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81. 发明授权

US08007460B2 Patient hydration system and method 有权
标题翻译：患者水合系统及方法
公开(公告)号：US08007460B2
公开(公告)日：2011-08-30
申请号：US12800699
申请日：2010-05-20
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61M31/00 , A61M1/00
CPC分类号： A61M5/1723 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/142 , A61M5/16895 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.
摘要翻译：一种患者水合系统，包括用于向患者施用水合流体的输注装置，以及响应于水合流体源的水合流体测量装置，患者尿液输出测量装置。控制器响应于水合流体测量装置和患者尿液输出测量装置。控制器响应于患者尿液输出测量装置和水合流体测量装置操作输液装置，以基于患者的尿液输出水合患者。控制器还监测输注装置的操作历史，从而在测量给予患者的水合液量的量方面提供冗余。

82. 发明申请

US20110208106A1 METHOD AND APPARATUS FOR ULTRAFILTRATION OF BLOOD 有权
标题翻译：血液超滤的方法和装置
公开(公告)号：US20110208106A1
公开(公告)日：2011-08-25
申请号：US13098853
申请日：2011-05-02
申请人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
发明人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
IPC分类号： A61M1/16
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译：一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。

83. 发明申请

US20100191112A1 ULTRASOUND APPARATUSES FOR THERMALLY-INDUCED RENAL NEUROMODULATION 有权
标题翻译：用于热诱导的肾脏神经调节的超声波设备
公开(公告)号：US20100191112A1
公开(公告)日：2010-07-29
申请号：US12754337
申请日：2010-04-05
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC分类号： A61N7/02 , A61B8/12
CPC分类号： A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。

84. 发明申请

US20090024070A1 CONTROLLER FOR ULTRAFILTRATION BLOOD CIRCUIT WHICH PREVENTS HYPOTENSION BY MONITORING OSMOTIC PRESSURE IN BLOOD 有权
标题翻译：用于通过监测血液中的压力来预防血压的超声波血液循环的控制器
公开(公告)号：US20090024070A1
公开(公告)日：2009-01-22
申请号：US12172303
申请日：2008-07-14
申请人： Mark Gelfand , John J. O'Mahony , Howard R. Levin
发明人： Mark Gelfand , John J. O'Mahony , Howard R. Levin
IPC分类号： B01D61/32 , B01D61/22 , B01D61/12 , A61M1/34
CPC分类号： A61M1/34 , A61M1/1611 , A61M1/3403 , A61M1/341 , A61M1/3609 , A61M1/3639 , A61M1/367 , A61M2205/3306 , A61M2205/3331 , A61M2205/3344 , A61M2205/3375 , A61M2205/50 , A61M2230/20
摘要： A device for continuously measuring osmotic pressure of blood flowing through an extracorporeal blood circuit including: a blood passage further comprising a withdrawal blood passage connectable to a blood vessel in a patient and an infusion blood passage connectable to a blood vessel in a patient; a filter further comprising a filtrate chamber, a blood chamber and a permeable membrane separating the filtrate chamber and blood chamber, wherein the blood chamber is in fluid communication with the blood passage; a pressure sensor measuring a pressure difference between the filtrate chambers and the blood chamber, and a controller receiving a pressure signal from the pressure sensor, determining an osmotic pressure across the permeable membrane of the filter, and adjusting a rate of removal of fluid from blood in the filter if the determined osmotic pressure level varies from a predetermined osmotic pressure setting.
摘要翻译：一种用于连续测量流过体外血液循环的血液的渗透压的装置，包括：血液通道，其还包括可连接到患者血管的抽血血道和可连接到患者血管的输注血液通道; 过滤器还包括滤液室，血液室和分离滤液室和血液室的可渗透膜，其中血液室与血液通道流体连通; 测量滤液室和血液室之间的压力差的压力传感器，以及接收来自压力传感器的压力信号的控制器，确定过滤器的渗透膜上的渗透压，以及调节从血液中去除流体的速率如果确定的渗透压水平从预定的渗透压设定变化，则在过滤器中。

85. 发明授权

US07399289B2 Controller for ultrafiltration blood circuit which prevents hypotension by monitoring osmotic pressure in blood 有权
标题翻译：用于超滤血液回路的控制器，通过监测血液中的渗透压来预防低血压
公开(公告)号：US07399289B2
公开(公告)日：2008-07-15
申请号：US10648233
申请日：2003-08-27
申请人： Mark Gelfand , John J. O'Mahony , Howard R. Levin
发明人： Mark Gelfand , John J. O'Mahony , Howard R. Levin
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/34 , A61M1/1611 , A61M1/3403 , A61M1/341 , A61M1/3609 , A61M1/3639 , A61M1/367 , A61M2205/3306 , A61M2205/3331 , A61M2205/3344 , A61M2205/3375 , A61M2205/50 , A61M2230/20
摘要： A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures osmotic pressure across a filter membrane of a blood filter. The filter is permeable to water and electrolytes, but not to blood protein. The osmotic pressure indicates the protein concentration in the blood. Osmotic pressure is used to detect when hypotension is about to occur in a patient, as a result of excessive blood volume reduction during treatment of the blood. Using the osmotic pressure measurement as a feedback signal, the rate of fluid extraction is automatically controlled to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.
摘要翻译：公开了一种用于体外处理血液以从流体过载的患者中去除流体的方法和系统，其非侵入性地测量穿过血液过滤器的过滤膜的渗透压。过滤器对水和电解质是可渗透的，而不是血液蛋白质。渗透压表示血液中的蛋白质浓度。渗透压用于检测在治疗血液期间血容量减少过多时患者何时会出现低血压。使用渗透压测量作为反馈信号，自动控制流体提取的速率以达到期望的临床结果，并避免引起患者的低血压危象。

