C12N15/113 , A61K31/704 , A61K31/4015 , A61K31/713 , B82Y5/00
摘要： Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.

88. 发明申请

US20220390810A1 Tunable Orbital Angular Momentum System 有权
公开(公告)号：US20220390810A1
公开(公告)日：2022-12-08
申请号：US17838632
申请日：2022-06-13
申请人： Clemson University
发明人： Eric G. Johnson , Jerome Keith Miller , Richard Watkins , Kaitlyn Morgan , Wenzhe Li , Yuan Li
IPC分类号： G02F1/33 , H04B10/27
摘要： This system and method of for providing a tunable orbital angular momentum system for providing higher order Bessel beams comprising: an acousto-optical deflector configured to receive an input beam, deflect a first portion of the input beam a first deflection angle relative to an axis of propagation and along an optical axis and deflect a second portion of the input beam a second deflection angle relative to the optical axis; a line generator disposed along the optical angle for receiving the first portion and the second portion of the input beam and provide an elliptical Gaussian mean; a log-polar optics assembly disposed along the optical angle for receiving the elliptical Gaussian beam and wrapping the elliptical Gaussian beam with an asymmetric ring; and, a Fourier lens configured to receive the wrapped elliptical Gaussian beam.

89. 发明授权

US11510906B1 Diazacyclobutene derivatives as anti-parasitic drug substances 有权
公开(公告)号：US11510906B1
公开(公告)日：2022-11-29
申请号：US16811135
申请日：2020-03-06
申请人： Clemson University
发明人： Daniel C. Whitehead , James C. Morris , Chandima J. Narangoda
IPC分类号： A61K31/4196 , A61P33/02 , A61K31/502
摘要： A drug product and method for treating a parasitic disease in a host is described. The drug product comprises:
a carrier matrix; and
a drug substance having the formula: wherein:
R1 is selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;
each R3 is independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;
Y represents those elements necessary to form a 5 or 6 membered ring;
X is selected from the group consisting of B, O, N, S, Se and P; and
n is 1-4 as necessary to complete the valence of X.

90. 发明授权

US11452294B2 Use of tebuconazole for annual bluegrass (Poa annua) control in turfgrasses 有权
公开(公告)号：US11452294B2
公开(公告)日：2022-09-27
申请号：US16770442
申请日：2018-12-06
申请人： North Carolina State University , Clemson University Research Foundation
发明人： Fred H. Yelverton , Lambert McCarty
IPC分类号： A01N43/90 , A01N43/653 , A01N33/04 , A01N33/18
摘要： Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.

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