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81. 发明授权

US08906685B2 Hanging drop devices, systems and/or methods 有权
标题翻译：悬挂设备，系统和/或方法
公开(公告)号：US08906685B2
公开(公告)日：2014-12-09
申请号：US13575558
申请日：2011-01-28
申请人： Shuichi Takayama , Yi-Chung Tung , Amy Yu-Ching Hsiao , Edward Jan
发明人： Shuichi Takayama , Yi-Chung Tung , Amy Yu-Ching Hsiao , Edward Jan
IPC分类号： C12N5/00 , C40B30/06 , B01L3/00 , C12M1/32 , C12M1/12 , G01N35/10 , G01N35/02
CPC分类号： C12N5/0062 , B01L3/50853 , B01L3/50857 , B01L3/5088 , B01L2200/025 , B01L2200/141 , B01L2200/142 , B01L2300/0829 , B01L2300/161 , B33Y80/00 , C12M23/12 , C12M25/01 , G01N35/028 , G01N2035/1046
摘要： The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.
摘要翻译：本公开内容涉及在产生和处理悬滴液体中使用这些装置的装置，系统和方法。本公开还涉及使用这种装置的细胞培养装置，方法和/或系统以及细胞培养装置的使用，例如用于研究和高通量筛选。

82. 发明授权

US08865464B2 Microfluidic cell culture device 有权
标题翻译：微流体细胞培养装置
公开(公告)号：US08865464B2
公开(公告)日：2014-10-21
申请号：US12854465
申请日：2010-08-11
申请人： Shuichi Takayama , Lourdes Marcella Cabrera , Yun Seok Heo , Gary Daniel Smith
发明人： Shuichi Takayama , Lourdes Marcella Cabrera , Yun Seok Heo , Gary Daniel Smith
IPC分类号： C12N5/07 , C12N5/16 , C12N5/00 , C12M1/00 , C12M3/06 , B01L3/00
CPC分类号： C12N5/0075 , B01L3/5027 , B01L3/5085 , C12M23/12 , C12M23/16 , C12M23/34
摘要： Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.
摘要翻译：公开了用于细胞培养的微流体装置及其使用方法。一个装置包括基底和膜。衬底包括与通道流体连通的储存器。可以将生物相容的流体添加到储存器和通道中。储存器被配置为接收和保留细胞块的至少一部分。膜作为生物相容性流体从通道蒸发的障碍。可以加入覆盖流体以覆盖生物相容性流体以防止生物相容性流体的蒸发。

83. 发明申请

US20130040855A1 HANGING DROP DEVICES, SYSTEMS AND/OR METHODS 有权
标题翻译：悬挂装置，系统和/或方法
公开(公告)号：US20130040855A1
公开(公告)日：2013-02-14
申请号：US13575558
申请日：2011-01-28
申请人： Shuichi Takayama , Yi-Chung Tung , Amy Yu-Ching Hsiao , Edward Jan
发明人： Shuichi Takayama , Yi-Chung Tung , Amy Yu-Ching Hsiao , Edward Jan
IPC分类号： C40B60/14 , C40B40/10 , C40B30/06 , C40B40/02 , C40B40/00 , B82Y15/00
CPC分类号： C12N5/0062 , B01L3/50853 , B01L3/50857 , B01L3/5088 , B01L2200/025 , B01L2200/141 , B01L2200/142 , B01L2300/0829 , B01L2300/161 , B33Y80/00 , C12M23/12 , C12M25/01 , G01N35/028 , G01N2035/1046
摘要： The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.
摘要翻译：本公开内容涉及在产生和处理悬滴液体中使用这些装置的装置，系统和方法。本公开还涉及使用这种装置的细胞培养装置，方法和/或系统以及细胞培养装置的使用，例如用于研究和高通量筛选。

84. 发明授权

US08345166B2 Broadcast receiving circuit and broadcast receiving apparatus 有权
标题翻译：广播接收电路和广播接收装置
公开(公告)号：US08345166B2
公开(公告)日：2013-01-01
申请号：US13099745
申请日：2011-05-03
申请人： Hiroki Kawai , Keiichi Kuroda , Shuichi Takayama
发明人： Hiroki Kawai , Keiichi Kuroda , Shuichi Takayama
IPC分类号： H04N5/268
CPC分类号： H04N21/23424 , H04H20/10 , H04H20/26 , H04H60/37 , H04N5/4401 , H04N5/602 , H04N21/41422 , H04N21/4307 , H04N21/4394 , H04N21/44008 , H04N21/44016
摘要： A broadcast receiving apparatus in the present invention includes: a first audio data characteristics extracting unit extracting a first soundless period and first interval information from first audio data included in the first service; a second audio data characteristics extracting unit extracting a second soundless period and second interval information from second audio data included in the second service; a simulcast determining unit determining whether or not the broadcast waves are simulcast by comparing the first interval information with the second interval information; and a broadcasting switching control unit switching between (i) the output of the audio data and the video data included in the first service and (ii) the output of the audio data and the video data included in the second service based on a result of the determination by the simulcast determining unit.
摘要翻译：本发明的广播接收装置包括：第一音频数据特征提取单元，从第一服务中包括的第一音频数据提取第一无声周期和第一间隔信息; 第二音频数据特征提取单元，从第二服务中包括的第二音频数据中提取第二无声周期和第二间隔信息; 联播决定单元，通过将所述第一间隔信息与所述第二间隔信息进行比较来确定所述广播波是否是同步播放; 以及广播切换控制单元，其在（i）音频数据的输出与第一服务中包括的视频数据之间切换，以及（ii）音频数据的输出和包括在第二服务中的视频数据的输出基于联播决定单元的确定。

