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81. 发明申请

US20070179591A1 INTRALUMINAL GRAFTING SYSTEM 审中-公开
标题翻译：腹腔牵引系统
公开(公告)号：US20070179591A1
公开(公告)日：2007-08-02
申请号：US11625755
申请日：2007-01-22
申请人： Steven Baker , Dinah Quiachon , Alec Piplani , Wesley Sterman , Ronald Williams
发明人： Steven Baker , Dinah Quiachon , Alec Piplani , Wesley Sterman , Ronald Williams
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/11 , A61F2/04 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/958 , A61F2002/075 , A61F2002/3008 , A61F2002/30451 , A61F2002/8486 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0098 , A61M25/10 , A61M2025/1068
摘要： An intraluminal grafting system having a delivery catheter comprising a flexible elongate tubular member having proximal and distal extremities and a capsule mounted on the distal extremity of the tubular member and including a graft disposed within the capsule. The graft is comprised of a tubular body configured to be secured to a blood vessel by a self expanding attachment system. The attachment system comprises a generally sinusoidal wire frame having apices which extend longitudinally outward from the end of the tubular body apices which are secured within the tubular body. Both the protruding apices and the base apices are formed with helices which bias the attachment system radially outward. The attachment system further includes a plurality of lumen piercing members that are oriented in a responsive relationship to the radially outward bias of the attachment system. Furthermore, the graft may be configured with a plurality of synthetic fiber tufts secured to the outer surface of the tubular body to facilitate sealing the graft within the vessel. The graft may also include a plurality of crimps formed in the tubular body of the graft.
摘要翻译：一种管腔内接枝系统，其具有递送导管，其包括具有近端和远端的柔性细长管状构件和安装在管状构件的远端上的胶囊，并且包括设置在囊内的移植物。移植物由构造成通过自扩张附接系统固定到血管的管状体构成。连接系统包括大致正弦的线框架，其具有从管状体顶点的端部纵向向外延伸的顶点，其固定在管状体内。突出的顶点和基部顶点均形成有将附件系统径向向外偏置的螺旋。附接系统还包括多个内腔穿刺构件，其以与附接系统的径向向外偏置成反应的关系定向。此外，移植物可以配置有固定到管状体的外表面的多个合成纤维束，以便于将移植物密封在血管内。移植物还可以包括形成在移植物的管状体中的多个卷曲。

82. 发明授权

US07204313B2 Equalizing flapper for high slam rate applications 有权
标题翻译：平衡挡板适用于高速弹药应用
公开(公告)号：US07204313B2
公开(公告)日：2007-04-17
申请号：US11031585
申请日：2005-01-07
申请人： Ronald Williams , Van McVicker , Scott Strattan , Jason B. Ives
发明人： Ronald Williams , Van McVicker , Scott Strattan , Jason B. Ives
IPC分类号： E21B34/14
CPC分类号： F16K39/024 , E21B34/101 , E21B2034/005 , F16K15/181
摘要： A flapper valve assembly is described having an equalizing port assembly with a bleed valve member that is moveable between an open position and a closed position. The equalizing port assembly features a structural support member in the form of a retainer key that is secured to the flapper valve member both axially and radially. Additionally, a compressible spring is located between the structural support member and provides biasing force upon the valve member to urge it toward a closed position. Additionally, the flapper valve member presents a pair of raised, substantially flat actuator contact portions upon its downstream face to meet an actuating tube in a mating contact arrangement and resist material deformation that could tend to clog or block the equalizing fluid flow port.
摘要翻译：描述了一种瓣阀组件，其具有均衡端口组件，其具有可在打开位置和关闭位置之间移动的排放阀构件。平衡端口组件具有保持键形式的结构支撑构件，其沿轴向和径向固定到挡板阀构件。此外，可压缩弹簧位于结构支撑构件之间，并且在阀构件上提供偏压力以将其推向关闭位置。此外，挡板阀构件在其下游面上呈现一对凸起的，基本上平坦的致动器接触部分，以与配合接触装置中的致动管相遇，并抵抗容易堵塞或阻塞均衡流体流动端口的材料变形。

