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81. 发明申请

US20120295892A1 GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES 有权
标题翻译：化合物受体亚型选择性配体及其用途
公开(公告)号：US20120295892A1
公开(公告)日：2012-11-22
申请号：US13458168
申请日：2012-04-27
申请人： James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-Jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
发明人： James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-Jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
IPC分类号： A61K31/5517 , A61P25/18 , A61P25/22 , A61P25/08 , C07D487/04 , C07D487/14
CPC分类号： A61K31/695 , A61K31/551 , C07D487/04 , C07D487/14 , C07D519/00
摘要： Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.
摘要翻译：本文描述的是α3或α2或α2/α3GABA能受体亚型选择性配体，药物组合物，以及这些配体和组合物在治疗焦虑症，癫痫和精神分裂症以及降低镇静和共济失调副作用中的应用的方法。在实施方案中，诸如α3或α2或α2/α3GABA能受体亚型选择性配体缺少酯键，因此可能因酯酶水解而相对不敏感。

82. 发明申请

US20120293733A1 Displays and Sensors Integrated with Multi-State Cholesteric Liquid Crystal Devices 有权
标题翻译：与多态胆固醇液晶器件集成的显示器和传感器
公开(公告)号：US20120293733A1
公开(公告)日：2012-11-22
申请号：US13453655
申请日：2012-04-23
申请人： Le Li , Yongxin Tang , Haiping Yu , Jie Yang , Jiangbin Zhao
发明人： Le Li , Yongxin Tang , Haiping Yu , Jie Yang , Jiangbin Zhao
IPC分类号： G02F1/1335
CPC分类号： G02F1/13718
摘要： A sensing device may include a cholesteric crystal device including two optically transparent substrates; a liquid crystal having portions adapted for producing a plurality of optical states, said liquid crystal being arranged between the two optically transparent substrates; an optical sensor for changing optical states of respective portions of said liquid crystal to produce a range of respective optical states including all optical states produced by said liquid crystal ranging from one state to any combination of broadband reflection, tunable narrow band reflection, light scattering, and transparency in accordance with an amount of voltage applied across said cholesteric crystal device for changing optical states.
摘要翻译：感测装置可以包括胆甾醇晶体装置，其包括两个光学透明基板; 具有适于产生多种光学状态的部分的液晶，所述液晶布置在两个光学透明基板之间; 一种光学传感器，用于改变所述液晶的各部分的光学状态，以产生包括由所述液晶产生的所有光学状态的范围，所述光学状态从一种状态到宽带反射，可调窄带反射，光散射，并且根据用于改变光学状态的所述胆甾型晶体装置两端施加的电压量的透明度。

