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81. 发明授权

US07801602B2 Controlling stimulation parameters of implanted tissue stimulators 有权
标题翻译：控制植入组织刺激器的刺激参数
公开(公告)号：US07801602B2
公开(公告)日：2010-09-21
申请号：US11388836
申请日：2006-03-24
申请人： Kelly H. McClure , Rafael Carbunaru , George Vamos
发明人： Kelly H. McClure , Rafael Carbunaru , George Vamos
IPC分类号： A61N1/00
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/37211 , A61N1/3787
摘要： Systems and techniques for controlling the stimulation of tissue. In one aspect, an apparatus includes an implantable stimulation device to elicit a response in a tissue by delivering one or more stimuli. The stimulation device includes a stimulus delivery element to deliver the one or more stimuli to elicit the response, a memory to store a range value identifying a range of values of a stimulation parameter relative to a first value, and a controller to control delivery of the stimuli by the stimulus delivery element in accordance with the range value. The stimulation parameter characterizes the stimuli to be delivered by the stimulation device.
摘要翻译：用于控制组织刺激的系统和技术。在一个方面，一种装置包括可植入的刺激装置，通过递送一个或多个刺激来在组织中引发反应。刺激装置包括刺激递送元件以递送一个或多个刺激以引起响应;存储器，用于存储识别相对于第一值的刺激参数的值的范围的范围值;以及控制器，用于控制由刺激递送元素根据范围值刺激。刺激参数表征刺激装置传递的刺激。

82. 外观设计

USD607565S1 Visor for a visual prosthesis 有权
标题翻译：视觉假肢的遮阳
公开(公告)号：USD607565S1
公开(公告)日：2010-01-05
申请号：US29323164
申请日：2008-08-20
申请人： Kelly H. McClure , Sanjay Gaikwald , Timothy M. Nugent
设计人： Kelly H. McClure , Sanjay Gaikwald , Timothy M. Nugent

83. 发明申请

US20090112287A1 SALIENCY-BASED APPARATUS AND METHODS FOR VISUAL PROSTHESES 有权
标题翻译：基于SALIENCY的设备和视觉展示的方法
公开(公告)号：US20090112287A1
公开(公告)日：2009-04-30
申请号：US12043830
申请日：2008-03-06
申请人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
发明人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
IPC分类号： A61F9/08
CPC分类号： A61N1/36046 , A61F9/08 , G06K9/4604 , G06K9/4628 , G06K9/605 , G09B21/008
摘要： Saliency-based apparatus and methods for visual prostheses are disclosed. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.
摘要翻译：公开了用于视觉假体的基于显着性的装置和方法。基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

84. 发明申请

US20080262569A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262569A1
公开(公告)日：2008-10-23
申请号：US11875724
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：刺激受试者视网膜的方法。所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜，其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

85. 发明申请

US20080154336A1 Visual prosthetic apparatus for retinal stimulation 有权
标题翻译：用于视网膜刺激的视觉假体装置
公开(公告)号：US20080154336A1
公开(公告)日：2008-06-26
申请号：US11893260
申请日：2007-08-15
申请人： Kelly H. McClure , Richard Agustin Castro , Sanjay Gaikwad , Da-Yu Chang , Scott M. Loftin , Rongqing Dai , Robert J. Greenberg
发明人： Kelly H. McClure , Richard Agustin Castro , Sanjay Gaikwad , Da-Yu Chang , Scott M. Loftin , Rongqing Dai , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/0543
摘要： A visor for retinal stimulation of visually impaired subjects is shown. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.
摘要翻译：显示视网膜刺激视力障碍受试者的遮阳板。遮阳板包括框架，外部线圈，照相机和安装系统。连接器允许外部线圈沿第一方向定位。滑动装置允许外部线圈沿第二方向定位。遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。

