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81. 发明授权

US09248257B2 Tunneler device and method of use 有权
标题翻译：隧道设备及使用方法
公开(公告)号：US09248257B2
公开(公告)日：2016-02-02
申请号：US12894882
申请日：2010-09-30
申请人： Peter Martin , Steven B. Cote , Dillon Burgess
发明人： Peter Martin , Steven B. Cote , Dillon Burgess
IPC分类号： A61B17/00 , A61M25/01 , A61B17/34 , A61B17/32
CPC分类号： A61M25/0194 , A61B17/32 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B17/3462 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/320056 , A61B2017/3445 , A61B2017/3447 , A61B2017/3456 , A61M25/01 , A61M25/0102 , A61M2025/0197
摘要： A tunneler device is provided. The tunneler device includes a handle formed on a proximal end thereof configured for operable engagement by a user, a shaft extending distally from the handle, a collet supported on the distal end of the shaft, the collet including a plurality of distally extending fingers defining a longitudinal opening, the opening being configured to receive an end of a catheter tube and a connector configured for operable engagement with the collet, wherein the connector is configured to bias the fingers of the collet radially inward upon engagement of the connector with the collet.
摘要翻译：提供隧道设备。隧道装置包括形成在其近端上的手柄，其构造成用于与使用者可操作地接合，从手柄向远侧延伸的轴，支撑在所述轴的远端上的夹头，所述夹头包括多个向远侧延伸的指状物，所述开口被构造成接收导管管的一端和被配置为与所述夹头可操作地接合的连接器，其中所述连接器构造成在所述连接器与所述夹头接合时径向向内偏压所述夹头的指状物。

82. 发明授权

US08728745B2 Method for prediction of the progression risk of tumors 有权
标题翻译：预测肿瘤进展风险的方法
公开(公告)号：US08728745B2
公开(公告)日：2014-05-20
申请号：US13062185
申请日：2009-09-04
申请人： Peter Martin , Rüdiger Ridder
发明人： Peter Martin , Rüdiger Ridder
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/118 , G01N33/57496 , G01N2333/4704 , G01N2333/4706 , G01N2800/50 , G01N2800/56
摘要： The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.
摘要翻译：本发明涉及一种用于在基于细胞的检测程序中预测侵袭性生长的潜力和/或进展为高等级肿瘤的风险的方法。一方面，本发明涉及检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达，作为预测肿瘤侵袭性生长的进展风险和/或潜力的工具。在第二方面，本发明涉及基于同时共检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达以及活性标志物的表达来预测肿瘤侵袭性生长的进展风险和/或潜力细胞增殖。此外，本发明涉及用于诊断的探针的准备，即用于预测肿瘤的进展风险和/或潜在的侵袭性生长。

83. 发明授权

US08460322B2 Suture passer systems and methods for tongue or other tissue suspension and compression 有权
标题翻译：用于舌头或其他组织悬挂和压缩的缝合路人系统和方法
公开(公告)号：US08460322B2
公开(公告)日：2013-06-11
申请号：US13077813
申请日：2011-03-31
申请人： Erik van der Burg , Peter Martin , Chris Feezor , Mark Hirotsuka , Jasper Jackson , Christopher T. Cheng , Michael Kolber , Adam H. Liston
发明人： Erik van der Burg , Peter Martin , Chris Feezor , Mark Hirotsuka , Jasper Jackson , Christopher T. Cheng , Michael Kolber , Adam H. Liston
IPC分类号： A61B17/04
CPC分类号： A61B17/0483 , A61B17/0401 , A61B17/0469 , A61B17/0485 , A61B17/0487 , A61B90/39 , A61B2017/00814 , A61B2017/0414 , A61B2017/044 , A61B2017/0448 , A61B2017/0454 , A61B2017/0461 , A61B2017/0472 , A61B2017/06052 , A61B2017/248 , A61B2090/309 , A61B2090/3966
摘要： Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described.
摘要翻译：描述了用于组织悬浮和组织压缩的缝合路口系统，并且更具体地用于舌头悬挂。该系统可以包括至少第一细长管状体或轴，具有由细长主体承载的横向偏置的针以及可操作地连接到细长管状体的回收元件。当位于细长管状体内时，针可以具有基本上直的构造，并且被配置为离开细长管状体的远端处或附近的开口并呈现横向偏置或弯曲的形状以形成通过组织的路径。针被配置为携带缝合线。回收元件可以被配置成在针已经形成弯曲的或以其他方式成角度的通过组织的路径之后检索由针承载的缝合线。该系统还可以包括一个或多个骨锚，以固定缝线环。还描述了将一个或多个缝合线环放置到组织中的方法，例如舌的基部。

