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81. 发明申请

US20130288899A1 SUBSTITUTED PYRIDINES HAVING HERBICIDAL ACTIVITY 有权
标题翻译：具有除草活性的替代吡啶
公开(公告)号：US20130288899A1
公开(公告)日：2013-10-31
申请号：US13995975
申请日：2011-12-19
申请人： Matthias Witschel , William Karl Moberg , Liliana Parra Rapado , Gilbert Besong , Michael Rack , Andree Van Der Kloet , Thomas Seitz , Ruediger Reingruber , Helmut Kraus , Johannes Hutzler , Trevor William Newton , Jens Lerchl , Klaus Kreuz , Klaus Grossmann , Richard Roger Evans
发明人： Matthias Witschel , William Karl Moberg , Liliana Parra Rapado , Gilbert Besong , Michael Rack , Andree Van Der Kloet , Thomas Seitz , Ruediger Reingruber , Helmut Kraus , Johannes Hutzler , Trevor William Newton , Jens Lerchl , Klaus Kreuz , Klaus Grossmann , Richard Roger Evans
IPC分类号： A01N43/90
CPC分类号： A01N43/90 , C07D495/04
摘要： The present invention provides substituted pyridine compounds of the formula I or N-oxides or agriculturally suitable salts thereof, wherein the variables in the formula I are defined as in the description. Substituted pyridines of formula I are useful as herbicides.
摘要翻译：本发明提供取代的式I的吡啶化合物或N-氧化物或其农业上合适的盐，其中式I中的变量如描述中所定义。式I的取代的吡啶可用作除草剂。

82. 发明授权

US07879761B2 Heteroaroyl-substituted serineamides 有权
标题翻译：杂环酰取代的丝氨酰胺
公开(公告)号：US07879761B2
公开(公告)日：2011-02-01
申请号：US11915227
申请日：2006-03-29
申请人： Matthias Witschel , Cyrill Zagar , Eike Hupe , Toralf Kühn , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Michael Rack , Robert Reinhard , Bernd Sievernich , Klaus Groβmann , Thomas Ehrhardt
发明人： Matthias Witschel , Cyrill Zagar , Eike Hupe , Toralf Kühn , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Michael Rack , Robert Reinhard , Bernd Sievernich , Klaus Groβmann , Thomas Ehrhardt
IPC分类号： A01N43/56 , C07D231/10
CPC分类号： C07D231/14 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D409/12
摘要： The present invention relates to heteroaroyl-substituted serineamides of the formula I in which the variables A and R1 to R6 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation, and to the use of these compounds or of the compositions comprising these compounds for controlling unwanted plants.
摘要翻译：本发明涉及式I的杂芳酰取代的丝氨酰胺，其中变量A和R 1至R 6如说明书中所定义，以及其农业上有用的盐，其制备方法和中间体以及这些化合物或包含这些化合物的组合物用于防治不期望的植物。

