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81. 发明授权

US07890159B2 Cardiac activation sequence monitoring and tracking 有权
标题翻译：心脏激活序列监测和跟踪
公开(公告)号：US07890159B2
公开(公告)日：2011-02-15
申请号：US10955397
申请日：2004-09-30
申请人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
发明人： Yi Zhang , Scott A. Meyer , Aaron McCabe , Jeffrey E. Stahmann , Yinghong Yu , Carlos Alberto Ricci
IPC分类号： A61B5/0428 , A61B5/0452
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

82. 发明申请

US20100134763A1 METHOD FOR DETERMINING THE POWER OF AN INTRAOCULAR LENS 有权
标题翻译：确定内镜镜片功率的方法
公开(公告)号：US20100134763A1
公开(公告)日：2010-06-03
申请号：US12630656
申请日：2009-12-03
申请人： Rudolf Murai VON BÜNAU , Burkhard Wagner , Scott A. Meyer , Xunchang Chen
发明人： Rudolf Murai VON BÜNAU , Burkhard Wagner , Scott A. Meyer , Xunchang Chen
IPC分类号： A61B3/10
CPC分类号： A61B3/0025 , A61B3/1005 , A61B3/117 , A61B3/1173 , A61F2/16 , A61F2/1605 , A61F2240/002
摘要： For the pre-operative calculation of the power of an intraocular lens, three input parameters are needed: the axial length of the eye (AL), the refractive power of the cornea, and the distance between the front of the cornea and the back focal plane of the intraocular lens, the so-called effective lens position (ELP). The invention shows a novel approach to the determination of the ELP.
摘要翻译：对于术前计算眼内透镜的功率，需要三个输入参数：眼睛的轴向长度（AL），角膜的屈光度以及角膜前部和背部焦点之间的距离眼内透镜的平面，所谓的有效透镜位置（ELP）。本发明显示了一种确定ELP的新方法。

83. 发明申请

US20100016916A1 APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION 审中-公开
标题翻译：用于治疗角膜移植和感染的装置和方法
公开(公告)号：US20100016916A1
公开(公告)日：2010-01-21
申请号：US12504593
申请日：2009-07-16
申请人： Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Allan C. Shuros , Scott A. Meyer , Robert Shipley , Jason J. Hamann
发明人： Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Allan C. Shuros , Scott A. Meyer , Robert Shipley , Jason J. Hamann
IPC分类号： A61N1/368
CPC分类号： A61N1/36564 , A61N1/36528 , A61N1/36571 , A61N1/368
摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for different purposes. The system delivers electrical stimulation to modulate myocardial strain for anti-atherosclerosis therapy and/or to provide therapy for myocardial infarction (MI). In one embodiment, a medical device for treating atherosclerosis is provided. The medical device includes a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals. The device also includes a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas. According to various embodiments, a controller communicates with the sensing circuit and controls the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to induce myocardial strain changes. The stimulation is targeted to attenuate or prevent atherosclerosis associated with the CAD, according to various embodiments.
摘要翻译：起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。起搏系统接收一组输入，并为不同目的提供优化的心脏保护起搏。该系统提供电刺激以调节用于抗动脉粥样硬化治疗的心肌应变和/或提供心肌梗塞（MI）治疗。在一个实施方案中，提供了用于治疗动脉粥样硬化的医疗装置。医疗设备包括感测电路，用于接收感测到的信号，以使用感测到的信号来识别冠状动脉疾病（CAD）或CAD风险区域。该装置还包括起搏器电路，其适于将电信号通过至少一个电极传递到与所识别的区域相邻的心肌靶。根据各种实施例，控制器与感测电路通信并控制起搏器电路，以向心肌靶标提供间歇性电刺激，以诱导由于诱发心肌应变变化而在血管上延伸的时间段。根据各种实施方案，刺激旨在减弱或预防与CAD相关的动脉粥样硬化。

