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81. 发明授权

US4962300A Preheating control apparatus for diesel engines 失效
标题翻译：柴油机预热控制装置
公开(公告)号：US4962300A
公开(公告)日：1990-10-09
申请号：US239608
申请日：1981-03-02
申请人： Kiyoshi Watanabe
发明人： Kiyoshi Watanabe
IPC分类号： F02B3/06 , F02P19/02
CPC分类号： F02P19/025 , F02B3/06
摘要： A preheating control apparatus for diesel engines of the present invention is provided wherein the voltage developed across a sensing resistor connected in series with a glow plug, which voltage is indicative of the temperature of the glow plug, is amplified by an amplifier. The amplified voltage is compared with a predetermined reference voltage to control the preheating current through the glow plug so that the temperature of the glow plug can be precisely controlled without increasing the resistance value of the sensing resistor. Further, a protection circuit may be provided to end the preheating current to the glow plug in response to an abnormal change in the voltage applied to the glow plug.
摘要翻译：提供了本发明的柴油发动机的预热控制装置，其中跨越与电热塞串联的感测电阻器产生的电压被放大器放大，该电热塞指示电热塞的温度。将放大的电压与预定的参考电压进行比较，以控制通过电热塞的预热电流，使得可以精确地控制电热塞的温度而不增加感测电阻器的电阻值。此外，可以提供保护电路以响应于施加到电热塞的电压的异常变化而将预热电流结束到电热塞。

82. 发明授权

US4914199A Process for preparing 4-acetoxy-3-hydroxyethylazetidin-2-one derivatives 失效
公开(公告)号：US4914199A
公开(公告)日：1990-04-03
申请号：US156873
申请日：1988-02-18
申请人： Isao Sada , Kazunori Kan , Noboru Ueyama , Shingo Matsumoto , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Isao Sada , Kazunori Kan , Noboru Ueyama , Shingo Matsumoto , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C07D205/08 , C07F7/18
CPC分类号： C07F7/186 , C07D205/08 , Y02P20/55
摘要： A process for preparing a 4-acetoxy-3-hydroxyethylazetidin-2-one derivative having the formula (II): ##STR1## wherein R.sup.1 is a protective group for the hydroxyl group, which comprises reactig a .beta.-lactam compound having the formula (I): ##STR2## wherein R.sup.1 is as difined above and R.sup.2, R.sup.3 and R.sup.4 are the same or different and each is a lower alkyl group having 1 to 4 carbon atoms or an aralkyl group, with acetic anhydride in the presence of a base and a catalyst selected from the group consisting of an organic strong acid, a mineral acid, a Lewis acid, a halogenated acyl compound having the formula (IV):R.sup.8 --CO--X (IV)wherein R.sup.8 is an alkyl group, an aralkyl group or phenyl group and X is a halogen atom, a halogenated sulfonyl compound having the formula (V):R.sup.9 --SO.sub.2 --X (V)wherein R.sup.9 is an alkyl group, an aralkyl group or phenyl group and X is a halogen atom, and a compound having the formula (VI):(R.sup.10).sub.4-n --Si(X').sub.n (VI)wherein R.sup.10 is a lower alkyl group having 1 to 6 carbon atoms or phenyl group, X' is a halogen atom or CF.sub.3 SO.sub.2 O group and n is an integer of 1 to 4. According to the present invention, there can be obtained 4-acetoxy-3-hydroxyethylazetidin-2-one derivatives, which are useful intermediates for preparing carbapenem .beta.-lactam antibiotics, in high yield.

83. 发明授权

US4863530A Fc-Pt-Nb permanent magnet with an ultra-high coercive force and a large maximum energy product, and method for producing the same 失效
标题翻译：具有超高矫顽力和大的最大能量积的Fc-Pt-Nb永磁体及其制造方法
公开(公告)号：US4863530A
公开(公告)日：1989-09-05
申请号：US278346
申请日：1988-12-01
申请人： Hakaru Masumoto, deceased , by Hiroshi Matushima, executor , Kiyoshi Watanabe
发明人： Hakaru Masumoto, deceased , by Hiroshi Matushima, executor , Kiyoshi Watanabe
IPC分类号： C21D6/00 , C22C30/00 , C22C38/00 , C22F1/14 , H01F1/04
CPC分类号： C21D6/00 , C22C30/00 , C22F1/14 , H01F1/04
摘要： The disclosed permanent magnet has a coercive force of larger than 500 Oe, a residual magnetic flux density of larger than 5 kG, and a maximum energy product of larger than 2 MGOe, and it consisting essentially of 48.about.66.9 Atm % of iron, 33.about.47 Atm % of platinum, and 0.1.about.10 Atm % of niobium. It includes a crystal structure of an incomplete single .gamma.1 phase of a face-centered tetragonal system due to either the composition thereof or heat treatment applied thereto. The permanent magnet are made by heating an alloy of the above main composition at 900.degree..about.1,400.degree. for one minute to ten hours and quenching the alloy at a high speed of faster than 30.degree. C./minute but slower than 2,000.degree. C./sec.
摘要翻译：所公开的永磁体具有大于500Oe的矫顽力，大于5kG的剩余磁通密度和大于2MGOe的最大能量乘积，并且其基本上由48差异66.9％的铁，33％差异47铂的百分比，和0.1的差异10 Atm％的铌。由于其组成或施加于其上的热处理，它包括面心四方系的不完全单一γ1相的晶体结构。永久磁铁是通过将上述主要组合物的合金在900℃-140℃下加热1分钟至10小时而制成的，并以高于30℃/分钟但低于2000℃的高速淬火该合金。 /秒。