83. 发明授权

US07081112B2 Cryogenically enhanced intravascular interventions 有权
标题翻译：低密度血管内介入治疗
公开(公告)号：US07081112B2
公开(公告)日：2006-07-25
申请号：US10215357
申请日：2002-08-07
申请人： James Joye , Kristine Tatsutani , Ronald Williams , Richard S. Williams
发明人： James Joye , Kristine Tatsutani , Ronald Williams , Richard S. Williams
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22002 , A61B2017/22062 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The invention provides techniques and devices for treating atherosclerotic disease using controlled cryogenic cooling, often in combination with angioplusty. The efficacy of endolusninal cryogenic cooling is enhanced by cooling of target tissues using an insulated cryogenic balloon, the lnsulation ideally comprising a fluid which undergoes a phase change at a predetermined temperature. A combination cryogenic/angioplasty catheter avoids exchange procedures between dilation of a stenotic region within a vessel wall and the application of cryogenic cooling. The combination angioplasty/cryogenic cooling catheter may cool the diseased blood vessel before, during, and/or after dilation. Controlled cooling of the vessel wall may change its mechanical properties, weakening the vessel and allowing it to be expanded at a much lower pressure than with conventional uncooled angioplasty. Similar reductions in restenosis may be provided for other primary treatments of the blood vessel, including directional arthrectomy, rotational arthrectomy, laser angioplasty, stenting, and the like.
摘要翻译：本发明提供了使用受控低温冷却治疗动脉粥样硬化疾病的技术和装置，其通常与血管舒张相结合。通过使用绝热低温球体冷却靶组织来增强内膜下低温冷却的功效，理想地包括在预定温度下经历相变的流体。组合式低温/血管成形术导管避免血管壁内狭窄区域的扩张与低温冷却的应用之间的交换程序。组合血管成形术/低温冷却导管可以在扩张之前，期间和/或之后冷却患病血管。容器壁的受控冷却可能改变其机械性能，弱化容器并允许其以比常规非冷却血管成形术更低的压力膨胀。对于血管的其他主要治疗可以提供再狭窄的类似减少，包括定向性关节切除术，旋转关节切除术，激光血管成形术，支架置入术等。

84. 发明授权

US06972015B2 Cryosurgical fluid supply 有权
标题翻译：冷冻液供应
公开(公告)号：US06972015B2
公开(公告)日：2005-12-06
申请号：US10785503
申请日：2004-02-23
申请人： James Joye , Richard S. Williams , Ronald Williams
发明人： James Joye , Richard S. Williams , Ronald Williams
IPC分类号： F25D3/10 , A61B17/00 , A61B17/22 , A61B18/02 , A61F7/12 , A61M25/00 , A61B18/18
CPC分类号： A61B18/0218 , A61B18/02 , A61B2017/00292 , A61B2017/22054 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Improved systems, devices, and methods for delivering cryogenic cooling fluid to cryosurgical probes such as cryosurgical endovascular balloon catheters take advantage of the transients during the initiation and termination of cryogenic fluid flow to moderate the treatment temperatures of tissues engaged by the probe. A flow limiting element along a cryogenic fluid path intermittently interrupts the flow of cooling fluid, often cycling both the fluid flow and treatment temperature. This can maintain the tissue treatment temperature within a predetermined range which is above the treatment temperature provided by a steady flow of cryogenic fluid. In another aspect, room temperature single-use cooling fluid cartridges are filled with a sufficient quantity of cryosurgical fluid to effect a desired endovascular cryosurgical treatment.
摘要翻译：用于将低温冷却流体递送到诸如冷冻手术血管内气囊导管的冷冻手术探针的改进的系统，装置和方法利用在低温流体流动的起始和终止期间的瞬变以缓和由探针接合的组织的治疗温度。沿着低温流体路径的限流元件间歇性地中断冷却流体的流动，通常循环流体流动和处理温度。这可以将组织处理温度保持在由稳定流动的低温流体提供的处理温度之上的预定范围内。在另一方面，室温一次性冷却流体筒填充足够量的冷冻手术液以实现所需的血管内冷冻治疗。

85. 发明申请

US20050209587A1 Apparatus and method for cryogenic inhibition of hyperplasia 审中-公开
标题翻译：低温抑制增生的装置和方法
公开(公告)号：US20050209587A1
公开(公告)日：2005-09-22
申请号：US11122165
申请日：2005-05-04
申请人： James Joye , Ronald Williams
发明人： James Joye , Ronald Williams
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/02 , A61M25/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0275
摘要： Post-angioplasty hyperplasia in blood vessels is treated using a cryosurgical balloon catheter. The balloon catheter is positioned at a target region within the blood vessel, and the balloon inflated by expanding a cryogenic fluid, such as liquid nitrogen, across an expansion orifice into a balloon. The balloon will be constructed so that cooling is achieved primarily in the central regions of the balloon, with the proximal and distal regions being less cold and acting to insulate adjacent regions of the blood vessel from excessive cooling.
摘要翻译：使用冷冻手术气囊导管治疗血管内血管成形术后增生。气囊导管位于血管内的目标区域，并且球囊通过将低温液体（例如液氮）膨胀穿过扩张孔而膨胀成球囊。气囊将被构造成主要在气球的中心区域中实现冷却，其中近端区域和远端区域较不冷，并且用于使血管的相邻区域绝缘而不会过度冷却。

