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81. 发明申请

US20160015564A1 DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE 有权
公开(公告)号：US20160015564A1
公开(公告)日：2016-01-21
申请号：US14802503
申请日：2015-07-17
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
IPC分类号： A61F9/007 , A61M5/142 , A61M5/145 , A61F9/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

82. 发明申请

US20140336563A1 ULTRASOUND AND MICROBUBBLES IN OCULAR DIAGNOSTICS AND THERAPIES 审中-公开
标题翻译：超声诊断和治疗中的超声和微生物
公开(公告)号：US20140336563A1
公开(公告)日：2014-11-13
申请号：US14278320
申请日：2014-05-15
申请人： Amani Fawzi , Hossein Ameri , Mark S. Humayun
发明人： Amani Fawzi , Hossein Ameri , Mark S. Humayun
IPC分类号： A61M37/00 , A61B8/08 , A61B8/10
CPC分类号： A61M37/0092 , A61B8/08 , A61B8/10 , A61B8/481 , A61B8/483 , A61F9/008 , A61F2009/00863 , A61K38/00 , A61K41/0014 , A61K49/223 , A61M31/00 , A61N7/00 , G01N2203/0076 , G01N2203/0658
摘要： The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.
摘要翻译：本公开描述了用于应用对比度增强的超声来定位视网膜血管内的阻塞区域并破坏导致损伤的血块的方法，系统和技术。研究人员除了识别受损区域之外，还预期初始图像可以作为监测血管治疗效果的基准，这可以通过多种方式实现。超声波本身的振动效应足以消除凝块。微泡也可以用药物涂覆或填充，超声冲击波激活涂层或引起微小的爆炸以释放药物。使用治疗剂加载微泡，使用超声诊断模式观察其在患病部位的存在，然后激活微泡以在目标病变处释放其内容物可能是一种强有力的有效方式来反向阻塞而不伤害其他区域眼睛或身体。

83. 发明授权

US08886329B2 Retinal prosthesis with separate electrode array and return electrodes 有权
标题翻译：视网膜假体具有独立的电极阵列和返回电极
公开(公告)号：US08886329B2
公开(公告)日：2014-11-11
申请号：US13227132
申请日：2011-09-07
申请人： Robert Jay Greenberg , Mark S. Humayun
发明人： Robert Jay Greenberg , Mark S. Humayun
IPC分类号： A61N1/05 , A61N1/36 , A61F9/08
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array external to the sclera near the periphery of the retina. It is advantageous to encourage current to flow through the retina by providing a physically separate and distinct electrode array and return electrode. The high-resolution electrode array and lower-resolution electrode array may be return electrodes for the other, or completely separate return electrodes may be provided.
摘要翻译：光的人造感知可以通过电刺激视网膜的神经元来产生。虽然在视网膜内部的光刻阵列提供优异的分辨率，但在视网膜外部的阵列提供更容易的植入和改进的可制造性。因此，在中央凹附近提供巩膜内部的高分辨率电极阵列和在视网膜周围附近的巩膜外部的较低分辨率的电极阵列是有利的。通过提供物理上分离和不同的电极阵列和返回电极来鼓励电流流过视网膜是有利的。高分辨率电极阵列和低分辨率电极阵列可以是另一个的返回电极，或者可以提供完全分离的返回电极。

