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81. 发明授权

US06706059B2 Reforming wet-tantalum capacitors in implantable medical devices 失效
标题翻译：在植入式医疗设备中改造湿钽电容器
公开(公告)号：US06706059B2
公开(公告)日：2004-03-16
申请号：US09990180
申请日：2001-11-21
申请人： Robert S. Harguth , Ron A. Balczewski , William J. Linder , Gregory S. Munson , Michael W. Paris
发明人： Robert S. Harguth , Ron A. Balczewski , William J. Linder , Gregory S. Munson , Michael W. Paris
IPC分类号： A61N100
CPC分类号： H01G9/042 , A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Critical to this function, aluminum-electrolytic capacitors store and deliver life-saving bursts of electric charge to the heart. This type of capacitor requires regular “reform” to preserve its charging efficiency over time. Because reform expends valuable battery energy, manufacturers developed wet-tantalum capacitors, which are generally understood not to require reform. Yet, the present inventors discovered through extensive study that wet-tantalum capacitors exhibit progressively worse charging efficiency over time. Accordingly, to address this problem, the inventors devised unique reform techniques for wet-tantalum capacitors. One exemplary technique entails charging wet-tantalum capacitors to a voltage equal to about 90% of their rated voltage and allowing the charge to dissipate through system leakage for a period of time, before discharging through a non-therapeutic load.
摘要翻译：微型除颤器和心脏转复器检测异常心律，并自动应用电疗法恢复正常的心脏功能。这个功能至关重要的是，铝电解电容器可以将心脏中的电荷充满拯救生命。这种类型的电容器需要经常的“改造”以保持其充电效率随着时间的推移。由于改革耗费了宝贵的电池能量，所以制造商开发了湿钽电容器，通常被认为不需要改造。然而，本发明人通过广泛的研究发现，湿钽电容器随着时间的推移呈现逐渐变差的充电效率。因此，为了解决这个问题，本发明人为湿钽电容器设计了独特的改进技术。一个示例性技术需要将湿钽电容器充电至等于其额定电压的约90％的电压，并且在通过非治疗负载放电之前允许电荷通过系统泄漏耗散一段时间。

82. 发明授权

US06574510B2 Telemetry apparatus and method for an implantable medical device 有权
公开(公告)号：US06574510B2
公开(公告)日：2003-06-03
申请号：US09727093
申请日：2000-11-30
申请人： Jeffrey A. Von Arx , Mark D. Amundson , William R. Mass , Ron Balczewski , William J. Linder
发明人： Jeffrey A. Von Arx , Mark D. Amundson , William R. Mass , Ron Balczewski , William J. Linder
IPC分类号： A61N1372
CPC分类号： A61N1/37223 , A61N1/37229 , A61N1/3727 , Y10S128/901 , Y10S128/903
摘要： An apparatus and method for enabling radio-frequency communications with an implantable medical device utilizing far-field electromagnetic radiation. Such radio-frequency communications can take place over much greater distances than with inductively coupled antennas.

83. 发明授权

US06317632B1 Apparatus and method for treating ventricular tachyarrhythmias 有权
标题翻译：用于治疗室性快速性心律失常的装置和方法
公开(公告)号：US06317632B1
公开(公告)日：2001-11-13
申请号：US09686585
申请日：2000-10-11
申请人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
发明人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
IPC分类号： A61N1262
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A system and method for selectively treating a ventricular tachycardia based on sensed atrial and ventricular intervals from the patient's heart. A detection window of the ten most recent atrial and ventricular intervals are analyzed for the occurrence of either tachycardia or fibrillation. When a majority of the sensed intervals are satisfied, the apparatus starts a duration time interval. Ventricular intervals and atrial intervals are compare, ventricular interval greater than the atrial interval by a bias factor the system delivers tachycardia therapy to the heart. Alternatively, the method withholds tachycardia therapy to the heart when the atrial rate is classified as atrial fibrillation and the ventricular response is unstable.
摘要翻译：一种系统和方法，用于根据来自患者心脏的感觉的心房和心室间隔选择性地治疗室性心动过速。分析十个最近的心房和心室间隔的检测窗口，用于心动过速或颤动的发生。当满足感测间隔的大部分时，设备开始持续时间间隔。比较心室间隔和心房间隔，心室间隔大于心房间隔，系统将心动过速治疗提供给心脏。或者，当心房率被分类为心房颤动和心室反应不稳定时，该方法禁止对心脏的心动过速治疗。