85. 发明申请

US20110054552A1 ELECTRODE LAYOUT METHOD OF HEART TREATMENT APPARATUS 审中-公开
标题翻译：心脏治疗装置的电极布局方法
公开(公告)号：US20110054552A1
公开(公告)日：2011-03-03
申请号：US12550772
申请日：2009-08-31
申请人： Shuichi Takayama , Toshiki Terayama , Hiroki Hibino
发明人： Shuichi Takayama , Toshiki Terayama , Hiroki Hibino
IPC分类号： A61N1/08
CPC分类号： A61N1/056 , A61N1/046
摘要： The purpose is to provide an electrode layout method of a heart treatment apparatus, which is capable of improving the heart treatment efficiency by setting electrodes in the heart as well as reducing the invasion into the patient so as to effectively stimulate a site which needs to be stimulated. There is provided an electrode layout method of a heart treatment apparatus comprising: inserting at least two lines of leads which are provided to the heart treatment apparatus and which have electrodes on their distal ends, into a vein communicated to the interior of a right atrium and extending along a cardiac wall; and placing the electrodes provided on the respective leads in the vein located at approximately opposite positions across a heart.
摘要翻译：目的是提供一种心脏治疗装置的电极布置方法，其能够通过在心脏中设置电极来改善心脏治疗效率，并且减少对患者的侵入，从而有效地刺激需要刺激。提供了一种心脏治疗装置的电极布置方法，包括：插入提供给心脏治疗装置并且在其远端具有电极的至少两条引线，连接到连通到右心房内部的静脉，以及沿心墙延伸; 并且将设置在相应引线上的电极放置在位于穿过心脏的大致相对位置处的静脉中。

86. 发明申请

US20070090166A1 Microfluidic cell culture device 审中-公开
标题翻译：微流体细胞培养装置
公开(公告)号：US20070090166A1
公开(公告)日：2007-04-26
申请号：US11582027
申请日：2006-10-17
申请人： Shuichi Takayama , Lourdes Cabrera , Yun Heo , Gary Smith
发明人： Shuichi Takayama , Lourdes Cabrera , Yun Heo , Gary Smith
IPC分类号： A47J36/02
CPC分类号： C12N5/0075 , B01L3/5027 , B01L3/5085 , C12M23/12 , C12M23/16 , C12M23/34
摘要： Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.
摘要翻译：公开了用于细胞培养的微流体装置及其使用方法。一个装置包括基底和膜。衬底包括与通道流体连通的储存器。可以将生物相容的流体添加到储存器和通道中。储存器被配置为接收和保留细胞块的至少一部分。膜作为生物相容性流体从通道蒸发的障碍。可以加入覆盖流体以覆盖生物相容性流体以防止生物相容性流体的蒸发。

87. 发明申请

US20070084706A1 Microfluidic cell culture device and method for using same 审中-公开
标题翻译：微流体细胞培养装置及其使用方法
公开(公告)号：US20070084706A1
公开(公告)日：2007-04-19
申请号：US11582035
申请日：2006-10-17
申请人： Shuichi Takayama , Lourdes Cabrera , Nobuyuki Futai , Yun Heo , Gary Smith
发明人： Shuichi Takayama , Lourdes Cabrera , Nobuyuki Futai , Yun Heo , Gary Smith
IPC分类号： H01H29/00
CPC分类号： B01L3/502738 , B01L2200/142 , B01L2300/0816 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/34
摘要： Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.
摘要翻译：公开了用于细胞培养的微流体装置及其使用方法。一个装置包括基底和膜。衬底包括与通道流体连通的储存器。可以将生物相容的流体添加到储存器和通道中。储存器被配置为接收和保留细胞块的至少一部分。膜作为生物相容性流体从通道蒸发的障碍。可以加入覆盖流体以覆盖生物相容性流体以防止生物相容性流体的蒸发。