84. 发明授权

US08852290B2 Biocompatible implants and methods of making and attaching the same 有权
标题翻译：生物相容性植入物及其制造和附着方法
公开(公告)号：US08852290B2
公开(公告)日：2014-10-07
申请号：US12041651
申请日：2008-03-03
申请人： Adrian P. Rowley , Lucien D. Laude , Mark S. Humayun , James D. Weiland , Atoosa Lotfi , Francis S. Markland, Jr.
发明人： Adrian P. Rowley , Lucien D. Laude , Mark S. Humayun , James D. Weiland , Atoosa Lotfi , Francis S. Markland, Jr.
IPC分类号： A61F2/02 , A61L27/34 , A61L27/50 , A61N1/05 , A61N1/36 , A61F2/14
CPC分类号： A61F2/148 , A61L27/34 , A61L27/50 , A61L2400/18 , A61N1/0543 , A61N1/36 , A61N1/36046 , C08L89/00
摘要： The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.
摘要翻译：本发明提供了一种生物相容的硅氧烷植入物，其通过与整合的蛋白质（整联蛋白）的相互作用可靠地固定在生物体组织上。使用含有激光激活表面的硅胶制品来制造植入物。一个例子是用于治疗由视网膜外变性疾病引起的失明的可植入假体。该装置绕过受损的光感受器并电刺激视网膜的未损伤的神经元。使用硅微电极阵列（MEA）实现电刺激。使用安全的蛋白质粘合剂将MEA附着到视网膜表面并有助于减轻焦点压力的影响。还提供了制造和附接这种植入物的方法。

85. 发明授权

US08655452B2 Method and apparatus for treating ischemic diseases 有权
标题翻译：治疗缺血性疾病的方法和装置
公开(公告)号：US08655452B2
公开(公告)日：2014-02-18
申请号：US13488302
申请日：2012-06-04
申请人： Elias Greenbaum , Mark S. Humayun
发明人： Elias Greenbaum , Mark S. Humayun
IPC分类号： A61N1/36
CPC分类号： A61N1/20 , A61N1/205 , A61N1/32 , A61N1/326
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译：本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病性视网膜病变和视网膜和脉络膜组织缺血。在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。

86. 发明授权

US08583242B2 Subchoroidal retinal prosthesis 有权
标题翻译：脉络膜视网膜假体
公开(公告)号：US08583242B2
公开(公告)日：2013-11-12
申请号：US12348860
申请日：2009-01-05
申请人： Hossein Ameri , Mark S. Humayun , James D. Weiland
发明人： Hossein Ameri , Mark S. Humayun , James D. Weiland
IPC分类号： A61N1/32
CPC分类号： A61N1/0543
摘要： Embodiments of the present disclosure are directed to utilization of one or more arrays that are placed under the choroid. In this approach, an array is placed under the choroid. To achieve this, a scleral incision can be made without cutting the underlying choroid or retina. The array can then be inserted into the space between the sclera and choroid and is pushed to the desired place. It is possible to make several of such scleral incisions in each quadrant of the eye to insert arrays of similar or different shapes into the subchoroidal space. Following insertion of the electrode array the scleral wound may be sutured around the cable to make the array and the eye more stable.
摘要翻译：本公开的实施例涉及利用位于脉络膜下方的一个或多个阵列。在这种方法中，阵列位于脉络膜下方。为了实现这一点，可以在不切割下面的脉络膜或视网膜的情况下进行巩膜切口。然后将阵列插入巩膜和脉络膜之间的空间中，并将其推到所需的位置。可以在眼睛的每个象限中进行几个这样的巩膜切口，以将类似或不同形状的阵列插入到亚脉管空间中。在插入电极阵列之后，可以将巩膜伤口缝合在电缆周围，使阵列和眼睛更稳定。

87. 发明申请

US20130267776A1 SCANNING ENDOSCOPIC IMAGING PROBES AND RELATED METHODS 审中-公开
标题翻译：扫描内窥镜成像探针及相关方法
公开(公告)号：US20130267776A1
公开(公告)日：2013-10-10
申请号：US13908589
申请日：2013-06-03
申请人： Jeffrey Brennan , Mark S. Humayun
发明人： Jeffrey Brennan , Mark S. Humayun
IPC分类号： A61B1/00
CPC分类号： A61B5/0059 , A61B1/0002 , A61B1/00094 , A61B1/00096 , A61B1/00165 , A61B1/00172 , A61B1/00179 , A61B1/00188 , A61B1/018 , A61B1/313 , A61B3/102 , A61B5/0066 , A61F9/00763 , A61M5/178
摘要： An imaging probe may be responsive to a detector and an activator for processing an interferometric signal received from the detector and, in response to user actuation of the activator, for causing capture of an image or a video of the sample and storage thereof in a memory.
摘要翻译：成像探针可以响应于检测器和激活器，用于处理从检测器接收的干涉信号，并且响应于激活器的用户致动，用于引起样本的图像或视频的捕获并将其存储在存储器中。

