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81. 发明授权

US08246651B2 Removable vena cava filter for reduced trauma in collapsed configuration 有权
标题翻译：可拆卸的腔静脉过滤器可减少塌陷形态的创伤
公开(公告)号：US08246651B2
公开(公告)日：2012-08-21
申请号：US12717637
申请日：2010-03-04
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne , Rolf Gunther
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery. In the expanded state, the secondary struts centralize the filter in the blood vessel and the anchoring hooks engage with the blood vessel.
摘要翻译：本发明提供了一种在血管中捕获血栓的方法，其包括在血管内以折叠状态递送可移除的过滤器，并将该过滤器展开至血管内的扩张状态。过滤器包括多个主支柱和从轮毂发出并沿着纵向轴线弧形延伸并且线性地径向延伸的多个辅助支柱。每个主支柱具有包括第一和第二弯曲部分的弓形段。每个辅助支柱包括第一和第二弧。主支柱终止于锚钩。每个主支柱在收缩状态下沿着纵向轴线跨越另一个主支柱，使得弓形段占据第一直径，并且锚定钩占据第二直径，第一直径大于用于过滤器取出或输送的第二直径。在扩张状态下，副支柱将过滤器集中在血管中，并且锚钩与血管接合。

82. 发明授权

US08246641B2 Thrombus removal device 有权
标题翻译：血栓清除装置
公开(公告)号：US08246641B2
公开(公告)日：2012-08-21
申请号：US11936525
申请日：2007-11-07
申请人： Thomas A. Osborne , Shyam Kuppurathanam
发明人： Thomas A. Osborne , Shyam Kuppurathanam
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/221 , A61B2017/00685 , A61B2017/00867 , A61B2017/2212 , A61B2217/005 , A61M1/0023
摘要： A thrombus removal device includes a shaft with a distal end and a proximal end, a sheath with a distal end and a proximal end, and a helical coil attached at a proximal end to the distal end of the shaft and is disposed within the lumen of the sheath in a closed configuration. The helical coil includes a plurality of body portions with turns spaced apart longitudinally and laterally to facilitate screwing the helical coil into a thrombus and also providing an open area into which the thrombus can be captured. A distal tip of the helical coil is provided with a loop, an angle of which is about the same as the angle of at least one body portion. The helical coil assumes an open configuration when the sheath is retracted proximally from the distal tip. An aspiration device may be provided in fluid communication with the center of the helical coil.
摘要翻译：血栓去除装置包括具有远端和近端的轴，具有远端和近端的护套，以及螺旋线圈，其在近端附接到轴的远端，并且设置在腔的内腔内护套处于闭合状态。螺旋线圈包括多个主体部分，其具有纵向和横向隔开的匝，以便于将螺旋线圈拧入血栓并且还提供可以捕获血栓的开放区域。螺旋线圈的远端设置有环，其角度与至少一个主体部分的角度大致相同。当护套从远侧末端向近侧缩回时，螺旋线圈呈现打开构型。可以提供与螺旋线圈的中心流体连通的抽吸装置。

83. 发明授权

US08167901B2 Removable vena cava filter comprising struts having axial bends 有权
标题翻译：可移动的腔静脉过滤器包括具有轴向弯曲的支柱
公开(公告)号：US08167901B2
公开(公告)日：2012-05-01
申请号：US11235801
申请日：2005-09-27
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/008
摘要： A removable vena cava filter configured for simplified delivery to and retrieval from the vena cava of a patient is disclosed. The filter includes struts configured to be arranged in consistent orientation together between expanded (opened) and collapsed (closed) configurations, thereby minimizing entanglement of the struts. Each of the struts has a circumferential bend relative to the longitudinal axis of the filter. The circumferential bends allow for consistent orientation of the struts when moved between the expanded and collapsed configurations and when placed in the closed configuration of the filter.
摘要翻译：公开了一种可移动的腔静脉过滤器，其被配置为简化输送到患者的腔静脉和从腔静脉取出。过滤器包括构造成在膨胀（打开）和折叠（闭合）构造之间一致定向布置的支柱，从而最小化支柱的缠结。每个支柱相对于过滤器的纵向轴线具有圆周弯曲。当在膨胀和收缩构型之间移动时以及当放置在过滤器的关闭构造中时，圆周弯曲允许支柱一致地定向。