84. 发明授权

US06310512B1 Integrated self-adjustable continuous time band pass filter based upon Gm cell with bipolar transistors 失效
标题翻译：基于具有双极晶体管的Gm单元的集成自调节连续时间带通滤波器
公开(公告)号：US06310512B1
公开(公告)日：2001-10-30
申请号：US09447176
申请日：1999-11-22
申请人： Boris Briskin , William J. Linder
发明人： Boris Briskin , William J. Linder
IPC分类号： H03K500
CPC分类号： A61N1/36521
摘要： An improved integrated self-adjustable continuous time band pass filter based upon a Gm cell with Gm compensation and bipolar transistors for use in a low power processing system for processing bursted amplitude modulated signals performing impedance-related measurements across a load. The system may be used for estimating stroke volume using the output and/or estimating hemodynamic maximum sensor rate using the output. The improved Gm cell provides for stabilization of the transconductance by compensating for manufacturing process variation of the value of the linearizing resistance RG by varying the transconductance bias current using a feedback signal proportional to the resistance of a resistor which is a replicate of the linearizing resistor.
摘要翻译：基于具有Gm补偿的Gm单元和用于低功率处理系统的双极晶体管的改进的集成自调节连续时间带通滤波器，用于处理在负载上执行阻抗相关测量的突发幅度调制信号。该系统可以用于使用输出来估计冲程体积和/或使用输出来估计血流动力学最大传感器速率。通过使用与线性化电阻器的重复电阻的电阻成比例的反馈信号来改变跨导偏置电流来补偿线性化电阻RG的值的制造工艺变化，改进的Gm单元提供跨导的稳定性。

85. 发明授权

US06292050B1 Current and temperature compensated voltage reference having improved power supply rejection 有权
标题翻译：电流和温度补偿电压基准具有改进的电源抑制
公开(公告)号：US06292050B1
公开(公告)日：2001-09-18
申请号：US09260206
申请日：1999-03-01
申请人： Michael W. Dooley , Terrence L. Marshall , William J. Linder , Suneel Arora
发明人： Michael W. Dooley , Terrence L. Marshall , William J. Linder , Suneel Arora
IPC分类号： G05F110
CPC分类号： G05F3/245 , A61N1/3706
摘要： A current and temperature compensated voltage reference circuit uses a power supply voltage as low as 1.3 Volts. A folded-cascode amplifier measures the temperature dependent voltages provided by first and second bias circuits, each including two series-coupled diodes or diode-connected bipolar junction transistors (BJTs), and provides a resulting proportional to absolute temperature (PTAT) current through a cascode-protected output transistor. A voltage reference circuit uses a PTAT current through a resistor to create a PTAT voltage in series with a diode-voltage. The resistor value is adjusted until the sum of these voltages is equal to the bandgap voltage of silicon, providing a temperature compensated voltage reference. The reference circuit is suitable for use with an implantable cardiac rhythm management system having a battery that provides a power supply voltage varying approximately between 1.3 Volts and 3.25 Volts. Cascode-protected current mirrors further improve rejection of such variations in the power supply voltage.
摘要翻译：电流和温度补偿电压参考电路使用低至1.3伏的电源电压。折叠共源共栅放大器测量由第一和第二偏置电路提供的与温度相关的电压，每个电压包括两个串联耦合的二极管或二极管连接的双极结型晶体管（BJT），并提供与绝对温度（PTAT）电流成比例的结果共源共栅保护的输出晶体管。电压参考电路使用通过电阻器的PTAT电流来产生与二极管电压串联的PTAT电压。调整电阻值，直到这些电压之和等于硅的带隙电压，提供温度补偿电压基准。参考电路适用于具有电池的可植入心律管理系统，该电池提供约1.3伏至3.25伏变化的电源电压。串联保护的电流镜进一步改善了对电源电压的这种变化的抑制。

86. 发明授权

US5869970A Power management system for an implantable device 失效
公开(公告)号：US5869970A
公开(公告)日：1999-02-09
申请号：US550835
申请日：1995-10-31
申请人： William A. Palm , Lloyd A. Van Hofwegen , Jean-Cheui Hsung , Michael W. Dooley , Keith R. Maile , William J. Linder , David W. Kelly , Jeffrey Laackmann , Richard J. Wessels
发明人： William A. Palm , Lloyd A. Van Hofwegen , Jean-Cheui Hsung , Michael W. Dooley , Keith R. Maile , William J. Linder , David W. Kelly , Jeffrey Laackmann , Richard J. Wessels
IPC分类号： A61N1/37 , A61N1/378 , A61N1/39
CPC分类号： A61N1/378 , A61N1/3708 , A61N1/3937 , A61N1/3975 , A61N1/3981 , Y10T307/826 , Y10T307/839 , Y10T307/858
摘要： A power management system for an implantable device is disclosed. One application is an implantable cardioverter/defibrillator. Charging circuits for implantable cardioverter/defibrillators require relatively large currents from the power supply. The present power management system provides extended device operation and reduced charge cycle time. The present system monitors both current and voltage drawn from the power supply to prevent a loss of system voltage. Elective replacement indication is performed using charging information provided by the present power management system.