84. 发明授权

US08425122B2 Angular contact rolling-element bearing, especially double row ball roller bearing in tandem arrangement 失效
标题翻译：角接触滚动体轴承，特别是串列排列的双列滚珠轴承
公开(公告)号：US08425122B2
公开(公告)日：2013-04-23
申请号：US12989263
申请日：2009-04-02
申请人： Andreas Bohr , Horst Doeppling , Heinrich Hofmann , Peter Martin
发明人： Andreas Bohr , Horst Doeppling , Heinrich Hofmann , Peter Martin
IPC分类号： F16C33/36 , F16C19/38
CPC分类号： F16C19/38 , F16C19/505 , F16C33/36 , F16C33/485 , F16C33/585
摘要： A double row roller bearing which has an outer and inner bearing ring and ball rollers, which have lateral faces and are arranged next to each other in rows, arranged between the bearing rings. The rollers roll in raceways incorporated into the inner face of the outer bearing ring and outer face of the inner hearing ring. The raceways run in parallel and have pressure angle axes that are pitched at a pressure angle relative to a bearing radial axis. The rollers have a distance relative to each other which excludes mutual frictional contacts. For this purpose, the distance of the pressure angle axes of the raceways is enlarged and both rows of rollers are guided in separate bearing cages, while the raceway of the rollers of the row with the larger reference circle arranged on the inner bearing ring has a one-sided axial extension using the distance.
摘要翻译：一种双列滚子轴承，其具有设置在轴承环之间的具有侧面并彼此排列配置的外轴承环和内轴承圈和滚珠滚子。滚子滚动在并入外轴承环的内表面和内听筒外表面的滚道中。滚道平行运行并具有相对于轴承径向轴线以压力角倾斜的压力角轴。辊子具有相对于彼此的距离，排除相互摩擦接触。为此，滚道的压力角轴线的距离增大，两列滚子分开的轴承保持架被引导，而排列在内轴承环上的具有较大基准圆的列的滚道的滚道具有单向轴向延伸使用距离。

85. 发明授权

US08092409B2 Reinforced connector 有权
标题翻译：加强连接器
公开(公告)号：US08092409B2
公开(公告)日：2012-01-10
申请号：US11750452
申请日：2007-05-18
申请人： Henry Mros , Peter Martin
发明人： Henry Mros , Peter Martin
IPC分类号： A61H23/00 , A61F5/00
CPC分类号： A61H1/008 , A61M39/12 , A61M2039/1027 , A61M2039/1083 , A61M2039/1088 , F16L37/56 , F16L39/02 , Y10T403/1616
摘要： A connector for attaching a flexible tube to a fluid passage of another object includes a housing and a connector port on the body. The connector port is sized and shaped for connecting the connector port in fluid communication with the fluid passage of the object. The connector includes a tube port projecting from the body. The tube port is adapted for fluid communication with the connector port and is sized and shaped for being received in an end of the flexible tube to establish fluid communication with the flexible tube. The tube port includes a tube retainer that projects from the body toward the tube port. The retainer has an engaging end portion disposed in relation to the tube port to engage the flexible tube when the tube port is received in the flexible tube. The flexible tube is restrained from lateral movement with respect to the tube port.
摘要翻译：用于将柔性管附接到另一物体的流体通道的连接器包括壳体和主体上的连接器端口。连接器端口的尺寸和形状用于连接与物体的流体通道流体连通的连接器端口。连接器包括从主体突出的管端口。管端口适于与连接器端口流体连通，并且其尺寸和形状适于容纳在柔性管的端部中以与柔性管建立流体连通。管口包括从本体朝向管口突出的管保持器。当所述管口容纳在所述柔性管中时，所述保持器具有相对于所述管端口设置的接合端部，以与所述柔性管接合。柔性管相对于管口被限制在横向运动。