84. 发明授权

US08057495B2 Aneurysm occlusion device 有权
标题翻译：动脉瘤闭塞装置
公开(公告)号：US08057495B2
公开(公告)日：2011-11-15
申请号：US11519366
申请日：2006-09-12
申请人： Dharmendra Pal , Roy S. Collins , Andrew W. Conder , Kian Olsen , Thomas A. Osborne
发明人： Dharmendra Pal , Roy S. Collins , Andrew W. Conder , Kian Olsen , Thomas A. Osborne
IPC分类号： A61B17/08
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/1215 , A61B2017/1205 , A61F2002/823
摘要： A system and method for occluding an aneurysm formed in a dilatation area of a body vessel are disclosed. The system comprises a wire guide, a core wire, and an occlusion device. The wire guide comprises a proximal end and a distal end, and has a passageway that extends from the proximal end to the distal end. The core wire comprises a distal end and a proximal end, and is disposed through the passageway so that the proximal end of the core wire proximally extends beyond the proximal end of the wire guide. The occlusion device comprises a distal end and a proximal end, and has a deployed state and an undeployed state. The occlusion device has a pre-set spiraled coil shape when in the deployed state in the vessel. The occlusion device is disposed distally from the core wire in the passageway.
摘要翻译：公开了一种用于闭塞在身体容器的扩张区域中形成的动脉瘤的系统和方法。该系统包括导线器，芯线和闭塞装置。线引导件包括近端和远端，并且具有从近端延伸到远端的通道。芯线包括远端和近端，并且穿过通道设置，使得芯线的近端近端延伸超过线引导件的近端。闭塞装置包括远端和近端，并且具有展开状态和未部署状态。当在容器中处于展开状态时，遮挡装置具有预定的螺旋形线圈形状。闭塞装置在通道中远离芯线设置。

85. 发明申请

US20110276024A1 Treatment Fluid Delivery Method, And Turbulator For Promoting Uptake Of A Treatment Agent 有权
标题翻译：处理流体输送方法和用于促进处理剂摄取的搅拌器
公开(公告)号：US20110276024A1
公开(公告)日：2011-11-10
申请号：US13101380
申请日：2011-05-05
申请人： James R. Randolph , Thomas A. Osborne
发明人： James R. Randolph , Thomas A. Osborne
IPC分类号： A61M5/00 , A61M25/00
CPC分类号： A61M25/0023 , A61B17/22 , A61M25/0021 , A61M25/0043 , A61M25/0067 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0102 , A61M2025/0057 , A61M2025/0063 , A61M2025/0073
摘要： A turbulator for promoting mixing of fluids passing through a body lumen includes an elongate flow perturbing component and an elongate shape controlling component freely slidable within the flow perturbing component. The turbulator is adjustable from a low profile, lumen access configuration to a deployed configuration via sliding the shape controlling component within the flow perturbing component. Adjusting the turbulator within a body lumen of a patient induces turbulence within a flow of fluid passing through the body lumen to increase mixing of a treatment fluid with the body fluid by way of the induced turbulence.
摘要翻译：用于促进通过体腔的流体的混合的湍流器包括细长的流动扰动部件和在流动扰动部件内可自由滑动的细长形状控制部件。通过在流动扰动部件内滑动形状控制部件，可以将紊流器从低轮廓，内腔存取配置调整到展开配置。调节患者体腔内的湍流器在通过体腔的流体流中引起湍流，以通过诱导的湍流增加治疗流体与体液的混合。