84. 发明授权

US4748176A 7-hydroxyguanine compounds 失效
标题翻译： 7-羟基鸟嘌呤化合物
公开(公告)号：US4748176A
公开(公告)日：1988-05-31
申请号：US867032
申请日：1986-05-27
申请人： Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： A61K31/52 , A61K31/522 , A61P35/00 , C07D473/18 , C12P17/18 , C12R1/465
CPC分类号： C07D473/18
摘要： Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom, tetrahydropyranyl group or tetrahydrofuryl group, and R.sub.2 is hydrogen atom, tetrahydropyranyl group or tetrahydrofuryl group, provided that when R.sub.1 is hydrogen atom, R.sub.2 is tetrahydropyranyl group or tetrahydrofuryl group, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.
摘要翻译：下式的新型7-羟基鸟嘌呤化合物：其中R是氢原子，四氢吡喃基或四氢呋喃基，R2是氢原子，四氢吡喃基或四氢呋喃基，条件是当R1是氢原子时，R2是四氢吡喃基基团或四氢呋喃基及其盐，其具有优异的抗肿瘤活性，制备该化合物的方法，以及含有所述化合物作为活性成分的抗肿瘤剂。

85. 发明授权

US4745066A Method for producing optically active glycol derivatives 失效
标题翻译：光学活性二醇衍生物的制备方法
公开(公告)号：US4745066A
公开(公告)日：1988-05-17
申请号：US846766
申请日：1986-04-01
申请人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C07B31/00 , C07C67/00 , C07C301/00 , C07C303/22 , C07C309/72 , C12P11/00 , C12P41/00 , C12R1/01 , C12R1/38 , C12R1/66 , C12R1/785 , C12R1/845
CPC分类号： C12P41/004 , C07C309/00 , C12P11/00
摘要： A method for producing optically active glycol derivatives by biochemical resolution which comprises contacting a racemic ester of the general formula 1 ##STR1## (wherein R.sub.1 is an aliphatic hydrocarbon group of 1 to 16 carbon atoms, R.sub.2 is an aliphatic hydrocarbon group of 1 to 8 carbon atoms, and R.sub.3 is an aromatic hydrocarbon group such as phenyl, tolyl or naphtyl) with a microorganism- or animal organ-derived enzyme having stereoselective hydrolytic activity to asymmetrically hydrolyze said racemic ester of general formula 1 to produce an optically active alcohol of general formula 2* ##STR2## (wherein R.sub.1 and R.sub.3 have the same meanings as defined above) and an unreacted ester of the general formula 1* ##STR3## (wherein R.sub.1, R.sub.2 and R.sub.3 have the same meanings as defined hereinbefore), separating the optically active compounds from each other, hydrolyzing said ester of general formula 1* to give an optically active glycol derivative which is antipodal to the alcohol of general formula 2* and, then, isolating the same optically active glycol derivative. The invention provides a method for producing optically active glycol derivatives, which is expedient, does not require costly reagents and is suited to commercial scale production.
摘要翻译：一种通过生物化学拆分制备光学活性二醇衍生物的方法，其包括使通式1的外消旋酯1（其中R 1是1至16个碳原子的脂族烃基，R 2是1的脂族烃基， 8个碳原子，并且R 3是芳族烃基如苯基，甲苯基或萘基）与具有立体选择性水解活性的微生物或动物器官衍生的酶不对称地水解所述通式1的外消旋酯以产生光学活性的醇通式2 * 2 *（其中R 1和R 3具有与上述相同的含义）和通式1 *未反应的酯*（其中R 1，R 2和R 3具有与定义相同的含义）将光学活性化合物彼此分离，水解所述通式1 *的酯，得到对通式为醇的对映体的光学活性二醇衍生物 2 *，然后分离相同的光学活性二醇衍生物。本发明提供了一种制备光学活性二醇衍生物的方法，这是有利的，不需要昂贵的试剂并且适于商业规模生产。

