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1. 发明授权

US09222888B2 Pulse amplitude modulated chlorophyll fluorometer 有权
标题翻译：脉冲调幅叶绿素荧光计
公开(公告)号：US09222888B2
公开(公告)日：2015-12-29
申请号：US13438562
申请日：2012-04-03
申请人： Elias Greenbaum , Jie Wu
发明人： Elias Greenbaum , Jie Wu
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N2201/0625
摘要： Chlorophyll fluorometry may be used for detecting toxins in a sample because of changes in micro algae. A portable lab on a chip (“LOAC”) based chlorophyll fluorometer may be used for toxin detection and environmental monitoring. In particular, the system may include a microfluidic pulse amplitude modulated (“PAM”) chlorophyll fluorometer. The LOAC PAM chlorophyll fluorometer may analyze microalgae and cyanobacteria that grow naturally in source drinking water.
摘要翻译：由于微藻的变化，叶绿素荧光测定法可用于检测样品中的毒素。基于芯片的便携式实验室（“LOAC”）叶绿素荧光计可用于毒素检测和环境监测。特别地，该系统可以包括微流体脉冲幅度调制（“PAM”）叶绿素荧光计。 LOAC PAM叶绿素荧光计可以分析在源饮用水中自然生长的微藻和蓝细菌。

2. 发明授权

US08655452B2 Method and apparatus for treating ischemic diseases 有权
标题翻译：治疗缺血性疾病的方法和装置
公开(公告)号：US08655452B2
公开(公告)日：2014-02-18
申请号：US13488302
申请日：2012-06-04
申请人： Elias Greenbaum , Mark S. Humayun
发明人： Elias Greenbaum , Mark S. Humayun
IPC分类号： A61N1/36
CPC分类号： A61N1/20 , A61N1/205 , A61N1/32 , A61N1/326
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译：本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病性视网膜病变和视网膜和脉络膜组织缺血。在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。

3. 发明授权

US08198075B2 Method and apparatus for enhanced detection of toxic agents 有权
标题翻译：用于增强毒性剂检测的方法和装置
公开(公告)号：US08198075B2
公开(公告)日：2012-06-12
申请号：US11271643
申请日：2005-11-10
申请人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
发明人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
IPC分类号： C12M1/00 , C12M1/34 , C12M1/36 , C12M1/38 , C12M3/00 , C12N1/00
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.
摘要翻译：根据本发明的用于实时检测的水质分析器包括偏置AC电渗透（ACEO）电池，用于接收待分析的流体，其中具有多个光合生物，并将多个光合生物浓缩成至少一个集中区域。提供光电检测器用于获得在浓缩区域中的多个光合生物测量的光合活性，其中化学，生物或放射剂降低光合生物的标称光合活性。电子组件分析测量的光合活性以指示流体中化学，生物或放射性剂的存在。

4. 发明授权

US08209024B2 Method and apparatus for treating ischemic diseases 有权
标题翻译：治疗缺血性疾病的方法和装置
公开(公告)号：US08209024B2
公开(公告)日：2012-06-26
申请号：US12523990
申请日：2008-01-22
申请人： Elias Greenbaum , Mark S. Humayun
发明人： Elias Greenbaum , Mark S. Humayun
IPC分类号： A61N1/00
CPC分类号： A61N1/20 , A61N1/205 , A61N1/32 , A61N1/326
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译：本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病视网膜病变和视网膜和脉络膜组织缺血。在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。

5. 发明申请

US20120149789A1 Apparatus and Method for the Electrolysis of Water 有权
标题翻译：水电解装置及方法
公开(公告)号：US20120149789A1
公开(公告)日：2012-06-14
申请号：US12963857
申请日：2010-12-09
申请人： Elias Greenbaum
发明人： Elias Greenbaum
IPC分类号： C07C27/00 , C25B9/04 , C25B1/10 , C01C1/04 , C25B1/34 , C10G45/00 , C07C5/02 , C25B9/00 , C25B1/04
CPC分类号： C25B1/04 , C01B13/0207 , C10G2/32 , C10G45/02 , C10G49/00 , C25B1/34 , C25B9/06 , C25B9/08 , C25B11/02 , Y02E60/366 , Y02P20/133 , Y02P20/134
摘要： An apparatus for the electrolytic splitting of water into hydrogen and/or oxygen, the apparatus comprising: (i) at least one lithographically-patternable substrate having a surface; (ii) a plurality of microscaled catalytic electrodes embedded in said surface; (iii) at least one counter electrode in proximity to but not on said surface; (iv) means for collecting evolved hydrogen and/or oxygen gas; (v) electrical powering means for applying a voltage across said plurality of microscaled catalytic electrodes and said at least one counter electrode; and (vi) a container for holding an aqueous electrolyte and housing said plurality of microscaled catalytic electrodes and said at least one counter electrode. Electrolytic processes using the above electrolytic apparatus or functional mimics thereof are also described.
摘要翻译：一种用于将水电解成氢和/或氧的装置，所述装置包括：（i）至少一个具有表面的可光滑图案化的基底; （ii）嵌入所述表面中的多个微型催化电极; （iii）在所述表面附近但不在所述表面上的至少一个对电极; （iv）用于收集放出的氢气和/或氧气的装置; （v）用于在所述多个微量催化电极和所述至少一个对电极之间施加电压的电力供电装置; 和（vi）用于容纳含水电解质并容纳所述多个微细化的催化电极和所述至少一个对电极的容器。还描述了使用上述电解设备的电解方法或其功能模拟物。