86. 发明授权

US08043322B2 Removable vena cava filter having inwardly positioned anchoring hooks in collapsed configuration 有权
标题翻译：可拆卸的腔静脉过滤器具有向内定位的收缩构型的锚定钩
公开(公告)号：US08043322B2
公开(公告)日：2011-10-25
申请号：US11108264
申请日：2005-04-18
申请人： Per Hendriksen , Allan Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
发明人： Per Hendriksen , Allan Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/008
摘要： The present invention involves a removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts and a plurality of secondary struts. The plurality of primary struts has first ends attached together along a longitudinal axis. Each primary strut has an arcuate segment extending from the first end to an anchoring hook. The primary struts are configured to move between an expanded state for engaging the anchoring hooks with the blood vessel and a collapsed state for filter retrieval or delivery. Each primary strut is configured to cross another primary strut along the longitudinal axis in the collapsed state such that each anchoring hook faces the longitudinal axis away from the blood vessel for filter retrieval or delivery. The plurality of secondary struts has connected ends attached together along the longitudinal axis. The secondary struts extend therefrom to free ends to centralize the filter in the expanded in the blood vessel.
摘要翻译：本发明涉及用于在血管中捕获血栓的可移除过滤器。过滤器包括多个主支柱和多个辅助支柱。多个主支柱具有沿着纵向轴线连接在一起的第一端。每个主支柱具有从第一端延伸到锚钩的弓形段。主支柱构造成在用于使锚钩与血管接合的扩张状态和用于过滤器取出或输送的折叠状态之间移动。每个主支柱构造成在收缩状态下沿着纵向轴线穿过另一个主支柱，使得每个锚定钩面向远离血管的纵向轴线用于过滤器取出或输送。多个辅助支柱具有沿着纵向轴线连接在一起的连接端。次级支柱从其延伸到自由端以将过滤器集中在血管中扩张的过滤器中。

87. 发明申请

US20110054585A1 PROSTHESIS DEPLOYMENT SYSTEM 有权
标题翻译： PROSTHESIS部署系统
公开(公告)号：US20110054585A1
公开(公告)日：2011-03-03
申请号：US12158400
申请日：2006-12-22
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2002/9511 , A61F2002/9517 , A61F2002/9665
摘要： A trigger wire release mechanism is disclosed that includes a control member for selectively releasing a trigger wire (22, 44) from a prosthesis retaining device. The control member includes an elongate body member (36) and a guide member (24, 25, 93, 94) slidably disposed on the elongate body member. The trigger wire 1 (22, 44) includes a distal end coupled to the prosthesis retaining device and a proximal end coupled to the guide member. The guide member (24, 25, 93, 94) can be moved from a distal end of the elongate body (36) to a proximal end of the elongate body, thereby disengaging the trigger wire (22, 44) from the retaining device. The control member may include a locking mechanism (120) for limiting the axial position of the guide member (24, 25, 93, 94) along the elongate body member (36). A prosthesis control member (81) is also disclosed. The prosthesis control member (81) is adapted to control the position of the prosthesis during deployment.
摘要翻译：公开了一种触发线释放机构，其包括用于从假体保持装置选择性地释放触发线（22,44）的控制构件。控制构件包括细长主体构件（36）和可滑动地设置在细长主体构件上的引导构件（24,25,93,94）。触发线1（22,44）包括联接到假体保持装置的远端和联接到引导构件的近端。引导构件（24,25,93,94）可以从细长体（36）的远端移动到细长体的近端，从而使触发线（22,44）与保持装置分离。控制构件可以包括用于限制引导构件（24,25,93,94）沿着细长主体构件（36）的轴向位置的锁定机构（120）。还公开了假体控制构件（81）。假体控制构件（81）适于在展开期间控制假体的位置。