88. 发明授权

US08527056B2 Encoding of size and brightness of percepts in a visual prosthesis 有权
标题翻译：视觉假体感知的尺寸和亮度的编码
公开(公告)号：US08527056B2
公开(公告)日：2013-09-03
申请号：US13097534
申请日：2011-04-29
申请人： Devyani Nanduri , Mark S. Humayun , James D. Weiland , Jessy Dorn , Robert J. Greenberg , Ione Fine
发明人： Devyani Nanduri , Mark S. Humayun , James D. Weiland , Jessy Dorn , Robert J. Greenberg , Ione Fine
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/0543
摘要： Methods of electrically stimulating percepts in a patient with a visual prosthesis are discussed. Changes in amplitude of stimulation increase both the perceived brightness and the perceived size of the precept. Changes in frequency of stimulation change the perceived brightness without altering the perceived size of the percept. Hence, a source image may be mapped to a combination of amplitude and frequency that best induces the desired image.
摘要翻译：讨论了在具有视觉假体的患者中电刺激感觉的方法。刺激幅度的变化增加了感觉的亮度和感知的尺寸。刺激频率的变化会改变感知亮度，而不会改变感知的感知尺寸。因此，源图像可以被映射到最佳地诱导期望图像的幅度和频率的组合。

89. 发明申请

US20120239125A1 Flexible Circuit Electrode Array for Improved Layer Adhesion 有权
标题翻译：柔性电路电极阵列，用于改进层粘附
公开(公告)号：US20120239125A1
公开(公告)日：2012-09-20
申请号：US13466692
申请日：2012-05-08
申请人： Robert Jay Greenberg , Mark S. Humayun
发明人： Robert Jay Greenberg , Mark S. Humayun
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The present invention is a flexible circuit electrode array for improved layer adhesions where the metal conductors overlap the polymer insulator. The steps to build the flexible circuit are as follows. Deposit a base polymer layer. Deposit a conductive trace over the base polymer layer. Deposit a top polymer layer over the trace and prepare a void in the top polymer layer smaller than the surface of the trace. Deposit an electrode on the trace through the void with a periphery larger than, and overlapping the void.
摘要翻译：本发明是用于改善层间粘附的柔性电路电极阵列，其中金属导体与聚合物绝缘体重叠。构建柔性电路的步骤如下。沉积基础聚合物层。在基础聚合物层上沉积导电迹线。将顶部聚合物层沉积在迹线上并在顶部聚合物层中制备小于痕迹表面的空隙。通过空隙将电极沉积在轨迹上，周边大于并与空隙重叠。

90. 发明授权

US08239036B2 Method of improving electrode tissue interface 有权
标题翻译：改善电极组织界面的方法
公开(公告)号：US08239036B2
公开(公告)日：2012-08-07
申请号：US13179186
申请日：2011-07-08
申请人： Samip Shah , Amy Chu Peishuan Hines , Dao Min Zhou , Robert J. Greenberg , Mark S. Humayun , James D. Weiland
发明人： Samip Shah , Amy Chu Peishuan Hines , Dao Min Zhou , Robert J. Greenberg , Mark S. Humayun , James D. Weiland
IPC分类号： A61N1/18
CPC分类号： A61N1/0543
摘要： A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.
摘要翻译：视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。通过该界面，视网膜假体电刺激神经细胞产生光的感知。电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。

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