88. 发明申请

US20060177937A1 Flow cytometers and detection system of lesser size 有权
公开(公告)号：US20060177937A1
公开(公告)日：2006-08-10
申请号：US11384477
申请日：2006-03-20
申请人： Katsuo Kurabayashi , Shuichi Takayama , Steven Skerlos , Dongeun Huh , James Grotberg , Yi-Chung Tung
发明人： Katsuo Kurabayashi , Shuichi Takayama , Steven Skerlos , Dongeun Huh , James Grotberg , Yi-Chung Tung
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1413 , G01N2015/149 , Y10T436/2575
摘要： Gas focusing flow cytometers are fabricatable employing simple and inexpensive manufacturing techniques. When such cytometers or conventional cytometers are combined with fiber optical light paths and laser diode and semiconductor photodetectors, light weight and handheld, optionally disposable devices which maintain high performance are possible.

89. 发明授权

US5850551A Compiler and processor for processing loops at high speed 失效
标题翻译：用于高速处理回路的编译器和处理器
公开(公告)号：US5850551A
公开(公告)日：1998-12-15
申请号：US588051
申请日：1996-01-22
申请人： Shuichi Takayama , Nobuo Higaki , Nobuki Tominaga , Shinya Miyaji
发明人： Shuichi Takayama , Nobuo Higaki , Nobuki Tominaga , Shinya Miyaji
IPC分类号： G06F9/32 , G06F9/38 , G06F9/45
CPC分类号： G06F9/3804 , G06F8/447 , G06F9/325
摘要： A compiler comprises a loop detecting unit for extracting information of loops, and a high-speed loop applying unit generating a first loop exclusive instruction, placing the instruction immediately before the entry of a loop, generating second loop exclusive instructions, and placing the instruction at each place to branch to the entry of the loop. A processor comprises: a pipeline comprising: an instruction fetching unit, an instruction decoding unit, and an executing unit; a branch target storage unit; a branch target registering unit for, after the instruction decoding unit has decoded a first loop exclusive instruction, registering branch target information of an instruction succeeding to the first loop exclusive instruction in the branch target registering unit; and a branch executing unit for, after the decoding unit has decoded a second loop exclusive instruction, judging whether to execute a loop, if judges to execute, reading the branch target information registered in the branch target storage unit, and controlling the pipeline so that the program executes the loop using the read branch target information.
摘要翻译：编译器包括一个用于提取循环信息的循环检测单元和一个生成第一循环专用指令的高速循环应用单元，在循环进入之前立即进行指令，产生第二循环专用指令，并将指令置于每个地方分支到循环的入口。一种处理器，包括：流水线，包括：指令获取单元，指令解码单元和执行单元; 分支目标存储单元; 分支目标登记单元，用于在所述指令解码单元解码了第一循环专用指令之后，将在所述分支目标登记单元中的所述第一循环专用指令之后的指令的分支目标信息注册; 以及分支执行单元，用于在解码单元解码了第二循环专用指令之后，判断是否执行循环，如果判断执行，读取登记在分支目标存储单元中的分支目标信息，并且控制流水线，使得该程序使用读分支目标信息执行循环。

90. 发明授权

US5766887A Synthesis of 9-0-acetyl N-acetylneuraminic acid oligosaccharides 失效
标题翻译： 9-0-乙酰基N-乙酰神经氨酸寡糖的合成
公开(公告)号：US5766887A
公开(公告)日：1998-06-16
申请号：US703093
申请日：1996-08-26
申请人： Chi-Huey Wong , Shuichi Takayama
发明人： Chi-Huey Wong , Shuichi Takayama
IPC分类号： C07H15/10 , C12P19/26 , C12P19/44 , C12N9/24
CPC分类号： C07H15/10 , C12P19/26
摘要： Regioselective acetylation of the 9-hydroxyl group on N-acetylneuraminic acid is achieved enzymatically for producing oligosaccharides which contain a terminal N-acetylneuraminic acid moiety. This method provides access to O-acylated disialogangliosides as well as other N-acetyl-neuraminic acid oligosaccharides. These compounds are biologically and medicinally important and are difficult to obtain from nature or by chemical acylations. The methodology affords simple reaction conditions and minimal purification steps. In addition, the process affords good yields and the enzymes and reagents employed are commercially available with high stability and low costs.
摘要翻译：在N-乙酰神经氨酸的N-羟基上的区域选择性乙酰化被酶促用于制备含有末端N-乙酰神经氨酸部分的寡糖。该方法提供了获得O-酰化二唾液酸神经节苷脂以及其它N-乙酰神经氨酸寡糖。这些化合物在生物学和医学上是重要的，并且难以从自然或通过化学酰化获得。该方法提供简单的反应条件和最小的纯化步骤。此外，该方法提供良好的产率，所用的酶和试剂可以高稳定性和低成本商业获得。

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