83. 发明申请

US20100152047A1 Piperazine Compounds Whith a Herbicidal Action 审中-公开
标题翻译：哌嗪化合物具有除草作用
公开(公告)号：US20100152047A1
公开(公告)日：2010-06-17
申请号：US12663784
申请日：2008-06-11
申请人： Eike Hupe , Thomas Seitz , Matthias Witschel , Dschun Song , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Trevor William Newton , Robert Reinhard , Bernd Sievernich , Klaus Grossmann , Thomas Ehrhardt , Michael Rack , Elmar Kibler
发明人： Eike Hupe , Thomas Seitz , Matthias Witschel , Dschun Song , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Trevor William Newton , Robert Reinhard , Bernd Sievernich , Klaus Grossmann , Thomas Ehrhardt , Michael Rack , Elmar Kibler
IPC分类号： A01N43/58 , C07D403/10 , C07D401/10 , C07D241/02 , C07D413/10 , A01N43/54 , A01N43/60 , A01P13/00
CPC分类号： C07D241/08 , C07D403/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention relates to piperazine compounds of the general formula I defined below and to their use as herbicides. Moreover, the invention relates to compositions for crop protection and to a method for controlling unwanted vegetation. In formula I, the variables have the following meanings: R1 is selected from the group consisting of halogen, cyano, nitro, Z—C(═O)—R11, phenyl and a 5- or 6-membered heterocyclic radical which has 1, 2, 3 or 4 heteroatoms selected from the group consisting of O, N and S as ring atoms, where phenyl and the heterocyclic radical are unsubstituted or may have 1, 2, 3 or 4 substituents R1a; Z is a covalent bond or a CH2 group; R11 is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C5-C6-cycloalkenyl, C2-C6-alkynyl and the like; R2 is hydrogen, halogen, nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C1-C4-alkoxy, C1-C4-haloalkoxy, benzyl or a group S(O)nR21 in which R21 is C1-C4-alkyl or C1-C4-haloalkyl and n is 0, 1 or 2; R3 is hydrogen or halogen; R4 is C1-C4-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; R5 is hydrogen, C1-C4-alkyl, C3-C4-alkenyl, C3-C4-alkynyl or a group C(═O)R51 in which R51 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy; R6 is C1-C4-alkyl, C1-C4-hydroxyalkyl or C1-C4-haloalkyl; R7, R8 independently of one another are hydrogen, OH, C1-C4-alkoxy, C1-C4-haloalkyloxy, C1-C4-alkyl or C1-C4-haloalkyl; and R9, R10 independently of one another are selected from the group consisting of hydrogen, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C1-C4-alkoxy and C1-C4-haloalkoxy.
摘要翻译：本发明涉及下面定义的通式I的哌嗪化合物及其作为除草剂的用途。此外，本发明涉及用于作物保护的组合物和用于防治不想要的植物的方法。在式I中，变量具有以下含义：R 1选自卤素，氰基，硝基，Z-C（= O）-R 11，苯基和具有1， 2,3或4个选自O，N和S作为环原子的杂原子，其中苯基和杂环基是未取代的或可以具有1,2,3或4个取代基R 1a; Z是共价键或CH2基; R11是氢，C1-C6-烷基，C3-C6-环烷基，C2-C6-烯基，C5-C6-环烯基，C2-C6-炔基等; R2是氢，卤素，硝基，氰基，C1-C4-烷基，C1-C4卤代烷基，C2-C4-烯基，C1-C4-烷氧基，C1-C4-卤代烷氧基，苄基或基团S（O）其中R 21为C 1 -C 4烷基或C 1 -C 4卤代烷基，n为0,1或2; R3是氢或卤素; R4是C1-C4-烷基，C3-C4-烯基或C3-C4-炔基; R 5为氢，C 1 -C 4 - 烷基，C 3 -C 4 - 烯基，C 3 -C 4 - 炔基或C（= O）R 51，其中R 51为氢，C 1 -C 4 - 烷基，C 1 -C 4 - 卤代烷基， C 4 - 烷氧基或C 1 -C 4 - 卤代烷氧基; R 6是C 1 -C 4烷基，C 1 -C 4羟基烷基或C 1 -C 4卤代烷基; R 7，R 8彼此独立地是氢，OH，C 1 -C 4 - 烷氧基，C 1 -C 4卤代烷氧基，C 1 -C 4 - 烷基或C 1 -C 4卤代烷基; R 9，R 10彼此独立地选自氢，卤素，CN，NO 2，C 1 -C 4 - 烷基，C 1 -C 4 - 卤代烷基，C 2 -C 4 - 烯基，C 1 -C 4 - 烷氧基和C 1 -C 4 卤代烷氧基。

84. 发明申请

US20080200338A1 Heteroaroyl-Substituted Serineamides 有权
标题翻译：异环酰取代的丝氨酸酰胺
公开(公告)号：US20080200338A1
公开(公告)日：2008-08-21
申请号：US11915227
申请日：2006-03-29
申请人： Matthias Witschel , Cyrill Zagar , Eike Hupe , Toralf Kuhn , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Michael Rack , Robert Reinhard , Bernd Sievernich , Klaus Grossmann , Thomas Ehrhardt
发明人： Matthias Witschel , Cyrill Zagar , Eike Hupe , Toralf Kuhn , William Karl Moberg , Liliana Parra Rapado , Frank Stelzer , Andrea Vescovi , Michael Rack , Robert Reinhard , Bernd Sievernich , Klaus Grossmann , Thomas Ehrhardt
IPC分类号： A01N43/56 , C07D231/14 , A01P13/00
CPC分类号： C07D231/14 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D409/12
摘要： The present invention relates to heteroaroyl-substituted serineamides of the formula I in which the variables A and R1 to R6 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation, and to the use of these compounds or of the compositions comprising these compounds for controlling unwanted plants.
摘要翻译：本发明涉及式I的杂芳酰取代的丝氨酰胺，其中变量A和R 1至R 6如说明书中所定义，并且其农业上有用的盐，其制备方法和中间体，以及这些化合物或包含这些化合物的组合物用于防治不想要的植物的用途。