83. 发明申请

US20120244080A1 PROTEIN AGENT FOR DIABETES TREATMENT AND BETA CELL IMAGING 有权
标题翻译：用于糖尿病治疗和细胞成像的蛋白剂
公开(公告)号：US20120244080A1
公开(公告)日：2012-09-27
申请号：US13503194
申请日：2010-10-20
申请人： Zhi-Ren Liu , Jie Yang , Bing Xu , Wangda Zhou , Shenghui Xue
发明人： Zhi-Ren Liu , Jie Yang , Bing Xu , Wangda Zhou , Shenghui Xue
IPC分类号： C07K19/00 , G01N21/75 , A61K49/14 , C12N5/071
CPC分类号： A61K38/26 , A61K38/00 , A61K47/60 , A61K49/085 , C07K14/605 , C07K2319/00
摘要： Glucagon-like peptide-1 (GLP-1) is a member of a large family of incretin hormones secreted in nutrient-dependent response. GLP-1 acts on GLP-1 receptor (GLP-1 R) that is highly expressed on pancreatic β-cells. The peptide has great potential for development of diabetes treatment and diagnosis. However, the pharmaceutical effects of the peptide suffer from in vivo instability and short life due to degradation by Dipeptidylpeptidase-1 (DPP-4). The 30 amino acid peptide GLP-1 has been integrated into a stable host protein human calbindin D9k. The fusion protein binds to GLP-1 R as demonstrated by immunostaining analyses of GLP-1 R expressing cells. The fusion protein agents can be useful for both diabetes treatment and GLP-1 R receptor targeting MR imaging. The fusion protein has a size about 14 kDa, which enables efficient tissue penetration and retention, and an extended circulation time, is stable, remaining intact and retaining activity after 48 hours incubation with 75% human serum. The protein retains its native folded structure after boiling for ten minutes forming the basis of an experimental protocol for large scale production of the fusion protein (>30 mg/l bacterial culture). No toxicity has been observed with tests on mice. One aspect of the disclosure, therefore, provides a fusion protein comprising a first peptide characterized by selectively binding to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone. In embodiments of this aspect of the disclosure, the fusion protein may further comprise a detectable label attached thereto. In some embodiments of this aspect of the disclosure, the first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-1)(7-36), or glucagon-like peptide-1 (GLP-1) (9-36), or a conservative variant thereof.
摘要翻译：胰高血糖素样肽-1（GLP-1）是营养依赖性反应中分泌的大肠激素的成员之一。 GLP-1作用于在胰腺细胞上高度表达的GLP-1受体（GLP-1R）。该肽具有发展糖尿病治疗和诊断的巨大潜力。然而，由于二肽基肽酶-1（DPP-4）的降解，肽的药物作用遭受体内不稳定性和短寿命。 30个氨基酸的肽GLP-1已经被整合到稳定的宿主蛋白人类calbindin D9k中。如通过GLP-1R表达细胞的免疫染色分析所证明的，融合蛋白与GLP-1R结合。融合蛋白剂可用于糖尿病治疗和靶向MR-1的受体受体。融合蛋白具有约14kDa的大小，其能够有效的组织穿透和保留，并且延长的循环时间是稳定的，在75％人血清孵育48小时后保持完整和保留活性。蛋白质在煮沸10分钟后保持其天然折叠结构，形成用于大规模生产融合蛋白（> 30mg / l细菌培养物）的实验方案的基础。在小鼠试验中没有观察到毒性。因此，本公开的一个方面提供了包含第一肽的融合蛋白，其特征在于选择性结合靶细胞的位点并连接到第二个肽，其中融合蛋白比单独的第一个肽更稳定。在本公开的该方面的实施方案中，融合蛋白还可包含附着于其上的可检测标记。在本公开的该方面的一些实施方案中，融合蛋白的第一肽可以是胰高血糖素样肽-1（GLP-1），胰高血糖素样肽-1（GLP-1）（7-36）或胰高血糖素样肽-1（GLP-1）（9-36）或其保守变体。

84. 发明授权

US08206960B1 Endoglucanases 有权
公开(公告)号：US08206960B1
公开(公告)日：2012-06-26
申请号：US13323724
申请日：2011-12-12
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/00
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.

85. 发明申请

US20120009631A1 VARIANT ENDOGLUCANASES AND RELATED POLYNUCLEOTIDES 有权
标题翻译：各种内切酶和相关多核苷酸
公开(公告)号：US20120009631A1
公开(公告)日：2012-01-12
申请号：US13203909
申请日：2010-03-10
申请人： Jie Yang , Xiyun Zhang , Ish Kumar Dhawan , Andrew Shaw
发明人： Jie Yang , Xiyun Zhang , Ish Kumar Dhawan , Andrew Shaw
IPC分类号： C12P19/12 , C07H21/00 , C12N15/63 , C12P7/14 , C12P19/02 , C12P19/00 , C12P7/02 , C12N9/42 , C12N1/21
CPC分类号： C12N9/2408 , C12N9/2437 , C12P7/10 , C12P19/12 , C12P19/14 , C12Y302/01004 , C12Y302/01091 , Y02E50/16 , Y02E50/17 , Y02P20/52
摘要： The invention provides variants of the Clostridium thermocellum endoglucanase (CeIG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.
摘要翻译：本发明提供了与野生型酶相比具有改善的内切葡聚糖酶活性的热梭菌内切葡聚糖酶（CeIG）的变体。还提供了相关多核苷酸，组合物，载体，宿主细胞和使用方法。

86. 发明授权

US08084621B2 3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof 有权
标题翻译： 3-吡咯并[b]环己基-2-二氢吲哚啉酮衍生物及其用途
公开(公告)号：US08084621B2
公开(公告)日：2011-12-27
申请号：US12517351
申请日：2007-12-03
申请人： Feng Tang , Han Shen , Qiu Jin , Lei Ding , Jie Yang , Xiaojin Yin , Shiyue Lu
发明人： Feng Tang , Han Shen , Qiu Jin , Lei Ding , Jie Yang , Xiaojin Yin , Shiyue Lu
IPC分类号： C07D209/02 , A61K31/40
CPC分类号： C07D209/42 , C07D401/14 , C07D403/14
摘要： 3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.
摘要翻译：式（I）的3-吡咯并[b]亚环己基-2-二氢 - 二氢吲哚酮衍生物或其药学上可接受的盐和用途。用于制备上述化合物的式（II）的中间体。生物测定显示，上述化合物及其药学上可接受的盐可调节蛋白激酶（PK）的活性，抑制酪氨酸激酶（PTK）的活性并抑制多种肿瘤细胞。

