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81. 发明申请

US20050090814A1 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：US20050090814A1
公开(公告)日：2005-04-28
申请号：US10624272
申请日：2003-07-22
申请人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche
发明人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61B18/18 , A61F7/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00119 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温度。

82. 发明授权

US06468268B1 Cryogenic catheter system 有权
标题翻译：低温导管系统
公开(公告)号：US06468268B1
公开(公告)日：2002-10-22
申请号：US09489644
申请日：2000-01-24
申请人： Marwan Abboud , Johnny Al Asmar , Jean-Pierre Lalonde
发明人： Marwan Abboud , Johnny Al Asmar , Jean-Pierre Lalonde
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00119 , A61B2018/0212 , A61B2018/0262 , A61F7/12
摘要： A cryogenic catheter system provides safe and effective treatment of tissue. The system includes a catheter that is coupled to a console via fluid and electrical umbilicals. The console controls the overall operation of the system based to provide and maintain a predetermined temperature at the catheter tip. The console also controls and monitors operating parameters for providing warning indications to the user and terminating operation of the system in the event of a failure that may compromise patient safety.
摘要翻译：低温导管系统提供安全有效的组织治疗。该系统包括通过流体和电气脐带耦合到控制台的导管。控制台控制系统的总体操作，以提供并保持导管尖端处的预定温度。控制台还控制和监视操作参数，以便在出现可能危及患者安全的故障的情况下向用户提供警告指示并终止系统的操作。

83. 发明授权

US06440126B1 Cryoblation catheter handle 有权
标题翻译：冷冻导管手柄
公开(公告)号：US06440126B1
公开(公告)日：2002-08-27
申请号：US09556042
申请日：2000-04-21
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M39/1011
摘要： A cryocatheter system includes a first handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; a second handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; and a catheter having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path. The distal end of the first handle portion is matable with the proximal end of the second handle portion to place the respective first and second fluid flow paths of each handle portion in fluid communication; and the distal end of the second handle portion is matable with the proximal end of the catheter to place the respective first and second fluid flow paths of the second handle portion and the catheter in fluid communication.
摘要翻译：一种低温切管系统包括具有近端，远端，第一流体流动路径和第二流体流路的第一手柄部分; 具有近端，远端，第一流体流动路径和第二流体流路的第二手柄部分; 以及具有近端，远端，第一流体流动路径和第二流体流动路径的导管。第一手柄部分的远端可与第二手柄部分的近端配合，以使每个手柄部分的相应的第一和第二流体流动路径流体连通; 并且第二手柄部分的远端可与导管的近端配合，以使第二手柄部分和导管的相应的第一和第二流体流动路径流体连通。

84. 发明授权

US09555223B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US09555223B2
公开(公告)日：2017-01-31
申请号：US12238865
申请日：2008-09-26
申请人： Marwan Abboud , Rachid Mahrouche
发明人： Marwan Abboud , Rachid Mahrouche
IPC分类号： A61B18/02 , A61M25/10 , A61B18/14 , A61B17/22 , A61B18/00
CPC分类号： A61M25/10187 , A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/10182 , A61M25/10185 , A61M2025/1013 , A61M2205/15 , A61M2205/3337
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，控制台，加压气体或液体充气源，以及将加压冷却剂输送到球囊导管的脐带系统。该系统可以包括监控气囊导管内的压力和体积的量的控制器。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

85. 发明授权

US08696656B2 System and method for monitoring bioimpedance and respiration 有权
标题翻译：监测生物阻抗和呼吸的系统和方法
公开(公告)号：US08696656B2
公开(公告)日：2014-04-15
申请号：US12355883
申请日：2009-01-19
申请人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/02
CPC分类号： A61B18/00 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B18/02 , A61B18/1492 , A61B2017/00026 , A61B2017/22051 , A61B2018/0022 , A61B2018/00702 , A61B2018/00875 , A61B2018/0212
摘要： A method of treating tissue is provided, including positioning a portion of a catheter in proximity to cardiac tissue; measuring an impedance value with the catheter; determining a respiratory rate based at least in part on the measured impedance value; and thermally treating the cardiac tissue with the catheter.
摘要翻译：提供一种治疗组织的方法，包括将导管的一部分定位在心脏组织附近; 用导管测量阻抗值; 至少部分地基于所测量的阻抗值确定呼吸频率; 并用导管热心处理心脏组织。

86. 发明授权

US08545491B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US08545491B2
公开(公告)日：2013-10-01
申请号：US11301768
申请日：2005-12-13
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted. In one embodiment, an intermediate console is placed between the console and the balloon catheter and coupled thereto. If a leak is detected, a shut off valve in the intermediate station is activated and the flow of pressurized coolant is interrupted. The balloon catheter can be re-inflated by a separate coolant source in the intermediate station or by a syringe. A further embodiment provides a second balloon to envelope the first balloon and in order to provide a safety vacuum between the two balloons.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括气囊导管，具有加压气体或液体充气源的控制台，以及将加压冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。在一个实施例中，将中间控制台放置在控制台和气囊导管之间并与其连接。如果检测到泄漏，则中间站中的截止阀被激活，并且加压冷却剂的流动被中断。气囊导管可以通过中间站中的单独的冷却剂源或注射器重新充气。另一实施例提供第二气囊以包围第一气囊并且为了在两个气球之间提供安全真空。

87. 发明授权

US08475440B2 Wide area ablation of myocardial tissue 有权
标题翻译：广泛消融心肌组织
公开(公告)号：US08475440B2
公开(公告)日：2013-07-02
申请号：US11953189
申请日：2007-12-10
申请人： Marwan Abboud , Fredric L. Milder , George Klein
发明人： Marwan Abboud , Fredric L. Milder , George Klein
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分心脏组织的形貌。消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

88. 发明授权

US08225643B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US08225643B2
公开(公告)日：2012-07-24
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： G01M3/26
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

89. 发明授权

US07740627B2 Surgical method and apparatus for treating atrial fibrillation 有权
标题翻译：用于治疗房颤的手术方法和装置
公开(公告)号：US07740627B2
公开(公告)日：2010-06-22
申请号：US11184045
申请日：2006-01-06
申请人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
发明人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

90. 发明授权

US07727228B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US07727228B2
公开(公告)日：2010-06-01
申请号：US10806995
申请日：2004-03-23
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter is provided. The system includes a balloon catheter, a console having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：提供了一种用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，具有加压气体或液体充气源的控制台，以及将加压的冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

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