86. 发明授权

US4455637A Disc record player with automatic loading/unloading assembly 失效
标题翻译：光盘录音机带自动装卸装置
公开(公告)号：US4455637A
公开(公告)日：1984-06-19
申请号：US286467
申请日：1981-07-24
申请人： Hiroyuki Suzuki , Masayuki Taoka , Kiyoshi Watanabe
发明人： Hiroyuki Suzuki , Masayuki Taoka , Kiyoshi Watanabe
IPC分类号： G11B3/095 , G11B17/028 , G11B17/04 , G11B19/20 , G11B25/04 , G11B1/00 , G11B3/60 , G11B17/02
CPC分类号： G11B17/0284 , G11B17/0404 , G11B19/20 , G11B3/0955
摘要： A record player is disclosed which includes a turntable (35) movable at least between a first position for record loading and a second position for record unloading, a record support (10R) having at least a first position for removal of the record out of said player and a second position for mounting the record onto said turntable and a transmission device (13a) maintained in engaging relationship with said turntable for transmission of rotating torque from said turntable to said record support when said turntable is in the second position.
摘要翻译：公开了一种记录播放器，其包括至少在用于记录装载的第一位置和用于记录卸载的第二位置之间可移动的转盘（35），具有至少第一位置的记录支架（10R），用于从所述播放器和用于将记录安装到所述转盘上的第二位置和与所述转台保持啮合关系的传动装置（13a），用于当所述转盘处于第二位置时将转动扭矩从所述转台传递到所述记录支架。

87. 发明授权

US4371699A Process for preparation of optically active N-mercaptoalkanoylamino acids 失效
标题翻译：光学活性N-巯基烷酰氨基酸的制备方法
公开(公告)号：US4371699A
公开(公告)日：1983-02-01
申请号：US214780
申请日：1980-12-09
申请人： Takehisa Ohashi , Masami Shimazaki , Kazunori Kan , Hideo Kondo , Kiyoshi Watanabe
发明人： Takehisa Ohashi , Masami Shimazaki , Kazunori Kan , Hideo Kondo , Kiyoshi Watanabe
IPC分类号： C07C51/60 , C07D207/16 , C07D211/60 , C07D277/06 , C07K5/078
CPC分类号： C07K5/06165 , C07C51/60 , C07D207/16 , C07D211/60 , C07D277/06
摘要： A process is disclosed wherein an optically active N-mercaptoalkanoylamino acid is prepared by(1) reacting an optically active .beta.-hydroxyalkanoic acid, with a halogenating reagent to prepare an optically active .beta.-haloalkanoyl halide(2) reacting the .beta.-haloalkanoyl halide with an amino acid to produce an optically active N-.beta.-haloalkanoylamino acid and(3) reacting the N-.beta.-haloalkanoylamino acid with a reagent capable of converting the halogen into the thiol group, the configuration of the formulas (II), (III), (IV), (V), and (VI) being retained in all the optically active compounds throughout the process to prepare the compound represented by formula (I). The product of the present invention, for example, N-(3-mercapto-2-D-methylpropanoyl)-L-proline inhibits the enzymatic conversion of angiotensin I into angiotensin II and therefore is useful for relieving angiotensin-related hypertension.
摘要翻译：公开了一种方法，其中光学活性N-巯基烷酰基氨基酸通过（1）使光学活性β-羟基链烷酸与卤化试剂反应制备光学活性β-卤代烷酰基卤化物（2）使β-卤代烷酰卤与氨基酸以产生光学活性的N-β-卤代烷酰基氨基酸和（3）使N-β-卤代烷酰基氨基酸与能够将卤素转化成硫醇基团的试剂反应，式（II），（III ），（IV），（V）和（VI）在整个过程中保留在所有光学活性化合物中以制备由式（I）表示的化合物。本发明的产物，例如N-（3-巯基-2-D-甲基丙酰基）-L-脯氨酸抑制血管紧张素I的酶促转化为血管紧张素II，因此可用于缓解血管紧张素相关的高血压。