86. 发明授权

US07373204B2 Implantable device and method for treatment of hypertension 有权
标题翻译：植入式装置及治疗高血压的方法
公开(公告)号：US07373204B2
公开(公告)日：2008-05-13
申请号：US10921162
申请日：2004-08-19
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61N1/18 , A61N1/32
CPC分类号： A61N1/36114 , A61N1/36117 , Y10S128/907
摘要： A method and apparatus for treatment of hypertension with electrostimulation of peripheral nerves. Treatment is performed by periodically stimulating a nerve such as a median nerve. Apparatus for stimulation is permanently implanted in the body. The nerve is stimulated by electric current applied to electrodes that are placed near the target nerve or the muscle innervated by the target nerve.
摘要翻译：一种用电刺激周围神经治疗高血压的方法和装置。通过周期性地刺激诸如中枢神经的神经来进行治疗。用于刺激的装置被永久植入体内。神经被施加到放置在目标神经附近的电极的电流或由目标神经支配的肌肉所刺激。

87. 发明授权

US06978174B2 Methods and devices for renal nerve blocking 有权
标题翻译：肾神经阻滞的方法和装置
公开(公告)号：US06978174B2
公开(公告)日：2005-12-20
申请号：US10900199
申请日：2004-07-28
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61N1/32 , A61N1/36 , A61N1/362 , A61N1/08
CPC分类号： A61M5/14276 , A61N1/326 , A61N1/36007 , A61N1/3605 , A61N1/36114 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump eluting implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译：一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。该装置可以是药物泵洗脱植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。

88. 发明授权

US06890315B1 Method and apparatus for vein fluid removal in heart failure 有权
标题翻译：心力衰竭中静脉液清除的方法和装置
公开(公告)号：US06890315B1
公开(公告)日：2005-05-10
申请号：US09618759
申请日：2000-07-18
申请人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
发明人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
IPC分类号： A61M1/14 , A61M1/18 , A61M1/22 , A61M1/34 , A61M1/36 , A61M37/00 , C02F1/44
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译：一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和公开了血液中的蛋白质，并将浓缩血液返回到二次血管。使用小规格针头取出血液并返回。当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。

89. 发明授权

US06514226B1 Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney 有权
标题翻译：通过改善肾脏灌注治疗充血性心力衰竭的方法和装置
公开(公告)号：US06514226B1
公开(公告)日：2003-02-04
申请号：US09501234
申请日：2000-02-10
申请人： Howard R. Levin , Mark Gelfand
发明人： Howard R. Levin , Mark Gelfand
IPC分类号： A61M100
CPC分类号： A61M1/3621 , A61M1/3653 , A61M1/3659 , A61M2027/004
摘要： A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificially perfusion of at least one kidney. The kidney is perfused with the patient's blood or other suitable perfusion fluid. A catheter inserted into the aorta of the patient has a distal end that supplies the perfusion fluid into a renal artery of the patient. The catheter may be coupled to an implanted blood pump or to an external supply of perfusion pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF.
摘要翻译：已经开发了治疗充血性心力衰竭（CHF）的方法，其通过人工灌注至少一个肾来恢复肾脏肾功能。肾脏用患者的血液或其他合适的灌注液灌注。插入患者主动脉的导管具有将灌注流体供应到患者的肾动脉中的远端。导管可以联接到植入的血液泵或外部的灌注压力供应。肾功能的恢复通过从病人身上清除多余的液体，尿液和毒素，以及使患者的肾素 - 血管紧张素系统和其他神经激素物质正常化来帮助心脏。该方法适用于慢性和急性CHF。

90. 发明授权

US06282445B1 Passive defibrillation electrodes for use with cardiac assist device 失效
标题翻译：用于心脏辅助装置的被动除颤电极
公开(公告)号：US06282445B1
公开(公告)日：2001-08-28
申请号：US09417812
申请日：1999-10-14
申请人： Robert W. Reinhardt , Howard R. Levin , William A. Easterbrook, III , Michael Guttman
发明人： Robert W. Reinhardt , Howard R. Levin , William A. Easterbrook, III , Michael Guttman
IPC分类号： A61N139
CPC分类号： A61N1/0587 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M2205/33 , A61M2205/3303 , A61N1/05 , A61N1/39
摘要： A cardiac support system includes a ventricular assist device adapted to be extended over a portion of a patient's heart to assist the ventricles of the heart to properly contract. One or more stimulating electrodes are mounted on the ventricular assist device in selected locations such that when the ventricular assist device is extended over the heart, the stimulation electrodes are in close proximity to the surface of the heart. The system further includes one or more external pick-up electrodes that receive externally applied energy and conduct that energy to the one or more stimulating electrodes via conductive leads. The external pick-up electrodes may be mounted on the outer surface of the ventricular assist device, or can be located at some other location inside the patient's body. The externally-applied energy will typically be supplied by standard defibrillation paddles located outside of the patient's body. In place of the pick-up electrodes, the stimulating electrodes can be wired directly to, respectively, a source of electrical energy and a ground plate.
摘要翻译：心脏支持系统包括适于延伸到患者心脏的一部分上以协助心脏心室的心室辅助装置以适当地收缩。一个或多个刺激电极安装在心室辅助装置的选定位置，使得当心室辅助装置在心脏上延伸时，刺激电极紧邻心脏表面。该系统还包括一个或多个外部拾取电极，其接收外部施加的能量并且经由导电引线将该能量传导到一个或多个刺激电极。外部拾取电极可以安装在心室辅助装置的外表面上，或者可以位于患者体内的其他位置。外部施加的能量通常由位于患者身体外部的标准除颤桨提供。代替拾取电极，刺激电极可以分别直接连接到电能源和接地板。

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