87. 发明申请

US20110253663A1 SEMI-PERMANENT VEHICLE COUPLER FOR LIGHT RAIL 有权
标题翻译：用于轻轨的半永久车辆联轴器
公开(公告)号：US20110253663A1
公开(公告)日：2011-10-20
申请号：US13172811
申请日：2011-06-29
申请人： Fenggang Liu , Jie Yang , Minggang Li
发明人： Fenggang Liu , Jie Yang , Minggang Li
IPC分类号： B61G9/04
CPC分类号： B61G9/06
摘要： The present invention relates to a semi-permanent vehicle coupler for a light rail, which comprises a buffer end and a buffer-free end. The buffer end comprises a buffer, a joint bearing connected with the buffer and a mounting seat, wherein the joint bearing is connected with the mounting seat through a coupler yoke key; the buffer-free end comprises a left pull ring, a joint bearing connected with the left pull ring and a mounting seat, wherein the joint bearing is connected with the mounting seat through a coupler yoke key; the buffer is a double-acting buffer and comprises a shell, a left end cover, a right pull ring, elastic bodies, a central shaft and a middle partition plate, wherein the central shaft passes through the centers of the left end cover and the right pull ring and is glidingly contacted with the left end cover and the right pull ring, one end of the central shaft extends out of the left end cover, the middle partition plate is fixedly arranged on the central shaft and divides the inner part of the shell into two elastic body accommodating cavities, and the elastic bodies are positioned in the two elastic body accommodating cavities; and the other end of the left pull ring is provided with a lug boss, one end of the central shaft extending out of the left end cover is also provided with a lug boss, and the two lug bosses are connected through a connecting ring.
摘要翻译：本发明涉及一种用于轻轨的半永久性车辆耦合器，其包括缓冲端和无缓冲端。缓冲端包括缓冲器，与缓冲器连接的关节轴承和安装座，其中关节轴承通过联接器轭扣与安装座连接; 无缓冲端包括左拉环，与左拉环连接的关节轴承和安装座，其中，关节轴承通过联接器轭扣与安装座连接; 缓冲器是双作用缓冲器，包括外壳，左端盖，右拉环，弹性体，中心轴和中间隔板，其中中心轴穿过左端盖的中心和右拉环与左端盖和右拉环滑动接触，中心轴的一端从左端盖延伸出来，中间隔板固定地布置在中心轴上，弹性体位于两个弹性体容纳腔中，并且左拉环的另一端设置有凸耳凸起，从左端盖延伸出的中心轴的一端还设置有凸耳凸台，并且两个凸耳凸起通过连接环连接。

88. 发明申请

US20110241187A1 LEAD FRAME WITH RECESSED DIE BOND AREA 审中-公开
标题翻译：带框架的引导框架
公开(公告)号：US20110241187A1
公开(公告)日：2011-10-06
申请号：US13018438
申请日：2011-02-01
申请人： Liping Guo , Qingchun He , Zhaojun Tian , Jie Yang
发明人： Liping Guo , Qingchun He , Zhaojun Tian , Jie Yang
IPC分类号： H01L23/495 , H01L21/48
CPC分类号： H01L23/3107 , H01L23/49503 , H01L23/49541 , H01L24/29 , H01L24/32 , H01L24/48 , H01L24/73 , H01L24/83 , H01L24/85 , H01L2224/27013 , H01L2224/291 , H01L2224/2919 , H01L2224/32245 , H01L2224/32257 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2224/83385 , H01L2224/85 , H01L2924/00014 , H01L2924/01046 , H01L2924/01079 , H01L2924/14 , H01L2924/15153 , H01L2924/181 , H01L2924/014 , H01L2924/00012 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A lead frame having a recessed die bond area. The lead frame has top and bottom surfaces and a first lead frame thickness defined as the distance between the top and bottom surfaces. The lead frame has a die bond area surface located within a reduced die bond area. A second thickness is defined as the distance between the die bond area surface and the bottom surface. The second lead frame thickness is less than the first lead frame thickness such that a semiconductor die disposed and attached to the die bond area surface has a reduced overall package thickness. A side wall formed between the die bond area surface and the top surface contains the adhesive material used to attach the die, which reduces adhesive bleeding and prevents wire bonding contamination.
摘要翻译：引线框架，具有凹陷的焊盘区域。引线框架具有顶部和底部表面以及被定义为顶部和底部表面之间的距离的第一引线框架厚度。引线框架具有位于减小的管芯接合区域内的管芯接合区域表面。第二厚度被定义为管芯接合区域表面和底部表面之间的距离。第二引线框架厚度小于第一引线框架厚度，使得设置并附接到管芯接合区域表面的半导体管芯具有减小的整体封装厚度。形成在芯片接合区域表面和顶表面之间的侧壁包含用于附接模具的粘合材料，这降低了粘合剂渗出并防止引线接合污染。