88. 发明授权

US4369177A Stable composition of S-adenosyl-L-methionine 失效
标题翻译： S-腺苷-L-甲硫氨酸的稳定组成
公开(公告)号：US4369177A
公开(公告)日：1983-01-18
申请号：US208842
申请日：1980-11-20
申请人： Yuichi Kozaki , Shingo Hata , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Yuichi Kozaki , Shingo Hata , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： C07H19/16 , Y10S514/97 , Y10S514/973
摘要： A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceutically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a salt of S-adenosyl-L-methionine with hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, formic acid, acetic acid, citric acid, tartaric acid, or maleic acid; or a double salt of S-adenosyl-L-methionine with the foregoing acids. The salt of a bivalent or trivalent metal is, for example, calcium chloride, ferric chloride, magnesium chloride, or magnesium sulfate. A process for preparing the composition is also disclosed. The composition is suitable for preparing pharmaceutical preparations of S-adenosyl-L-methionine.
摘要翻译：公开了S-腺苷-L-甲硫氨酸的稳定组合物，其包括S-腺苷-L-甲硫氨酸的盐和二价或三价金属的药学上可接受的水溶性盐。 S-腺苷-L-甲硫氨酸的盐例如是S-腺苷-L-甲硫氨酸与盐酸，硫酸，对甲苯磺酸，磷酸，甲酸，乙酸，柠檬酸，酒石酸的盐酸或马来酸; 或S-腺苷-L-甲硫氨酸与上述酸的双重盐。二价或三价金属的盐是例如氯化钙，氯化铁，氯化镁或硫酸镁。还公开了制备该组合物的方法。该组合物适用于制备S-腺苷-L-甲硫氨酸的药物制剂。

89. 发明授权

US4310635A Fermentative production of D(-)-.beta.-hydroxyisobutyric acid 失效
标题翻译：发酵生产D（ - ） - β-羟基异丁酸
公开(公告)号：US4310635A
公开(公告)日：1982-01-12
申请号：US201337
申请日：1980-10-27
申请人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/911 , Y10S435/913 , Y10S435/917 , Y10S435/921 , Y10S435/938 , Y10S435/94 , Y10S435/942
摘要： A process is disclosed wherein D(-)-.beta.-hydroxyisobutyric acid is produced fermentatively from isobutyric acid or methacrylic acid by the stereoselective action of microorganisms having the ability to convert isobutyric acid or methacrylic acid into D(-)-.beta.-hydroxyisobutyric acid in an aqueous medium, and D(-)-.beta.-hydroxyisobutyric acid is recovered from the aqueous medium.
摘要翻译：公开了一种方法，其中通过具有将异丁酸或甲基丙烯酸转化为D（ - ） - β-羟基异丁酸的能力的微生物的立体选择性作用，从（异）酸或甲基丙烯酸发酵得到D（ - ） - β-羟基异丁酸）从水介质中回收水性介质和D（ - ） - β-羟基异丁酸。

90. 发明授权

US08651480B2 Sheet stacking apparatus and image forming apparatus 有权
标题翻译：片材堆垛装置和成像装置
公开(公告)号：US08651480B2
公开(公告)日：2014-02-18
申请号：US13545247
申请日：2012-07-10
申请人： Kiyoshi Watanabe , Hideki Kushida , Toshiyuki Iwata
发明人： Kiyoshi Watanabe , Hideki Kushida , Toshiyuki Iwata
IPC分类号： B65H31/36
CPC分类号： B65H31/10 , B65H31/26 , B65H31/34 , B65H31/38 , B65H2301/42192 , B65H2404/1114 , B65H2404/7414 , B65H2404/742 , B65H2801/27 , G03G15/6552
摘要： A finisher 100 includes a pair of bundle discharge rollers 130, a lower stack tray 137, and a width-direction aligning portion 200. The width-direction aligning portion includes a pair of aligning members 1 and a driving motor. The aligning member includes a pair of first aligning members 91 that is rotatably supported while being movable in the sheet width direction orthogonal to the discharge direction and a pair of second aligning members 92. The driving motor rotates the pair of first aligning members and moves the pair of first aligning members in the width direction. When the pair of first aligning members rotates and one of the pair of second aligning members abuts on the sheet, the pair of second aligning members forms opposite surfaces in which the sheet can be aligned in the width direction, and the pair of first aligning members align the sheet by the opposite surfaces.
摘要翻译：整理器100包括一对排纸辊130，下堆叠托盘137和宽度方向对准部分200.宽度方向对准部分包括一对对准构件1和驱动电机。对准构件包括一对第一对准构件91，该一对第一对准构件91可在与放电方向正交的片材宽度方向上可移动地可旋转地支撑，以及一对第二对准构件92.驱动电机使一对第一对准构件旋转，一对第一对准构件在宽度方向上。当一对第一对准构件旋转并且一对第二对准构件中的一个抵接在片材上时，一对第二对准构件形成相对的表面，在该表面中片材可以在宽度方向上对齐，并且一对第一对准构件将纸张对准表面。

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