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81. 发明申请

US20090264474A1 SULFONAMIDES AS TRPM8 MODULATORS 有权
标题翻译：磺酰胺作为TRPM8调节剂
公开(公告)号：US20090264474A1
公开(公告)日：2009-10-22
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。

82. 发明申请

US20090258910A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20090258910A1
公开(公告)日：2009-10-15
申请号：US12492081
申请日：2009-06-25
申请人： Nathanael S. Gray , Jiqing Jiang , Yi Liu , Ruo Steensma
发明人： Nathanael S. Gray , Jiqing Jiang , Yi Liu , Ruo Steensma
IPC分类号： A61K31/4439 , C07D401/04 , A61P35/00
CPC分类号： C07D401/04 , C07D401/02 , C07D405/12 , C07D405/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2α, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and FLT4 kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，PDGF-R，lck，SAPK2alpha，p38，TGFbeta，KDR，c-Kit，b-RAF，c-RAF，FLT1和FLT4激酶。

83. 发明申请

US20090206820A1 REAL-TIME MONITORING OF PARTICLES IN SEMICONDUCTOR VACUUM ENVIRONMENT 有权
标题翻译：半导体真空环境中颗粒的实时监测
公开(公告)号：US20090206820A1
公开(公告)日：2009-08-20
申请号：US11773197
申请日：2007-07-03
申请人： David Y. Pui , Yi Liu , Christof Asbach , Heinz Fissan
发明人： David Y. Pui , Yi Liu , Christof Asbach , Heinz Fissan
IPC分类号： G01N27/00
CPC分类号： G03F7/70908 , G01N15/0656 , Y10T436/107497 , Y10T436/108331
摘要： An apparatus includes semiconductor processing equipment. A particle detecting integrated circuit is positioned in a vacuum environment, the particle detecting integrated circuit containing a device having a pair of conductive lines exposed to the vacuum environment. The pair of conductive lines is spaced at a critical pitch corresponding to diameters of particles of interest. A computer system is linked to the particle detecting integrated circuit to detect a change in an electrical property of the conductive lines when a particle becomes lodged between or on the lines.
摘要翻译：一种装置包括半导体处理设备。粒子检测集成电路位于真空环境中，粒子检测集成电路包含具有暴露于真空环境的一对导线的器件。一对导线以对应于感兴趣的颗粒的直径的临界间距隔开。计算机系统连接到粒子检测集成电路，以当粒子在线路之间或线路上时检测导线的电特性的变化。

84. 发明申请

US20090012094A1 DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS 有权
标题翻译：含二氨基苯胺的化合物和组合物及其作为C-kit接受体的调节剂
公开(公告)号：US20090012094A1
公开(公告)日：2009-01-08
申请号：US11933030
申请日：2007-10-31
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： A61K31/496 , C07D239/42 , C07D407/14 , C12N9/12 , A61K31/505
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
摘要翻译：本文描述的是包括二芳基胺结构特征的化合物。本文还描述了制备这种化合物的方法，使用这些化合物调节c-kit受体的活性的方法，以及包含这些化合物的药物组合物和药物。本文还描述了使用这些化合物，药物组合物和药物来治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或病症的方法。

85. 发明授权

US07449582B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07449582B2
公开(公告)日：2008-11-11
申请号：US10961646
申请日：2004-10-08
申请人： Qiang Ding , Yongping Xie , Nathanael S. Gray , Shuli You , Greg Chopiuk , Jiqing Jiang , Yi Liu , Ruo Steensma , Xing Wang , Taebo Sim
发明人： Qiang Ding , Yongping Xie , Nathanael S. Gray , Shuli You , Greg Chopiuk , Jiqing Jiang , Yi Liu , Ruo Steensma , Xing Wang , Taebo Sim
IPC分类号： C07D215/38 , C07D471/02 , C07D251/38
CPC分类号： C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGFβ, SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2β kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，CSK，JNK1，JNK2，PDGF-R，p38，p70S6K，TGFbeta，SRC，EGFR，c-Kit，trkB，FGFR3，Fes，Lck，Syk，RAF，MKK4，MKK6和SAPK2β激酶。

86. 发明授权

US07423038B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07423038B2
公开(公告)日：2008-09-09
申请号：US11570661
申请日：2005-06-23
申请人： Pingda Ren , Xia Wang , Nathanael Schiander Gray , Yi Liu , Taebo Sim
发明人： Pingda Ren , Xia Wang , Nathanael Schiander Gray , Yi Liu , Taebo Sim
IPC分类号： A61K31/5355 , C07D413/10 , C07D475/00 , A61P35/00
CPC分类号： C07D475/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders than involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3β, IR, JNK1α 1, JNK2α 2, Lck, MKK4, MKK6, p70S6K, PDGFRα, Rsk1, SAPK2α, SAPK2β, Syk and Trkβ kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性特别是疾病或病症相关的疾病或病症的方法，而不是涉及Abl，Bcr-abl的异常活化，Bmx，c-RAF，CSK，Fes，FGFR3，Flt3，GSK3beta，IR，JNK1alpha1，JNK2alpha2，Lck，MKK4，MKK6，p70S6K，PDGFRalpha，Rsk1，SAPK2alpha，SAPK2beta，Syk和Trkbeta激酶。