6. 发明申请

US20100168646A1 METHOD AND APPARATUS FOR TREATING ISCHEMIC DISEASES 有权
标题翻译：用于治疗疾病的方法和装置
公开(公告)号：US20100168646A1
公开(公告)日：2010-07-01
申请号：US12523990
申请日：2008-01-22
申请人： Elias Greenbaum , Mark S. Humayun , Yu-Chong Tai
发明人： Elias Greenbaum , Mark S. Humayun , Yu-Chong Tai
IPC分类号： A61N1/18
CPC分类号： A61N1/20 , A61N1/205 , A61N1/32 , A61N1/326
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译：本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病视网膜病变和视网膜和脉络膜组织缺血。在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。

7. 发明申请

US20070259420A1 Modulating Photoreactivity in a Cell 审中-公开
标题翻译：调节细胞中的光反应性
公开(公告)号：US20070259420A1
公开(公告)日：2007-11-08
申请号：US11754556
申请日：2007-05-29
申请人： Elias Greenbaum , Tanya Kuritz , Mark Humayun
发明人： Elias Greenbaum , Tanya Kuritz , Mark Humayun
IPC分类号： C12N5/06
CPC分类号： C07K14/705 , A61K38/00 , A61K41/0071
摘要： Photoreactivity in a cell is modulated by incorporating an isolated optical trigger on the surface or in the membrane of the cell. Exposure of a cell bearing incorporated optical triggers causes the generation of a measurable physiological signal.
摘要翻译：细胞中的光反应性通过在细胞的表面或细胞膜上并入隔离的光触发来调节。带有结合光学触发器的细胞的暴露导致产生可测量的生理信号。

8. 发明授权

US07258836B2 Freeze resistant buoy system 有权
标题翻译：防冻浮标系统
公开(公告)号：US07258836B2
公开(公告)日：2007-08-21
申请号：US10689261
申请日：2003-10-20
申请人： David E. Hill , Miguel Rodriguez, Jr. , Elias Greenbaum , James W. Klett
发明人： David E. Hill , Miguel Rodriguez, Jr. , Elias Greenbaum , James W. Klett
IPC分类号： G01N21/00
CPC分类号： B63B22/24 , B63B2035/4453
摘要： A freeze resistant buoy system includes a tail-tube buoy having a thermally insulated section disposed predominantly above a waterline, and a thermo-siphon disposed predominantly below the waterline.
摘要翻译：防冻浮标系统包括具有主要位于水线以上的绝热部分的尾管浮标和主要位于水线下方的热虹吸管。

9. 发明申请

US20070105184A1 Biosensor method and system based on feature vector extraction 有权
标题翻译：基于特征向量提取的生物传感器方法和系统
公开(公告)号：US20070105184A1
公开(公告)日：2007-05-10
申请号：US11216282
申请日：2005-08-31
申请人： Elias Greenbaum , Miguel Rodriguez , Qi Hairong , Xiaoling Wang
发明人： Elias Greenbaum , Miguel Rodriguez , Qi Hairong , Xiaoling Wang
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025
摘要： A method of biosensor-based detection of toxins comprises the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.
摘要翻译：一种基于生物传感器的毒素检测方法包括以下步骤：在气体或液体介质中提供由生物传感器产生的至少一个时间依赖的控制信号，并从气体或液体介质中的生物传感器获得时间依赖的生物传感器信号被监测或分析一种或多种选自化学，生物或放射剂的毒素的存在。处理时间依赖的生物传感器信号以使用幅度统计和时间 - 频率分析中的至少一个来获得多个特征向量。然后，基于对控制信号的参考，从特征向量确定与气体或液体介质的毒性有关的至少一个参数。

10. 发明授权

US06569384B2 Tissue-based water quality biosensors for detecting chemical warfare agents 有权
标题翻译：用于检测化学战剂的组织水质生物传感器
公开(公告)号：US06569384B2
公开(公告)日：2003-05-27
申请号：US09773641
申请日：2001-01-31
申请人： Elias Greenbaum , Charlene A. Sanders
发明人： Elias Greenbaum , Charlene A. Sanders
IPC分类号： G01N1506
CPC分类号： G01N33/5097 , C12Q1/02 , G01N2021/635 , G01N2520/00
摘要： A water quality sensor for detecting the presence of at least one chemical or biological warfare agent includes: a cell; apparatus for introducing water into the cell and discharging water from the cell adapted for analyzing photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms in water; a fluorometer for measuring photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms drawn into the cell; and an electronics package that analyzes raw data from the fluorometer and emits a signal indicating the presence of at least one chemical or biological warfare agent in the water.
摘要翻译：用于检测至少一种化学或生物战剂的存在的水质传感器包括：电池; 将水引入细胞并从适用于分析水中天然存在的，自由生活的本地光合生物的光合作用的细胞中排出水的装置; 用于测量被吸入细胞的天然存在的，自由生活的本地光合生物的光合作用的荧光计; 以及分析来自荧光计的原始数据并发出指示在水中存在至少一种化学或生物战剂的信号的电子封装。

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