85. 发明申请

US20070149582A1 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating insects, arachnids and nematodes 失效
标题翻译：用于防治昆虫，蜘蛛和线虫的1-（唑啉-2-基）氨基-1,2-二苯基乙烷化合物
公开(公告)号：US20070149582A1
公开(公告)日：2007-06-28
申请号：US10583710
申请日：2004-12-22
申请人： Markus Kordes , Michael Hofmann , Michael Puhl , Norbert Gotz , Michael Rack , Ernst Baumann , Wolfgang Deyn , Thomas Schmidt , Livio Tedeschi , Michael Treacy , Deborah Culbertson , Toni Bucci , David Kuhn
发明人： Markus Kordes , Michael Hofmann , Michael Puhl , Norbert Gotz , Michael Rack , Ernst Baumann , Wolfgang Deyn , Thomas Schmidt , Livio Tedeschi , Michael Treacy , Deborah Culbertson , Toni Bucci , David Kuhn
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D263/28 , A01N43/76 , A01N43/78 , C07D277/18
摘要： The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula (I) wherein A is a radical of the formulae A′ or A2: N R A′ A2 and wherein m is 0, 1, 2, 3, 4 or 5, n is 0, 1, 2, 3, 4 or 5, X is sulfur or oxygen, and wherein the variables R1, R2, R3, R4, R5a, R5b, R5c, R5d are as defined in the claims, and to the agriculturally acceptable salts thereof. The invention relates also to a method of combating animal pests, selected from insects, arachnids and nematodes and to a method for protecting crops from attack or infestation by insects, arachnids or nematodes, which comprises contacting a crop with a pesticidally effective amount of a 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the general formula I and/or at least one salt thereof.
摘要翻译：本发明涉及通式（I）的1-（唑啉-2-基）氨基-1,2-二苯基乙烷化合物，其中A是式A'或A 2的基团： NRA'A ^{2，其中m是0,1,2,3,4或5，n是0,1,2,3,4或5，X是硫或氧，并且其中变量R 1，R 2，R 3，R 4，R 5，S 5， R 5b，R 5c，R 5d如权利要求中所定义，以及其农业上可接受的盐。本发明还涉及一种对抗昆虫，蜘蛛和线虫的动物害虫的方法，还涉及一种保护作物免受昆虫，蜘蛛或线虫袭击或侵染的方法，其中包括使农作物与杀虫有效量的1 - （唑啉-2-基）氨基-1,2-二苯基乙烷化合物和/或其至少一种盐。}

86. 发明授权

US08115012B2 Process for preparing difluoromethylpyrazolyl carboxylates 失效
标题翻译：制备二氟甲基吡唑羧酸酯的方法
公开(公告)号：US08115012B2
公开(公告)日：2012-02-14
申请号：US12513003
申请日：2007-11-02
申请人： Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
发明人： Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
IPC分类号： C07D231/10 , C07F7/08
CPC分类号： C07D231/14
摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2 (III) in which R2 has one of the meanings given above.
摘要翻译：本发明涉及制备式Ⅰ的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基等。 R 2是氢，C 1 -C 4 - 烷基，苄基或苯基，其中a）通式II的化合物，其中X是氟，氯或溴，R 1具有上面给出的含义之一，R 4是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 2 -C 8 - 烯基，苄基或苯基与通式R 3 n SiCl（4-n）的硅烷化合物反应，其中n为1,2或3，取代基R 3独立地为选自由C 1 -C 8 - 烷基和苯基组成的组中的一种，以及选自元素周期表第1,2,3,4和12族金属的金属，其氧化还原电位小于-0.7 V，基于正常的氢电极（在25℃和101.325kPa）; 和b）将来自步骤a）的反应混合物与通式III的化合物R2HN-NH2（III）反应，其中R2具有上述含义之一。

87. 发明申请

US20100069646A1 Process for preparing difluoromethylpyrazolyl carboxylates 失效
标题翻译：制备二氟甲基吡唑羧酸酯的方法
公开(公告)号：US20100069646A1
公开(公告)日：2010-03-18
申请号：US12513003
申请日：2007-11-02
申请人： Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
发明人： Martin Sukopp , Michael Rack , Sebastian Peer Smidt , Sandra Löhr , Michael Keil , Jochen Dietz , Joachim Rheinheimer , Thomas Grote , Thomas Zierke , Jan Klaas Lohmann
IPC分类号： C07D231/10 , C07F7/08
CPC分类号： C07D231/14
摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula II in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula III R2HN—NH2 (III) in which R2 has one of the meanings given above.
摘要翻译：本发明涉及制备式Ⅰ的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基等。并且R 2是氢，C 1 -C 4 - 烷基，苄基或苯基，其中a）通式II的化合物，其中X是氟，氯或溴，R 1具有上面给出的含义之一，R 4是C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 2 -C 8 - 烯基，苄基或苯基与通式R 3 n SiCl（4-n）的硅烷化合物反应，其中n为1,2或3，取代基R 3独立地为选自由C 1 -C 8 - 烷基和苯基组成的组中的一种，以及选自元素周期表第1,2,3,4和12族金属的金属，其氧化还原电位小于-0.7 V，基于正常的氢电极（在25℃和101.325kPa）; 和b）将来自步骤a）的反应混合物与通式III的化合物R2HN-NH2（III）反应，其中R2具有上述含义之一。