89. 发明申请

US20110035577A1 ENHANCED DIGITAL RIGHT MANAGEMENT FRAMEWORK 有权
标题翻译：增强数字权限管理框架
公开(公告)号：US20110035577A1
公开(公告)日：2011-02-10
申请号：US12532143
申请日：2007-03-26
申请人： Yunbiao Lin , Jie Yang , Chuan Song
发明人： Yunbiao Lin , Jie Yang , Chuan Song
IPC分类号： H04L9/00 , G06F15/16
CPC分类号： H04L63/0428 , G06F21/10 , G06F21/51 , G06F21/53 , G06F21/57 , G06F21/575 , G06F2221/0773 , G06F2221/2153 , H04L63/10 , H04L2463/101
摘要： Machine-readable media, methods, apparatus and system for enhanced digital right management framework are described. A server platform may receive a request of downloading content and first attestation information from a client platform. The server platform may examine if the client platform attests to a client platform characteristic that affects integrity of the client platform by using the attestation information, and then encrypt and download the content to the client platform if the client platform attests to the client platform characteristic. The server platform may further receive a request of viewing the content and second attestation information from the client platform. The server platform may then examine if the client platform attests to its integrity by using the second attestation information; and then send a content key to the client platform if the client platform attests to its integrity, so that the client platform can decrypt and view the content.
摘要翻译：描述了用于增强数字版权管理框架的机器可读介质，方法，装置和系统。服务器平台可以从客户端平台接收下载内容和第一认证信息的请求。服务器平台可以检查客户端平台是否通过使用认证信息来证明影响客户端平台完整性的客户端平台特性，然后如果客户端平台证明客户端平台特性，则将内容加密并下载到客户端平台。服务器平台还可以从客户端平台接收查看内容和第二认证信息的请求。然后，服务器平台可以通过使用第二认证信息检查客户端平台是否证实其完整性; 然后如果客户端平台验证其完整性，则将内容密钥发送到客户端平台，以便客户端平台可以解密和查看内容。

90. 发明申请

US20100223618A1 SCHEDULING JOBS IN A CLUSTER 失效
标题翻译：在集会中安排工作
公开(公告)号：US20100223618A1
公开(公告)日：2010-09-02
申请号：US12713740
申请日：2010-02-26
申请人： ZHI WEN FU , Zi Ming Hu , Peng Liu , Jie Yang
发明人： ZHI WEN FU , Zi Ming Hu , Peng Liu , Jie Yang
IPC分类号： G06F9/46
CPC分类号： G06F9/50 , G06F9/5044 , G06F9/505 , G06F9/5077 , H04L67/1002
摘要： There is provided a method and system for scheduling a job in a cluster, the cluster comprises multiple computing nodes, and the method comprises: defining rules for constructing virtual sub-clusters of the multiple computing nodes; constructing the multiple nodes in the cluster into multiple virtual sub-clusters based on the rules, wherein one computing node can only be included in one virtual sub-cluster; dispatching a received job to a selected virtual sub-cluster; and scheduling at least one computing node for the dispatched job in the selected virtual sub-cluster. Further, the job is dispatched to the selected virtual sub-cluster based on characteristics of the job and/or characteristics of virtual sub-clusters. The present invention can increase the throughput of scheduling effectively.
摘要翻译：提供了一种用于调度集群中的作业的方法和系统，所述集群包括多个计算节点，并且所述方法包括：定义用于构建所述多个计算节点的虚拟子集群的规则; 基于规则将簇中的多个节点构建成多个虚拟子集群，其中一个计算节点只能包含在一个虚拟子集群中; 将所接收的作业调度到所选择的虚拟子集群; 以及为所选择的虚拟子集群中的所分配的作业调度至少一个计算节点。此外，基于作业的特性和/或虚拟子集的特征将作业调度到所选择的虚拟子集群。本发明可以有效地提高调度的吞吐量。

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