86. 发明申请

US20110245850A1 SUTURE PASSER SYSTEMS AND METHODS FOR TONGUE OR OTHER TISSUE SUSPENSION AND COMPRESSION 有权
标题翻译：用于穿刺或其他组织悬挂和压缩的接头传呼系统和方法
公开(公告)号：US20110245850A1
公开(公告)日：2011-10-06
申请号：US13077813
申请日：2011-03-31
申请人： Erik van der Burg , Peter Martin , Chris Feezor , Mark Hirotsuka , Jasper Jackson , Christopher T. Cheng , Michael Kolber , Adam H. Liston
发明人： Erik van der Burg , Peter Martin , Chris Feezor , Mark Hirotsuka , Jasper Jackson , Christopher T. Cheng , Michael Kolber , Adam H. Liston
IPC分类号： A61B17/04
CPC分类号： A61B17/0483 , A61B17/0401 , A61B17/0469 , A61B17/0485 , A61B17/0487 , A61B90/39 , A61B2017/00814 , A61B2017/0414 , A61B2017/044 , A61B2017/0448 , A61B2017/0454 , A61B2017/0461 , A61B2017/0472 , A61B2017/06052 , A61B2017/248 , A61B2090/309 , A61B2090/3966
摘要： Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described.
摘要翻译：描述了用于组织悬浮和组织压缩的缝合路口系统，并且更具体地用于舌头悬挂。该系统可以包括至少第一细长管状体或轴，具有由细长主体承载的侧向偏置的针以及可操作地连接到细长管状体的回收元件。当位于细长管状体内时，针可以具有基本上直的构造，并且被配置为离开细长管状体的远端处或附近的开口并呈现横向偏置或弯曲的形状以形成通过组织的路径。针被配置为携带缝合线。回收元件可以被配置成在针已经形成弯曲的或以其他方式成角度的通过组织的路径之后检索由针承载的缝合线。该系统还可以包括一个或多个骨锚，以固定缝线环。还描述了将一个或多个缝合线环放置到组织中的方法，例如舌的基部。

87. 发明申请

US20110183333A1 METHOD FOR PREDICTION OF THE PROGRESSION RISK OF TUMORS 有权
标题翻译：预测肿瘤进展风险的方法
公开(公告)号：US20110183333A1
公开(公告)日：2011-07-28
申请号：US13062185
申请日：2009-09-04
申请人： Peter Martin , Rüdiger Ridder
发明人： Peter Martin , Rüdiger Ridder
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/118 , G01N33/57496 , G01N2333/4704 , G01N2333/4706 , G01N2800/50 , G01N2800/56
摘要： The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.
摘要翻译：本发明涉及一种用于在基于细胞的检测程序中预测侵袭性生长的潜力和/或进展为高等级肿瘤的风险的方法。一方面，本发明涉及检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达，作为预测肿瘤侵袭性生长的进展风险和/或潜力的工具。在第二方面，本发明涉及基于同时共检测细胞周期蛋白依赖性激酶抑制剂基因产物的过表达以及活性标志物的表达来预测肿瘤侵袭性生长的进展风险和/或潜力细胞增殖。此外，本发明涉及用于诊断的探针的准备，即用于预测肿瘤的进展风险和/或潜在的侵袭性生长。