88. 发明申请

US20100184994A1 Method for Producing Difluoromethyl-Substituted Pyrazole Compounds 有权
标题翻译：二氟甲基取代吡唑化合物的制备方法
公开(公告)号：US20100184994A1
公开(公告)日：2010-07-22
申请号：US12664448
申请日：2008-06-13
申请人： Markus Nett , Thomas Grote , Jan Klaas Lohmann , Jochen Dietz , Sebastian Peer Smidt , Michael Rack , Thomas Zierke
发明人： Markus Nett , Thomas Grote , Jan Klaas Lohmann , Jochen Dietz , Sebastian Peer Smidt , Michael Rack , Thomas Zierke
IPC分类号： C07D231/14 , C07C229/06
CPC分类号： C07D231/12 , C07D231/14
摘要： The present invention relates to a process for preparing 3-difluoromethyl-substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.
摘要翻译：本发明涉及制备式（I）的3-二氟甲基取代的吡唑化合物的方法，其中R 1是H，卤素，硝基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，苯基，萘基，杂芳基，氰基，-C（= O）-OR1a，-C（= O）-NR1bR1c，-C（= O）-SR1d或-C（= S）-SR1e; R2是H，C1-C4-烷基，苄基或苯基; R 3是H，卤素，C 1 -C 8 - 烷氧基，C 1 -C 8 - 卤代烷氧基，C 3 -C 8 - 环烷氧基，C 2 -C 8 - 烯氧基，C 1 -C 8 - 烷硫基，C 1 -C 8 - 卤代烷硫基，C 3 -C 8环 - C 2 -C 8 - 烯硫基; 式（II.a）或（II.b）化合物，其中R 1和R 3各自具有上述定义之一; R4是卤素，-OR4a，-SR4a，-O-SO2-R4a或-NR4bR4c基团; R 5和R 6各自为C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，苄基或苯基，或与它们所键合的氮原子一起为3-至8-元杂环; 式（II.b）化合物的路易斯酸加合物; 使用式（II.a）或（II.b）化合物和路易斯酸加成物制备式（I）或（VI）化合物的方法; 以及将这些化合物转化为相应的3-二氟 - 吡唑-4-基羧酸的方法。

89. 发明授权

US07301034B2 Preparation of -4-thioalkybrobenzene derivatives 有权
标题翻译： 4-硫代烷基苯衍生物的制备
公开(公告)号：US07301034B2
公开(公告)日：2007-11-27
申请号：US10332861
申请日：2001-07-17
申请人： Rene Lochtman , Michael Keil , Joachim Gebhardt , Michael Rack , Wolfgang von Deyn
发明人： Rene Lochtman , Michael Keil , Joachim Gebhardt , Michael Rack , Wolfgang von Deyn
IPC分类号： C07D261/04 , C07D261/08
CPC分类号： C07D413/04 , C07C319/14 , C07D261/04 , C07C323/62
摘要： A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, halogen, R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical, R3 is C1-C6-alkyl, which comprises reacting a compound of the formula II, in which R1 and R2 are as defined above, with a dialkyl disulfide of the formula III R3—S—S—R3III in the presence of a nitrite and a catalyst in a suitable solvent is described.
摘要翻译：制备式I的4-硫代烷基溴苯衍生物的方法，其中：R 1是C 1 -C 6 - 烷基，C 1 -C 6 - C 1 -C 6 - 卤代烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - C 6 - 卤代烷氧基，C 3 -C 8 - 环烷基，卤素，R 2是C 1 -C 6烷基， C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 3 - C 8 - 环烷基，C 2 -C 6 - 烯基，氰基或杂环基，R 3是 C 1 -C 6 - C 6 - 烷基，其包括使式II化合物（其中R 1和R 2） / SUP>如上所定义，与式III的二烷基二硫化物<？in-line-formula description =“In-line Formulas”end =“lead”？> R 3 -SSR < 描述了在合适的溶剂中存在亚硝酸盐和催化剂的情况下，在实施例3中描述的“In-line-formula description =”In-Line Formulas“end =”tail“？>

90. 发明申请

US20070161800A1 Preparation of Isoxazolin-3-Ylacylbenzene 有权
标题翻译：异恶唑啉-3-酰基苯的制备
公开(公告)号：US20070161800A1
公开(公告)日：2007-07-12
申请号：US11684630
申请日：2007-03-11
申请人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Gotz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Boumann
发明人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Gotz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Boumann
IPC分类号： C07D261/02 , C07C317/32
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52
摘要： A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.
摘要翻译：描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体并描述了制备中间体的新方法。

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