87. 发明授权

US08509888B2 Implantable medical device with hall sensor 有权
标题翻译：具有霍尔传感器的植入式医疗设备
公开(公告)号：US08509888B2
公开(公告)日：2013-08-13
申请号：US13397995
申请日：2012-02-16
申请人： William J. Linder , Angela M. Muttonen
发明人： William J. Linder , Angela M. Muttonen
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/3718 , Y10T29/49117
摘要： An implantable medical device can include a Hall effect sensor. The Hall effect sensor can include a first pair of electrical contacts and a second pair of electrical contacts. In an example, the Hall effect sensor can be configured to sense a magnetic field and can be configured to provide a voltage corresponding to a magnitude of the sensed magnetic field.
摘要翻译：可植入医疗装置可以包括霍尔效应传感器。霍尔效应传感器可以包括第一对电触点和第二对电触头。在一个示例中，霍尔效应传感器可以被配置为感测磁场，并且可以被配置为提供对应于所感测的磁场的大小的电压。

88. 发明授权

US08452401B2 Method and device for comprehensive anti-tachyarrhythmia therapy 有权
标题翻译：综合性抗心律失常治疗方法和装置
公开(公告)号：US08452401B2
公开(公告)日：2013-05-28
申请号：US13287842
申请日：2011-11-02
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/3962
摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. In one embodiment, neural stimulation, anti-tachycardia pacing, and shock therapy are employed in a progressive sequence upon detection of a ventricular tachycardia.
摘要翻译：描述了用于递送治疗以治疗室性快速性心律失常的方法和装置。在一个实施例中，在检测到室性心动过速时，采用进行性顺序的神经刺激，抗心动过速起搏和休克疗法。

89. 发明授权

US08369945B2 Implantable cardioverter defibrillator with programmable capacitor charging level 有权
标题翻译：可植入式心律转复除颤器，具有可编程电容充电等级
公开(公告)号：US08369945B2
公开(公告)日：2013-02-05
申请号：US13190107
申请日：2011-07-25
申请人： Nick A. Youker , Kenneth N. Hayes , William J. Linder
发明人： Nick A. Youker , Kenneth N. Hayes , William J. Linder
IPC分类号： A61N1/39
CPC分类号： A61N1/3708 , A61N1/37235 , A61N1/3925 , A61N1/3956 , A61N1/3975 , A61N1/3981
摘要： An implantable cardioverter defibrillator (ICD) has a programmable ICD energy level corresponding to the maximum defibrillation energy deliverable with each defibrillation shock pulse. The ICD energy level is programmable within the maximum energy capacity of the defibrillation capacitor(s) of the ICD. In various embodiments, after a user enters the ICD energy level, one or more corresponding ICD performance parameters are presented. Restrictions are applied to the energy level programming of the ICD to ensure the predictability of the one or more ICD performance parameters.
摘要翻译：植入式心律转复除颤器（ICD）具有对应于每个除颤冲击脉冲可递送的最大除颤能量的可编程ICD能量水平。 ICD能量级可在ICD的除颤电容器的最大能量容量内编程。在各种实施例中，在用户进入ICD能级之后，呈现一个或多个相应的ICD性能参数。限制适用于ICD的能量级编程，以确保一个或多个ICD性能参数的可预测性。

90. 发明申请

US20120143274A1 DEFIBRILLATION SHOCK OUTPUT CIRCUIT 有权
标题翻译：去颤动输出电路
公开(公告)号：US20120143274A1
公开(公告)日：2012-06-07
申请号：US13368882
申请日：2012-02-08
申请人： William J. Linder , Hari Sree
发明人： William J. Linder , Hari Sree
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： This document discusses, among other things, techniques for generating and delivering a high voltage defibrillation shock using an implantable cardiac rhythm management device. An output energy delivery bridge can be programmed to provide desired shock vectors or polarities. A bootstrapped fully solid-state switch control voltage generation circuit is described. Automatic polarity or vector reconfiguration embodiments are described, such as in response to an unsuccessful attempt to convert the heart to a normal rhythm.
摘要翻译：本文件尤其涉及使用可植入式心律管理装置产生和递送高压除颤电击的技术。输出能量输送桥可以被编程以提供期望的震动矢量或极性。描述了自举完全固态开关控制电压产生电路。描述了自动极性或向量重新配置实施例，例如响应于将心脏转换成正常节奏的不成功的尝试。

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