88. 发明申请

US20100211087A1 LOOP THROMBECTOMY DEVICE 有权
标题翻译：环路造影装置
公开(公告)号：US20100211087A1
公开(公告)日：2010-08-19
申请号：US12372352
申请日：2009-02-17
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/320708 , A61B2017/320716 , A61B2017/320733
摘要： A thrombectomy device may include an elongate torsion member having a proximal end and a distal end, and a plurality of helically arranged engagement members disposed at a distal portion of the elongate torsion member. Preferably, at least a portion of the engagement members has a rounded, atraumatic shape. The engagement members have a collapsed state where the engagement members are compressed toward the elongate torsion member, and an expanded state where the engagement members are expanded radially outward. Preferably, the engagement members are attached to and extends radially outward from the elongate torsion member at a different longitudinal point such that the engagement members are spaced longitudinally and circumferentially from each other when in the expanded state. When the thrombectomy device is deployed in a body lumen or cavity, the engagement members expands out to contact a wall of the body lumen or cavity.
摘要翻译：血栓切除装置可以包括具有近端和远端的细长扭转构件，以及设置在细长扭转构件的远侧部分处的多个螺旋布置的接合构件。优选地，至少一部分接合构件具有圆形的无创伤形状。接合构件具有接合构件朝向细长扭转构件被压缩的折叠状态，以及接合构件径向向外延伸的展开状态。优选地，接合构件在不同的纵向点处从细长扭转构件附接并径向向外延伸，使得接合构件在处于膨胀状态时彼此纵向和周向间隔开。当血栓切除装置部署在体腔或空腔中时，接合构件膨胀以接触体腔或空腔的壁。

89. 发明授权

US07763045B2 Removable vena cava filter 有权
标题翻译：可移动的腔静脉过滤器
公开(公告)号：US07763045B2
公开(公告)日：2010-07-27
申请号：US10776721
申请日：2004-02-11
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/0078 , A61F2230/008
摘要： A removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends connected to each other to define a central axis of the filter. Each primary strut has a curved member extending from the central axis and terminates at an anchoring hook to engage the blood vessel at a first axial plane. The filter further comprises a plurality of secondary struts connected to the curved members of the primary struts and extending therefrom to a free end at a second axial plane to centralize the filter in the blood vessel.
摘要翻译：用于在血管中捕获血栓的可移除的过滤器。过滤器包括多个主支柱，其具有彼此连接以限定过滤器的中心轴线的第一端。每个主支柱具有从中心轴线延伸的弯曲构件，并终止于锚定钩以在第一轴向平面处接合血管。过滤器还包括连接到主支柱的弯曲构件并从其延伸到第二轴向平面处的自由端的多个次撑杆，以将过滤器集中在血管中。

90. 发明授权

US07749196B2 Small gauge needle catheterization apparatus 有权
标题翻译：小规格针导管装置
公开(公告)号：US07749196B2
公开(公告)日：2010-07-06
申请号：US10879409
申请日：2004-06-29
申请人： Thomas A. Osborne , David G. Burton
发明人： Thomas A. Osborne , David G. Burton
IPC分类号： A61M5/178
CPC分类号： A61M25/008 , A61M25/0105 , A61M2025/0063 , A61M2025/0081
摘要： An apparatus for percutaneous catheterization. The apparatus comprises a catheter, and an inner cannula received within the lumen of the catheter. The inner cannula has a distal portion that tapers toward the distal end, and is sized to extend through the distal opening of the catheter to provide a generally smooth diametrical transition between the distal end of the catheter and the distal open end of the inner cannula. A stiffening cannula is sized to be received in the lumen of the inner catheter, and has an inner diameter sized to receive a wire guide therethrough. The stiffening cannula as a distal section of greater flexibility than the flexibility of a proximal section for providing kink resistance to the apparatus.
摘要翻译：一种用于经皮导管插入术的装置。该装置包括导管和容纳在导管内腔内的内插管。内套管具有朝向远端逐渐变细的远侧部分，并且其尺寸设置成延伸穿过导管的远端开口，以在导管的远端和内套管的远端开口端之间提供大致平滑的直径过渡。加强插管的尺寸被设计成容纳在内导管的内腔中，并且具有尺寸适于容纳线引导件的内径。作为远端部分的加强插管具有比用于向装置提供扭结阻力的近端部分的柔性更大的灵活性。

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