87. 发明申请

US20080139559A1 DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS 有权
公开(公告)号：US20080139559A1
公开(公告)日：2008-06-12
申请号：US11933056
申请日：2007-10-31
申请人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号： A61K31/5377 , A61K31/506 , C12N9/12 , A61K31/505
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

88. 发明申请

US20080135773A1 Data Display System and Method 有权
标题翻译：数据显示系统和方法
公开(公告)号：US20080135773A1
公开(公告)日：2008-06-12
申请号：US11659364
申请日：2005-08-05
申请人： James Richard Tickner , Yi Liu
发明人： James Richard Tickner , Yi Liu
IPC分类号： G01N23/05 , G01D18/00 , G01N23/06
CPC分类号： G01N23/06
摘要： A method for processing transmission data from neutron and gamma-ray radiation to form an image, the neutron and gamma-ray radiation having traversed through an object and representing a measure of neutron attenuation and gamma-ray attenuation introduced by the object, comprising forming a neutron mass attenuation matrix ‘n’ and gamma-ray mass attenuation matrix ‘g’ from the measure of neutron attenuation and gamma-ray attenuation respectively; calculating a composition matrix R whose elements Rij are defined as a function of elements nij from ‘n’ and the corresponding elements gij from ‘g’, R representing an average composition of material between a source which generated the radiation and a point (i,j); calculating a density matrix X whose elements Xij are defined as a function of the elements nij from ‘n’ and the corresponding elements gij from ‘g’, X representing an approximate amount of material between the radiation source and the point (i,j); calculating a quality matrix Q as a function of the elements nij from the ‘n’ and the elements gij from ‘g’, Q representing a measure of the reliability of the elements of Rij; and forming an image for display; wherein the image contains information from R, X and Q.
摘要翻译：一种用于处理从中子和伽马射线辐射的透射数据以形成图像的方法，中子和伽马射线已经穿过物体并表示由物体引入的中子衰减和伽马射线衰减的测量，包括形成分别测量中子衰减和伽马射线衰减的中子质量衰减矩阵'n'和伽马射线质量衰减矩阵'g' 计算其元素R ij ij的组成矩阵R被定义为来自'n'的元素n ij的函数，并且相应元素g'ij < “g”，R表示产生辐射的源和点（i，j）之间的材料的平均组成; 计算其元素X ij ij的密度矩阵X被定义为来自'n'的元素n'ij的函数，并且相应的元素g ij ij < 来自'g'，X表示辐射源和点（i，j）之间的物质的大致量; 作为来自'n'的元素n 的元素的质量矩阵Q和来自'g'的元素g ij i'，Q表示可靠性的度量 R ij的元素; 并形成用于显示的图像; 其中图像包含来自R，X和Q的信息。

89. 发明授权

US07338957B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07338957B2
公开(公告)日：2008-03-04
申请号：US10927992
申请日：2004-08-26
申请人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Tetsuo Uno
发明人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Tetsuo Uno
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2α and SAPK2β kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，CSK，TrkB，FGFR3，Fes，Lck，B-RAF，C-RAF，MKK6，SAPK2alpha和SAPK2β激酶。

90. 发明申请

US20060278784A1 Mounting device 审中-公开
标题翻译：安装装置
公开(公告)号：US20060278784A1
公开(公告)日：2006-12-14
申请号：US11371271
申请日：2006-03-08
申请人： Yi Liu
发明人： Yi Liu
IPC分类号： A47B96/06 , E04G5/06
CPC分类号： G01C15/004
摘要： The present invention discloses a mounting device comprising a supporting frame comprising a chamber therein which is covered by a bottom cover. The chamber includes at least one positioning pin and at least one first spring. A first button is located on the supporting frame and cooperates with the positioning pin. The bottom cover includes at least one aperture corresponding to the positioning pin. A second button acting as a safety switch is located on the supporting frame. When pressing both the first button and the second button, the positioning pin can be pushed out of the bottom cover. If the second button is not pressed, the first button is thus locked, so that the positioning pin is incapable of extending out of the chamber. Due to the second button being added as a safety switch, the operator can press the first button downward so as to push the positioning pins out only after the second button is pressed first. Thus, the operator will not be accidentally stabbed if either one of the two buttons is pressed carelessly so that the overall safety of the device is improved greatly.
摘要翻译：本发明公开了一种安装装置，其包括支撑框架，该支撑框架包括由底盖覆盖的室。所述腔室包括至少一个定位销和至少一个第一弹簧。第一按钮位于支撑框架上并与定位销配合。底盖包括对应于定位销的至少一个孔。作为安全开关的第二按钮位于支撑框架上。当按下第一按钮和第二按钮时，定位销可以从底盖推出。如果没有按下第二按钮，则第一按钮被锁定，使得定位销不能伸出室。由于第二按钮被添加为安全开关，操作者可以向下按第一按钮，以便仅在第一按钮被按下之后才将定位销推出。因此，如果两个按钮中的任一个不小心被按压，则操作者不会被意外地刺伤，从而大大提高了装置的整体安全性。

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