86. 植物专利

USPP14791P2 Rhamnus plant named ‘Ron Williams’ 有权
标题翻译： Rhamnus植物命名为“Ron Williams”
公开(公告)号：USPP14791P2
公开(公告)日：2004-05-18
申请号：US10624108
申请日：2003-07-21
申请人： Ronald Williams
发明人： Ronald Williams
IPC分类号： A01H500
CPC分类号： A01H5/00
摘要： A new and distinct cultivar of Rhamnus plant named ‘Ron Williams’, characterized by its upright and columnar plant habit; freely branching growth habit; linear undulate foliage which gives a feathery appearance to the plant; low seed set; and nonviable seed.
摘要翻译：一种新颖而独特的品种为“Ron Williams”的Rhamnus植物，其特征是其直立和柱状的植物习性; 自由分支生长习惯; 线性起伏的叶子，给植物带来羽毛状的外观; 低种子集和不可食用的种子。

87. 发明授权

US06432102B1 Cryosurgical fluid supply 有权
公开(公告)号：US06432102B1
公开(公告)日：2002-08-13
申请号：US09268205
申请日：1999-03-15
申请人： James Joye , Richard S. Williams , Ronald Williams
发明人： James Joye , Richard S. Williams , Ronald Williams
IPC分类号： A61B1818
摘要： Improved systems, devices, and methods for delivering cryogenic cooling fluid to cryosurgical probes such as cryosurgical endovascular balloon catheters take advantage of the transients during the initiation and termination of cryogenic fluid flow to moderate the treatment temperatures of tissues engaged by the probe. A flow limiting element along a cryogenic fluid path intermittently interrupts the flow of cooling fluid, often cycling both the fluid flow and treatment temperature. This can maintain the tissue treatment temperature within a predetermined range which is above the treatment temperature provided by a steady flow of cryogenic fluid. In another aspect, room temperature single-use cooling fluid cartridges are filled with a sufficient quantity of cryosurgical fluid to effect a desired endovascular cryosurgical treatment.

88. 发明授权

US06355029B1 Apparatus and method for cryogenic inhibition of hyperplasia 有权
标题翻译：低温抑制增生的装置和方法
公开(公告)号：US06355029B1
公开(公告)日：2002-03-12
申请号：US09203011
申请日：1998-12-01
申请人： James Joye , Ronald Williams
发明人： James Joye , Ronald Williams
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0275
摘要： Post-angioplasty hyperplasia in blood vessels is treated using a cryosurgical balloon catheter. The balloon catheter is positioned at a target region within the blood vessel, and the balloon inflated by expanding a cryogenic fluid, such as liquid nitrogen, across an expansion orifice into a balloon. The balloon will be constructed so that cooling is achieved primarily in the central regions of the balloon, with the proximal and distal regions being less cold and acting to insulate adjacent regions of the blood vessel from excessive cooling.
摘要翻译：使用冷冻手术气囊导管治疗血管内血管成形术后增生。气囊导管位于血管内的目标区域，并且球囊通过将低温液体（例如液氮）膨胀穿过扩张孔而膨胀成球囊。气囊将被构造成主要在气球的中心区域中实现冷却，其中近端区域和远端区域较不冷，并且用于使血管的相邻区域绝缘而不会过度冷却。

89. 发明授权

US06328062B1 Torsion spring connections for downhole flapper 有权
标题翻译：井下挡板的扭转弹簧连接
公开(公告)号：US06328062B1
公开(公告)日：2001-12-11
申请号：US09481590
申请日：2000-01-12
申请人： Ronald Williams , Michael S. Rawson
发明人： Ronald Williams , Michael S. Rawson
IPC分类号： F16K1503
CPC分类号： E21B34/06 , E21B2034/005 , F16K15/033 , Y10T137/7898 , Y10T137/79
摘要： A torsion spring return system for a valve closure member, preferably for downhole use in an SSV, is described. The closure member or flapper uses torsion springs which can be wrapped circumferentially within the body of the downhole tool, generally following the periphery of the flapper. Downward rotation of the flapper stresses the torsion springs so that subsequently, when a flow tube or other device holding the flapper in one position is released, the torsion springs return the flapper to its seat. The connection between the torsion springs and the pin supporting the flapper is either a universal joint or involves an alignment rod running through the torsion spring, as well as other mechanisms which facilitate stress relief in the connection between the torsion spring and pivot pin.
摘要翻译：描述了用于阀关闭构件的扭转弹簧返回系统，优选地用于SSV中的井下使用。封闭构件或挡板使用扭转弹簧，其可以围绕在井下工具的主体内沿圆周包裹，通常沿挡板的周边。挡板的向下旋转迫使扭转弹簧使得随后，当将挡板保持在一个位置的流动管或其它装置被释放时，扭转弹簧将挡板返回到其座椅。扭转弹簧和支撑挡板的销之间的连接是万向接头，或涉及穿过扭转弹簧的对准杆以及促进扭转弹簧和枢转销之间的连接中的应力释放的其它机构。

90. 外观设计

USD416358S Spray hood for use with a life jacket 失效
公开(公告)号：USD416358S
公开(公告)日：1999-11-09
申请号：US59480
申请日：1996-09-12
申请人： Ronald Williams , James David Oliver
设计人： Ronald Williams , James David Oliver

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