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81. 发明申请

US20110137307A1 IONTOPHORETIC APPARATUS AND METHOD FOR MARKING OF THE SKIN 有权
标题翻译：用于标记皮肤的静电装置和方法
公开(公告)号：US20110137307A1
公开(公告)日：2011-06-09
申请号：US12632647
申请日：2009-12-07
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/30
CPC分类号： A61M37/0084 , A61M2037/0007 , A61M2210/04 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/303 , A61N1/325 , A61N1/328
摘要： Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin.
摘要翻译：实施例提供了用于在皮肤中产生标记的装置和方法。一个实施例提供了一种用于标记皮肤的装置，包括用于存储皮肤着色剂的壳体和储存器。电极定位在壳体内以便电耦合到储存器中的着色剂，并且被配置为耦合到电流源和返回电极。具有至少一个流体通道的着色剂施加器联接到壳体远端。施放器近端被定位成使得流体通路与储存器联接。当施用器移动穿过皮肤时，施用器远端通过流体通道将着色剂施加到皮肤表面。电极从电流源传递电流到皮肤，以使用电动驱动力将着色剂的带电颜料元件输送到皮肤中，以在皮肤中产生标记。

82. 发明申请

US20110082411A1 PATCH AND PATCH ASSEMBLY FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES 有权
标题翻译：用于治疗和药物用途的活性剂的静电转运的配对和分配组件
公开(公告)号：US20110082411A1
公开(公告)日：2011-04-07
申请号：US12898671
申请日：2010-10-05
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61M37/00 , A61M2037/0007
摘要： Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent. Embodiments of the assembly may used to deliver a variety of therapeutic agents.
摘要翻译：本发明的实施方案提供了用于治疗剂的离子电渗透皮递送的贴片组件。一个实施方案提供一种贴片组件，其包括用于递送药剂并具有包括粘合剂的组织接触侧的适形贴片。壳体具有用于接合贴片的非组织接触侧的底表面，诸如电池的电流源和用于控制药剂递送的控制器。外壳具有足够的灵活性，使得当其与贴片接合以形成贴片组件并且贴片粘附到患者皮肤上的目标部位时，该组件具有足够的柔性以随着患者皮肤的运动而变形以保持充分粘附在延长的时间段内向皮肤透皮递送所需剂量的试剂。该组件的实施方案可用于递送各种治疗剂。

83. 发明申请

US20100076413A1 DIAPHRAGM DRUG PUMP 有权
公开(公告)号：US20100076413A1
公开(公告)日：2010-03-25
申请号：US12564859
申请日：2009-09-22
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61K9/22
CPC分类号： F04B45/024 , A61M5/14216 , A61M5/14224 , A61M5/14276 , A61M5/16809 , A61M2205/3653 , F04B43/0072 , F04B43/043 , F04B43/084
摘要： Embodiments of the invention provide apparatus, systems and methods for delivering drugs using an implantable diaphragm based drug pump which can deliver precisely controlled doses of drug to selected target tissue sites in the brain, digestive system, blood stream heart or other selected site. Various embodiments of the pump include multi-chamber bellows or other diaphragm based pumps which can rapidly deliver drug to the selected target tissue site.
摘要翻译：本发明的实施方案提供了使用可植入隔膜的药物泵递送药物的装置，系统和方法，其可将准确控制剂量的药物递送至脑，消化系统，血流心脏或其他选定部位中的选定靶组织部位。泵的各种实施例包括多室波纹管或其它隔膜式泵，其可以快速地将药物输送到所选择的靶组织部位。