88. 发明申请

US20110095939A1 PROCESS AND SYSTEM FOR DETERMINING THE POSITION AND VELOCITY OF AN OBJECT 审中-公开
标题翻译：确定对象位置和速度的过程和系统
公开(公告)号：US20110095939A1
公开(公告)日：2011-04-28
申请号：US12995594
申请日：2009-06-09
申请人： Peter Martin , Adam Bryce Maclean
发明人： Peter Martin , Adam Bryce Maclean
IPC分类号： G01S13/42 , G01S15/42
CPC分类号： G01S13/227 , G01S13/582
摘要： A process for determining the position and velocity of an object is disclosed. The process comprises: -generating a first burst of pulses at a first pulse repetition frequency and subsequently receiving a first set of signals characteristic of the range and velocity of the object; -generating a second burst of pulses at a second pulse repetition frequency and subsequently receiving a second set of signals characteristic of range and velocity of the object; -generating a first data set representative of range and corresponding velocity values from the first set of signals; -generating a second data set representative of range and corresponding velocity values from the second set of signals; -summing a magnitude of a signal strength from each of the first and second data sets at corresponding range and velocity values; and, -comparing the magnitude of the summed signal strengths to a threshold value.
摘要翻译：公开了一种用于确定物体的位置和速度的过程。该过程包括： - 以第一脉冲重复频率产生第一脉冲串，随后接收特征为对象的范围和速度的第一组信号; - 以第二脉冲重复频率产生第二脉冲串，随后接收特征为所述对象的范围和速度的第二组信号; - 从第一组信号产生表示范围和相应速度值的第一数据集; - 产生代表来自所述第二组信号的范围和对应速度值的第二数据集; 在对应的范围和速度值下，从第一和第二数据组中的每个数据集中的信号强度的大小; 并且将相加的信号强度的幅度与阈值进行比较。

89. 发明申请

US20090202789A1 Process for the Production of a Laminated Composite Product and a Composite Product made by the Lamination Process 有权
标题翻译：层压复合制品生产工艺及复合制品复合制品生产工艺
公开(公告)号：US20090202789A1
公开(公告)日：2009-08-13
申请号：US11920780
申请日：2006-05-22
申请人： Karl Wagner , Florian Himmler , Peter Martin
发明人： Karl Wagner , Florian Himmler , Peter Martin
IPC分类号： B29C70/30 , B29C70/06 , B29C70/54 , B29C51/08 , B32B27/12
CPC分类号： B29C70/026 , B29C45/14 , B29C47/00 , B29C47/0023 , B29C47/003 , B29C47/0038 , B29C47/0054 , B29C47/0057 , B29C47/02 , B29C47/021 , B29C47/062 , B29C51/082 , B29C70/086 , B29C70/542 , B29C70/78 , B29C70/86 , B29C2791/001 , B29C2793/00 , B29K2033/00 , B29K2033/12 , B29K2067/00 , B29K2067/006 , B29K2069/00 , B29K2077/00 , B29K2105/12 , B29L2009/00 , B29L2009/001 , B29L2009/006 , B32B5/26 , Y10T156/1031 , Y10T428/24802 , Y10T428/249921 , Y10T428/24994 , Y10T428/31504 , Y10T428/31507 , Y10T428/31551 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855
摘要： The invention is directed to a process for the making of a product out of laminated composite material. The process in general comprises preforming at least one layer of material such that it corresponds to a surface of a part; applying layers of fibers to the preformed layer of material; and bonding the fibers by a resin to form a laminated composite material.
摘要翻译：本发明涉及一种由层压复合材料制造产品的方法。该方法通常包括预先形成至少一层材料，使其对应于零件的表面; 将纤维层施加到预成型的材料层上; 并通过树脂粘合纤维以形成层压复合材料。

90. 发明授权

US07422859B2 Method for discrimination of metaplasias from neoplastic or preneoplastic lesions 有权
标题翻译：从肿瘤或肿瘤前病变中鉴别化生的方法
公开(公告)号：US07422859B2
公开(公告)日：2008-09-09
申请号：US10511108
申请日：2003-04-08
申请人： Ruediger Ridder , Magnus Von Knebel Doeberitz , Peter Martin
发明人： Ruediger Ridder , Magnus Von Knebel Doeberitz , Peter Martin
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/158 , G01N33/57411 , G01N2333/025
摘要： The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16INK4a based detection of anogenital lesions in cytological testing procedures.
摘要翻译：本发明涉及通过测定高风险HPV编码的基因产物的水平来鉴定过表达p16 INK4a过表达病毒的p16，INK4a，p16，INK4a，例如 HPV E2和/或HPV E7分子在生物样品中的细胞学检测过程中。因此，该方法能够在细胞学检测程序中基于p16 INK4a 的检测肛门生殖器损伤中减少假阳性结果。

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