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    • 85. 发明授权
    • Target substance detection element, target substance detection method, and method for producing target substance detection element
    • 靶物质检测元件,目标物质检测方法以及靶物质检测元件的制造方法
    • US08183058B2
    • 2012-05-22
    • US12524348
    • 2008-03-17
    • Satoru HatakeyamaTakashi Ikeda
    • Satoru HatakeyamaTakashi Ikeda
    • G01N33/543
    • G01N33/54386G01N33/54393Y10S435/97Y10S436/807Y10T156/10
    • It is intended to provide a target substance detection element wherein a target substance capturing body for capturing target substances is immobilized with good orientation in a desired region on the surface of the target substance detection element, a method for producing the target substance detection element, and a detection method using the target substance detection element. The present invention provides a target substance detection element for detecting the presence or absence or concentration of a target substance in a sample, characterized in that: the target substance detection element includes at least a detection substrate including plural layers and a target substance capturing body immobilized on the surface of the detection substrate; the target substance capturing body has at least a first peptide region specifically recognizing a first layer of the plural layers constituting the detection substrate and binding to the first layer and a second peptide region specifically recognizing a second layer different from the first layer of the plural layers and binding to the second layer; and the first layer and the second layer are adjacent to each other.
    • 旨在提供一种目标物质检测元件,其中用于捕获目标物质的目标物质捕获体被固定在目标物质检测元件的表面上的期望区域中具有良好取向,该目标物质检测元件的制造方法和 使用目标物质检测元件的检测方法。 本发明提供了一种用于检测样品中目标物质的存在或不存在或浓度的目标物质检测元件,其特征在于:所述目标物质检测元件至少包括包含多层的检测基板和固定的靶物质捕获体 在检测基板的表面上; 目标物质捕捉体具有至少第一肽区域,其具体地识别构成检测基板的多层的第一层并与第一层结合,以及特异性识别与多层的第一层不同的第二层的第二肽区域 并与第二层结合; 并且第一层和第二层彼此相邻。
    • 90. 发明申请
    • PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
    • 苯并噻唑类化合物和含有其作为活性成分的NFkB抑制剂
    • US20110201638A1
    • 2011-08-18
    • US13125698
    • 2009-10-23
    • Takashi IkedaSeigo SawadaTakashi YaegashiTakeshi MatsuzakiShusuke HashimotoRyuta Yamazaki
    • Takashi IkedaSeigo SawadaTakashi YaegashiTakeshi MatsuzakiShusuke HashimotoRyuta Yamazaki
    • A61K31/437C07D471/04A61P29/00A61P35/00
    • C07D471/04C07D491/147
    • A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; R2 represents a hydroxyl group, or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).
    • 提供了具有优异的NF&Kgr B抑制效果的新化合物,具体公开了下式(1)表示的化合物或其盐:其中,R1表示氢原子,低级烷基,低级烷氧基, 或卤素原子; R2表示羟基或低级烷氧基; R3表示氢原子,低级烷基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子,低级烷氧基,卤素原子,羟基或亚甲二氧基; R6表示与R5一起形成的氢原子,低级烷氧基或亚甲二氧基,或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; 并且R 8表示氢原子,羟基,氨基或低级烷基羰基氧基(R 1,R 3,R 4和R 7为氢原子的情况除外,R 2和R 8为羟基,R 5和R 6为甲氧基 )。