84. 发明授权

US07583998B2 Multi-chamber cardiac capture detection using cross chamber sensing 有权
标题翻译：使用交叉腔感测的多室心脏捕获检测
公开(公告)号：US07583998B2
公开(公告)日：2009-09-01
申请号：US11157426
申请日：2005-06-21
申请人： Scott A. Meyer , David J. Yonce , David J. Ternes
发明人： Scott A. Meyer , David J. Yonce , David J. Ternes
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： Methods and systems involve multi-chamber cardiac capture detection utilizing sensing during a cross-chamber refractory period. First and second pacing pulses are delivered to first and second heart chamber. Capture or non-capture of the second heart chamber is determined. Sensing in the first heart chamber is performed to sense for cross-chamber propagation initiated by the second pacing pulse. Capture of the first chamber is detected if capture of the second heart chamber is detected and if the cross-chamber propagation is not detected.
摘要翻译：方法和系统涉及在跨室不应期期间利用感测的多室心脏捕获检测。第一和第二起搏脉冲被输送到第一和第二心室。确定第二心室的捕获或非捕获。执行在第一心室中的感测以感测由第二起搏脉冲发起的交叉腔传播。如果检测到第二心室的捕获并且未检测到横隔室传播，则检测到第一腔室的捕获。

85. 发明申请

US20090198301A1 Automatic Capture Verification using Electrocardiograms Sensed from Multiple Implanted Electrodes 失效
标题翻译：使用从多个植入电极感测的心电图进行自动捕获验证
公开(公告)号：US20090198301A1
公开(公告)日：2009-08-06
申请号：US12409348
申请日：2009-03-23
申请人： Yi Zhang , Jiang Ding , Aaron R. McCabe , Scott A. Meyer
发明人： Yi Zhang , Jiang Ding , Aaron R. McCabe , Scott A. Meyer
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/365
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。装置和方法使用可植入电极感测复合心脏信号。使用复合信号进行源分离。产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

86. 发明授权

US07485892B2 Optical broadband emitters and methods of making the same 失效
标题翻译：光纤宽带发射器及其制作方法
公开(公告)号：US07485892B2
公开(公告)日：2009-02-03
申请号：US11322814
申请日：2005-12-29
申请人： Boon-Siew Ooi , Hery Susanto Djie , Yan Zhou , Scott A. Meyer
发明人： Boon-Siew Ooi , Hery Susanto Djie , Yan Zhou , Scott A. Meyer
IPC分类号： H01L29/06
CPC分类号： H01L33/0045 , B82Y20/00 , H01S5/026 , H01S5/0425 , H01S5/0602 , H01S5/22 , H01S5/34313 , H01S5/4031 , H01S5/50 , H01S2301/02 , H01S2301/04
摘要： An optical broadband emitter and the method of making such a broadband emitter are described. Intermixing of closely coupled multiple quantum wells, especially carrier tunneled coupled quantum wells, is described using nano-imprinting of a gel like dielectric layer such as a sol-gel derived SiO2 layer into multiple stepped or graded sections to form intermixing cap regions of different thickness. A thermal annealing process is performed to condense the SiO2 intermixing cap and induce intermixing. A superluminescent diode is described having multiple electrodes deposited over multiple sections of different bandgaps in which each individual electrode can be either forward or reverse biased to different degrees such that each diode section can individually function as a sub-band spontaneous emitter, an amplifier/attenuator, a photon-absorber, a transparent waveguide, or a photodetector/optical power monitor.
摘要翻译：描述了光学宽带发射器和制造这种宽带发射器的方法。使用诸如溶胶 - 凝胶衍生的SiO 2层之类的诸如凝胶状电介质层的纳米压印，将多个量子阱，特别是载流子隧道耦合量子阱的混合描述为多个阶梯或分级部分，以形成不同厚度的混合盖区域。进行热退火处理以冷凝SiO 2混合盖并引起混合。描述了一种超发光二极管，其具有沉积在不同带隙的多个部分上的多个电极，其中每个单独的电极可以被正向或反向偏置到不同的程度，使得每个二极管部分可以单独地用作子带自发发射极，放大器/衰减器光子吸收器，透明波导或光电检测器/光功率监视器。