86. 发明授权

US06539259B1 System and method of automatically adjusting sensitivity in an implantable cardiac stimulation device 有权
标题翻译：在可植入心脏刺激装置中自动调节灵敏度的系统和方法
公开(公告)号：US06539259B1
公开(公告)日：2003-03-25
申请号：US09354244
申请日：1999-07-15
申请人： Lisa P. Weinberg , Gene A. Bornzin , Kelly H. McClure
发明人： Lisa P. Weinberg , Gene A. Bornzin , Kelly H. McClure
IPC分类号： A61N118
CPC分类号： A61N1/368 , A61N1/3704
摘要： A system and method are disclosed for automatically adjusting the sense amplifier sensitivity based on the sensing threshold of the undesired signals (i.e., far-field signals or undesired near-field signals). Specifically, R-wave sensitivity is based on the peak amplitude of the T-waves. Since the relationship between R-waves and T-waves is so repeatable, high confidence is achieved in setting the sensitivity above the T-wave sensing threshold. For atrial sensing, P-wave sensitivity is based on the sensing threshold of R-waves and/or T-waves, whichever is larger. Several embodiments are disclosed for determining the threshold for sensing the undesired signals, such as, double sensing until single sensing occurs, or otherwise detecting the peak amplitude of two or more cardiac signals. Additional error checking may be employed, particularly for atrial sensitivity adjustment, to ensure proper detection of the sensing threshold for the undesired signals in patients with heart block: including analysis of the respective amplitude, cardiac signal duration, and time relationships to appropriately classify the cardiac signals.
摘要翻译：公开了一种系统和方法，用于基于不需要的信号（即，远场信号或不期望的近场信号）的感测阈值自动调整感测放大器灵敏度。具体来说，R波灵敏度基于T波的峰值振幅。由于R波和T波之间的关系是如此重复，所以在将灵敏度设置在T波感测阈值之上时，可以获得高置信度。对于心房感测，P波灵敏度基于R波和/或T波的感测阈值，以较大者为准。公开了用于确定用于感测不需要的信号的阈值的几个实施例，例如直到发生单次感测的双重感测，或以其它方式检测两个或更多个心脏信号的峰值振幅。可以采用额外的错误检查，特别是对于心房敏感性调整，以确保正确检测心脏阻塞患者中不需要的信号的感测阈值：包括相应幅度，心脏信号持续时间和时间关系的分析以适当地分类心脏信号。

87. 发明授权

US06275734B1 Efficient generation of sensing signals in an implantable medical device such as a pacemaker or ICD 失效
标题翻译：在诸如起搏器或ICD的可植入医疗装置中高效地产生感测信号
公开(公告)号：US06275734B1
公开(公告)日：2001-08-14
申请号：US09223422
申请日：1998-12-30
申请人： Kelly H. McClure , Gabriel Mouchawar
发明人： Kelly H. McClure , Gabriel Mouchawar
IPC分类号： A61N137
CPC分类号： A61N1/3704 , A61N1/3925
摘要： An implantable cardiac device such as a pacemaker or an implantable cardioverter defibrillator (ICD) that stores a broad band electrogram signal in response to the detecting of a particular cardiac event. The system includes an external programmer which is capable of accessing the stored electrogram via a telemetry circuit so that the stored electrogram can be downloaded and reviewed on a display of the external programmer. The external programmer is also equipped with a digital filter emulator that is capable of emulating the filtering of the broad band electrogram signal that is being provided to the processor of the implanted cardiac device. The emulator therefore allows a treating physician to review an emulation of the waveform that the processor of the implanted cardiac device is seeing when the processor is initiating the delivery of therapeutic electrical stimulation to the heart.
摘要翻译：可植入心脏装置，例如起搏器或植入式心律转复除颤器（ICD），其响应于特定心脏事件的检测而存储宽带电描记图信号。该系统包括外部编程器，其能够经由遥测电路访问存储的电描记图，以便可以在外部编程器的显示器上下载和检查所存储的电描记图。外部编程器还配备有数字滤波器仿真器，其能够模拟正在提供给植入的心脏装置的处理器的宽带电描记信号的滤波。因此，仿真器允许治疗医师检查当处理器开始向心脏递送治疗性电刺激时植入的心脏设备的处理器看到的波形的仿真。