84. 发明申请

US20100063557A1 ENERGY HARVESTING MECHANISM 有权
标题翻译：能源采收机制
公开(公告)号：US20100063557A1
公开(公告)日：2010-03-11
申请号：US12556524
申请日：2009-09-09
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/378 , H02N2/18 , H01L41/04 , H01L41/193
CPC分类号： H02N2/186 , A61N1/3785 , H01L41/082 , H01L41/113
摘要： Embodiments of the invention provide an energy harvesting mechanism comprising a central conductive element and a plurality of transductive elements. Each transductive element is positioned to be in contact with a corresponding peripheral length segment of the central conductive element. Also each transductive element is deformable in a characteristic radial direction to convert its deformation into a corresponding electrical signal. The plurality of transductive elements are arranged so that any one of the plurality of transductive elements is capable of being deformed in the characteristic radial direction to trigger the corresponding electrical signal. Embodiments of the mechanism can be used for harvesting energy from a variety of bio-kinetic events such as a heartbeat, respiration, muscle contraction or other movement. Such embodiments can be used for powering a variety of implanted medical devices such as pacemakers, defibrillators and various monitoring devices.
摘要翻译：本发明的实施例提供一种包括中心导电元件和多个换能元件的能量收集机构。每个传导元件被定位成与中心导电元件的对应的周边长度段接触。每个转换元件也可以在特征径向方向上变形，以将其变形转换成相应的电信号。多个传导元件被布置成使得多个传导元件中的任何一个能够在特征径向方向上变形以触发相应的电信号。该机理的实施方案可用于从各种生物动力学事件如心跳，呼吸，肌肉收缩或其它运动中收集能量。这样的实施例可以用于为诸如起搏器，除颤器和各种监视装置的各种植入的医疗装置供电。

85. 发明申请

US20100051124A1 MICRO-FLUIDIC DEVICE 有权
标题翻译：微流体装置
公开(公告)号：US20100051124A1
公开(公告)日：2010-03-04
申请号：US12541797
申请日：2009-08-14
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： F04F5/48 , F04F5/00
CPC分类号： B01L3/50273 , B01J19/0093 , B01J2219/00783 , B01J2219/00869 , B01J2219/00873 , B01J2219/00891 , B01J2219/00961 , B01J2219/00966 , B01J2219/00981 , B01J2219/00986 , B01L3/502715 , B01L3/502738 , B01L2200/0621 , B01L2200/10 , B01L2300/022 , B01L2300/023 , B01L2300/0627 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/18 , B01L2300/1827 , B01L2300/1866 , B01L2400/0442 , B01L2400/049 , B01L2400/06 , B01L2400/0605 , F04B19/006 , Y10T137/2877 , Y10T137/7559 , Y10T137/85978 , Y10T137/85986 , Y10T137/86075
摘要： Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber.
摘要翻译：本文所述的实施例提供用于执行各种诊断和分析测试的微流体系统和装置。根据一个实施例，微流体装置包括用于接收样品的样品室和用于进行化学反应的反应室。气泡喷射泵被构造在装置上以控制流体从样品室传送到反应室。泵使用诸如毛细管的流体通道流体地耦合到装置的一个或多个室。阀可以联接到一个或多个室以控制流入和流出这些室。此外，传感器可以定位在一个或多个室中，例如反应物室，用于感测室内的流体的性质以及室内的化学物质的存在。

86. 发明申请

US20070299481A1 ENDOSCOPIC DEVICE DELIVERY SYSTEM 有权
标题翻译：内窥镜装置输送系统
公开(公告)号：US20070299481A1
公开(公告)日：2007-12-27
申请号：US11766660
申请日：2007-06-21
申请人： Baber Syed , Kurt Sparks , Ken Wong , Michael Wei , Mir Imran
发明人： Baber Syed , Kurt Sparks , Ken Wong , Michael Wei , Mir Imran
IPC分类号： A61N1/05 , A61M25/09 , A61M25/10 , A61M29/00
CPC分类号： A61N1/36007 , A61B2017/00278 , A61N1/05 , A61N1/0558 , A61N1/37205 , A61N1/3756
摘要： A system and method are disclosed for an implantable gastric stimulation system within the stomach. The stimulation system includes an electronics anchor, electrode lead anchor, implantable pulse generator and external programmer. The electronics anchor is configured to attach to the stomach wall at a first location and the electrode lead anchor configured to attach to the stomach wall at a second location. The electrode lead anchor includes one or more electrodes configured to contact the stomach wall and a flexible lead portion coupled to the one or more electrodes at one end with an the electrical connector portion at the other end. The implantable pulse generator has electronic circuitry and is attached to the electronics anchor; the electronic circuitry is connected to the electrical connector of the electrode lead anchor and can communicate with the one or more electrodes. The external programmer is used to communicate with the electronic circuitry of the pulse generator via a telemetry device to provide stimulation instructions to the pulse generator.
摘要翻译：公开了一种用于胃内的可植入胃刺激系统的系统和方法。刺激系统包括电子锚，电极引线锚，可植入脉冲发生器和外部编程器。电子锚固件被配置成在第一位置处附接到胃壁，并且电极引线锚定构造成在第二位置处附接到胃壁。电极引线锚定器包括被配置为接触胃壁的一个或多个电极和在一端处与一个或多个电极在另一端处与电连接器部分耦合的柔性引线部分。该植入式脉冲发生器具有电子电路并连接到电子锚定器; 电子电路连接到电极引线锚的电连接器，并且可以与一个或多个电极连通。外部编程器用于通过遥测装置与脉冲发生器的电子电路进行通信，以向脉冲发生器提供刺激指令。