87. 发明授权

US07433046B2 Patterned spinning disk based optical phase shifter for spectral domain optical coherence tomography 失效
标题翻译：用于光谱相干层析成像的基于旋转圆盘的光学移相器
公开(公告)号：US07433046B2
公开(公告)日：2008-10-07
申请号：US10933795
申请日：2004-09-03
申请人： Matthew J. Everett , Scott A. Meyer , Yan Zhou
发明人： Matthew J. Everett , Scott A. Meyer , Yan Zhou
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , A61B3/1005 , G01B9/02012 , G01B9/02044 , G01B9/02049 , G01B9/02069 , G01B9/02091 , G01B2290/35
摘要： A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.
摘要翻译：公开了一种低成本图案旋转盘，用于实现光束的相对快速的离散光学相移。本发明在频域光学相干断层摄影系统中特别有用。盘包含不同高度和/或折射率分布的阶梯图案，使得当其旋转时，通过或被盘反射的光束将经历不同的离散光学相位延迟。磁盘可以作为移相器来操作，或者可以与强度调制斩波盘同步操作，也可以与光源进行直接强度调制。磁盘还可以包含强度调制模式，使得可以同时实现相移和强度调制。还公开了用于制造盘的各种可能的方法。

88. 发明授权

US07319900B2 Cardiac response classification using multiple classification windows 有权
公开(公告)号：US07319900B2
公开(公告)日：2008-01-15
申请号：US10733869
申请日：2003-12-11
申请人： Jaeho Kim , Joseph Bocek , Scott A. Meyer , Paul A. Haefner , Haris J. Sih
发明人： Jaeho Kim , Joseph Bocek , Scott A. Meyer , Paul A. Haefner , Haris J. Sih
IPC分类号： A61N1/37
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.

89. 发明申请

US20080004669A1 POST-MI PACING WITH AUTOCAPTURE FUNCTION 有权
标题翻译：具有自动功能的后置放大器
公开(公告)号：US20080004669A1
公开(公告)日：2008-01-03
申请号：US11427517
申请日：2006-06-29
申请人： Alok S. Sathaye , Joseph M. Pastore , Scott A. Meyer
发明人： Alok S. Sathaye , Joseph M. Pastore , Scott A. Meyer
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/37 , A61N1/371 , A61N1/3712
摘要： A method and apparatus is described for preventing or reducing the ventricular remodeling that normally occurs after a myocardial infarction using pacing therapy. By pacing sites in proximity to the infarct with appropriately timed pacing pulses, the infarct region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the stimulus for remodeling. If capture by the pacing pulses is not being achieved, the device may be configured to change the pacing pulse energy and/or pacing site as appropriate.
摘要翻译：描述了一种用于预防或减少通常在使用起搏治疗的心肌梗塞后发生的心室重塑的方法和装置。通过用适当的定时起搏脉冲对位于梗塞范围附近的部位进行起搏，梗塞区域以减轻其受到的机械应力的方式预激发，从而减少重塑的刺激。如果没有实现通过起搏脉冲的捕获，则该装置可以被配置为适当地改变起搏脉冲能量和/或起搏部位。

90. 发明授权

US07203543B2 Method and system for detecting capture using a coronary vein electrode 有权
标题翻译：使用冠状静脉电极检测捕获的方法和系统
公开(公告)号：US07203543B2
公开(公告)日：2007-04-10
申请号：US10278732
申请日：2002-10-23
申请人： Scott A. Meyer , Haris J. Sih , Paul A. Haefner
发明人： Scott A. Meyer , Haris J. Sih , Paul A. Haefner
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3712 , A61N1/3714
摘要： A method and device provide for determining capture in multiple chambers of a patient's heart using an electrode inserted into a coronary vein of the patient's heart. The coronary vein electrode is positioned adjacent to multiple heart chambers and is responsive to cardiac signals originating in the multiple chambers. The coronary vein electrode may be coupled to a single sense amplifier to detect the cardiac signals. Pace pulses may be applied to multiple heart chambers simultaneously or according to a phased timing sequence. Cardiac signals responsive to the pace pulses sensed using the coronary vein electrode may be used to verify capture in the multiple chambers of the heart.
摘要翻译：一种方法和装置用于使用插入到患者心脏的冠状静脉中的电极来确定在患者心脏的多个腔室中的捕获。冠状静脉电极位于多个心室附近，并且响应于源自多个腔室的心脏信号。冠状静脉电极可以耦合到单个读出放大器以检测心脏信号。步态脉冲可以同时或根据定相序列施加到多个心室。可以使用响应于使用冠状静脉电极感测到的步速脉冲的心脏信号来验证心脏的多个腔室中的捕获。

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