88. 发明授权

US6161043A Implantable cardiac device having event recording capability with compression 有权
标题翻译：具有压缩事件记录能力的可植入心脏装置
公开(公告)号：US6161043A
公开(公告)日：2000-12-12
申请号：US255140
申请日：1999-02-22
申请人： Kelly H. McClure , Gabriel Mouchawar , Timothy J. Starkweather , James D. Causey, III
发明人： Kelly H. McClure , Gabriel Mouchawar , Timothy J. Starkweather , James D. Causey, III
IPC分类号： A61B5/00 , A61N1/365 , A61N1/37 , A01B5/0452
CPC分类号： A61B5/0006 , A61B5/7232 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is disclosed having a converter that provides a digital electrocardiogram signal to a controller which is stored in memory or transmitted via the telemetry circuit in an improved compressed fashion. The improved compression scheme comprises sampling the electrogram signal, transmitting the starting value in an uncompressed format followed by a plurality of delta signals in a compressed format. The delta signals may be determined by subtracting successive signals or by subtracting a predicted value from the current value. In either case, the delta signal is then transmitted in a truncated number of bits, e.g., 2 or 4 bits. When the delta signal is too large to be represented in the compressed number of bits, the controller then provides an indicator signal followed by the delta signal in the uncompressed format. In addition, whenever successive delta signals are below a minimum threshold (e.g., zero), they may be compressed into a count.
摘要翻译：公开了一种可植入心脏装置，其具有向控制器提供数字心电图信号的转换器，该控制器存储在存储器中或者以经改进的压缩方式通过遥测电路传输。改进的压缩方案包括对电描记图信号进行采样，以未压缩格式发送起始值，然后以压缩格式传送多个delta信号。 Δ信号可以通过减去连续信号或从当前值减去预测值来确定。在任一种情况下，然后以截断的位数（例如2或4位）发送增量信号。当增量信号太大而不能在压缩位数中表示时，控制器随后以未压缩格式提供指示符信号，后跟增量信号。此外，每当连续的delta信号低于最小阈值（例如，零）时，它们可以被压缩成计数。

89. 发明授权

US5718242A Cardiac arrhythmia detection system for an implantable stimulation device and method 失效
公开(公告)号：US5718242A
公开(公告)日：1998-02-17
申请号：US670946
申请日：1996-06-26
申请人： Kelly H. McClure , Gene A. Bornzin
发明人： Kelly H. McClure , Gene A. Bornzin
IPC分类号： A61N1/362 , A61N1/37 , A61B5/0456 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3704
摘要： A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.

90. 发明授权

US5560369A Cardiac arrhythmia detection system for an implantable stimulation device and method 失效
标题翻译：用于植入式刺激装置和方法的心律失常检测系统
公开(公告)号：US5560369A
公开(公告)日：1996-10-01
申请号：US310688
申请日：1994-09-22
申请人： Kelly H. McClure , Gene A. Bornzin
发明人： Kelly H. McClure , Gene A. Bornzin
IPC分类号： A61B5/0452 , A61N1/365 , A61N1/37 , A61B5/0402
CPC分类号： A61N1/3702 , A61N1/3704 , Y10S128/901
摘要： A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
摘要翻译：心脏事件和心律失常检测系统和方法从心脏的电描记图信号检测心律失常心脏活动或其他信息。该系统通过电导线感测电描记图信号，预先处理信号，并将其转换为多个离散数字信号，每个离散数字信号表示规定采样时间的电描记图信号的幅度。离散数字信号被应用于心脏事件检测器和形态检测器。形态检测器检测电描记图信号的形态（形状）中的选择的变化，其中这种变化自动控制用于检测心脏事件的灵敏度（增益和/或阈值）。随着时间的推移，检测到的形态的规定量的变化的发生表明规定的心律失常心脏病的发生。

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