87. 发明申请

US20060129237A1 Stomach peristalsis device and method 有权
公开(公告)号：US20060129237A1
公开(公告)日：2006-06-15
申请号：US11349309
申请日：2006-02-06
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F5/003 , A61F5/0033 , A61F5/0053 , A61F5/0079 , A61F2002/045 , A61F2002/482 , A61F2250/0003
摘要： The invention relates to an implantable stomach prosthesis for surgically replacing or augmenting all or part of the antrum and/or pylorus of a stomach. The prosthesis controls the passage of food from the stomach to the small intestine. The prosthesis may be configured to chum ingested material and release it from the stomach through a prosthetic pyloric valve. At least one expandable member is arranged to be expanded to control the passage of food and/or to mimic the churning action of a patient's stomach. The prosthesis includes an outer support structure, a flexible inner member forming a conduit for the movement of material, and at least one expandable member located between the outer support structure and inner member. An implantable pump system is provided for inflating and deflating the expandable member(s).

88. 发明申请

US20060116735A1 Gastric device and endoscopic delivery system 有权
标题翻译：胃装置和内镜递送系统
公开(公告)号：US20060116735A1
公开(公告)日：2006-06-01
申请号：US11281049
申请日：2005-11-16
申请人： Mir Imran , Olivier Colliou , Ted Layman , Deepak Gandhi , Sharon Lake
发明人： Mir Imran , Olivier Colliou , Ted Layman , Deepak Gandhi , Sharon Lake
IPC分类号： A61N1/18
CPC分类号： A61B5/6882 , A61B5/4238 , A61B17/3421 , A61B17/3478 , A61B2017/00004 , A61B2017/00017 , A61B2017/00026 , A61B2017/00084 , A61B2017/00477 , A61B2017/306 , A61B2017/3488 , A61F5/0003 , A61M25/02 , A61M2025/0233 , A61M2025/028 , A61N1/0509 , A61N1/0517 , A61N1/36007 , A61N1/372 , G01N27/126 , G06F19/00
摘要： A system is provided for endoscopically attaching a functional device to a stomach wall wherein the functional device is configured to perform a therapeutic or diagnostic function at the stomach.
摘要翻译：提供了一种用于将功能装置内窥镜地附接到胃壁的系统，其中功能装置构造成在胃处执行治疗或诊断功能。

89. 发明申请

US20060079944A1 Device and method for treating obesity 有权
标题翻译：用于治疗肥胖症的装置和方法
公开(公告)号：US20060079944A1
公开(公告)日：2006-04-13
申请号：US11281041
申请日：2005-11-16
申请人： Mir Imran
发明人： Mir Imran
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： A device and method are provided for treating obesity by implanting an electrode in the duodenum and stimulating the duodenum with a stimulator, causing the pylorus to contract.
摘要翻译：提供了通过将电极植入十二指肠并用刺激器刺激十二指肠来治疗肥胖的装置和方法，导致幽门收缩。

90. 发明申请

US20060052836A1 Neurostimulation system 审中-公开
公开(公告)号：US20060052836A1
公开(公告)日：2006-03-09
申请号：US11221576
申请日：2005-09-07
申请人： Daniel Kim , Mir Imran
发明人： Daniel Kim , Mir Imran
IPC分类号： A61N1/18
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

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